ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Cheesy biscuits | Heel bone mineral density (ebi-a-GCST006979) | rs150893688 | 0.837120359110631 | 0.265358284916453 | 0.001606744690073 |
| Cheesy biscuits | Heel bone mineral density (ebi-a-GCST006979) | rs73190296 | 0.989132596245625 | 0.306102847597836 | 0.0012319688938837 |
| Cheesy biscuits | Knee osteoarthritis (ebi-a-GCST007090) | rs117807208 | -3.24555997218091 | 1.56058284376643 | 0.0375521270166555 |
| Cheesy biscuits | Knee osteoarthritis (ebi-a-GCST007090) | rs144060822 | -4.27259755897033 | 1.56741474695932 | 0.0064128691616218 |
| Cheesy biscuits | Knee osteoarthritis (ebi-a-GCST007090) | rs72759617 | -2.92720810060038 | 1.40386510947161 | 0.0370596450031468 |
| Cheesy biscuits | Knee osteoarthritis (ebi-a-GCST007090) | rs74967048 | -3.54963637300216 | 1.5594048973743 | 0.0228294791068214 |
| Cheesy biscuits | Knee osteoarthritis (ebi-a-GCST007090) | rs79165324 | -3.29165346163819 | 1.48136410345059 | 0.026280457926106 |
| Cheesy biscuits | Knee osteoarthritis (ebi-a-GCST007090) | All - Inverse variance weighted | -0.72275841063961 | 0.361894855407827 | 0.0458088606822354 |
| Cheesy biscuits | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | rs144060822 | -3.68382247635617 | 1.28098362568757 | 0.0040303510913518 |
| Cheesy biscuits | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | rs150893688 | 2.34953234547884 | 1.09594799501569 | 0.0320460604444461 |
| Cheesy biscuits | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | rs74967048 | -3.43256393325934 | 1.27374814440183 | 0.0070419703202454 |
| Cheesy biscuits | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | rs79165324 | -3.10678306299039 | 1.20285804834481 | 0.0097992365561316 |
| Cheesy biscuits | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | All - Inverse variance weighted | -0.625196049060039 | 0.270028804911489 | 0.020596852511963 |
| Cheesy biscuits | Osteoclast-associated immunoglobulin-like receptor levels (ebi-a-GCST90010135) | All - Inverse variance weighted | 3.21183962539171 | 1.54381928291091 | 0.0374842298310851 |
| Cheesy biscuits | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | rs9560935 | -3.10516476097668 | 1.23923104416333 | 0.0122202697974114 |
| Cheesy biscuits | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | All - Inverse variance weighted | -0.641917263117067 | 0.268033688163933 | 0.0166243264267361 |
| Cheesy biscuits | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | rs9560935 | -3.10143789731574 | 1.2352429945655 | 0.0120460742592125 |
| Cheesy biscuits | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | All - Inverse variance weighted | -0.642439934514912 | 0.268079624373985 | 0.0165546645517273 |
| Cheesy biscuits | Neck circumference (ebi-a-GCST90017133) | rs62332751 | -12.3743060355399 | 5.30645916479008 | 0.019704228051228 |
| Cheesy biscuits | Neck circumference (ebi-a-GCST90017135) | rs11722366 | -18.7894816321458 | 7.08280602065239 | 0.0079820016042975 |
| Cheesy biscuits | Neck circumference (ebi-a-GCST90017135) | rs12123737 | -16.4736469676643 | 6.72393753782215 | 0.0142856214705428 |
| Cheesy biscuits | Neck circumference (ebi-a-GCST90017135) | rs62332751 | -13.7492289283777 | 6.34322534614613 | 0.0301932917572461 |
| Cheesy biscuits | Neck circumference (ebi-a-GCST90017135) | All - Inverse variance weighted | -5.03455946455226 | 1.95930873270076 | 0.0101828039025353 |
| Cheesy biscuits | Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) | rs150467162 | 60.1107882967053 | 30.5300719701993 | 0.0489640880230959 |
| Cheesy biscuits | Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) | rs77086194 | 18.0289721912904 | 8.64871342897519 | 0.0371070512297986 |
| Cheesy biscuits | Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) | All - Inverse variance weighted | 5.06829147209579 | 2.52200771258261 | 0.0444708208913549 |
| Cheesy biscuits | Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) | All - MR Egger | 8.93057828954541 | 4.14313877981502 | 0.0423253159083185 |
| Cheesy biscuits | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | rs62139637 | 52.9642632363611 | 22.8020248950856 | 0.0201905595195099 |
| Cheesy biscuits | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | All - Inverse variance weighted | 10.8337277481249 | 4.35976360597625 | 0.0129575210631825 |
| Cheesy biscuits | Bicipital tendinitis (finn-b-M13_BICIPITALTEND) | rs9560935 | -20.4672020723806 | 9.30188512095505 | 0.0277836032173612 |
| Cheesy biscuits | Bicipital tendinitis (finn-b-M13_BICIPITALTEND) | All - Inverse variance weighted | -3.48536579108743 | 1.56937776955249 | 0.0263605540881237 |
| Cheesy biscuits | Chondromalacia (finn-b-M13_CHONDROMALACIA) | rs61948341 | -35.4492180629911 | 11.8891007196775 | 0.0028669318737688 |
| Cheesy biscuits | Chondromalacia (finn-b-M13_CHONDROMALACIA) | All - Inverse variance weighted | -4.04906674860909 | 2.00687143114448 | 0.0436327837140162 |
| Cheesy biscuits | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | rs12123737 | 9.46154067822117 | 4.17844689850376 | 0.0235515017239316 |
| Cheesy biscuits | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | rs78427380 | 8.71984897291759 | 4.32308005417886 | 0.0436907700231382 |
| Cheesy biscuits | Patellar tendinitis (finn-b-M13_PATELLARTEND) | All - Inverse variance weighted | -5.66345699287259 | 2.80988037110025 | 0.0438469554107002 |
| Cheesy biscuits | Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) | rs9560935 | -26.515718505711 | 9.69900993728483 | 0.0062596982729594 |
| Cheesy biscuits | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | rs117807208 | -50.7359052794065 | 16.7423398564942 | 0.0024423398143668 |
| Cheesy biscuits | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | rs56322115 | 91.9640568159323 | 41.1483905722158 | 0.0254214910498359 |
| Cheesy biscuits | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | All - Inverse variance weighted | -8.7313363724258 | 3.93120556489377 | 0.0263487421500148 |
| Cheesy biscuits | Seronegative rheumatoid arthritis (finn-b-RHEUMA_SERONEG) | rs62139637 | 11.1030492611558 | 5.02878219832011 | 0.0272512303558248 |
| Cheesy biscuits | Seronegative rheumatoid arthritis (finn-b-RHEUMA_SERONEG) | All - MR Egger | -3.65717444991698 | 1.58352957830122 | 0.0306850609651979 |
| Cheesy biscuits | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | rs145326237 | 19.1842019150056 | 7.97017940728727 | 0.0160842799293457 |
| Cheesy biscuits | Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) | rs114718866 | -8.8729077192408 | 4.4742377108024 | 0.0473550896189127 |
| Cheesy biscuits | Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) | rs74967048 | -20.8997719428874 | 10.2368141311118 | 0.0411883915477512 |
| Cheesy biscuits | Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) | All - Inverse variance weighted | -3.78441562362216 | 1.51712097840433 | 0.0126144720049621 |
| Cheesy biscuits | Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) | All - MR Egger | -6.42351084985082 | 2.44873793907898 | 0.0155257605960212 |
| Cheesy biscuits | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs78427380 | 11.6919665101656 | 3.25985500838649 | 0.0003349504498927 |
| Cheesy biscuits | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs9560935 | 7.07187653694941 | 3.28391675041927 | 0.0312803169734008 |
| Cheesy biscuits | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs150893688 | 5.17572700385834 | 1.81657133420409 | 0.0043832962424316 |
| Cheesy biscuits | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | All - Inverse variance weighted | 0.825583178581021 | 0.396629136837758 | 0.0373882493384497 |
| Cheesy biscuits | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs11722366 | 3.60822193504933 | 1.63038176324451 | 0.0268897351665657 |
| Cheesy biscuits | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs4527950 | 3.05007866787059 | 1.41934353851404 | 0.0316394600986086 |
| Cheesy biscuits | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs62139637 | -3.46055490154669 | 1.44276911303155 | 0.016460096529306 |
| Cheesy biscuits | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs72759617 | -3.85316168344335 | 1.41382159960971 | 0.0064232944654203 |
| Cheesy biscuits | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | All - MR Egger | -1.12801048534745 | 0.524908822502123 | 0.0428989794825938 |
| Cheesy biscuits | Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) | All - Inverse variance weighted | -1.04486810478291 | 0.510139154769227 | 0.0405401975706214 |
| Cheesy biscuits | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | rs114718866 | -6.99945843146639 | 3.50760085139611 | 0.0459871026758844 |
| Cheesy biscuits | Superficial injury of shoulder and upper arm (finn-b-ST19_SUPERF_INJURY_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -2.19899427966157 | 1.11760292134912 | 0.0491142063105816 |
| Cheesy biscuits | Hip osteoarthritis (ieu-a-1169) | All - Inverse variance weighted | -5.60095144363609 | 2.3063263689093 | 0.0151607388298603 |
| Cheesy biscuits | Knee and hip osteoarthritis (ieu-a-1170) | rs61948341 | -8.99301427395583 | 3.45798363665783 | 0.0093046615028432 |
| Cheesy biscuits | Knee and hip osteoarthritis (ieu-a-1170) | All - Inverse variance weighted | -4.91597207989781 | 1.71137078278105 | 0.0040719326641347 |
| Cheesy biscuits | Psoriatic arthritis (ieu-b-5116) | rs12123737 | -8.04701633276447 | 3.84769320914327 | 0.0364933685330981 |
| Cheesy biscuits | Psoriatic arthritis (ieu-b-5116) | All - MR Egger | 4.51030011493172 | 1.84569119217313 | 0.025741371461509 |
| Cheesy biscuits | Bone sialoprotein 2 (prot-a-1396) | rs11722366 | 10.3034781923075 | 3.96904412855427 | 0.009432715662454 |
| Cheesy biscuits | Bone sialoprotein 2 (prot-a-1396) | rs12064775 | 9.25668444691626 | 4.13327603205501 | 0.0251200557843332 |
| Cheesy biscuits | Bone sialoprotein 2 (prot-a-1396) | rs77086194 | 10.3639750126085 | 4.24695772017517 | 0.0146738823599132 |
| Cheesy biscuits | Bone sialoprotein 2 (prot-a-1396) | All - Inverse variance weighted | 2.12381206677298 | 0.935812361777224 | 0.023238851698892 |
| Cheesy biscuits | Osteomodulin (prot-a-2147) | rs11722366 | 9.0071910526787 | 3.96904412855427 | 0.0232464262027998 |
| Cheesy biscuits | Osteomodulin (prot-a-2147) | All - Inverse variance weighted | 2.5368798797723 | 0.852518730208788 | 0.0029227607103492 |
| Cheesy biscuits | Osteocrin (prot-a-2157) | rs77086194 | 11.4575478999905 | 4.24695772017517 | 0.0069794160064802 |
| Cheesy biscuits | Osteocalcin (prot-a-246) | rs73190296 | 8.87885777919186 | 4.081490614063 | 0.0296004645800076 |
| Cheesy biscuits | Osteocalcin (prot-a-246) | rs74967048 | 9.84813363116562 | 4.25207101145905 | 0.0205539395644853 |
| Cheesy biscuits | Osteocalcin (prot-a-246) | All - MR Egger | 3.66560296458873 | 1.67829602564194 | 0.0416929164718708 |
| Cheesy biscuits | Operative procedures - secondary OPCS: Z66.5 Lumbar vertebra (ukb-b-17671) | All - Inverse variance weighted | 0.019799227615206 | 0.0089834020891674 | 0.0275258361597143 |
| Cheesy biscuits | Fractured bone site(s): Other bones (ukb-b-17738) | rs12123737 | -0.151733975416004 | 0.0759998655212492 | 0.0458791767844071 |
| Cheesy biscuits | Fractured bone site(s): Other bones (ukb-b-17738) | rs73190296 | -0.152020362710786 | 0.0769144726376074 | 0.0480997828545679 |
| Cheesy biscuits | Fractured bone site(s): Other bones (ukb-b-17738) | rs78427380 | -0.15122920044073 | 0.0733976180951779 | 0.0393593433129377 |
| Cheesy biscuits | Fractured heel (right) (ukb-b-3499) | rs12064775 | 0.175408060941595 | 0.0679112841385006 | 0.0097973694663688 |
| Cheesy biscuits | Fractured heel (right) (ukb-b-3499) | rs139074210 | 0.135519874795311 | 0.0617772110075789 | 0.0282579072718345 |
| Cheesy biscuits | Fractured heel (right) (ukb-b-3499) | rs62332751 | 0.143267708635259 | 0.0656276708806195 | 0.0290330013428836 |
| Cheesy biscuits | Fractured heel (right) (ukb-b-3499) | All - Inverse variance weighted | 0.0281376690939091 | 0.0140619762773432 | 0.045395037266669 |
| Cheesy biscuits | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | rs117807208 | -0.0558097219787738 | 0.0228277648043334 | 0.0144925401611247 |
| Cheesy biscuits | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | All - Inverse variance weighted | -0.0108847140740988 | 0.0052889540470986 | 0.0395892868059789 |
| Cheesy biscuits | Cervicalgia (ukb-d-M13_CERVICALGIA) | rs62332751 | 0.0708430878538568 | 0.0200652159372143 | 0.0004145529168563 |
| Cheesy biscuits | Cervicalgia (ukb-d-M13_CERVICALGIA) | All - Inverse variance weighted | 0.014274370134045 | 0.0056349380482806 | 0.011302958679154 |
| Cheesy biscuits | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | rs117807208 | -0.0813730867310878 | 0.0286108550976212 | 0.0044532408054449 |
| Cheesy biscuits | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | All - Inverse variance weighted | -0.0129931514875728 | 0.0055243419566754 | 0.0186736908795977 |
| Cheesy biscuits | Ankle spacing width (ukb-e-3143_CSA) | All - MR Egger | 6.43048038376562 | 2.44836349704005 | 0.0340885244926429 |
| Cheesy biscuits | Osteoarthrosis (ukb-e-740_CSA) | rs145326237 | 18.4273051915717 | 7.75392320059186 | 0.0174771094616319 |
| Cheesy biscuits | Osteoarthrosis (ukb-e-740_CSA) | rs9560935 | -34.1680082357577 | 12.2940678716859 | 0.0054488393846938 |
| Cheesy biscuits | Osteoarthrosis (ukb-e-740_CSA) | All - MR Egger | 19.7941424381887 | 7.52843822976929 | 0.0339496213966999 |