ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Grapefruit (ukb-b-18758)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Grapefruit (👉 📊) Heel bone mineral density (ebi-a-GCST006288) Weighted median 16 -0.340588911 0.162981012 0.036640627
Grapefruit (👉 📊) Heel bone mineral density (ebi-a-GCST006288) Inverse variance weighted 16 -0.282318787 0.123198265 0.021929841
Grapefruit (👉 📊) Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) Inverse variance weighted 16 3.024343643 1.445265661 0.036386068
Grapefruit (👉 📊) Bone mineral density (ebi-a-GCST90014022) Inverse variance weighted 12 -0.188762737 0.087225579 0.030458556
Grapefruit (👉 📊) Neck circumference (ebi-a-GCST90017135) Inverse variance weighted 12 -4.280870009 2.04013743 0.035876505
Grapefruit (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017138) Inverse variance weighted 13 -3.58199544 1.679083582 0.03289981
Grapefruit (👉 📊) Other joint disorder (ebi-a-GCST90038688) Inverse variance weighted 15 0.020138604 0.007510509 0.007331702
Grapefruit (👉 📊) Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) Weighted median 16 14.45635339 4.403857716 0.001028338
Grapefruit (👉 📊) Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) Inverse variance weighted 16 10.61827342 3.137729347 0.000714216
Grapefruit (👉 📊) Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) Simple mode 16 16.6377389 7.783582583 0.049427182
Grapefruit (👉 📊) Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) Weighted mode 16 15.81050731 6.551287674 0.029056623
Grapefruit (👉 📊) Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) Weighted median 16 14.33870281 4.406657156 0.001138432
Grapefruit (👉 📊) Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) Inverse variance weighted 16 10.70778017 3.144000549 0.000659749
Grapefruit (👉 📊) Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) Simple mode 16 16.51244076 7.716266097 0.04920232
Grapefruit (👉 📊) Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) Weighted mode 16 16.01462963 6.336346906 0.023213081
Grapefruit (👉 📊) Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) MR Egger 16 1.947320165 0.802791322 0.02938532
Grapefruit (👉 📊) Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) MR Egger 16 3.99007604 1.129100145 0.003305233
Grapefruit (👉 📊) Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) Weighted median 16 1.587367417 0.801447699 0.047633334
Grapefruit (👉 📊) Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) Inverse variance weighted 16 1.728759739 0.63514017 0.006491653
Grapefruit (👉 📊) Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) Inverse variance weighted 16 -5.537422632 2.786873683 0.046926189
Grapefruit (👉 📊) Calcific tendinitis (finn-b-M13_CALCTENDINITIS) Inverse variance weighted 16 9.738343592 4.563139568 0.032831952
Grapefruit (👉 📊) Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) Weighted median 16 -5.199764706 2.325619982 0.02536083
Grapefruit (👉 📊) Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) MR Egger 16 -9.465547339 3.874278901 0.028414294
Grapefruit (👉 📊) Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) Weighted median 16 1.036493045 0.495339217 0.036394581
Grapefruit (👉 📊) Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) Inverse variance weighted 16 1.22135497 0.357286373 0.000629858
Grapefruit (👉 📊) Burn and corrosion of head and neck (finn-b-ST19_BURN_CORROSION_HEAD_NECK) MR Egger 16 12.33144536 5.13596581 0.030809959
Grapefruit (👉 📊) Burn and corrosion of head and neck (finn-b-ST19_BURN_CORROSION_HEAD_NECK) Weighted median 16 7.386602199 3.698519722 0.045805851
Grapefruit (👉 📊) Contusion of ankle (finn-b-ST19_CONTU_ANKLE) Inverse variance weighted 16 -5.703759141 2.346991937 0.015088731
Grapefruit (👉 📊) Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) Weighted median 16 4.661991571 2.145043003 0.029751799
Grapefruit (👉 📊) Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) Weighted mode 16 5.809042217 2.713343438 0.049112585
Grapefruit (👉 📊) Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) Inverse variance weighted 16 -4.612482432 2.181907373 0.034517998
Grapefruit (👉 📊) Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) Inverse variance weighted 16 0.800611198 0.407526758 0.049465063
Grapefruit (👉 📊) Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) MR Egger 16 4.42908305 1.98404874 0.042442078
Grapefruit (👉 📊) Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) Weighted median 16 -1.78655133 0.7432966 0.016236699
Grapefruit (👉 📊) Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) Inverse variance weighted 16 -1.273991314 0.539059629 0.018110127
Grapefruit (👉 📊) Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) MR Egger 16 -5.206761377 2.308634892 0.040642316
Grapefruit (👉 📊) Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) Weighted median 16 -3.262439228 1.63058273 0.045415977
Grapefruit (👉 📊) Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) Inverse variance weighted 16 -2.513571268 1.148771318 0.028665822
Grapefruit (👉 📊) Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) MR Egger 16 -8.174832088 3.623167814 0.040571488
Grapefruit (👉 📊) Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) Weighted median 16 -5.845735549 2.436589277 0.016433322
Grapefruit (👉 📊) Non-cancer illness code self-reported: bone disorder (ukb-a-84) Inverse variance weighted 16 0.008449595 0.004264972 0.04757325
Grapefruit (👉 📊) Non-cancer illness code self-reported: joint disorder (ukb-a-86) MR Egger 16 -0.035056705 0.013853017 0.024002204
Grapefruit (👉 📊) Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) MR Egger 5 -0.401714651 0.090609812 0.021326264
Grapefruit (👉 📊) Operation code: bone surgery/joint surgery (ukb-b-12974) Inverse variance weighted 5 0.031270521 0.014959863 0.036591344
Grapefruit (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) Wald ratio 1 0.052576518 0.020473491 0.010227859
Grapefruit (👉 📊) Fractured bone site(s): Wrist (ukb-b-9571) Weighted median 6 0.049795477 0.021495639 0.02052888
Grapefruit (👉 📊) Fractured bone site(s): Wrist (ukb-b-9571) Inverse variance weighted 6 0.044132129 0.017467111 0.011517773
Grapefruit (👉 📊) Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) MR Egger 15 0.03375273 0.015117837 0.043787235
Grapefruit (👉 📊) Osteoarthrosis (ukb-e-740_CSA) MR Egger 11 -12.89909889 5.2983673 0.037700633
Grapefruit (👉 📊) Osteoarthrosis (ukb-e-740_CSA) Weighted median 11 -6.328702395 3.111344543 0.041944221

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Grapefruit Heel bone mineral density (ebi-a-GCST006288) All - Inverse variance weighted -0.282318786682285 0.123198264929371 0.0219298406163964
Grapefruit Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) rs117297639 33.5191605130198 10.6262883793237 0.0016084941729706
Grapefruit Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) All - Inverse variance weighted 3.02434364333102 1.44526566125563 0.0363860683932922
Grapefruit Bone mineral density (ebi-a-GCST90014022) rs141702692 -0.620834607153776 0.289014872228317 0.0317053285428883
Grapefruit Bone mineral density (ebi-a-GCST90014022) rs67996343 -0.738679883901 0.291435844175113 0.0112568521353009
Grapefruit Bone mineral density (ebi-a-GCST90014022) All - Inverse variance weighted -0.188762737270039 0.087225578906399 0.0304585563617153
Grapefruit Neck circumference (ebi-a-GCST90017135) rs77584237 -14.8979829284029 6.48382217615265 0.0215779497637895
Grapefruit Neck circumference (ebi-a-GCST90017135) All - Inverse variance weighted -4.28087000916054 2.04013742981749 0.03587650453885
Grapefruit Neck circumference (BMI adjusted) (ebi-a-GCST90017138) rs58148876 -9.76090612134449 4.46488973075362 0.0288048387376224
Grapefruit Neck circumference (BMI adjusted) (ebi-a-GCST90017138) rs74352714 -10.0758840013854 4.54674265562518 0.0266869493629537
Grapefruit Neck circumference (BMI adjusted) (ebi-a-GCST90017138) All - Inverse variance weighted -3.58199544030281 1.6790835816387 0.0328998100133457
Grapefruit Other joint disorder (ebi-a-GCST90038688) rs7293017 0.0634528561839828 0.0297288656516056 0.0328112474287231
Grapefruit Other joint disorder (ebi-a-GCST90038688) All - Inverse variance weighted 0.020138604413199 0.0075105093573569 0.0073317022112374
Grapefruit Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) rs75128811 18.4945563323942 8.06984590768375 0.0219165894784015
Grapefruit Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) All - Inverse variance weighted 10.6182734170428 3.13772934710149 0.0007142164375781
Grapefruit Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) rs75128811 18.7067376256565 8.09767296253783 0.0208805452791679
Grapefruit Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) All - Inverse variance weighted 10.7077801681237 3.14400054913136 0.0006597486150103
Grapefruit Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) rs58148876 -3.16021416007886 1.48829657691787 0.0337223044931005
Grapefruit Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) rs74352714 5.71806417078623 2.72678610787493 0.0359937797832092
Grapefruit Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) rs75128811 2.00702633135066 0.907857664614421 0.0270546804762154
Grapefruit Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) All - MR Egger 1.94732016456826 0.802791322209801 0.0293853203468475
Grapefruit Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs149410520 3.06209495677417 1.29444069551784 0.0180021564059769
Grapefruit Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs74352714 10.6804370414686 4.0618407380585 0.0085521255048909
Grapefruit Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs75128811 4.48363421336394 1.35656892413649 0.000949329640918
Grapefruit Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) All - Inverse variance weighted 1.72875973892429 0.635140169861441 0.0064916528797442
Grapefruit Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) All - MR Egger 3.9900760404511 1.1291001450097 0.0033052334958468
Grapefruit Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) All - Inverse variance weighted -5.53742263231103 2.7868736827477 0.0469261894672882
Grapefruit Calcific tendinitis (finn-b-M13_CALCTENDINITIS) rs149410520 35.3700614965432 10.7672001459959 0.0010198879202484
Grapefruit Calcific tendinitis (finn-b-M13_CALCTENDINITIS) rs75128811 20.4320150266096 9.85425580020175 0.0381331718119638
Grapefruit Calcific tendinitis (finn-b-M13_CALCTENDINITIS) All - Inverse variance weighted 9.73834359226692 4.56313956798176 0.0328319516233061
Grapefruit Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) rs72861422 -12.7198273386018 6.08910444209196 0.036712333474458
Grapefruit Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) All - MR Egger -9.46554733867268 3.87427890110274 0.028414294179157
Grapefruit Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) rs116982845 4.68287124952526 1.8951766046335 0.0134757716622923
Grapefruit Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) rs74352714 7.85289209357977 2.72048868037407 0.0038946105876398
Grapefruit Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) rs75128811 1.97224251278305 0.907857664614421 0.0298244655601351
Grapefruit Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) All - Inverse variance weighted 1.22135497047883 0.35728637320748 0.0006298577469456
Grapefruit Burn and corrosion of head and neck (finn-b-ST19_BURN_CORROSION_HEAD_NECK) All - MR Egger 12.3314453561986 5.1359658099861 0.0308099588149921
Grapefruit Contusion of ankle (finn-b-ST19_CONTU_ANKLE) rs149410520 -14.0521086651133 4.97616955899891 0.0047446056825947
Grapefruit Contusion of ankle (finn-b-ST19_CONTU_ANKLE) All - Inverse variance weighted -5.70375914068462 2.34699193671138 0.0150887308286812
Grapefruit Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) rs77584237 -15.7335815449055 6.52613096686164 0.0159150000430337
Grapefruit Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) All - Inverse variance weighted -4.6124824319542 2.18190737287496 0.0345179979268775
Grapefruit Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) rs61919156 7.00541579638084 2.38442912330641 0.0033035354365037
Grapefruit Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) All - Inverse variance weighted 0.8006111976962 0.407526757962386 0.0494650631766386
Grapefruit Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) rs13027142 -10.5265438399965 4.33295993413901 0.0151233455617858
Grapefruit Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) rs28569399 -10.0751485136337 4.63272342641144 0.0296466994176744
Grapefruit Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) All - MR Egger 4.42908304993482 1.98404874043606 0.0424420782864803
Grapefruit Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) All - Inverse variance weighted -1.27399131427316 0.539059628869365 0.0181101267226575
Grapefruit Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs149410520 -6.48705771507875 2.7841085123269 0.0198045398044936
Grapefruit Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) All - Inverse variance weighted -2.5135712681511 1.14877131776685 0.0286658218048587
Grapefruit Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) All - MR Egger -5.20676137701076 2.30863489152372 0.0406423164135317
Grapefruit Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) All - MR Egger -8.17483208784655 3.62316781382093 0.0405714883880725
Grapefruit Non-cancer illness code self-reported: bone disorder (ukb-a-84) rs7293017 0.0350442470060409 0.0174660861271064 0.0448118073158743
Grapefruit Non-cancer illness code self-reported: bone disorder (ukb-a-84) All - Inverse variance weighted 0.0084495951037909 0.0042649719964508 0.0475732497207616
Grapefruit Non-cancer illness code self-reported: joint disorder (ukb-a-86) All - MR Egger -0.0350567050955845 0.0138530173580174 0.0240022035535085
Grapefruit Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) rs13027142 0.116894975423196 0.0273808659038108 1.96156593829593e-05
Grapefruit Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) All - MR Egger -0.401714651265386 0.0906098121407329 0.0213262635073502
Grapefruit Operation code: bone surgery/joint surgery (ukb-b-12974) rs61919156 0.0877810946193231 0.0278551228258258 0.0016252054560097
Grapefruit Operation code: bone surgery/joint surgery (ukb-b-12974) All - Inverse variance weighted 0.0312705207010131 0.0149598629634584 0.0365913444747651
Grapefruit Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) rs13027142 0.0525765181608369 0.0204734905688029 0.0102278589791784
Grapefruit Fractured bone site(s): Wrist (ukb-b-9571) All - Inverse variance weighted 0.0441321288522893 0.0174671108639153 0.0115177728187325
Grapefruit Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) rs13027142 -0.0611517007504941 0.0245494040268491 0.0127396748477702
Grapefruit Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) rs141702692 -0.0544346934738432 0.0231861995791897 0.0188887387366402
Grapefruit Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) All - MR Egger 0.0337527298832869 0.0151178371961656 0.0437872347577113
Grapefruit Osteoarthrosis (ukb-e-740_CSA) rs13027142 25.7046476092894 11.4555814258752 0.0248418224772044
Grapefruit Osteoarthrosis (ukb-e-740_CSA) All - MR Egger -12.8990988908855 5.2983672996619 0.0377006334033512