ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Goat's cheese | Rheumatoid arthritis (ebi-a-GCST002318) | All - Inverse variance weighted | -0.872626765588573 | 0.435566072304238 | 0.045130999129277 |
| Goat's cheese | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) | rs79888670 | 1.68695754701532 | 0.649371491455035 | 0.0093814588163878 |
| Goat's cheese | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) | All - Inverse variance weighted | 0.810727594854885 | 0.363809658716578 | 0.0258512616497213 |
| Goat's cheese | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | rs149866188 | 7.26577256375941 | 3.3742418633788 | 0.0312947000804928 |
| Goat's cheese | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | rs151088223 | 10.9082439409428 | 3.41179160035024 | 0.0013875967283974 |
| Goat's cheese | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | rs79888670 | 1.68672173349142 | 0.648487190740389 | 0.0092949717114573 |
| Goat's cheese | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | All - Inverse variance weighted | 0.80575885472371 | 0.337865334664182 | 0.0170859886615491 |
| Goat's cheese | Heel bone mineral density T score (ebi-a-GCST90025982) | rs17006127 | -0.922451295630793 | 0.35444738667171 | 0.0092545313719788 |
| Goat's cheese | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | rs117552259 | 0.107408131240264 | 0.0290823183174207 | 0.0002214103857295 |
| Goat's cheese | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | rs402308 | 0.0756475721548377 | 0.0342037548536888 | 0.0269891641940146 |
| Goat's cheese | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | All - Inverse variance weighted | 0.012825586982703 | 0.0064234282656334 | 0.0458590045093597 |
| Goat's cheese | Cervicalgia (finn-b-M13_CERVICALGIA) | rs117172335 | 9.94931370879169 | 4.12303318982985 | 0.0158172442172337 |
| Goat's cheese | Cervicalgia (finn-b-M13_CERVICALGIA) | rs192800126 | 28.9362319335188 | 11.3134139890449 | 0.0105369279013561 |
| Goat's cheese | Cervicalgia (finn-b-M13_CERVICALGIA) | rs73127831 | 2.87522255906838 | 1.33936448358276 | 0.0318166480574476 |
| Goat's cheese | Cervicalgia (finn-b-M13_CERVICALGIA) | All - Inverse variance weighted | 1.45254533802468 | 0.636483987626546 | 0.0224810973665007 |
| Goat's cheese | Contracture of joint (finn-b-M13_CONTRACTUREJOINT) | rs402308 | 44.6899643729234 | 19.6229134141948 | 0.022760096160616 |
| Goat's cheese | Contracture of joint (finn-b-M13_CONTRACTUREJOINT) | rs73127831 | 16.4172401071492 | 5.614102625796 | 0.0034524769486685 |
| Goat's cheese | Contracture of joint (finn-b-M13_CONTRACTUREJOINT) | rs7734657 | -52.0339555613674 | 22.6297761359385 | 0.0214846219203627 |
| Goat's cheese | Contracture of joint (finn-b-M13_CONTRACTUREJOINT) | rs77508780 | 45.5999492085818 | 15.9260398810309 | 0.0041934321202353 |
| Goat's cheese | Contracture of joint (finn-b-M13_CONTRACTUREJOINT) | All - Inverse variance weighted | 5.5648655600532 | 2.71261080917238 | 0.0402202706481021 |
| Goat's cheese | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs6899522 | -21.0165146817073 | 7.81485299717524 | 0.0071601200939314 |
| Goat's cheese | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | All - Inverse variance weighted | -1.96129261950528 | 0.967544156857969 | 0.0426538926379932 |
| Goat's cheese | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | All - Inverse variance weighted | -3.92361295654108 | 1.59597269024098 | 0.0139539691769743 |
| Goat's cheese | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs11750339 | -8.85004990106722 | 4.25984720188894 | 0.0377507314046867 |
| Goat's cheese | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | rs79888670 | 4.02848103338726 | 1.80462849544421 | 0.0255948182409091 |
| Goat's cheese | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | All - MR Egger | 1.74037567161657 | 0.785288281500431 | 0.0336826189662882 |
| Goat's cheese | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | All - MR Egger | -1.2663675612609 | 0.617190670054177 | 0.048190624893478 |
| Goat's cheese | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs143702642 | 13.0897265376517 | 6.11624956203163 | 0.0323421836186417 |
| Goat's cheese | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | All - MR Egger | 5.56709523589128 | 2.64018924387271 | 0.0426540783053638 |
| Goat's cheese | Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) | All - Inverse variance weighted | -2.1152648382686 | 0.907805458896477 | 0.0198016034375372 |
| Goat's cheese | Knee osteoarthritis (ieu-a-1171) | rs59138812 | -15.9361464325631 | 5.71321956671559 | 0.0052814599255595 |
| Goat's cheese | Knee osteoarthritis (ieu-a-1171) | All - MR Egger | -14.1297663070171 | 4.77034816137737 | 0.0414720687955895 |
| Goat's cheese | Femoral neck bone mineral density (ieu-a-980) | rs59138812 | -3.12047620577974 | 1.32695583241384 | 0.0186926041718549 |
| Goat's cheese | Femoral neck bone mineral density (ieu-a-980) | All - MR Egger | -0.900471685265112 | 0.405721190294254 | 0.0334431200151481 |
| Goat's cheese | Bone sialoprotein 2 (prot-a-1395) | rs77105420 | -10.598419961949 | 4.72455424396523 | 0.0248798293486112 |
| Goat's cheese | Bone sialoprotein 2 (prot-a-1395) | rs7734657 | 16.291259385182 | 4.88556162164322 | 0.0008543062976869 |
| Goat's cheese | Bone sialoprotein 2 (prot-a-1395) | All - MR Egger | -3.70831657464273 | 1.37152551889814 | 0.0117163996240026 |
| Goat's cheese | Bone sialoprotein 2 (prot-a-1396) | All - Inverse variance weighted | 1.45126879728434 | 0.704468663094143 | 0.0393899445947014 |
| Goat's cheese | Osteocrin (prot-a-2157) | rs79806864 | -10.7289511871314 | 4.73617586217543 | 0.0234930847771279 |
| Goat's cheese | Osteocrin (prot-a-2157) | rs79888670 | -10.1858341575889 | 4.38547650707768 | 0.0201991007048523 |
| Goat's cheese | Osteocrin (prot-a-2157) | All - Inverse variance weighted | -1.62578834360156 | 0.704537126388407 | 0.0210215153575775 |
| Goat's cheese | Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) | All - Inverse variance weighted | 0.0172545116412811 | 0.0071004205957699 | 0.0150959505805158 |
| Goat's cheese | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | rs10947005 | -0.0902130601664346 | 0.0426915721540782 | 0.0345892050461485 |
| Goat's cheese | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | All - Inverse variance weighted | -0.0205230517529687 | 0.008837341724958 | 0.020216220913923 |
| Goat's cheese | Fractured heel (ukb-b-18389) | rs73127831 | 0.0612270022296008 | 0.0287324158285613 | 0.03309423449159 |
| Goat's cheese | Fractured heel (ukb-b-18389) | rs7981232 | -0.0604821877100506 | 0.0291653400313676 | 0.0381007386770781 |
| Goat's cheese | Fractured heel (ukb-b-18389) | All - Inverse variance weighted | -0.0098657630384987 | 0.0047043262197232 | 0.0359786943112443 |
| Goat's cheese | Operative procedures - main OPCS: W15.1 Osteotomy of neck of first metatarsal bone (ukb-b-6551) | All - Inverse variance weighted | 0.0211952612106659 | 0.0100112056883268 | 0.0342468050214651 |
| Goat's cheese | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | rs151329415 | 0.0897891006274692 | 0.0441275114613483 | 0.0418745590910464 |
| Goat's cheese | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | rs72725654 | 0.099647331022141 | 0.0447234431274475 | 0.0258752972113172 |
| Goat's cheese | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | rs7734657 | 0.0932050737193109 | 0.0446703789670215 | 0.036932690771918 |
| Goat's cheese | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | All - Inverse variance weighted | 0.0126615053640601 | 0.0064447373293344 | 0.0494574174406012 |
| Goat's cheese | Other joint disorders (ukb-d-M13_OTHERJOINT) | rs73127831 | 0.0697484080008983 | 0.031164284683124 | 0.0252153245279546 |
| Goat's cheese | Other joint disorders (ukb-d-M13_OTHERJOINT) | rs7734657 | 0.24264532275582 | 0.12184245607535 | 0.0464294865238256 |
| Goat's cheese | Fractured/broken bones in last 5 years (ukb-e-2463_CSA) | All - Inverse variance weighted | -3.29707946122929 | 1.51854726515138 | 0.0299155777528395 |
| Goat's cheese | Ankle spacing width (left) (ukb-e-4100_AFR) | rs150170933 | 19.9383045064309 | 10.0803246650022 | 0.047935172024443 |
| Goat's cheese | Ankle spacing width (left) (ukb-e-4100_AFR) | rs7981232 | -12.5234372236176 | 5.36353737966926 | 0.0195475367746866 |
| Goat's cheese | Ankle spacing width (left) (ukb-e-4100_AFR) | All - MR Egger | 1.63163385795126 | 0.700756262178103 | 0.0353899595774079 |
| Goat's cheese | Internal derangement of knee (ukb-e-835_CSA) | rs1039487 | -9.59825085167343 | 4.85763096046029 | 0.0481647554510698 |
| Goat's cheese | Internal derangement of knee (ukb-e-835_CSA) | rs10947005 | 37.650964962455 | 14.4383265638632 | 0.009115020700996 |
| Goat's cheese | Internal derangement of knee (ukb-e-835_CSA) | rs118059460 | -42.7489106107176 | 17.4302285189143 | 0.01418385339397 |
| Goat's cheese | Internal derangement of knee (ukb-e-835_CSA) | rs7981232 | 37.1261345188539 | 14.3748304854896 | 0.0098025389261473 |
| Goat's cheese | Internal derangement of knee (ukb-e-835_CSA) | All - MR Egger | -7.676126145389 | 3.50737830443641 | 0.0395330076531069 |
| Goat's cheese | M75 Shoulder lesions (ukb-e-M75_CSA) | rs117552259 | -15.9279420133241 | 8.06456248455202 | 0.0482620818926061 |
| Goat's cheese | M75 Shoulder lesions (ukb-e-M75_CSA) | All - Inverse variance weighted | -5.24020342152247 | 2.01693304798654 | 0.0093739881168641 |