ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Other fruit (ukb-b-18659)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Other fruit (👉 📊) Knee osteoarthritis (ebi-a-GCST007090) Weighted median 20 0.53537277 0.260843873 0.040124549
Other fruit (👉 📊) Knee osteoarthritis (ebi-a-GCST007090) Inverse variance weighted 20 0.378285481 0.187077789 0.043168515
Other fruit (👉 📊) Osteoarthritis (hip) (ebi-a-GCST007091) MR Egger 19 1.067819785 0.455123583 0.031347129
Other fruit (👉 📊) Osteoarthritis of the hip or knee (ebi-a-GCST007092) Inverse variance weighted 20 0.366772914 0.155508511 0.018347024
Other fruit (👉 📊) Bone mineral density (ebi-a-GCST90014022) MR Egger 16 0.25787359 0.119482627 0.048761371
Other fruit (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017138) MR Egger 13 -4.495613531 2.031270646 0.048943771
Other fruit (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017138) Inverse variance weighted 13 -1.784750266 0.866329242 0.03938618
Other fruit (👉 📊) Achilles tendon injury (ebi-a-GCST90018787) MR Egger 19 1.651725787 0.640208715 0.019468958
Other fruit (👉 📊) Bone disorder (ebi-a-GCST90038652) Inverse variance weighted 15 -0.016781841 0.00800386 0.036018504
Other fruit (👉 📊) Joint disorder (ebi-a-GCST90038654) Weighted median 15 0.04461698 0.019739955 0.023806532
Other fruit (👉 📊) Joint disorder (ebi-a-GCST90038654) Inverse variance weighted 15 0.032999365 0.014898104 0.026759768
Other fruit (👉 📊) Osteoporosis (ebi-a-GCST90038656) Inverse variance weighted 15 -0.019031004 0.008109161 0.01893275
Other fruit (👉 📊) Spine arthritis or spondylitis (ebi-a-GCST90038657) Inverse variance weighted 15 0.008876883 0.004226697 0.035711793
Other fruit (👉 📊) Fractures (ebi-a-GCST90038703) Inverse variance weighted 15 0.013315459 0.006050095 0.027745395
Other fruit (👉 📊) Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) Inverse variance weighted 20 -5.141383003 2.280606368 0.024171456
Other fruit (👉 📊) Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) Inverse variance weighted 20 -5.091789751 2.292269148 0.026331467
Other fruit (👉 📊) Cervicalgia (finn-b-M13_CERVICALGIA) Inverse variance weighted 20 -0.985569405 0.450148224 0.028565379
Other fruit (👉 📊) Chondromalacia (finn-b-M13_CHONDROMALACIA) Inverse variance weighted 20 2.889559721 1.221367492 0.017989231
Other fruit (👉 📊) Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) MR Egger 20 -4.437503814 1.715751499 0.018626589
Other fruit (👉 📊) Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) Inverse variance weighted 20 -0.817283637 0.365579249 0.025378941
Other fruit (👉 📊) Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) Weighted median 20 -0.680073289 0.272792936 0.012666819
Other fruit (👉 📊) Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) Inverse variance weighted 20 -0.714833597 0.209199888 0.00063318
Other fruit (👉 📊) Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) Weighted mode 20 -0.867207906 0.39953195 0.042844112
Other fruit (👉 📊) Other joint disorders (finn-b-M13_OTHERJOINT) MR Egger 20 0.88685903 0.285749819 0.006130569
Other fruit (👉 📊) Peroneal tendinitis (finn-b-M13_PERONEALTEND) Inverse variance weighted 20 -6.1100767 2.063290453 0.00306317
Other fruit (👉 📊) Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) Inverse variance weighted 20 -5.72296776 2.502541851 0.022203882
Other fruit (👉 📊) Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) MR Egger 20 10.25280387 4.763261177 0.04517532
Other fruit (👉 📊) Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) Inverse variance weighted 20 6.716623324 2.522232708 0.007745493
Other fruit (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) MR Egger 20 1.026500723 0.453489372 0.036194683
Other fruit (👉 📊) Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) Weighted median 20 -4.149533082 2.063423027 0.044326001
Other fruit (👉 📊) Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) Inverse variance weighted 20 -0.436474741 0.193358304 0.023987062
Other fruit (👉 📊) Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) MR Egger 20 -6.487942732 2.910378031 0.038776071
Other fruit (👉 📊) Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) Inverse variance weighted 20 -4.555515819 1.546636038 0.00322501
Other fruit (👉 📊) Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) Inverse variance weighted 20 -2.90483293 1.319707872 0.027727662
Other fruit (👉 📊) Osteocalcin (prot-a-246) Weighted median 19 -1.489127819 0.643826639 0.020726328
Other fruit (👉 📊) Osteocalcin (prot-a-246) Inverse variance weighted 19 -1.175976835 0.497248257 0.018031568
Other fruit (👉 📊) Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) MR Egger 19 0.021271385 0.00856055 0.023671558
Other fruit (👉 📊) Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) Weighted median 19 0.012033703 0.005756965 0.036592136
Other fruit (👉 📊) Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) Inverse variance weighted 19 0.009245454 0.004384058 0.034954886
Other fruit (👉 📊) Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) Inverse variance weighted 4 -0.03654064 0.016989628 0.031495024
Other fruit (👉 📊) Diagnoses - main ICD10: M25.5 Pain in joint (ukb-b-13019) Wald ratio 1 -0.022967138 0.010727254 0.032273391
Other fruit (👉 📊) Operative procedures - secondary OPCS: Z48.2 Skin of neck (ukb-b-14873) Inverse variance weighted 3 -0.019588086 0.009056764 0.030555582
Other fruit (👉 📊) Fractured bone site(s): Leg (ukb-b-3798) Weighted median 3 0.023917073 0.011010796 0.029844543
Other fruit (👉 📊) Fractured bone site(s): Leg (ukb-b-3798) Inverse variance weighted 3 0.024167819 0.008674267 0.0053338
Other fruit (👉 📊) Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) Inverse variance weighted 3 0.019998839 0.010010291 0.045735326
Other fruit (👉 📊) Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement (ukb-b-8136) Inverse variance weighted 2 -0.027595715 0.009838498 0.005033674
Other fruit (👉 📊) Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) Inverse variance weighted 13 0.007410611 0.003326073 0.025878127

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Other fruit Knee osteoarthritis (ebi-a-GCST007090) All - Inverse variance weighted 0.378285481499209 0.187077788990663 0.0431685152184265
Other fruit Osteoarthritis (hip) (ebi-a-GCST007091) rs77486291 2.26615249454673 1.09749655834932 0.0389383400003446
Other fruit Osteoarthritis (hip) (ebi-a-GCST007091) All - MR Egger 1.06781978475103 0.455123583449089 0.0313471293577065
Other fruit Osteoarthritis of the hip or knee (ebi-a-GCST007092) All - Inverse variance weighted 0.366772914278153 0.155508511242864 0.0183470236633237
Other fruit Bone mineral density (ebi-a-GCST90014022) rs1261880 0.392663747678487 0.189276227702673 0.0380278928584714
Other fruit Bone mineral density (ebi-a-GCST90014022) rs150927868 0.355504713534492 0.171383634991555 0.0380494868726158
Other fruit Bone mineral density (ebi-a-GCST90014022) rs77245046 -0.580823484559664 0.184373127825282 0.0016312463034923
Other fruit Bone mineral density (ebi-a-GCST90014022) All - MR Egger 0.25787359029238 0.119482627027256 0.0487613711259972
Other fruit Neck circumference (BMI adjusted) (ebi-a-GCST90017138) All - Inverse variance weighted -1.78475026563143 0.866329241771642 0.0393861802580105
Other fruit Neck circumference (BMI adjusted) (ebi-a-GCST90017138) All - MR Egger -4.49561353104997 2.0312706456925 0.0489437706309103
Other fruit Achilles tendon injury (ebi-a-GCST90018787) All - MR Egger 1.6517257867465 0.640208715274771 0.0194689580458638
Other fruit Bone disorder (ebi-a-GCST90038652) rs2980435 -0.0703371332926195 0.0268997534550225 0.008928304055196
Other fruit Bone disorder (ebi-a-GCST90038652) All - Inverse variance weighted -0.0167818412024952 0.0080038600468646 0.0360185043847496
Other fruit Joint disorder (ebi-a-GCST90038654) All - Inverse variance weighted 0.0329993652154891 0.0148981042153296 0.0267597679192753
Other fruit Osteoporosis (ebi-a-GCST90038656) rs118011111 -0.0516205578858527 0.0232711857937171 0.0265399876060039
Other fruit Osteoporosis (ebi-a-GCST90038656) rs28541551 -0.0606390600372546 0.0231596621365929 0.0088367772005778
Other fruit Osteoporosis (ebi-a-GCST90038656) rs2980435 -0.0686995317907308 0.0229427065662392 0.0027498945222457
Other fruit Osteoporosis (ebi-a-GCST90038656) rs75464830 0.0638694352670559 0.0238771638084494 0.0074747716918777
Other fruit Osteoporosis (ebi-a-GCST90038656) All - Inverse variance weighted -0.0190310044247823 0.0081091609720654 0.0189327497786418
Other fruit Spine arthritis or spondylitis (ebi-a-GCST90038657) rs2980435 0.0357282689828323 0.0169525118183258 0.0350699186226294
Other fruit Spine arthritis or spondylitis (ebi-a-GCST90038657) rs77245046 0.0414969228255542 0.017165016883612 0.0156262969640033
Other fruit Spine arthritis or spondylitis (ebi-a-GCST90038657) All - Inverse variance weighted 0.0088768833165787 0.004226697140389 0.0357117926444573
Other fruit Fractures (ebi-a-GCST90038703) rs4777390 0.0534346107463486 0.0245993568270133 0.0298409244342443
Other fruit Fractures (ebi-a-GCST90038703) All - Inverse variance weighted 0.0133154592372027 0.0060500954203703 0.0277453953084834
Other fruit Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) rs9902992 -21.7932668813303 9.62304443001453 0.0235313624786751
Other fruit Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) All - Inverse variance weighted -5.1413830029786 2.28060636759219 0.0241714560417144
Other fruit Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) rs9902992 -21.6459924622275 9.61969728412583 0.0244379037511494
Other fruit Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) All - Inverse variance weighted -5.09178975065203 2.29226914831786 0.0263314670559871
Other fruit Cervicalgia (finn-b-M13_CERVICALGIA) rs926923 -5.13617152293783 2.24620035267445 0.022218926448705
Other fruit Cervicalgia (finn-b-M13_CERVICALGIA) All - Inverse variance weighted -0.98556940505163 0.450148223847354 0.0285653786627448
Other fruit Chondromalacia (finn-b-M13_CHONDROMALACIA) All - Inverse variance weighted 2.88955972072117 1.22136749197683 0.0179892307129658
Other fruit Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) All - MR Egger -4.43750381421526 1.71575149892223 0.0186265887144628
Other fruit Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) rs181962294 -3.21402991688609 1.57416615568529 0.0411778387760265
Other fruit Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) rs75464830 -2.63539598701898 1.24902019676647 0.0348608819017275
Other fruit Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) rs926923 -3.91860497662832 1.81935231057743 0.0312522388569388
Other fruit Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) All - Inverse variance weighted -0.817283636737661 0.365579248821134 0.0253789408444161
Other fruit Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) rs150927868 -3.72770504174503 1.54282907897416 0.0156856382183082
Other fruit Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) rs926923 -3.27483415903938 0.986648753043916 0.0009029225784162
Other fruit Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) All - Inverse variance weighted -0.714833596653479 0.209199887618373 0.0006331796926924
Other fruit Other joint disorders (finn-b-M13_OTHERJOINT) All - MR Egger 0.88685903042803 0.285749819421594 0.0061305689518043
Other fruit Peroneal tendinitis (finn-b-M13_PERONEALTEND) rs118011111 -20.3280134700127 8.96162997332293 0.0233085614563915
Other fruit Peroneal tendinitis (finn-b-M13_PERONEALTEND) rs181906823 -15.0828206481206 7.31663458392168 0.0392608547259058
Other fruit Peroneal tendinitis (finn-b-M13_PERONEALTEND) rs183744115 -18.8445127564703 8.42759592369333 0.0253485980033174
Other fruit Peroneal tendinitis (finn-b-M13_PERONEALTEND) All - Inverse variance weighted -6.11007670015197 2.06329045298521 0.0030631702150251
Other fruit Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) rs926923 -25.7998152657654 12.3925882385871 0.0373539211013497
Other fruit Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) All - Inverse variance weighted -5.72296776043608 2.502541850714 0.022203881608499
Other fruit Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs118011111 25.4577302010747 10.6241756191074 0.016565705512372
Other fruit Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs183744115 24.5983332933068 10.1107135137731 0.0149785254342249
Other fruit Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs28541551 33.2609550262509 13.6049173160507 0.0144942732084648
Other fruit Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) All - Inverse variance weighted 6.71662332378033 2.52223270831021 0.0077454931616477
Other fruit Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) All - MR Egger 10.2528038684852 4.76326117667355 0.0451753196101171
Other fruit Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) rs150927868 -4.34579495226573 1.88062240216571 0.0208423558574396
Other fruit Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) rs2980435 -2.3184275406573 1.06308384791115 0.0291944342408815
Other fruit Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) All - MR Egger 1.02650072274258 0.453489371616906 0.0361946826405128
Other fruit Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) rs4777390 -2.49564518290232 0.979833846978427 0.010865077204122
Other fruit Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) All - Inverse variance weighted -0.436474741305898 0.193358304458894 0.0239870617434296
Other fruit Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) All - Inverse variance weighted -4.55551581905187 1.54663603847323 0.0032250096933761
Other fruit Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) All - MR Egger -6.48794273216574 2.91037803148392 0.0387760709134321
Other fruit Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) rs926923 -15.0516416155849 6.54966831807876 0.0215574114242074
Other fruit Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) All - Inverse variance weighted -2.90483292956752 1.31970787218781 0.0277276618118511
Other fruit Osteocalcin (prot-a-246) All - Inverse variance weighted -1.17597683469034 0.497248257297381 0.0180315683561201
Other fruit Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) All - Inverse variance weighted 0.0092454543603216 0.0043840576951601 0.0349548864358923
Other fruit Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) All - MR Egger 0.0212713846690453 0.0085605497144736 0.0236715580897439
Other fruit Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) rs28541551 -0.0559484313747102 0.0236868480900577 0.0181764431044064
Other fruit Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) rs2980435 -0.0745696772296487 0.023904853995612 0.001811972312013
Other fruit Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) All - Inverse variance weighted -0.0365406398722293 0.0169896284339128 0.0314950240704487
Other fruit Diagnoses - main ICD10: M25.5 Pain in joint (ukb-b-13019) rs4777390 -0.022967137880209 0.0107272544553129 0.0322733908726424
Other fruit Operative procedures - secondary OPCS: Z48.2 Skin of neck (ukb-b-14873) rs926923 -0.0313365241973857 0.0150538108433398 0.0373759150633018
Other fruit Operative procedures - secondary OPCS: Z48.2 Skin of neck (ukb-b-14873) All - Inverse variance weighted -0.0195880859136494 0.0090567644520103 0.0305555821522465
Other fruit Fractured bone site(s): Leg (ukb-b-3798) All - Inverse variance weighted 0.0241678189752289 0.008674267060793 0.0053337997613869
Other fruit Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) All - Inverse variance weighted 0.0199988387027576 0.010010291230456 0.0457353258504868
Other fruit Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement (ukb-b-8136) rs926923 -0.0306565762588519 0.0134548800626977 0.0226984320922946
Other fruit Operative procedures - main OPCS: W38.1 Primary total prosthetic replacement of hip joint not using cement (ukb-b-8136) All - Inverse variance weighted -0.0275957153726204 0.0098384976058846 0.0050336740878601
Other fruit Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) All - Inverse variance weighted 0.0074106108268631 0.0033260734912342 0.0258781274930067