ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Butternut squash | Osteoarthritis of the knee (hospital diagnosed) (ebi-a-GCST005813) | rs146267276 | 6.38453268650264 | 2.68821663727107 | 0.0175486287866495 |
| Butternut squash | Osteoarthritis of the knee (hospital diagnosed) (ebi-a-GCST005813) | All - Inverse variance weighted | 1.37354033041449 | 0.656639510022354 | 0.0364588904310656 |
| Butternut squash | Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) | rs6852243 | -0.592513590780489 | 0.263668547897317 | 0.0246278224022572 |
| Butternut squash | Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) | rs74413219 | -0.930855348659031 | 0.318638946271745 | 0.0034851994094175 |
| Butternut squash | Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016610) | All - Inverse variance weighted | -0.451332047824297 | 0.176388447313521 | 0.0105052497245725 |
| Butternut squash | Fractures (ebi-a-GCST90038703) | rs78400819 | 0.0685652478693938 | 0.0285150734238134 | 0.0161934349463239 |
| Butternut squash | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | rs5743134 | 32.6626795328789 | 15.3270990867376 | 0.0330857486615322 |
| Butternut squash | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | rs75010843 | 48.0290804093944 | 16.9297352342159 | 0.0045544485628688 |
| Butternut squash | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | All - Inverse variance weighted | 3.79740300144609 | 1.79272501750523 | 0.0341556367241215 |
| Butternut squash | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | rs5743134 | 31.730525436621 | 15.0884676380955 | 0.03546879382035 |
| Butternut squash | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | rs75010843 | 50.0415710639614 | 17.3776715048081 | 0.003981198204617 |
| Butternut squash | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | All - Inverse variance weighted | 3.81322494881761 | 1.79570610072349 | 0.033709969020076 |
| Butternut squash | Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) | rs75010843 | 52.6147876975431 | 20.2538090695816 | 0.0093830643983361 |
| Butternut squash | Benign neoplasm: Skin of scalp and neck (finn-b-CD2_BENIGN_SKIN_SCALPNECK) | All - Inverse variance weighted | -4.50404193672317 | 2.08605565383511 | 0.0308409530959208 |
| Butternut squash | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | All - Inverse variance weighted | 0.650930289349278 | 0.303512675315911 | 0.0319803588997482 |
| Butternut squash | Other bursitis of elbow (finn-b-M13_BURSELBOWOTH) | rs149640202 | -22.0479742818283 | 9.95136627787166 | 0.0267207883298683 |
| Butternut squash | Other bursitis of elbow (finn-b-M13_BURSELBOWOTH) | rs4817646 | -41.4235120370503 | 17.7795621065913 | 0.0198146773930468 |
| Butternut squash | Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) | All - MR Egger | 12.6647029304457 | 5.19200645093595 | 0.0286285181536563 |
| Butternut squash | Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) | rs143974372 | 21.8395801494216 | 8.99711823311388 | 0.0152075934701108 |
| Butternut squash | Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) | All - Inverse variance weighted | 3.71702145074127 | 1.56332973775211 | 0.0174242464570571 |
| Butternut squash | Other osteochondropathies (finn-b-M13_OSTEOCHONDROPATHY) | All - Inverse variance weighted | -2.27266404263898 | 1.13883509712932 | 0.0459770277759538 |
| Butternut squash | Pyogenic arthritis (finn-b-M13_PYOGARTH) | rs146267276 | 7.9769834377164 | 3.71494048826025 | 0.0317717247093781 |
| Butternut squash | Pyogenic arthritis (finn-b-M13_PYOGARTH) | rs6926290 | -9.75549416567023 | 4.21391168102915 | 0.0206091839635582 |
| Butternut squash | Pyogenic arthritis (finn-b-M13_PYOGARTH) | All - MR Egger | 5.69940952423751 | 2.41364114270648 | 0.0332372814581584 |
| Butternut squash | Transient synovitis (finn-b-M13_TRANSSYNOVITIS) | rs78400819 | 22.4740541072544 | 8.40793551639708 | 0.0075185780270658 |
| Butternut squash | Transient synovitis (finn-b-M13_TRANSSYNOVITIS) | All - Inverse variance weighted | 7.13462532658203 | 3.62312024640782 | 0.0489308595786644 |
| Butternut squash | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | rs6926290 | 26.0998639343586 | 12.8066630932256 | 0.0415508344257758 |
| Butternut squash | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | rs78400819 | 15.9059821677851 | 7.80335152441535 | 0.0415146791768777 |
| Butternut squash | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | All - Inverse variance weighted | 7.61877372272226 | 3.4640727604966 | 0.0278517057232407 |
| Butternut squash | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | rs149640202 | 2.53472365329926 | 0.960309936941021 | 0.0083032102876528 |
| Butternut squash | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | All - MR Egger | 1.83776069577081 | 0.72775244545325 | 0.0242527535928198 |
| Butternut squash | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs149640202 | 2.51617689486049 | 1.21584305320859 | 0.0384999857600955 |
| Butternut squash | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | rs78400819 | 3.12334919445711 | 1.15895336668923 | 0.0070394122976308 |
| Butternut squash | Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) | All - MR Egger | 3.04887913526755 | 0.984997591785572 | 0.0079055934625032 |
| Butternut squash | Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) | All - Inverse variance weighted | 4.41684283762183 | 2.15729284459601 | 0.0406187596432647 |
| Butternut squash | Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) | rs1427206 | -21.4388612126297 | 10.6492159953565 | 0.044094979984998 |
| Butternut squash | Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) | All - Inverse variance weighted | -6.13931151371762 | 2.3508198135447 | 0.0090129663762349 |
| Butternut squash | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -4.99957811062089 | 2.47238774173253 | 0.0431592188352955 |
| Butternut squash | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | All - MR Egger | -9.75671052860855 | 4.51930470691351 | 0.0487027967283979 |
| Butternut squash | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | rs78400819 | 4.26623388361859 | 1.72537424954255 | 0.0134118191966923 |
| Butternut squash | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | All - MR Egger | 3.45471343958423 | 1.50930738264608 | 0.0381413721703437 |
| Butternut squash | Femoral neck bone mineral density (ieu-a-980) | rs1427206 | 2.40859520457612 | 0.894300094906749 | 0.0070754093049056 |
| Butternut squash | Femoral neck bone mineral density (ieu-a-980) | All - MR Egger | -1.31479930101392 | 0.434073891939468 | 0.0096838726053296 |
| Butternut squash | Bone morphogenetic protein receptor type-1A (prot-a-259) | rs117108376 | -9.9004414562515 | 3.14798151847229 | 0.0016607969201595 |
| Butternut squash | Bone morphogenetic protein receptor type-1A (prot-a-259) | rs149640202 | -5.44862547912459 | 2.3781065820385 | 0.0219540933502183 |
| Butternut squash | Bone morphogenetic protein receptor type-1A (prot-a-259) | All - MR Egger | -3.54625167334638 | 1.43422610183636 | 0.0279979507252573 |
| Butternut squash | Fractured/broken bones in last 5 years (ukb-a-308) | rs1427206 | -0.201363801793515 | 0.0850639479569304 | 0.0179230027498224 |
| Butternut squash | Fractured/broken bones in last 5 years (ukb-a-308) | All - Inverse variance weighted | -0.0456067101979137 | 0.0209205077843543 | 0.0292574501144128 |
| Butternut squash | Heel bone mineral density (BMD) T-score automated (left) (ukb-a-361) | rs1427206 | 1.17567344588735 | 0.492285169620946 | 0.0169313119229259 |
| Butternut squash | Heel bone mineral density (BMD) T-score automated (left) (ukb-a-361) | rs6488515 | 1.74507927934879 | 0.490744955827321 | 0.0003765726347532 |
| Butternut squash | Heel bone mineral density (BMD) T-score automated (left) (ukb-a-361) | All - Inverse variance weighted | 0.328770347527378 | 0.146488468564279 | 0.0248103503224576 |
| Butternut squash | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs6488515 | 1.28951043555418 | 0.487785193472474 | 0.0082028786732026 |
| Butternut squash | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | All - Inverse variance weighted | 0.298484794241865 | 0.123653785804034 | 0.0157838720751707 |
| Butternut squash | Fractured bone site(s): Ankle (ukb-a-438) | All - Inverse variance weighted | -0.0171346820845359 | 0.0081321060109534 | 0.0351140118987571 |
| Butternut squash | Non-cancer illness code self-reported: bone disorder (ukb-a-84) | rs78400819 | -0.0243299863617099 | 0.0119953882895495 | 0.0425318473562752 |
| Butternut squash | Fractured/broken bones in last 5 years (ukb-b-13346) | rs1427206 | -0.173228807182487 | 0.0728734042266855 | 0.0174484233684399 |
| Butternut squash | Fractured/broken bones in last 5 years (ukb-b-13346) | rs6488515 | -0.157184522202076 | 0.0729717217699934 | 0.0312364821398476 |
| Butternut squash | Fractured/broken bones in last 5 years (ukb-b-13346) | rs74413219 | -0.147225156007776 | 0.0669460426116937 | 0.027866444513596 |
| Butternut squash | Fractured/broken bones in last 5 years (ukb-b-13346) | All - Inverse variance weighted | -0.0474548583384058 | 0.019632532416217 | 0.0156423886257246 |
| Butternut squash | Neck/shoulder pain for 3+ months (ukb-b-16118) | rs149640202 | -0.488824547665169 | 0.228846391625108 | 0.0326763312001469 |
| Butternut squash | Neck/shoulder pain for 3+ months (ukb-b-16118) | All - MR Egger | -0.252526273126743 | 0.106226526465485 | 0.0322426080626502 |
| Butternut squash | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | rs4817646 | 0.0516281920766242 | 0.0253362344608061 | 0.0415777833486326 |
| Butternut squash | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | All - Inverse variance weighted | 0.0325714708404979 | 0.0126911531197929 | 0.0102739346516319 |
| Butternut squash | Operative procedures - secondary OPCS: Z84.1 Sacroiliac joint (ukb-b-16715) | rs1427206 | 0.0336333837708289 | 0.0114371058473558 | 0.0032744503227287 |
| Butternut squash | Fractured bone site(s): Other bones (ukb-b-17738) | rs1427206 | -0.110164033033634 | 0.054924209178688 | 0.0448833154620451 |
| Butternut squash | Fractured bone site(s): Other bones (ukb-b-17738) | rs6488515 | -0.130206396358165 | 0.0550011959415146 | 0.0179165837010492 |
| Butternut squash | Fractured bone site(s): Other bones (ukb-b-17738) | All - Inverse variance weighted | -0.0386705504469793 | 0.0186974011134243 | 0.0386182771485573 |
| Butternut squash | Non-cancer illness code, self-reported: ankylosing spondylitis (ukb-b-18194) | rs1427206 | 0.0257405593529958 | 0.012998128780618 | 0.0476666760317362 |
| Butternut squash | Fractured bone site(s): Leg (ukb-b-3798) | All - Inverse variance weighted | -0.0288996664751736 | 0.0096085167788933 | 0.0026322108358394 |
| Butternut squash | Operative procedures - main OPCS: W91.9 Unspecified other manipulation of joint (ukb-b-4663) | rs1427206 | -0.0289103979647125 | 0.0116749110322367 | 0.0132757846566258 |
| Butternut squash | Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint (ukb-b-7012) | rs1427206 | 0.0331462113951292 | 0.0124561890083708 | 0.0077903524853562 |
| Butternut squash | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | rs186866610 | -0.0330298033569004 | 0.0157661516411255 | 0.0361725956611359 |
| Butternut squash | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | All - Inverse variance weighted | -0.0096003100219368 | 0.0042316406350483 | 0.023286763807354 |
| Butternut squash | Ankle spacing width (ukb-e-3143_EAS) | rs6926290 | 6.2260338927143 | 2.86562487114996 | 0.0298057755505105 |
| Butternut squash | Ankle spacing width (ukb-e-3143_EAS) | rs77569241 | 4.68972787414771 | 1.94211497266578 | 0.0157458852239443 |
| Butternut squash | Ankle spacing width (ukb-e-3143_EAS) | All - Inverse variance weighted | 5.03241331560978 | 1.42350403127965 | 0.0004074212799526 |
| Butternut squash | Osteoarthrosis (ukb-e-740_CSA) | rs75010843 | -6.25177240970378 | 3.00826265178272 | 0.0376909125207217 |
| Butternut squash | Osteoarthrosis (ukb-e-740_CSA) | All - Inverse variance weighted | -4.11885963557777 | 1.79208999684651 | 0.0215415724616796 |
| Butternut squash | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | rs4817646 | -28.217885665945 | 12.40984758327 | 0.022976200369795 |
| Butternut squash | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | rs74413219 | 9.85990627002682 | 4.33205758414395 | 0.0228440311081356 |