ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Cherry | Osteoarthritis (Firth correction) (ebi-a-GCST90013881) | rs149357475 | 1.65962808725564 | 0.801265502226412 | 0.0383346330474104 |
| Cherry | Osteoarthritis (Firth correction) (ebi-a-GCST90013881) | All - MR Egger | 0.89954264953053 | 0.384801507000979 | 0.0347699148517079 |
| Cherry | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | rs4488206 | -2.70984928837473 | 0.823069032995404 | 0.0009934617323999 |
| Cherry | Osteoarthritis (SPA correction) (ebi-a-GCST90013931) | rs149357475 | 1.68830061129596 | 0.828276131319597 | 0.0415168783086783 |
| Cherry | Osteoarthritis (SPA correction) (ebi-a-GCST90013931) | All - MR Egger | 0.89346437115749 | 0.38647713939268 | 0.0365221841739728 |
| Cherry | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | rs4488206 | -2.71682782039581 | 0.826482244312342 | 0.0010118225054426 |
| Cherry | Neck circumference (ebi-a-GCST90017133) | All - MR Egger | 5.01287631023511 | 2.17135649601751 | 0.0395737101084778 |
| Cherry | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | rs16897428 | 5.35552835012524 | 2.17595376422697 | 0.0138460565978234 |
| Cherry | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | All - MR Egger | 3.97353259680141 | 1.5811392692818 | 0.0272531927355446 |
| Cherry | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | rs139337488 | 10.0959385559008 | 4.54588631213277 | 0.0263580385825108 |
| Cherry | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | rs72671686 | -7.44756068819232 | 3.30897949563988 | 0.0244037683438184 |
| Cherry | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | All - MR Egger | 4.94789377932453 | 2.09156494162603 | 0.0356832619160253 |
| Cherry | Rheumatoid arthritis (ebi-a-GCST90018690) | All - Inverse variance weighted | 1.66019581499187 | 0.675697077367706 | 0.0140098014033554 |
| Cherry | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | All - MR Egger | -10.4174102587365 | 4.47241829082932 | 0.0342294405893296 |
| Cherry | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | All - MR Egger | -10.3555124242342 | 4.4945282345932 | 0.0359434116652946 |
| Cherry | Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) | rs118161273 | 34.3342871570443 | 17.1671435785221 | 0.0455002638963584 |
| Cherry | Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) | rs6676180 | 17.6627703265458 | 8.67342542864528 | 0.0417078134455376 |
| Cherry | Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) | All - Inverse variance weighted | 5.37495360595091 | 2.64745631543814 | 0.0423328445115055 |
| Cherry | Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) | rs118161273 | 35.9097794984009 | 17.4448746002357 | 0.0395448816397848 |
| Cherry | Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) | rs6676180 | 17.5000239332931 | 8.68299874589544 | 0.0438590377533842 |
| Cherry | Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) | All - Inverse variance weighted | 5.38940004120742 | 2.64900451839168 | 0.0419011953489874 |
| Cherry | Benign neoplasm: Skin of upper limb, including shoulder (finn-b-CD2_BENIGN_SKIN_UPPERLIMB) | rs72671686 | 17.6855998114542 | 8.94650011784115 | 0.0480622399074519 |
| Cherry | Benign neoplasm: Skin of upper limb, including shoulder (finn-b-CD2_BENIGN_SKIN_UPPERLIMB) | All - Inverse variance weighted | 5.4293033338077 | 2.62508379830107 | 0.0386174599656118 |
| Cherry | Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) | rs6676180 | 20.477325598093 | 5.66740381209493 | 0.0003024696233626 |
| Cherry | Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) | All - Inverse variance weighted | 4.56894052413982 | 1.78714897632723 | 0.010571505938238 |
| Cherry | Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) | rs55895617 | 23.9467245091673 | 8.75068337069388 | 0.0062086254733222 |
| Cherry | Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) | All - MR Egger | 7.99884928235683 | 3.49602458813117 | 0.0370747844753197 |
| Cherry | Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) | All - MR Egger | -7.73711038404718 | 3.52578412997453 | 0.0443639288788283 |
| Cherry | Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) | rs12601020 | -4.6146101353619 | 2.23738673229668 | 0.0391601575567549 |
| Cherry | Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) | All - MR Egger | -3.45241439710426 | 1.39285400073422 | 0.0255588761489024 |
| Cherry | Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) | rs2773155 | 11.3737668941059 | 5.48107242706437 | 0.0379773776192067 |
| Cherry | Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) | rs72839391 | -18.7012357924238 | 7.81957315279884 | 0.0167754369988404 |
| Cherry | Peroneal tendinitis (finn-b-M13_PERONEALTEND) | rs12601020 | 29.2482380579483 | 12.602080769661 | 0.020291946844132 |
| Cherry | Peroneal tendinitis (finn-b-M13_PERONEALTEND) | rs7039790 | -33.4530026109661 | 13.0140339425587 | 0.0101542176783128 |
| Cherry | Peroneal tendinitis (finn-b-M13_PERONEALTEND) | All - MR Egger | -19.5461297400603 | 8.47284372759245 | 0.0357431843291031 |
| Cherry | Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) | rs4488206 | 15.0978844461985 | 6.56742556917688 | 0.0215103606491153 |
| Cherry | Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) | All - Inverse variance weighted | 3.72580121849202 | 1.69685592266478 | 0.028112804010669 |
| Cherry | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | rs7039790 | -22.3971932114882 | 9.04658942558747 | 0.013295254811446 |
| Cherry | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | All - Inverse variance weighted | -4.74117219540367 | 2.40869966572332 | 0.0490273888200443 |
| Cherry | Spondylosis (finn-b-M13_SPONDYLOSIS) | rs2773155 | 4.27870278397317 | 1.74397759042957 | 0.0141506526173457 |
| Cherry | Osteoporosis with pathological fracture (FG) (finn-b-OSTEOPOROSIS_FRACTURE_FG) | rs12784730 | 14.7078152376876 | 5.77884616429086 | 0.0109242448442519 |
| Cherry | Osteoporosis with pathological fracture (FG) (finn-b-OSTEOPOROSIS_FRACTURE_FG) | All - MR Egger | -7.84933987676346 | 3.48284500438927 | 0.0396043041019832 |
| Cherry | Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) | rs2773155 | 11.0379699667561 | 4.92863232077922 | 0.0251194734215918 |
| Cherry | Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) | All - Inverse variance weighted | 2.91153440215061 | 1.48105246046344 | 0.0493153610672342 |
| Cherry | Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) | rs2773155 | 16.2482384201513 | 7.56084694484373 | 0.0316346270819229 |
| Cherry | Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) | All - Inverse variance weighted | 5.89237900916082 | 2.0847857354798 | 0.004707862716832 |
| Cherry | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | All - MR Egger | -3.0673976378228 | 1.26073136609996 | 0.0279572371189751 |
| Cherry | Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) | rs149357475 | 0.186619371539917 | 0.069060440217506 | 0.0068869565364037 |
| Cherry | Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) | All - MR Egger | 0.0770452449155821 | 0.0319599866199924 | 0.0292085699234783 |
| Cherry | Fractured bone site(s): Wrist (ukb-a-439) | rs118161273 | 0.067185322336307 | 0.033507658643326 | 0.044955177432658 |
| Cherry | Fractured bone site(s): Wrist (ukb-a-439) | rs4488206 | -0.0833509081341522 | 0.0383238573296169 | 0.0296369247872312 |
| Cherry | Fractured bone site(s): Wrist (ukb-a-439) | All - MR Egger | 0.0417956908043332 | 0.0161494269302546 | 0.020582196072798 |
| Cherry | Pain type(s) experienced in last month: Knee pain (ukb-a-476) | All - MR Egger | 0.110049538738944 | 0.0473123260813991 | 0.034444770353644 |
| Cherry | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | rs2773155 | -0.0211894360453088 | 0.0108023271810281 | 0.0498134834828132 |
| Cherry | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | rs55895617 | -0.0212465035305274 | 0.0104349687639881 | 0.0417416267826369 |
| Cherry | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | All - Inverse variance weighted | -0.0054326470860581 | 0.0025042838090385 | 0.0300567579171362 |
| Cherry | Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) | All - Inverse variance weighted | 0.0190068123287873 | 0.009371636051138 | 0.0425478952332874 |
| Cherry | Fractured/broken bones in last 5 years (ukb-b-13346) | rs4488206 | -0.272252164475469 | 0.0692759593169055 | 8.49578753118707e-05 |
| Cherry | Operative procedures - main OPCS: T67.6 Primary simple repair of tendon (ukb-b-16193) | rs2773155 | -0.0304422662176376 | 0.0125219757424633 | 0.0150527573922263 |
| Cherry | Operative procedures - main OPCS: T67.6 Primary simple repair of tendon (ukb-b-16193) | All - Inverse variance weighted | -0.0115397878645635 | 0.0050717774109308 | 0.0228882618777078 |
| Cherry | Operative procedures - secondary OPCS: Z84.1 Sacroiliac joint (ukb-b-16715) | All - Inverse variance weighted | 0.0131130116453653 | 0.005946947966416 | 0.0274541962530508 |
| Cherry | Ankle spacing width (ukb-b-4080) | rs2773155 | -0.699775882631391 | 0.247032800860507 | 0.0046153135669932 |
| Cherry | Ankle spacing width (ukb-b-4080) | rs4488206 | -0.768431957771145 | 0.254100786857749 | 0.0024935528374934 |
| Cherry | Ankle spacing width (ukb-b-4080) | rs6676180 | 1.47139971471515 | 0.223767674736973 | 4.8467563230097e-11 |
| Cherry | Ankle spacing width (ukb-b-4080) | rs7039790 | -0.570807155678851 | 0.260230193374674 | 0.0282735245031123 |
| Cherry | Ankle spacing width (ukb-b-4080) | rs72839391 | -0.474315354850615 | 0.215317944075059 | 0.0276045952129121 |
| Cherry | Ankle spacing width (ukb-b-4080) | rs74465951 | -0.481518216857661 | 0.242974466999008 | 0.047505584261053 |
| Cherry | Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) | All - Inverse variance weighted | 0.0098979764941854 | 0.0049572610849428 | 0.0458618763184658 |
| Cherry | Fractured heel (left) (ukb-b-8221) | rs72839391 | -0.0911124438472761 | 0.0336674144085439 | 0.0068047774911341 |
| Cherry | Fractured heel (left) (ukb-b-8221) | rs78163226 | -0.092433860967113 | 0.0401398552934328 | 0.0212903759269794 |
| Cherry | Fractured heel (left) (ukb-b-8221) | All - MR Egger | -0.0430715520830463 | 0.0175813951254738 | 0.0270500318766626 |
| Cherry | Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) | All - Inverse variance weighted | 0.0146785848652539 | 0.0067031392365154 | 0.0285381974278312 |
| Cherry | Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) | All - Inverse variance weighted | -4.01323557739024 | 1.73109176838097 | 0.0204315940201249 |