ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Plain cereal | Menstruation quality of life impact (stiff neck) (ebi-a-GCST006652) | All - Inverse variance weighted | -3.44485285617412 | 1.55393617444488 | 0.026632927850593 |
| Plain cereal | Osteoprotegerin levels (ebi-a-GCST90010243) | rs113962416 | 7.11973875765107 | 3.01216932493626 | 0.0180954983909645 |
| Plain cereal | Osteoprotegerin levels (ebi-a-GCST90010243) | rs833365 | 6.97108824722499 | 3.02625044559993 | 0.0212484923591059 |
| Plain cereal | Osteoprotegerin levels (ebi-a-GCST90010243) | All - Inverse variance weighted | 2.19958200275845 | 0.93919477231671 | 0.0191813799914707 |
| Plain cereal | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | rs113962416 | -1.16210819680042 | 0.518991948781057 | 0.025145233643615 |
| Plain cereal | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | rs117581586 | -1.22213010675071 | 0.540684862648685 | 0.0238003310778098 |
| Plain cereal | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | All - MR Egger | -0.92494027535199 | 0.3145719625161 | 0.0147775790317524 |
| Plain cereal | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | rs113962416 | -1.15002332520973 | 0.508805266671493 | 0.0238061999317158 |
| Plain cereal | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | rs117581586 | -1.19759245097829 | 0.520474648789912 | 0.0213937723313341 |
| Plain cereal | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | All - MR Egger | -0.930159214665404 | 0.31194241156842 | 0.0137645588283319 |
| Plain cereal | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | All - Inverse variance weighted | -1.46081481794619 | 0.551082405517378 | 0.0080298970774882 |
| Plain cereal | Juvenile rheumatoid arthritis (ebi-a-GCST90018873) | All - MR Egger | -6.49270398018226 | 2.61901829114061 | 0.0306247894927941 |
| Plain cereal | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | rs60034935 | -0.0342667959376231 | 0.0132492700648584 | 0.009700801736327 |
| Plain cereal | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | All - Inverse variance weighted | -0.0114506585606983 | 0.0049946231139857 | 0.0218712104163814 |
| Plain cereal | Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) | rs17379813 | 22.1578129405824 | 10.9116900660341 | 0.0422906093987403 |
| Plain cereal | Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) | All - MR Egger | -9.10762858844287 | 3.8703716105561 | 0.0382728082631062 |
| Plain cereal | Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) | rs17379813 | 22.2233880010754 | 10.9116900660341 | 0.0416842605898914 |
| Plain cereal | Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) | All - MR Egger | -9.12815959260452 | 3.87124591078916 | 0.0379517602091853 |
| Plain cereal | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | rs117581586 | 4.31791272694354 | 1.45796556628383 | 0.0030604379357064 |
| Plain cereal | Osteomyelitis (finn-b-M13_OSTEOMYELITIS) | All - MR Egger | 3.23898206915462 | 1.29220189766446 | 0.029164270660877 |
| Plain cereal | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | All - Inverse variance weighted | 1.72343800497502 | 0.669953951521582 | 0.01009750261135 |
| Plain cereal | Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) | rs117630356 | 22.9603059661472 | 10.2149277312328 | 0.0245939961155415 |
| Plain cereal | Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) | All - Inverse variance weighted | 4.9070435862929 | 2.21263704956725 | 0.0265728767685522 |
| Plain cereal | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | rs4920261 | 2.18723195686803 | 0.937385124372013 | 0.0196306572572906 |
| Plain cereal | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | All - MR Egger | -0.819915926511484 | 0.357060510227695 | 0.0423068273493043 |
| Plain cereal | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | rs17379813 | 12.6887742053942 | 6.05257808350328 | 0.0360445330188569 |
| Plain cereal | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | rs9607304 | 9.50676549112334 | 4.83295765315734 | 0.0491751536791598 |
| Plain cereal | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | All - Inverse variance weighted | 2.98065775255703 | 1.34372408785775 | 0.0265407432471761 |
| Plain cereal | Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) | rs148151996 | 6.03601961415498 | 2.78595465163932 | 0.0302661819261553 |
| Plain cereal | Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) | All - Inverse variance weighted | 2.48935716127223 | 1.21010537674744 | 0.0396726826201841 |
| Plain cereal | Bone sialoprotein 2 (prot-a-1396) | rs17379813 | -4.41975907722775 | 1.77052663331082 | 0.0125497725828278 |
| Plain cereal | Bone sialoprotein 2 (prot-a-1396) | All - MR Egger | 2.23547808118367 | 0.91955421537027 | 0.0333478540737964 |
| Plain cereal | Osteocrin (prot-a-2157) | rs17379813 | 3.53449576057234 | 1.77052663331082 | 0.0459016809600058 |
| Plain cereal | Osteocrin (prot-a-2157) | All - MR Egger | -2.30268533410108 | 0.919668671896794 | 0.0293066685412295 |
| Plain cereal | Fractured/broken bones in last 5 years (ukb-a-308) | rs117581586 | -0.119791406102968 | 0.0505360167523102 | 0.0177680586150585 |
| Plain cereal | Fractured/broken bones in last 5 years (ukb-a-308) | rs143645399 | -0.144962344382397 | 0.047350376556176 | 0.0022024394083643 |
| Plain cereal | Fractured/broken bones in last 5 years (ukb-a-308) | All - MR Egger | -0.0949668853250559 | 0.0282614406851635 | 0.0063605238195243 |
| Plain cereal | Fractured bone site(s): Arm (ukb-a-440) | All - Inverse variance weighted | -0.0096034975248108 | 0.0046963457012436 | 0.0408659735510787 |
| Plain cereal | Fractured bone site(s): Other bones (ukb-a-441) | rs117581586 | -0.0791315575693903 | 0.0380470646531495 | 0.0375408122519381 |
| Plain cereal | Fractured bone site(s): Other bones (ukb-a-441) | rs143645399 | -0.0982272657410728 | 0.0356487524975665 | 0.0058616937028611 |
| Plain cereal | Fractured bone site(s): Other bones (ukb-a-441) | All - MR Egger | -0.0600921470093261 | 0.0229265774769281 | 0.0237832169276771 |
| Plain cereal | Diagnoses - secondary ICD10: G55.1 Nerve root and plexus compressions in intervertebral disk disorders (ukb-b-1220) | All - Inverse variance weighted | 0.0105016679326139 | 0.0045316621194305 | 0.0204820227625304 |
| Plain cereal | Fractured/broken bones in last 5 years (ukb-b-13346) | rs113962416 | -0.103776673181639 | 0.0430034424792285 | 0.0158123671226149 |
| Plain cereal | Fractured/broken bones in last 5 years (ukb-b-13346) | All - MR Egger | -0.0718882830552838 | 0.0303977618970068 | 0.0422592846941563 |
| Plain cereal | Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) | rs12926199 | 0.0292787604769837 | 0.0122263292879617 | 0.0166325972035755 |
| Plain cereal | Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) | rs7692440 | 0.02769506205853 | 0.0125630857731717 | 0.0274906567928698 |
| Plain cereal | Fracture resulting from simple fall (ukb-b-15251) | All - Inverse variance weighted | -0.156896897905557 | 0.0700175240484287 | 0.0250375243462832 |
| Plain cereal | Diagnoses - main ICD10: M51.1 Lumbar and other intervertebral disk disorders with radiculopathy (ukb-b-18279) | rs7692440 | 0.019454158867228 | 0.0098832530018327 | 0.0490224546583297 |
| Plain cereal | Diagnoses - main ICD10: M51.1 Lumbar and other intervertebral disk disorders with radiculopathy (ukb-b-18279) | All - Inverse variance weighted | 0.0099976189746297 | 0.0044484984922064 | 0.0246135641105454 |
| Plain cereal | Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) | rs12926199 | 0.0213211178974644 | 0.0106732767510113 | 0.0457582108262003 |
| Plain cereal | Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) | rs4920261 | 0.0253462810930033 | 0.011203345178287 | 0.0236736212968304 |
| Plain cereal | Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) | All - Inverse variance weighted | 0.0090477889580225 | 0.0042565604137376 | 0.033535715399434 |
| Plain cereal | Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) | All - Inverse variance weighted | 0.0162731283989396 | 0.0059920234725086 | 0.0066116143314482 |
| Plain cereal | Internal derangement of knee (ukb-e-835_CSA) | All - Inverse variance weighted | 3.80365329040232 | 1.88899722020163 | 0.0440532993258822 |