ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Powdered/instant soup | Rheumatoid arthritis (bbj-a-151) | All - Inverse variance weighted | -3.45897990165065 | 1.65817449647195 | 0.0369770988545424 |
| Powdered/instant soup | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | All - Inverse variance weighted | 1.84944542006301 | 0.914891159882479 | 0.0432288303264876 |
| Powdered/instant soup | Osteoarthritis of the hip or knee (hospital diagnosed) (ebi-a-GCST005812) | rs72652725 | 4.67199616332662 | 2.35979391986007 | 0.0477223785220285 |
| Powdered/instant soup | Osteoarthritis of the hip or knee (hospital diagnosed) (ebi-a-GCST005812) | All - Inverse variance weighted | 1.31151908287869 | 0.571076792338424 | 0.0216431862895645 |
| Powdered/instant soup | Knee osteoarthritis (ebi-a-GCST007090) | All - MR Egger | 1.23653803628612 | 0.568054196675334 | 0.0438791699976057 |
| Powdered/instant soup | Osteoarthritis (hip) (ebi-a-GCST007091) | rs187551406 | 2.74117898245783 | 1.33959626152776 | 0.0407295683954113 |
| Powdered/instant soup | Osteoarthritis (hip) (ebi-a-GCST007091) | All - Inverse variance weighted | 0.676864350533786 | 0.328768846214058 | 0.0395148446365041 |
| Powdered/instant soup | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | All - Inverse variance weighted | 0.442299923329573 | 0.214486396783682 | 0.0391948772017298 |
| Powdered/instant soup | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | rs6555009 | -2.36346315217928 | 0.88777629695444 | 0.0077625217096706 |
| Powdered/instant soup | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | All - MR Egger | 1.57776091868886 | 0.535823941104214 | 0.0106602383418696 |
| Powdered/instant soup | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | rs6555009 | -2.35760896391727 | 0.883213386642973 | 0.007599736225796 |
| Powdered/instant soup | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | All - MR Egger | 1.57792621496827 | 0.535148160004956 | 0.0105756101948791 |
| Powdered/instant soup | Neck circumference (ebi-a-GCST90017133) | rs79726097 | -8.64981972805614 | 4.30065803301483 | 0.0442960802923545 |
| Powdered/instant soup | Neck circumference (ebi-a-GCST90017133) | All - Inverse variance weighted | -2.63045186368072 | 1.11561473886148 | 0.0183811340574203 |
| Powdered/instant soup | Neck circumference (ebi-a-GCST90017135) | rs72652725 | 11.1891219025386 | 5.40942735534014 | 0.0385978685306621 |
| Powdered/instant soup | Neck circumference (ebi-a-GCST90017135) | rs79726097 | -11.8025577597775 | 5.2319283439233 | 0.0240786832318529 |
| Powdered/instant soup | Neck circumference (ebi-a-GCST90017135) | All - Inverse variance weighted | -3.35551182552025 | 1.6542945091418 | 0.0425230869407084 |
| Powdered/instant soup | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | rs115248766 | -9.84864823017413 | 4.06443371655137 | 0.0153874508213214 |
| Powdered/instant soup | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | rs117037603 | -7.92513246674037 | 3.26687759691991 | 0.0152702956754158 |
| Powdered/instant soup | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | All - Inverse variance weighted | -2.4695583229563 | 0.855417302302117 | 0.0038897964981099 |
| Powdered/instant soup | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | rs115248766 | -13.3932768183502 | 5.15934239121419 | 0.0094336073366079 |
| Powdered/instant soup | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | rs79726097 | -10.6384698711419 | 4.22628575124089 | 0.0118286624922636 |
| Powdered/instant soup | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | All - Inverse variance weighted | -2.95275746317932 | 1.16403521823093 | 0.0111916717925215 |
| Powdered/instant soup | Rheumatoid arthritis (ebi-a-GCST90018910) | All - MR Egger | 1.78270516217927 | 0.682769965149488 | 0.0182600491554603 |
| Powdered/instant soup | Osteoarthritis (ebi-a-GCST90038686) | rs117037603 | 0.147383829527694 | 0.0688952845652423 | 0.0324159060721091 |
| Powdered/instant soup | Osteoarthritis (ebi-a-GCST90038686) | rs189989746 | 0.224231539212638 | 0.0701998134419952 | 0.0014022381538585 |
| Powdered/instant soup | Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) | All - Inverse variance weighted | -7.226393467313 | 3.42004457194617 | 0.0346047901320051 |
| Powdered/instant soup | Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) | All - MR Egger | -15.1978970606416 | 7.11009841457614 | 0.0483395236374961 |
| Powdered/instant soup | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | rs118026267 | 6.75230042647224 | 2.80780331804311 | 0.0161798206789941 |
| Powdered/instant soup | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | rs35641391 | -8.73078865719027 | 3.7328330567381 | 0.0193397022810969 |
| Powdered/instant soup | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | All - MR Egger | -12.6833931888654 | 5.90901265711709 | 0.047515778517876 |
| Powdered/instant soup | Spondylosis (finn-b-M13_SPONDYLOSIS) | rs118026267 | 5.58591687290449 | 2.27550827814218 | 0.014096313612689 |
| Powdered/instant soup | Spondylosis (finn-b-M13_SPONDYLOSIS) | rs143982244 | 6.17498307360122 | 2.75478352639451 | 0.0249905161349592 |
| Powdered/instant soup | Spondylosis (finn-b-M13_SPONDYLOSIS) | All - MR Egger | 2.55118833295678 | 1.03458312490506 | 0.0253518500016222 |
| Powdered/instant soup | Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) | rs6881144 | 3.99521969346721 | 1.94090913055994 | 0.0395491653555028 |
| Powdered/instant soup | Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) | All - MR Egger | 2.99572300634382 | 1.36388507759001 | 0.0431412298893406 |
| Powdered/instant soup | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | rs117888205 | 5.17995031869211 | 1.95933065028596 | 0.008199691053824 |
| Powdered/instant soup | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs12069309 | -3.32580432888114 | 1.58286943994878 | 0.0356301181216517 |
| Powdered/instant soup | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | All - MR Egger | 1.99575897417985 | 0.840632489682752 | 0.0304457086708571 |
| Powdered/instant soup | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs12906434 | 15.9898814592833 | 6.67263143143575 | 0.0165598037681049 |
| Powdered/instant soup | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs188243021 | 16.9656647261495 | 7.44623975288107 | 0.0227015407493915 |
| Powdered/instant soup | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | All - Inverse variance weighted | 5.73509651273383 | 2.83694730021817 | 0.0432204674023595 |
| Powdered/instant soup | Bone morphogenetic protein receptor type-1A (prot-a-259) | rs35641391 | -9.27916877119561 | 3.069004497679 | 0.0024985996844177 |
| Powdered/instant soup | Bone morphogenetic protein receptor type-1A (prot-a-259) | All - Inverse variance weighted | -1.75271327160563 | 0.851993232771713 | 0.0396678048925965 |
| Powdered/instant soup | Alkaline phosphatase, bone (prot-c-2795_23_3) | rs117812407 | 12.890489224887 | 5.05311522419187 | 0.0107414796186992 |
| Powdered/instant soup | Alkaline phosphatase, bone (prot-c-2795_23_3) | All - Inverse variance weighted | 6.64686599720167 | 3.35454926983951 | 0.0475410201238565 |
| Powdered/instant soup | Fractured bone site(s): Arm (ukb-a-440) | All - MR Egger | 0.037665709603133 | 0.0149734079811034 | 0.0222303336175092 |
| Powdered/instant soup | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | rs79726097 | 0.121711532554041 | 0.0403776818483129 | 0.0025755013342034 |
| Powdered/instant soup | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | All - Inverse variance weighted | 0.0216826127363616 | 0.0101331215805898 | 0.0323728547322383 |
| Powdered/instant soup | Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) | rs114508675 | 0.0534102869171281 | 0.0211737900212023 | 0.0116533313865345 |
| Powdered/instant soup | Diagnoses - main ICD10: M67 Other disorders of synovium and tendon (ukb-a-570) | All - Inverse variance weighted | 0.0150120558811779 | 0.0049964255301992 | 0.0026596606669932 |
| Powdered/instant soup | Heel bone mineral density (BMD), manual entry (ukb-b-11364) | rs117037603 | 2.8715053558495 | 0.843410970914497 | 0.0006625287565018 |
| Powdered/instant soup | Heel bone mineral density (BMD), manual entry (ukb-b-11364) | All - Inverse variance weighted | 0.604020643372352 | 0.210936515251882 | 0.0041896416178669 |
| Powdered/instant soup | Fractured/broken bones in last 5 years (ukb-b-13346) | rs6555009 | -0.148243249913619 | 0.0738190433881238 | 0.0446222632089544 |
| Powdered/instant soup | Fractured/broken bones in last 5 years (ukb-b-13346) | All - MR Egger | 0.107461017425929 | 0.0441109531848106 | 0.0277865393416022 |
| Powdered/instant soup | Fractured bone site(s): Ankle (ukb-b-15582) | rs115248766 | -0.0725985279561152 | 0.0302786487278599 | 0.016499246208256 |
| Powdered/instant soup | Fractured bone site(s): Ankle (ukb-b-15582) | rs12069309 | -0.0678942500933715 | 0.0302088854109236 | 0.0246085552066434 |
| Powdered/instant soup | Fractured bone site(s): Ankle (ukb-b-15582) | All - Inverse variance weighted | -0.0574472072729941 | 0.0173005684092862 | 0.0008984389568986 |
| Powdered/instant soup | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | rs12069309 | -0.23653227097302 | 0.104781510662137 | 0.0239839921189681 |
| Powdered/instant soup | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | rs143982244 | -0.241893273478225 | 0.109177697117371 | 0.0267194314032813 |
| Powdered/instant soup | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | All - MR Egger | 0.112877145132147 | 0.0520830342675106 | 0.0447069783646321 |
| Powdered/instant soup | Fractured heel (right) (ukb-b-3499) | rs12906434 | 0.127412405992073 | 0.0516620493638183 | 0.0136529532617854 |
| Powdered/instant soup | Fractured heel (right) (ukb-b-3499) | All - Inverse variance weighted | 0.0308172104393023 | 0.0117400815840484 | 0.0086659886725683 |
| Powdered/instant soup | Fractured bone site(s): Wrist (ukb-b-9571) | rs6555009 | -0.0822838244730737 | 0.034782269608569 | 0.0179968457886502 |
| Powdered/instant soup | Fractured bone site(s): Wrist (ukb-b-9571) | All - Inverse variance weighted | -0.0405422624808528 | 0.017935036626458 | 0.0237898486536757 |
| Powdered/instant soup | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs117037603 | 0.114943010711699 | 0.0512682499142302 | 0.0249618836160792 |
| Powdered/instant soup | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | All - MR Egger | 0.0554660792389398 | 0.02566018166985 | 0.0452075256409148 |
| Powdered/instant soup | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | rs114508675 | 0.0896371970286307 | 0.0412746533656706 | 0.0298764108557405 |
| Powdered/instant soup | Other joint disorders (ukb-d-M13_OTHERJOINT) | rs115248766 | 0.157658554388759 | 0.0777866255246437 | 0.0426820526845655 |
| Powdered/instant soup | Other joint disorders (ukb-d-M13_OTHERJOINT) | rs79726097 | 0.171275161274676 | 0.0701440558762187 | 0.0146157375558064 |
| Powdered/instant soup | Other joint disorders (ukb-d-M13_OTHERJOINT) | All - Inverse variance weighted | 0.0566272770721257 | 0.0175751614024895 | 0.001272964293852 |
| Powdered/instant soup | Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) | rs117888205 | -0.0429533900752922 | 0.0218166653829119 | 0.0489721697101662 |
| Powdered/instant soup | Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) | rs145052146 | 0.048918578345038 | 0.0237373711321214 | 0.0393196963684766 |
| Powdered/instant soup | Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) | All - MR Egger | -0.0275195499670362 | 0.0112718908632075 | 0.0258599305690485 |
| Powdered/instant soup | Ankle spacing width (right) (ukb-e-4119_EAS) | All - Inverse variance weighted | 1.89454760065378 | 0.811571293362753 | 0.0195737829633083 |
| Powdered/instant soup | M75 Shoulder lesions (ukb-e-M75_CSA) | rs6555009 | -29.0043931092354 | 8.63912335258404 | 0.0007869895400253 |
| Powdered/instant soup | M75 Shoulder lesions (ukb-e-M75_CSA) | All - MR Egger | 11.5694333440184 | 4.70306195008568 | 0.0393200511218594 |