ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Mixed fruit (ukb-b-18956)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Mixed fruit (👉 📊) Frozen shoulder (ebi-a-GCST90000513) Inverse variance weighted 9 0.682680519 0.333577067 0.040702768
Mixed fruit (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) Weighted median 16 -2.580657981 1.285233331 0.044650779
Mixed fruit (👉 📊) Cervical root disorders (finn-b-G6_CERVROOT) MR Egger 16 4.967982172 2.189134973 0.039579051
Mixed fruit (👉 📊) Cervical root disorders (finn-b-G6_CERVROOT) Weighted median 16 5.774128339 2.282932795 0.011430364
Mixed fruit (👉 📊) Cervical root disorders (finn-b-G6_CERVROOT) Inverse variance weighted 16 3.899598518 1.534678117 0.011053975
Mixed fruit (👉 📊) Cervical root disorders (finn-b-G6_CERVROOT) Weighted mode 16 5.372627582 2.037135547 0.018657048
Mixed fruit (👉 📊) Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) Inverse variance weighted 16 0.78442213 0.274679461 0.004293223
Mixed fruit (👉 📊) Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) MR Egger 16 2.185516644 0.753893931 0.011665748
Mixed fruit (👉 📊) Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) Weighted median 16 2.332828222 0.792762101 0.00325407
Mixed fruit (👉 📊) Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) Inverse variance weighted 16 1.820794194 0.52881819 0.000575005
Mixed fruit (👉 📊) Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) Weighted mode 16 2.082050051 0.729602598 0.01207632
Mixed fruit (👉 📊) Osteonecrosis (finn-b-M13_OSTEONECROSIS) MR Egger 16 2.302688228 1.020961693 0.040637031
Mixed fruit (👉 📊) Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) Inverse variance weighted 16 0.638726047 0.251060155 0.010955484
Mixed fruit (👉 📊) Burn and corrosion of shoulder and upper limb, except wrist and hand (finn-b-ST19_BURN_CORROSION_SHOUL_UPPER_LIMB_WRIST_HAND) Simple mode 16 -7.83422119 3.12009011 0.023984156
Mixed fruit (👉 📊) Contusion of ankle (finn-b-ST19_CONTU_ANKLE) Inverse variance weighted 16 -1.645290072 0.811955148 0.042730853
Mixed fruit (👉 📊) Contusion of ankle (finn-b-ST19_CONTU_ANKLE) Simple mode 16 -6.225652912 2.615397059 0.030989299
Mixed fruit (👉 📊) Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) Simple mode 16 -1.478750854 0.66292939 0.041398163
Mixed fruit (👉 📊) Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) Inverse variance weighted 16 0.734270851 0.362402735 0.042752653
Mixed fruit (👉 📊) Osteocrin (prot-a-2157) MR Egger 16 2.75617199 0.901969611 0.008552065
Mixed fruit (👉 📊) Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) MR Egger 18 -0.07558403 0.033854038 0.040212103
Mixed fruit (👉 📊) Pain type(s) experienced in last month: Knee pain (ukb-a-476) Weighted median 18 -0.056856282 0.027288447 0.037202995
Mixed fruit (👉 📊) Heel bone mineral density (BMD) T-score automated (ukb-a-500) MR Egger 18 0.28232071 0.10335557 0.014783996
Mixed fruit (👉 📊) Heel bone mineral density (BMD) T-score automated (ukb-a-500) Weighted median 18 0.198998715 0.087000534 0.022176714
Mixed fruit (👉 📊) Heel bone mineral density (BMD) T-score automated (ukb-a-500) Inverse variance weighted 18 0.130422288 0.063186424 0.039009452
Mixed fruit (👉 📊) Fractured/broken bones in last 5 years (ukb-b-13346) Weighted median 16 0.041057423 0.018682715 0.027976524
Mixed fruit (👉 📊) Heel bone ultrasound T-score, manual entry (ukb-b-17612) Inverse variance weighted 16 -0.326904943 0.141083842 0.02049845
Mixed fruit (👉 📊) Fractured bone site(s): Other bones (ukb-b-17738) Inverse variance weighted 10 0.028494398 0.012201829 0.019530039
Mixed fruit (👉 📊) Diagnoses - main ICD10: M51.1 Lumbar and other intervertebral disk disorders with radiculopathy (ukb-b-18279) Weighted median 6 0.013782468 0.006341552 0.029753331
Mixed fruit (👉 📊) Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) Weighted median 7 0.015881655 0.007972999 0.046378743
Mixed fruit (👉 📊) Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) Inverse variance weighted 7 0.016379619 0.005859201 0.005181346
Mixed fruit (👉 📊) Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) MR Egger 18 -0.018538939 0.007563103 0.02610817
Mixed fruit (👉 📊) Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) MR Egger 17 0.018672652 0.008158267 0.037016361
Mixed fruit (👉 📊) Ankle spacing width (left) (ukb-e-4100_EAS) MR Egger 7 -16.31221584 5.683517462 0.034990872
Mixed fruit (👉 📊) Ankle spacing width (right) (ukb-e-4119_EAS) MR Egger 7 -16.59995153 6.161151035 0.043076878
Mixed fruit (👉 📊) M51 Other intervertebral disk disorders (ukb-e-M51_CSA) Inverse variance weighted 12 4.515930417 1.964436631 0.021513884

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Mixed fruit Frozen shoulder (ebi-a-GCST90000513) All - Inverse variance weighted 0.682680519067333 0.333577067434858 0.0407027681290424
Mixed fruit Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) rs139486419 -2.90922489502901 1.15093552736534 0.0114810943710167
Mixed fruit Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) rs2229090 -11.9710323254935 5.28504399261725 0.0235079462478956
Mixed fruit Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) rs79042385 6.30006028765826 3.12419257600551 0.043743506776636
Mixed fruit Cervical root disorders (finn-b-G6_CERVROOT) rs139486419 6.16059245342608 2.12067715904168 0.0036723909862303
Mixed fruit Cervical root disorders (finn-b-G6_CERVROOT) All - Inverse variance weighted 3.89959851752177 1.53467811660307 0.0110539746439291
Mixed fruit Cervical root disorders (finn-b-G6_CERVROOT) All - MR Egger 4.96798217173336 2.18913497315819 0.0395790509830175
Mixed fruit Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) rs2229090 3.66913993877354 1.74191492042784 0.0351710986233715
Mixed fruit Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) All - Inverse variance weighted 0.784422130110154 0.274679461388709 0.0042932225375025
Mixed fruit Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) rs139215765 13.8279848515049 6.28418931189511 0.0277756550209
Mixed fruit Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) rs139486419 2.37272900276548 0.730849121158993 0.0011681809976894
Mixed fruit Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) All - Inverse variance weighted 1.82079419361148 0.528818190360228 0.0005750050672925
Mixed fruit Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) All - MR Egger 2.18551664412188 0.753893931491431 0.0116657483486664
Mixed fruit Osteonecrosis (finn-b-M13_OSTEONECROSIS) All - MR Egger 2.30268822800056 1.02096169299357 0.0406370308241345
Mixed fruit Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) rs12758262 3.45898588278945 1.74744615531924 0.0477651326584094
Mixed fruit Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) All - Inverse variance weighted 0.638726046647086 0.251060155430788 0.0109554835134025
Mixed fruit Contusion of ankle (finn-b-ST19_CONTU_ANKLE) All - Inverse variance weighted -1.64529007180417 0.811955148178525 0.0427308532884421
Mixed fruit Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) rs116028801 3.40794574048598 1.62382690702093 0.0358422568343899
Mixed fruit Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) rs6862703 6.34716363607477 2.25606316976875 0.0049023637027099
Mixed fruit Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) All - Inverse variance weighted 0.734270850874768 0.36240273515015 0.0427526526972636
Mixed fruit Osteocrin (prot-a-2157) rs116028801 3.57660072396197 1.60152542160261 0.0255327065338213
Mixed fruit Osteocrin (prot-a-2157) All - MR Egger 2.75617199005905 0.90196961057252 0.0085520648310956
Mixed fruit Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) rs12758262 -0.200670253319849 0.0806943106265073 0.0128899449123823
Mixed fruit Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) All - MR Egger -0.0755840304971948 0.0338540382298696 0.040212102637805
Mixed fruit Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs34863001 0.195514526904552 0.0866616603656326 0.0240664247570118
Mixed fruit Heel bone mineral density (BMD) T-score automated (ukb-a-500) rs116028801 0.490401301291674 0.228639010037062 0.0319631207889476
Mixed fruit Heel bone mineral density (BMD) T-score automated (ukb-a-500) All - Inverse variance weighted 0.130422288189394 0.0631864244476611 0.0390094519520838
Mixed fruit Heel bone mineral density (BMD) T-score automated (ukb-a-500) All - MR Egger 0.282320709730213 0.103355569520461 0.0147839955436354
Mixed fruit Heel bone ultrasound T-score, manual entry (ukb-b-17612) rs6862703 -1.25690522151522 0.553452014966278 0.0231452612343877
Mixed fruit Heel bone ultrasound T-score, manual entry (ukb-b-17612) All - Inverse variance weighted -0.326904942759396 0.141083841835589 0.0204984499121921
Mixed fruit Fractured bone site(s): Other bones (ukb-b-17738) rs56225269 0.0736705088775221 0.0369481189585933 0.0461640061226915
Mixed fruit Fractured bone site(s): Other bones (ukb-b-17738) All - Inverse variance weighted 0.028494397687197 0.0122018291621505 0.0195300387375739
Mixed fruit Diagnoses - main ICD10: M51.1 Lumbar and other intervertebral disk disorders with radiculopathy (ukb-b-18279) rs381390 0.0251806159447545 0.01239735507846 0.0422420042453786
Mixed fruit Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) rs2229090 0.0334164510892528 0.0157109607216716 0.0334241151974711
Mixed fruit Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) rs381390 0.0332106157943039 0.0160252456106038 0.0382287535000822
Mixed fruit Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) All - Inverse variance weighted 0.0163796186594223 0.0058592014816238 0.0051813457546113
Mixed fruit Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) All - MR Egger -0.0185389387758729 0.0075631031186271 0.0261081701794266
Mixed fruit Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) rs2935493 0.0378070690454655 0.0170693099332307 0.0267659056263379
Mixed fruit Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) rs6862703 -0.0332581841869037 0.0148448162182344 0.0250655870454753
Mixed fruit Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) All - MR Egger 0.0186726520588463 0.0081582666902306 0.0370163605878492
Mixed fruit Ankle spacing width (left) (ukb-e-4100_EAS) rs186577081 -12.8297643677077 4.379431925116 0.0033945330303198
Mixed fruit Ankle spacing width (left) (ukb-e-4100_EAS) All - MR Egger -16.3122158429189 5.68351746197599 0.034990872023348
Mixed fruit Ankle spacing width (right) (ukb-e-4119_EAS) rs11068761 -5.01433126147306 2.42697497665132 0.0388206617808907
Mixed fruit Ankle spacing width (right) (ukb-e-4119_EAS) rs186577081 -12.0738624189891 4.43428195314094 0.0064722417169541
Mixed fruit Ankle spacing width (right) (ukb-e-4119_EAS) All - MR Egger -16.5999515273135 6.16115103488559 0.0430768784454729
Mixed fruit M51 Other intervertebral disk disorders (ukb-e-M51_CSA) rs79042385 12.5462923090173 5.94909999138748 0.0349497990822491
Mixed fruit M51 Other intervertebral disk disorders (ukb-e-M51_CSA) All - Inverse variance weighted 4.51593041735266 1.96443663140749 0.021513884474944