ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Melon | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | All - Inverse variance weighted | -0.792520926938302 | 0.36136786417416 | 0.0282991656193925 |
| Melon | Heel bone mineral density (ebi-a-GCST006288) | rs62019153 | 1.00587706820394 | 0.31182526016321 | 0.0012563357126911 |
| Melon | Heel bone mineral density (ebi-a-GCST006288) | rs73212411 | 0.725072021326912 | 0.34630810078686 | 0.0362849753981392 |
| Melon | Heel bone mineral density (ebi-a-GCST006288) | rs75040752 | 0.627805323878864 | 0.311836336422519 | 0.0440880591931608 |
| Melon | Heel bone mineral density (ebi-a-GCST006288) | All - MR Egger | -0.364908489227184 | 0.168794588685896 | 0.0461270020083596 |
| Melon | Sciatica (ebi-a-GCST90038692) | rs142872754 | -0.0409761908172083 | 0.018349398683262 | 0.0255418166319185 |
| Melon | Sciatica (ebi-a-GCST90038692) | rs79508714 | -0.0506773375769174 | 0.0199078298191153 | 0.010909064667102 |
| Melon | Sciatica (ebi-a-GCST90038692) | All - MR Egger | -0.0343247255725317 | 0.0110088382720891 | 0.0088890218174638 |
| Melon | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | rs117641063 | 9.65384849123986 | 4.27908040881841 | 0.024067073604196 |
| Melon | Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) | All - Inverse variance weighted | 3.39605334248646 | 1.48419668161796 | 0.0221292303363679 |
| Melon | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | rs1946579 | 49.6542372881356 | 25.0231124807396 | 0.0472185096305777 |
| Melon | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | rs62019153 | 32.9190686531407 | 11.9263307628959 | 0.005776583006462 |
| Melon | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | All - MR Egger | -11.9027857474104 | 5.10742736764906 | 0.0352491815578537 |
| Melon | Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) | rs62019153 | -14.4942726660178 | 5.90701504828929 | 0.0141379590004402 |
| Melon | Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) | All - Inverse variance weighted | -3.6274022164954 | 1.2757247161241 | 0.0044634293562962 |
| Melon | Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) | rs79508714 | -10.773515156971 | 4.99472939891916 | 0.0310074765040445 |
| Melon | Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) | All - Inverse variance weighted | -2.36133735415209 | 0.985568482812775 | 0.0165789784082932 |
| Melon | Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) | All - MR Egger | -4.55129903992794 | 1.98410046392001 | 0.0377856916689824 |
| Melon | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | rs62019153 | -10.2343340570487 | 4.5818671857453 | 0.0255054441926195 |
| Melon | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | All - Inverse variance weighted | -2.22892396838976 | 1.11060888126526 | 0.0447561881896821 |
| Melon | Disorders of synovium and tendon (finn-b-M13_SYNOTEND) | rs148224585 | 3.04653040939305 | 1.17288935826552 | 0.0093916706905201 |
| Melon | Disorders of synovium and tendon (finn-b-M13_SYNOTEND) | rs73212411 | 4.17078728984822 | 1.85428043169798 | 0.0244949823214499 |
| Melon | Disorders of synovium and tendon (finn-b-M13_SYNOTEND) | All - Inverse variance weighted | 0.603593864128856 | 0.297597115215087 | 0.0425373048733543 |
| Melon | Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) | All - MR Egger | -13.350076439594 | 4.99464008201536 | 0.0181971384582773 |
| Melon | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | All - MR Egger | -6.42637076028201 | 2.53984504374435 | 0.0240206698653142 |
| Melon | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | rs4676860 | 32.4591015320696 | 10.7035866515508 | 0.0024250143691751 |
| Melon | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | All - Inverse variance weighted | 5.54353798672861 | 2.81436449284917 | 0.0488693304061804 |
| Melon | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | rs116518349 | 8.18177258363846 | 3.8902543010483 | 0.0354530131915814 |
| Melon | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | rs72736578 | 15.6185988602053 | 6.50374027026751 | 0.0163289244618791 |
| Melon | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | All - MR Egger | 5.50556368661328 | 2.27556132262882 | 0.0297402444186412 |
| Melon | Rheumatoid arthritis (ieu-a-832) | All - Inverse variance weighted | 1.36812507092018 | 0.692453370895685 | 0.0481814095924509 |
| Melon | Fractured/broken bones in last 5 years (ukb-a-308) | rs139186326 | 0.146119909421113 | 0.0694119306837176 | 0.03528153334131 |
| Melon | Fractured/broken bones in last 5 years (ukb-a-308) | All - MR Egger | 0.0746200295391899 | 0.032103897870975 | 0.0335968443127623 |
| Melon | Fractured bone site(s): Ankle (ukb-a-438) | rs117641063 | 0.0808138474902854 | 0.0271271176443251 | 0.0028911549695912 |
| Melon | Fractured bone site(s): Ankle (ukb-a-438) | rs148470410 | 0.0607929657304818 | 0.0272511380228463 | 0.0256916393659434 |
| Melon | Fractured bone site(s): Ankle (ukb-a-438) | rs1946579 | 0.0670175654853621 | 0.0282428351309707 | 0.0176488012563874 |
| Melon | Fractured bone site(s): Ankle (ukb-a-438) | All - Inverse variance weighted | 0.021496106091818 | 0.0084806564617518 | 0.0112536610852229 |
| Melon | Fractured bone site(s): Ankle (ukb-a-438) | All - MR Egger | 0.0434564564120882 | 0.0158660194404005 | 0.0145605571754486 |
| Melon | Operation code: bone surgery/joint surgery (ukb-b-12974) | rs4053618 | -0.0534639473261603 | 0.018169992846402 | 0.0032564651488193 |
| Melon | Operation code: bone surgery/joint surgery (ukb-b-12974) | All - Inverse variance weighted | -0.0215406245882829 | 0.010952132819108 | 0.0492065910390904 |
| Melon | Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) | rs62019153 | 0.029352174889571 | 0.012289511117766 | 0.0169222630433729 |
| Melon | Fractured bone site(s): Arm (ukb-b-19255) | rs73212411 | 0.047481940921013 | 0.0214203250634218 | 0.0266451747091232 |
| Melon | Fractured bone site(s): Arm (ukb-b-19255) | All - Inverse variance weighted | 0.0224272500152691 | 0.0109214175645376 | 0.0400230536690692 |
| Melon | Ankle spacing width (left) (ukb-b-2122) | rs116518349 | 0.680638009730652 | 0.319251642674424 | 0.0330085184134946 |
| Melon | Ankle spacing width (left) (ukb-b-2122) | rs142872754 | 0.609817289467528 | 0.288364676282005 | 0.0344518251433472 |
| Melon | Ankle spacing width (left) (ukb-b-2122) | All - Inverse variance weighted | 0.206565881277429 | 0.0701664389297753 | 0.0032406139924171 |
| Melon | Ankle spacing width (left) (ukb-b-2122) | All - MR Egger | 0.325104598570651 | 0.136864784261628 | 0.0303699970977672 |
| Melon | Fractured heel (right) (ukb-b-3499) | rs72736578 | -0.102261657090622 | 0.0361051620249215 | 0.0046210436849594 |
| Melon | Fractured heel (right) (ukb-b-3499) | All - Inverse variance weighted | -0.023397157801975 | 0.0094569680889754 | 0.0133585229824821 |
| Melon | Ankle spacing width (right) (ukb-b-8607) | rs116518349 | 0.777129959372022 | 0.323340522646336 | 0.0162415752315843 |
| Melon | Ankle spacing width (right) (ukb-b-8607) | All - Inverse variance weighted | 0.156037372668891 | 0.0770460832157734 | 0.0428419760767542 |
| Melon | Other joint disorders (ukb-d-M13_OTHERJOINT) | rs73212411 | -0.188789934213355 | 0.0638614180676785 | 0.0031141062286042 |
| Melon | Other joint disorders (ukb-d-M13_OTHERJOINT) | All - Inverse variance weighted | -0.0324646941013319 | 0.0143797060036558 | 0.023965966497144 |
| Melon | Ankle spacing width (ukb-e-3143_CSA) | All - Inverse variance weighted | -1.41374325458962 | 0.650052448289238 | 0.029644047237594 |
| Melon | Heel bone mineral density (BMD) (ukb-e-3148_EAS) | All - Inverse variance weighted | 5.63661545681543 | 2.32385619543748 | 0.0152854626295907 |
| Melon | Ankle spacing width (right) (ukb-e-4119_AFR) | rs4676860 | 3.76968921597811 | 1.72207408908677 | 0.0285939264227401 |
| Melon | Ankle spacing width (right) (ukb-e-4119_AFR) | rs73212411 | 7.30962720901234 | 3.3307176334007 | 0.0281915644022894 |
| Melon | Ankle spacing width (right) (ukb-e-4119_AFR) | All - MR Egger | -4.00897546124848 | 1.52456401802057 | 0.0465563656727949 |
| Melon | Heel bone mineral density (BMD) (right) (ukb-e-4124_AFR) | rs142872754 | 2.80009739469199 | 1.28188601956487 | 0.0289359855418552 |
| Melon | Heel bone mineral density (BMD) (right) (ukb-e-4124_AFR) | All - Inverse variance weighted | 2.20874522352654 | 0.828152177348859 | 0.0076514249734752 |
| Melon | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | rs1946579 | -4.15901386748844 | 1.84924499229584 | 0.0245103672099313 |
| Melon | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | All - Inverse variance weighted | -1.08471413819631 | 0.508216319830822 | 0.0328137169655382 |
| Melon | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_AFR) | rs142872754 | 2.57332053834439 | 1.26111803377304 | 0.041299825942479 |
| Melon | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_AFR) | All - Inverse variance weighted | 2.11404517616256 | 0.814454939936356 | 0.0094410424959929 |
| Melon | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | All - Inverse variance weighted | 5.58583208530194 | 2.35998428419664 | 0.0179380810437278 |