ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Bran cereal (ukb-b-19498)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Bran cereal (👉 📊) Heel bone mineral density (ebi-a-GCST006288) Weighted median 5 0.333662788 0.152331029 0.028496714
Bran cereal (👉 📊) Heel bone mineral density (ebi-a-GCST006288) Inverse variance weighted 5 0.365031073 0.140729074 0.009490599
Bran cereal (👉 📊) Heel bone mineral density (ebi-a-GCST006979) Weighted median 5 0.178733418 0.078015637 0.021963714
Bran cereal (👉 📊) Heel bone mineral density (ebi-a-GCST006979) Inverse variance weighted 5 0.214407019 0.057009371 0.000169297
Bran cereal (👉 📊) Bone mineral density (ebi-a-GCST90014022) Weighted median 4 0.247996148 0.091139198 0.006507096
Bran cereal (👉 📊) Bone mineral density (ebi-a-GCST90014022) Inverse variance weighted 4 0.244030044 0.071599599 0.000653786
Bran cereal (👉 📊) Heel bone mineral density T score (ebi-a-GCST90025982) Weighted median 3 0.215198805 0.099558542 0.0306544
Bran cereal (👉 📊) Heel bone mineral density T score (ebi-a-GCST90025982) Inverse variance weighted 3 0.256997876 0.098425915 0.009025694
Bran cereal (👉 📊) Heel bone mineral density (ebi-a-GCST90029004) Weighted median 5 0.165993624 0.080192403 0.038457775
Bran cereal (👉 📊) Heel bone mineral density (ebi-a-GCST90029004) Inverse variance weighted 5 0.227461227 0.071068527 0.001371465
Bran cereal (👉 📊) Sciatica (ebi-a-GCST90038692) Inverse variance weighted 3 0.01925741 0.00825067 0.019593532
Bran cereal (👉 📊) Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) Inverse variance weighted 4 -6.947037782 3.403206563 0.041218909
Bran cereal (👉 📊) Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) Weighted median 4 -3.320731126 1.58502593 0.036165283
Bran cereal (👉 📊) Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) Inverse variance weighted 4 -3.158839466 1.292884066 0.014555636
Bran cereal (👉 📊) Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) Weighted median 4 -5.042100481 2.152896919 0.019180335
Bran cereal (👉 📊) Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) Inverse variance weighted 4 -6.408434858 2.702287798 0.017716768
Bran cereal (👉 📊) Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) Inverse variance weighted 4 1.136933924 0.46532648 0.014553483
Bran cereal (👉 📊) Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) Inverse variance weighted 4 -0.792645662 0.282510324 0.005020386
Bran cereal (👉 📊) Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) Inverse variance weighted 4 0.605578147 0.281667355 0.031557087
Bran cereal (👉 📊) Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) Weighted median 4 -1.206278346 0.509067395 0.017808072
Bran cereal (👉 📊) Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) Inverse variance weighted 4 -0.946472666 0.440295298 0.03158437
Bran cereal (👉 📊) Osteoporosis (finn-b-M13_OSTEOPOROSIS) Weighted median 4 -1.986957698 0.795252686 0.01247118
Bran cereal (👉 📊) Osteoporosis (finn-b-M13_OSTEOPOROSIS) Inverse variance weighted 4 -1.54676333 0.745270882 0.037945982
Bran cereal (👉 📊) Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) Weighted median 4 -6.188425864 3.148162344 0.049330222
Bran cereal (👉 📊) Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) Inverse variance weighted 4 -5.218116807 2.385000959 0.028677706
Bran cereal (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) Inverse variance weighted 4 0.880387493 0.433473853 0.042254504
Bran cereal (👉 📊) Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) Weighted median 4 1.274003971 0.645847695 0.048540304
Bran cereal (👉 📊) Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) Inverse variance weighted 4 1.027316241 0.43255802 0.017549946
Bran cereal (👉 📊) Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) Weighted median 4 0.773265537 0.346999924 0.025851759
Bran cereal (👉 📊) Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) Inverse variance weighted 4 0.710364155 0.2700765 0.008532634
Bran cereal (👉 📊) Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) Weighted median 4 8.135219696 3.646464449 0.025681901
Bran cereal (👉 📊) Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) Inverse variance weighted 4 6.219123534 2.901488546 0.032078975
Bran cereal (👉 📊) Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) Inverse variance weighted 4 4.15363276 2.116985226 0.049756559
Bran cereal (👉 📊) Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) Inverse variance weighted 4 -3.654098231 1.699577998 0.031554957
Bran cereal (👉 📊) Osteocrin (prot-a-2157) Weighted median 5 2.311524301 1.05491406 0.028437555
Bran cereal (👉 📊) Heel bone mineral density (BMD) T-score automated (ukb-a-500) Weighted median 5 0.351344792 0.1284713 0.0062416
Bran cereal (👉 📊) Heel bone mineral density (BMD) T-score automated (ukb-a-500) Inverse variance weighted 5 0.329570377 0.103639423 0.001472897
Bran cereal (👉 📊) Neck/shoulder pain for 3+ months (ukb-b-16118) Inverse variance weighted 5 -0.140650424 0.062867449 0.025269772
Bran cereal (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) Weighted median 5 0.290463989 0.106051853 0.006164765
Bran cereal (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) Inverse variance weighted 5 0.254436057 0.08123045 0.001734577
Bran cereal (👉 📊) Heel bone mineral density (BMD) (ukb-b-8875) Weighted median 5 0.288495783 0.105957297 0.006474001
Bran cereal (👉 📊) Heel bone mineral density (BMD) (ukb-b-8875) Inverse variance weighted 5 0.269272131 0.079214832 0.000675674
Bran cereal (👉 📊) M75 Shoulder lesions (ukb-e-M75_CSA) Wald ratio 1 -18.83325472 7.902143079 0.01715775

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Bran cereal Heel bone mineral density (ebi-a-GCST006288) rs149553233 0.576837411121152 0.241486943578402 0.0169085697094095
Bran cereal Heel bone mineral density (ebi-a-GCST006288) rs8176599 0.76397019932944 0.251990229883753 0.0024314425789942
Bran cereal Heel bone mineral density (ebi-a-GCST006288) All - Inverse variance weighted 0.365031072622185 0.140729074165174 0.0094905993766127
Bran cereal Heel bone mineral density (ebi-a-GCST006979) rs185628064 0.323892400553389 0.131100484763176 0.0134899422673003
Bran cereal Heel bone mineral density (ebi-a-GCST006979) rs76586744 0.352388637903015 0.127792519006498 0.0058244144415481
Bran cereal Heel bone mineral density (ebi-a-GCST006979) All - Inverse variance weighted 0.214407019016993 0.0570093709836185 0.0001692974600087
Bran cereal Bone mineral density (ebi-a-GCST90014022) rs185628064 0.289022777949524 0.144309678381229 0.0451992404927335
Bran cereal Bone mineral density (ebi-a-GCST90014022) rs76586744 0.319040923488925 0.146319076689907 0.0292243780287493
Bran cereal Bone mineral density (ebi-a-GCST90014022) All - Inverse variance weighted 0.244030043755012 0.0715995994638834 0.0006537859208348
Bran cereal Heel bone mineral density T score (ebi-a-GCST90025982) rs76586744 0.4395044562722 0.129624653792246 0.0006974156313925
Bran cereal Heel bone mineral density T score (ebi-a-GCST90025982) All - Inverse variance weighted 0.256997875919619 0.0984259145804276 0.0090256941152249
Bran cereal Heel bone mineral density (ebi-a-GCST90029004) rs185628064 0.342960629161651 0.133408536304618 0.0101477159897999
Bran cereal Heel bone mineral density (ebi-a-GCST90029004) rs76586744 0.442110934017664 0.129837016901868 0.0006613440517867
Bran cereal Heel bone mineral density (ebi-a-GCST90029004) All - Inverse variance weighted 0.227461226769339 0.0710685273088404 0.0013714647065877
Bran cereal Sciatica (ebi-a-GCST90038692) rs558086810 0.0329385879189543 0.0144507323371416 0.022644989053764
Bran cereal Sciatica (ebi-a-GCST90038692) All - Inverse variance weighted 0.0192574096277844 0.0082506703433244 0.019593532215827
Bran cereal Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) All - Inverse variance weighted -6.94703778197546 3.40320656284775 0.0412189089405968
Bran cereal Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs8176599 -3.47084287682707 1.74904148894392 0.0472084036397042
Bran cereal Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) All - Inverse variance weighted -3.1588394655066 1.29288406613172 0.0145556356679797
Bran cereal Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) rs8176599 -4.9588333972719 2.11564784905352 0.0190840996542345
Bran cereal Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) rs185628064 -14.716103302134 5.90661238020693 0.0127218392483153
Bran cereal Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) All - Inverse variance weighted -6.40843485757905 2.70228779770558 0.0177167679431232
Bran cereal Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) rs185628064 2.23416407402779 1.07432816121061 0.0375629863785009
Bran cereal Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) All - Inverse variance weighted 1.13693392377991 0.465326480358718 0.0145534833999504
Bran cereal Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) rs185628064 -1.71234753858263 0.602939274148814 0.0045113533830846
Bran cereal Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) All - Inverse variance weighted -0.792645662450935 0.282510324149836 0.0050203857901151
Bran cereal Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) rs76586744 1.33229908773279 0.6035583115568 0.0272856093392781
Bran cereal Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) All - Inverse variance weighted 0.605578146849323 0.281667355103108 0.0315570870041155
Bran cereal Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) rs8176599 -1.36768007409307 0.469891743298368 0.0036070316546628
Bran cereal Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) All - Inverse variance weighted -0.946472666241635 0.44029529760096 0.0315843701781531
Bran cereal Osteoporosis (finn-b-M13_OSTEOPOROSIS) rs185628064 -2.85245089333675 1.34619896119044 0.0340995522450592
Bran cereal Osteoporosis (finn-b-M13_OSTEOPOROSIS) rs8176599 -2.00328243217782 0.791097934973339 0.0113323068499527
Bran cereal Osteoporosis (finn-b-M13_OSTEOPOROSIS) All - Inverse variance weighted -1.54676332972055 0.745270881503678 0.0379459815468759
Bran cereal Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) rs8176599 -6.49903411141655 3.21433192517144 0.0431874427021149
Bran cereal Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) All - Inverse variance weighted -5.21811680679159 2.38500095915725 0.0286777057636058
Bran cereal Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) All - Inverse variance weighted 0.880387492706476 0.433473852829457 0.0422545037214531
Bran cereal Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) rs8176599 1.97150231427359 0.663977463356389 0.0029854629880888
Bran cereal Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) All - Inverse variance weighted 1.02731624109756 0.432558019880865 0.0175499456025749
Bran cereal Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) rs8176599 0.806987993925457 0.36547135589873 0.02723907787727
Bran cereal Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) All - Inverse variance weighted 0.710364154802909 0.27007650015842 0.008532633597884
Bran cereal Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) rs8176599 8.62830201100046 3.9486796496015 0.0288807335422516
Bran cereal Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) All - Inverse variance weighted 6.21912353374609 2.90148854583518 0.0320789750668968
Bran cereal Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) All - Inverse variance weighted 4.15363276006542 2.11698522633038 0.0497565590183384
Bran cereal Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) rs76586744 -7.29411396522163 2.80542844816216 0.0093223760474375
Bran cereal Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) All - Inverse variance weighted -3.65409823135694 1.69957799760444 0.0315549571084154
Bran cereal Heel bone mineral density (BMD) T-score automated (ukb-a-500) rs149553233 0.560093472451017 0.219130807282861 0.0105889882989375
Bran cereal Heel bone mineral density (BMD) T-score automated (ukb-a-500) rs185628064 0.485497666076882 0.217299972155168 0.0254680798658235
Bran cereal Heel bone mineral density (BMD) T-score automated (ukb-a-500) All - Inverse variance weighted 0.329570376629458 0.103639423350333 0.0014728971359091
Bran cereal Neck/shoulder pain for 3+ months (ukb-b-16118) rs76586744 -0.285031530333276 0.141754834613846 0.0443533633682372
Bran cereal Neck/shoulder pain for 3+ months (ukb-b-16118) All - Inverse variance weighted -0.140650424186686 0.0628674485915742 0.0252697715144665
Bran cereal Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) rs76586744 0.464049160942177 0.179126271104981 0.0095801565973291
Bran cereal Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) All - Inverse variance weighted 0.254436057280976 0.0812304501224747 0.0017345769182445
Bran cereal Heel bone mineral density (BMD) (ukb-b-8875) rs76586744 0.449570467668275 0.179079104140634 0.0120574858827929
Bran cereal Heel bone mineral density (BMD) (ukb-b-8875) All - Inverse variance weighted 0.269272130897297 0.0792148317056413 0.0006756744665337
Bran cereal M75 Shoulder lesions (ukb-e-M75_CSA) rs76586744 -18.8332547217261 7.90214307908626 0.0171577501527737