ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Espresso | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | rs10000963 | -5.11161724447478 | 2.21083009993249 | 0.0207732455112812 |
| Espresso | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | rs1370699 | -4.15333814879785 | 2.10676572765109 | 0.048674875673469 |
| Espresso | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | All - MR Egger | 1.60512456890918 | 0.694237395549634 | 0.0286378942015733 |
| Espresso | Osteoarthritis (self-reported) (ebi-a-GCST005811) | rs28692629 | -2.74520547945205 | 1.29117199391172 | 0.033492051848813 |
| Espresso | Osteoarthritis (self-reported) (ebi-a-GCST005811) | rs76762868 | 2.69135008595973 | 1.29263244043269 | 0.0373361567983879 |
| Espresso | Osteoarthritis (self-reported) (ebi-a-GCST005811) | All - MR Egger | 0.893695179975452 | 0.435440376388881 | 0.0486564259525164 |
| Espresso | Frozen shoulder (ebi-a-GCST90000513) | All - MR Egger | -0.814126535441224 | 0.367888008640416 | 0.035539980230526 |
| Espresso | Osteoarthritis (Firth correction) (ebi-a-GCST90013881) | rs882549 | -1.56677508307997 | 0.767369016474581 | 0.0411764146846696 |
| Espresso | Osteoarthritis (Firth correction) (ebi-a-GCST90013881) | All - MR Egger | 0.57176995943379 | 0.254379746449876 | 0.0326570242664191 |
| Espresso | Osteoarthritis (SPA correction) (ebi-a-GCST90013931) | rs882549 | -1.56296401046454 | 0.763211482712296 | 0.0405719543027773 |
| Espresso | Osteoarthritis (SPA correction) (ebi-a-GCST90013931) | All - MR Egger | 0.572042440816816 | 0.254369236410284 | 0.03257405099253 |
| Espresso | Neck circumference (ebi-a-GCST90017135) | rs11680934 | -9.14361149628781 | 4.09339070902644 | 0.0254995270973125 |
| Espresso | Neck circumference (ebi-a-GCST90017135) | rs58240154 | -9.23390627799635 | 3.59867459754654 | 0.0102902957728706 |
| Espresso | Neck circumference (ebi-a-GCST90017135) | All - Inverse variance weighted | -2.09096586047437 | 0.735732311800485 | 0.0044828695358646 |
| Espresso | Other joint disorder (ebi-a-GCST90038688) | rs113541629 | 0.0399431586028484 | 0.0196117493289871 | 0.0416805811173209 |
| Espresso | Other joint disorder (ebi-a-GCST90038688) | rs139488143 | -0.0422885027258567 | 0.0190152842679128 | 0.0261537148795364 |
| Espresso | Other joint disorder (ebi-a-GCST90038688) | rs191325662 | -0.0511335739767912 | 0.0188148836503632 | 0.006573356183457 |
| Espresso | Other joint disorder (ebi-a-GCST90038688) | rs28692629 | -0.0544058853373922 | 0.0185039742939286 | 0.0032797184380389 |
| Espresso | Other joint disorder (ebi-a-GCST90038688) | rs73269888 | -0.0340716973624615 | 0.0166717955664295 | 0.0409858687733132 |
| Espresso | Other joint disorder (ebi-a-GCST90038688) | All - Inverse variance weighted | -0.0093218689245596 | 0.0037240151047036 | 0.0123083974549973 |
| Espresso | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | All - MR Egger | 7.67124534626227 | 3.29114834398653 | 0.0264387533605141 |
| Espresso | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs10245400 | -3.43518917015533 | 1.60413161704292 | 0.0322366857690649 |
| Espresso | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs117736290 | -6.05113627248722 | 1.62668403507477 | 0.0001992850202251 |
| Espresso | Cervical disc disorders (finn-b-M13_CERVICDISC) | All - Inverse variance weighted | -0.611066483590519 | 0.296622880986192 | 0.0393910163131193 |
| Espresso | Peroneal tendinitis (finn-b-M13_PERONEALTEND) | rs80138696 | 54.2253507991487 | 19.3776544253012 | 0.0051365310923855 |
| Espresso | Peroneal tendinitis (finn-b-M13_PERONEALTEND) | All - Inverse variance weighted | -3.58637557137875 | 1.54588532379443 | 0.0203436202963779 |
| Espresso | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | All - Inverse variance weighted | -0.534473740420549 | 0.257079885001915 | 0.0376156845965066 |
| Espresso | Shoulder lesions (finn-b-M13_SHOULDER) | rs139134126 | -2.52654463194953 | 1.19717085758074 | 0.0348213822102732 |
| Espresso | Shoulder lesions (finn-b-M13_SHOULDER) | rs77567794 | 1.95983010391734 | 0.857425670463837 | 0.0222709789592328 |
| Espresso | Shoulder lesions (finn-b-M13_SHOULDER) | rs78739967 | -2.5294282343538 | 1.08643369763162 | 0.0199018135298497 |
| Espresso | Shoulder lesions (finn-b-M13_SHOULDER) | rs79755398 | -6.42510293207101 | 2.65653294306782 | 0.0155801632302653 |
| Espresso | Spondylosis (finn-b-M13_SPONDYLOSIS) | rs62358564 | 2.82896546304664 | 1.4013856691944 | 0.0435192847757635 |
| Espresso | Spondylosis (finn-b-M13_SPONDYLOSIS) | rs78739967 | -3.02717759362115 | 1.46213874284784 | 0.0384171071025337 |
| Espresso | Spondylosis (finn-b-M13_SPONDYLOSIS) | All - Inverse variance weighted | -0.63765224946162 | 0.211032300402411 | 0.0025145418007112 |
| Espresso | Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) | rs115032220 | -8.01291023762083 | 3.70016631811221 | 0.0303452792157612 |
| Espresso | Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) | rs17655875 | 56.1867963407014 | 22.9235901948786 | 0.0142441363873022 |
| Espresso | Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) | rs76256974 | 20.9691334355828 | 10.5684432515337 | 0.0472416856555384 |
| Espresso | Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) | rs77567794 | 18.1979494615433 | 8.30610427487941 | 0.0284581094942283 |
| Espresso | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | rs12465802 | -2.04339787875839 | 0.628057356674657 | 0.0011398424918917 |
| Espresso | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | rs139488143 | -2.95402550623053 | 1.24123831775701 | 0.0173172446640034 |
| Espresso | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | All - Inverse variance weighted | -0.220238523675851 | 0.0991717537083276 | 0.0263659502493183 |
| Espresso | Seronegative rheumatoid arthritis (finn-b-RHEUMA_SERONEG) | rs73269888 | 7.43302447056632 | 3.23184179002129 | 0.0214519304783441 |
| Espresso | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | All - Inverse variance weighted | -0.6225332075219 | 0.294797638351753 | 0.0347095588126056 |
| Espresso | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs115032220 | -3.66393861050274 | 1.31407775783424 | 0.0052998449143142 |
| Espresso | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs11680934 | 7.28623546206706 | 3.63288425426096 | 0.0448953326504246 |
| Espresso | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs181774247 | 8.24185626107537 | 3.99435251902457 | 0.0390767962563501 |
| Espresso | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs58895686 | 9.522784742024 | 4.83536880615484 | 0.0489069523374126 |
| Espresso | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs76256974 | -8.16717791411043 | 3.69056748466258 | 0.0268985410246517 |
| Espresso | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | All - Inverse variance weighted | -0.581221827099052 | 0.292999171576581 | 0.0472895332498727 |
| Espresso | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs145046724 | 1.29881397776241 | 0.615227673676932 | 0.0347627626222285 |
| Espresso | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs28692629 | 4.1265009301539 | 1.81802807373584 | 0.023221696982371 |
| Espresso | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs79755398 | -8.6340752862809 | 4.24770693842472 | 0.0420885202843013 |
| Espresso | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | All - Inverse variance weighted | 0.718921044170094 | 0.252585910625455 | 0.0044238331933907 |
| Espresso | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | All - Inverse variance weighted | -2.15890042249486 | 1.07619891582135 | 0.0448517475945668 |
| Espresso | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | rs139165502 | 8.49842671530745 | 4.1574581920752 | 0.0409397155273931 |
| Espresso | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | rs78739967 | 17.4930183473285 | 6.43484628398994 | 0.0065582083764369 |
| Espresso | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | rs80138696 | 22.524261703719 | 9.72146836699103 | 0.0205058639914225 |
| Espresso | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | All - MR Egger | 3.2645548379853 | 1.56583578429647 | 0.04540959546105 |
| Espresso | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | rs115032220 | 1.45240173234311 | 0.492367480692279 | 0.0031794596658228 |
| Espresso | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | rs117736290 | 3.94639322118732 | 1.35717425411564 | 0.0036397938791548 |
| Espresso | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | All - Inverse variance weighted | 0.536416961535058 | 0.227193893864287 | 0.0182230964205443 |
| Espresso | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | rs115032220 | -1.71916939746735 | 0.744314719976287 | 0.0209028568089053 |
| Espresso | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | All - Inverse variance weighted | -0.642924397571973 | 0.29952590998911 | 0.0318352289953337 |
| Espresso | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | All - MR Egger | -1.14893975481983 | 0.499813175679646 | 0.0284229654459457 |
| Espresso | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs181774247 | -4.74701018211597 | 1.84341662405005 | 0.0100206702971758 |
| Espresso | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -0.596577821740864 | 0.25181200890954 | 0.0178295185541702 |
| Espresso | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | All - Inverse variance weighted | 0.425384641527706 | 0.180079658336903 | 0.0181667098099382 |
| Espresso | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | rs74821689 | -2.01274227736138 | 0.897945720097491 | 0.02499392560607 |
| Espresso | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -0.496712717757984 | 0.15759241434468 | 0.0016222173237012 |
| Espresso | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | rs191325662 | -6.69250106940941 | 3.03438335640729 | 0.0274151338784001 |
| Espresso | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | rs62310008 | -2.74085318276611 | 1.37042659138305 | 0.0455002638963584 |
| Espresso | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | rs76256974 | -5.40164877300613 | 2.59777607361963 | 0.0375864974314301 |
| Espresso | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | All - Inverse variance weighted | -1.4172448569106 | 0.368751095082875 | 0.0001213590317303 |
| Espresso | Bone morphogenetic protein receptor type-1A (prot-a-259) | rs1370699 | -5.42599662917484 | 2.36473704124101 | 0.0217591872701789 |
| Espresso | Fracture resulting from simple fall (ukb-a-332) | rs57447258 | 0.964113604561445 | 0.367486955157127 | 0.0087023396256611 |
| Espresso | Fracture resulting from simple fall (ukb-a-332) | All - MR Egger | 0.238235063597589 | 0.113848567548275 | 0.0449498706626656 |
| Espresso | Fractured bone site(s): Wrist (ukb-a-439) | rs139165502 | 0.0616936421580182 | 0.0276099203153847 | 0.0254519179214327 |
| Espresso | Fractured bone site(s): Wrist (ukb-a-439) | rs73051368 | 0.0642913831666055 | 0.0309591163895189 | 0.0378334744010136 |
| Espresso | Fractured bone site(s): Wrist (ukb-a-439) | rs73269888 | 0.0785155539000097 | 0.0301335912598469 | 0.0091718219457156 |
| Espresso | Fractured bone site(s): Wrist (ukb-a-439) | rs76762868 | 0.0621830317878296 | 0.0313687924982529 | 0.0474432692353334 |
| Espresso | Fractured bone site(s): Wrist (ukb-a-439) | All - Inverse variance weighted | 0.0167543995838085 | 0.0057888381929555 | 0.0038005399992488 |
| Espresso | Fractured bone site(s): Wrist (ukb-a-439) | All - MR Egger | 0.0251713921658736 | 0.010776566481128 | 0.0263796774150264 |
| Espresso | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | rs882549 | -0.207181644629852 | 0.0961175139645054 | 0.0311224494493816 |
| Espresso | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | All - Inverse variance weighted | -0.0339895638975147 | 0.0166667855815481 | 0.0414141829529998 |
| Espresso | Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) | rs117006792 | 0.103037554260101 | 0.0524465085420468 | 0.0494580263658371 |
| Espresso | Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) | rs12465802 | -0.136663511636753 | 0.0561876918449848 | 0.0150046102684256 |
| Espresso | Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) | rs62358564 | -0.111300800230508 | 0.0542208557620526 | 0.0400987296659476 |
| Espresso | Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) | rs882549 | -0.119640811708973 | 0.0538636781446652 | 0.0263389141810832 |
| Espresso | Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) | All - MR Egger | 0.0510790100536006 | 0.0184032444541488 | 0.0097097394820777 |
| Espresso | Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) | rs11680934 | 0.0424657050609659 | 0.019747079621566 | 0.0315172452149061 |
| Espresso | Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) | All - MR Egger | 0.0866988477356937 | 0.0356119606386773 | 0.0377005882475461 |
| Espresso | Fractured bone site(s): Leg (ukb-b-3798) | All - Inverse variance weighted | 0.0131991145673346 | 0.005310693506446 | 0.0129411625767015 |
| Espresso | Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) | rs3102538 | -0.0336668477147869 | 0.0108173877427455 | 0.0018564203709561 |
| Espresso | Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) | All - Inverse variance weighted | -0.0139719986433893 | 0.0067958637157955 | 0.0397867311179952 |
| Espresso | Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) | rs10245400 | -0.0362174576470128 | 0.0148290621698815 | 0.0145928163376129 |
| Espresso | Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) | rs12465802 | -0.0409918883296328 | 0.0155786531265757 | 0.0085062476154105 |
| Espresso | Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) | All - Inverse variance weighted | -0.0146232494917606 | 0.0052755064798038 | 0.0055727782660369 |
| Espresso | Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) | All - Inverse variance weighted | -0.0104747712160036 | 0.005241308958864 | 0.045662164570854 |
| Espresso | Ankle spacing width (right) (ukb-e-4119_AFR) | rs10000963 | -6.05530042807012 | 2.54616406139876 | 0.0173971449894585 |
| Espresso | Ankle spacing width (right) (ukb-e-4119_AFR) | All - Inverse variance weighted | -0.571369373560152 | 0.266176449812727 | 0.0318266347876936 |
| Espresso | Heel bone mineral density (BMD) (right) (ukb-e-4124_AFR) | rs80138696 | 3.27157626932123 | 1.21070704470719 | 0.0068881682426228 |
| Espresso | Heel bone mineral density (BMD) (right) (ukb-e-4124_AFR) | All - Inverse variance weighted | 0.813122501986642 | 0.36383229909945 | 0.0254250522250266 |
| Espresso | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_AFR) | rs80138696 | 2.98619931994486 | 1.19130887298487 | 0.0121879903408662 |
| Espresso | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_AFR) | All - Inverse variance weighted | 0.835461348211197 | 0.356225565682997 | 0.0190109839050956 |