ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Cereal bar (ukb-b-18788)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Cereal bar (👉 📊) Osteoporosis (bbj-a-137) MR Egger 6 0.963664776 0.316538316 0.038237673
Cereal bar (👉 📊) Osteoarthritis (Firth correction) (ebi-a-GCST90013881) Inverse variance weighted 11 -0.249163254 0.123074168 0.042919066
Cereal bar (👉 📊) Osteoarthritis (SPA correction) (ebi-a-GCST90013931) Inverse variance weighted 11 -0.251241877 0.122733007 0.040652156
Cereal bar (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) Inverse variance weighted 12 -4.331103703 2.189784989 0.0479437
Cereal bar (👉 📊) Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) Inverse variance weighted 12 -4.308485835 2.198198325 0.04999488
Cereal bar (👉 📊) Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) Inverse variance weighted 12 2.407672043 1.184065947 0.04201278
Cereal bar (👉 📊) Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) Inverse variance weighted 12 1.855872271 0.786946521 0.018357826
Cereal bar (👉 📊) Loose body in joint (finn-b-M13_LOOSEJOINT) MR Egger 12 5.32179396 2.377681209 0.049151729
Cereal bar (👉 📊) Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) MR Egger 12 3.019259944 1.322995005 0.045619419
Cereal bar (👉 📊) Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) Weighted median 12 -2.626746533 1.237658232 0.033808182
Cereal bar (👉 📊) Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) Inverse variance weighted 12 0.684694082 0.322428021 0.033707256
Cereal bar (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) Weighted median 12 -1.1737946 0.465870575 0.01174975
Cereal bar (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) Simple mode 12 -1.488810421 0.670637832 0.048366087
Cereal bar (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) Weighted mode 12 -1.470564532 0.617948952 0.036517182
Cereal bar (👉 📊) Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) Inverse variance weighted 12 -2.643543937 1.299919375 0.041989776
Cereal bar (👉 📊) Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) Weighted median 12 -3.490680329 1.292826362 0.006933155
Cereal bar (👉 📊) Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) Inverse variance weighted 12 -2.094341604 0.959132894 0.028993263
Cereal bar (👉 📊) Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) Inverse variance weighted 12 -4.478623182 2.162247139 0.038332468
Cereal bar (👉 📊) Rheumatoid arthritis (ieu-a-831) Inverse variance weighted 4 -1.543945741 0.772549667 0.045661746
Cereal bar (👉 📊) Psoriatic arthritis (ieu-b-5116) Inverse variance weighted 12 -0.917947037 0.409314394 0.024919691
Cereal bar (👉 📊) Osteocalcin (prot-a-246) MR Egger 13 2.025230444 0.740218531 0.019369814
Cereal bar (👉 📊) Operation code: elbow surgery (ukb-b-10324) Inverse variance weighted 6 -0.007562167 0.0034325 0.027587177
Cereal bar (👉 📊) Diagnoses - main ICD10: N32.0 Bladder-neck obstruction (ukb-b-123) Weighted median 5 -0.008749126 0.00332507 0.008506873
Cereal bar (👉 📊) Diagnoses - main ICD10: N32.0 Bladder-neck obstruction (ukb-b-123) Inverse variance weighted 5 -0.00861075 0.002643106 0.001122737
Cereal bar (👉 📊) Diagnoses - secondary ICD10: M47.82 Other spondylosis (Cervical region) (ukb-b-2625) Inverse variance weighted 5 0.004654741 0.002271353 0.040430319
Cereal bar (👉 📊) Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) Inverse variance weighted 6 -0.00991199 0.003669359 0.006907174
Cereal bar (👉 📊) Ankle spacing width (ukb-b-4080) MR Egger 13 -0.142960892 0.063460599 0.045669126
Cereal bar (👉 📊) Ankle spacing width (ukb-b-4080) Weighted median 13 -0.097886176 0.045212991 0.0303876
Cereal bar (👉 📊) Ankle spacing width (ukb-b-4080) Inverse variance weighted 13 -0.085839569 0.03299443 0.009277967
Cereal bar (👉 📊) Operation code: ankle surgery (ukb-b-4274) Weighted median 5 0.007190453 0.003318953 0.030274332
Cereal bar (👉 📊) Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) Inverse variance weighted 6 -0.007838381 0.003961442 0.04785331
Cereal bar (👉 📊) Fractured heel (left) (ukb-b-8221) Inverse variance weighted 13 -0.012914873 0.005072279 0.010891276
Cereal bar (👉 📊) Fractured bone site(s): Wrist (ukb-b-9571) Inverse variance weighted 7 -0.013018745 0.005730922 0.023106636
Cereal bar (👉 📊) Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) MR Egger 11 -0.012797378 0.004501951 0.019320101
Cereal bar (👉 📊) Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) MR Egger 10 -0.011129985 0.004336375 0.0333003
Cereal bar (👉 📊) Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) Inverse variance weighted 10 -0.004731302 0.002084635 0.023231415
Cereal bar (👉 📊) Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) MR Egger 11 -0.012302153 0.004403138 0.020918353
Cereal bar (👉 📊) Ankle spacing width (ukb-e-3143_AFR) Inverse variance weighted 5 1.987021377 0.854042921 0.019986245
Cereal bar (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_CSA) Inverse variance weighted 11 -0.828180225 0.416438525 0.046731958
Cereal bar (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_EAS) Weighted median 9 -1.647988309 0.790639939 0.037126279
Cereal bar (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_EAS) Inverse variance weighted 9 -1.1872103 0.52684587 0.024232048
Cereal bar (👉 📊) Ankle spacing width (left) (ukb-e-4100_EAS) Weighted median 8 -1.434742672 0.652244494 0.027828137
Cereal bar (👉 📊) Ankle spacing width (left) (ukb-e-4100_EAS) Inverse variance weighted 8 -1.256593612 0.468887503 0.007363384
Cereal bar (👉 📊) Ankle spacing width (right) (ukb-e-4119_EAS) Weighted median 8 -1.397559276 0.671208627 0.037328467
Cereal bar (👉 📊) Ankle spacing width (right) (ukb-e-4119_EAS) Inverse variance weighted 8 -1.291971291 0.476737793 0.006727816
Cereal bar (👉 📊) Osteoarthrosis (ukb-e-740_CSA) MR Egger 11 -4.946507659 1.674321832 0.016107072
Cereal bar (👉 📊) Osteoarthrosis (ukb-e-740_CSA) Weighted median 11 -4.046152788 1.391521175 0.003640751
Cereal bar (👉 📊) Osteoarthrosis (ukb-e-740_CSA) Inverse variance weighted 11 -2.737729712 0.974003552 0.004941841
Cereal bar (👉 📊) Osteoarthrosis (ukb-e-740_CSA) Weighted mode 11 -4.549616289 1.768784416 0.027786987
Cereal bar (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) Weighted median 9 -1.706676362 0.754074237 0.023618825
Cereal bar (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) Inverse variance weighted 9 -1.261329114 0.535143953 0.018423727
Cereal bar (👉 📊) Internal derangement of knee (ukb-e-835_CSA) Inverse variance weighted 11 -2.214948311 1.107543817 0.045513849
Cereal bar (👉 📊) M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) Weighted median 11 -2.805029398 1.297236479 0.030594171

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Cereal bar Osteoporosis (bbj-a-137) rs76116349 0.691107312308122 0.246545318169132 0.0050603705808508
Cereal bar Osteoporosis (bbj-a-137) All - MR Egger 0.963664776438949 0.316538315602563 0.0382376725561602
Cereal bar Osteoarthritis (Firth correction) (ebi-a-GCST90013881) rs74760533 -0.844699435171393 0.402648971907094 0.0359178956057957
Cereal bar Osteoarthritis (Firth correction) (ebi-a-GCST90013881) All - Inverse variance weighted -0.249163254040993 0.12307416843606 0.0429190660086337
Cereal bar Osteoarthritis (SPA correction) (ebi-a-GCST90013931) rs74760533 -0.832322786662531 0.391163468301015 0.0333525754622133
Cereal bar Osteoarthritis (SPA correction) (ebi-a-GCST90013931) All - Inverse variance weighted -0.251241876691687 0.122733006798868 0.0406521555391603
Cereal bar Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) rs62222385 -17.1092408702063 6.7338568028776 0.0110605858615351
Cereal bar Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) All - Inverse variance weighted -4.33110370287677 2.18978498854498 0.0479437004070051
Cereal bar Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) rs62222385 -17.0201817794996 6.73880453013908 0.0115468856888622
Cereal bar Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) All - Inverse variance weighted -4.30848583532982 2.19819832461465 0.0499948800529451
Cereal bar Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) All - Inverse variance weighted 2.40767204268434 1.18406594720245 0.042012779932589
Cereal bar Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) rs115958455 4.80939506471556 2.18290078584428 0.0275797499349485
Cereal bar Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) rs11862422 6.47723389493523 2.61471072497385 0.0132407391448349
Cereal bar Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) All - Inverse variance weighted 1.85587227140328 0.786946521347411 0.0183578257289517
Cereal bar Loose body in joint (finn-b-M13_LOOSEJOINT) rs11862422 -7.95286271992047 3.96607606996034 0.0449393264045855
Cereal bar Loose body in joint (finn-b-M13_LOOSEJOINT) All - MR Egger 5.32179395999268 2.37768120936086 0.0491517286181835
Cereal bar Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) rs115958455 3.63816797640714 1.84450733068931 0.0485601452974458
Cereal bar Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) rs11862422 -4.3699323799563 2.20567676997794 0.0475665336135145
Cereal bar Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) All - MR Egger 3.01925994385046 1.32299500525074 0.0456194194969285
Cereal bar Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) rs117538197 8.44948935583808 3.49616442690975 0.0156581199986603
Cereal bar Dislocation, sprain and strain of joints and ligaments of head (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_HEAD) rs17593774 -5.95797794882463 2.99563137091741 0.0467134684531165
Cereal bar Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) All - Inverse variance weighted 0.684694081514261 0.322428020582507 0.0337072559648372
Cereal bar Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) rs11077661 3.51377784051381 1.1847027152378 0.0030174223615523
Cereal bar Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) rs11077661 -11.9176051864772 4.72872828465129 0.0117269556383057
Cereal bar Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) All - Inverse variance weighted -2.643543936943 1.2999193748297 0.0419897764264691
Cereal bar Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) All - Inverse variance weighted -2.0943416041188 0.959132894125992 0.0289932626116964
Cereal bar Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) rs9839143 -17.354537716234 6.94460595291808 0.0124545958807909
Cereal bar Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) All - Inverse variance weighted -4.47862318222577 2.16224713919397 0.0383324675421048
Cereal bar Rheumatoid arthritis (ieu-a-831) All - Inverse variance weighted -1.5439457405447 0.772549666578001 0.0456617464670487
Cereal bar Psoriatic arthritis (ieu-b-5116) rs10857625 -4.24650633571257 1.22508821878258 0.0005277013167202
Cereal bar Psoriatic arthritis (ieu-b-5116) All - Inverse variance weighted -0.917947036757106 0.409314394086322 0.0249196911284976
Cereal bar Osteocalcin (prot-a-246) rs115958455 2.83338768668623 1.22207377327989 0.0204217346058652
Cereal bar Osteocalcin (prot-a-246) rs138513641 2.42491015991021 1.20267306444804 0.0437720508084609
Cereal bar Osteocalcin (prot-a-246) rs74760533 2.95082540112442 1.26136318959981 0.019315054907499
Cereal bar Osteocalcin (prot-a-246) All - MR Egger 2.02523044406453 0.740218531326531 0.0193698138941564
Cereal bar Operation code: elbow surgery (ukb-b-10324) All - Inverse variance weighted -0.0075621665835839 0.0034325001361099 0.027587177019985
Cereal bar Diagnoses - main ICD10: N32.0 Bladder-neck obstruction (ukb-b-123) rs10857625 -0.0129205930708156 0.005996872243163 0.0311966475961115
Cereal bar Diagnoses - main ICD10: N32.0 Bladder-neck obstruction (ukb-b-123) All - Inverse variance weighted -0.0086107504737777 0.0026431061950446 0.0011227365412312
Cereal bar Diagnoses - secondary ICD10: M47.82 Other spondylosis (Cervical region) (ukb-b-2625) All - Inverse variance weighted 0.004654741370988 0.002271353128392 0.0404303189025795
Cereal bar Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) rs11862422 -0.0209490105520405 0.0083852478538661 0.0124784413685499
Cereal bar Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) rs9839143 -0.0159583137585063 0.0080247177736328 0.0467404160969202
Cereal bar Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) All - Inverse variance weighted -0.0099119902615747 0.0036693586348575 0.0069071736047318
Cereal bar Ankle spacing width (ukb-b-4080) rs115958455 -0.261006553962359 0.10769924010506 0.0153727570742172
Cereal bar Ankle spacing width (ukb-b-4080) rs17593774 -0.246569169960474 0.120189307260245 0.0402176271465116
Cereal bar Ankle spacing width (ukb-b-4080) All - Inverse variance weighted -0.0858395690451175 0.0329944297433884 0.0092779672745192
Cereal bar Ankle spacing width (ukb-b-4080) All - MR Egger -0.142960892380475 0.063460599495024 0.045669125560666
Cereal bar Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) All - Inverse variance weighted -0.007838381105227 0.0039614417475789 0.0478533103225104
Cereal bar Fractured heel (left) (ukb-b-8221) rs115958455 -0.0358165802273022 0.017043949069155 0.0356036775839178
Cereal bar Fractured heel (left) (ukb-b-8221) rs74760533 -0.0408753751326889 0.0174717913323053 0.0193092185731273
Cereal bar Fractured heel (left) (ukb-b-8221) rs9839143 -0.0364074106806458 0.0180373231869834 0.043544556733355
Cereal bar Fractured heel (left) (ukb-b-8221) All - Inverse variance weighted -0.0129148732572069 0.0050722785521652 0.0108912762872645
Cereal bar Fractured bone site(s): Wrist (ukb-b-9571) rs9839143 -0.037716373548168 0.0147302860172941 0.0104532360437472
Cereal bar Fractured bone site(s): Wrist (ukb-b-9571) All - Inverse variance weighted -0.0130187449638669 0.0057309215975568 0.0231066361625176
Cereal bar Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) rs74760533 -0.0155509153892862 0.0072682477208095 0.0323896376997777
Cereal bar Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) All - MR Egger -0.0127973783558109 0.0045019511702044 0.0193201011804495
Cereal bar Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) rs74760533 -0.0140626160344925 0.0063210240303338 0.0260988989027505
Cereal bar Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) All - Inverse variance weighted -0.0047313022041244 0.0020846346582298 0.0232314154790119
Cereal bar Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) All - MR Egger -0.0111299853016537 0.0043363746481511 0.0333003000244892
Cereal bar Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) rs115958455 -0.0140354033194119 0.0066522542614782 0.0348694044308559
Cereal bar Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) rs11862422 0.0148602035850014 0.0074187368617258 0.0451704360561962
Cereal bar Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) rs74760533 -0.0154503339609207 0.0067640519135589 0.0223607646092608
Cereal bar Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) All - MR Egger -0.0123021526899282 0.0044031383367665 0.020918353454909
Cereal bar Ankle spacing width (ukb-e-3143_AFR) All - Inverse variance weighted 1.98702137670797 0.854042920857486 0.0199862453610743
Cereal bar Heel bone mineral density (BMD) (ukb-e-3148_CSA) rs62222385 -4.01903885450218 1.78464522321672 0.0243216413078204
Cereal bar Heel bone mineral density (BMD) (ukb-e-3148_CSA) All - Inverse variance weighted -0.828180225378996 0.416438525417161 0.0467319577713173
Cereal bar Heel bone mineral density (BMD) (ukb-e-3148_EAS) rs76116349 -1.69637873290539 0.663462880267932 0.0105623074816062
Cereal bar Heel bone mineral density (BMD) (ukb-e-3148_EAS) All - Inverse variance weighted -1.18721030013184 0.526845869768745 0.0242320483337938
Cereal bar Ankle spacing width (left) (ukb-e-4100_EAS) rs76116349 -1.45391431761094 0.586798771978789 0.0132230381130285
Cereal bar Ankle spacing width (left) (ukb-e-4100_EAS) All - Inverse variance weighted -1.25659361205576 0.468887503353735 0.0073633839294822
Cereal bar Ankle spacing width (right) (ukb-e-4119_EAS) rs76116349 -1.54025955902875 0.595869383198437 0.0097408765919321
Cereal bar Ankle spacing width (right) (ukb-e-4119_EAS) All - Inverse variance weighted -1.29197129057716 0.476737793171433 0.0067278157043459
Cereal bar Osteoarthrosis (ukb-e-740_CSA) rs138513641 -5.19682444886065 1.79886116745781 0.003865274689716
Cereal bar Osteoarthrosis (ukb-e-740_CSA) rs76116349 -5.88194250627965 2.86596427574658 0.0401363131791995
Cereal bar Osteoarthrosis (ukb-e-740_CSA) All - Inverse variance weighted -2.7377297122021 0.974003551792406 0.0049418410781084
Cereal bar Osteoarthrosis (ukb-e-740_CSA) All - MR Egger -4.94650765921485 1.67432183174681 0.0161070717193146
Cereal bar Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) rs76116349 -1.70771699692995 0.674016187552331 0.0112883383563642
Cereal bar Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) All - Inverse variance weighted -1.26132911434176 0.535143953251373 0.0184237274159258
Cereal bar Internal derangement of knee (ukb-e-835_CSA) All - Inverse variance weighted -2.2149483107914 1.10754381650883 0.0455138490707581
Cereal bar M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) rs117538197 12.0732510246059 5.15748051590117 0.0192362711580745