ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Tinned tuna (ukb-b-2237)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Tinned tuna (👉 📊) Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) Weighted median 13 -2.417432561 1.184640635 0.041285994
Tinned tuna (👉 📊) Rheumatoid arthritis (ebi-a-GCST90018910) Weighted median 13 0.936459977 0.466941987 0.044907832
Tinned tuna (👉 📊) Fracture of lower leg or ankle (ebi-a-GCST90038707) Inverse variance weighted 11 0.011309251 0.004008348 0.004781087
Tinned tuna (👉 📊) Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) MR Egger 13 -11.31301516 5.081971043 0.047851257
Tinned tuna (👉 📊) Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) Inverse variance weighted 13 3.659729702 1.824144237 0.044827224
Tinned tuna (👉 📊) Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) MR Egger 13 9.983761814 4.483314288 0.047787393
Tinned tuna (👉 📊) Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) Inverse variance weighted 13 -1.04069504 0.473891302 0.028087452
Tinned tuna (👉 📊) Infective bursitis (finn-b-M13_INFBURSA) Weighted median 13 -5.161758338 2.140700378 0.015898058
Tinned tuna (👉 📊) Infective bursitis (finn-b-M13_INFBURSA) Inverse variance weighted 13 -4.823064442 1.618970198 0.002891021
Tinned tuna (👉 📊) Peroneal tendinitis (finn-b-M13_PERONEALTEND) MR Egger 13 -12.80375517 4.880636523 0.023685445
Tinned tuna (👉 📊) Fracture of femur (finn-b-ST19_FRACT_FEMUR) Inverse variance weighted 13 1.529877887 0.617715653 0.013261442
Tinned tuna (👉 📊) Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) Weighted median 13 -0.92692241 0.402240513 0.021200288
Tinned tuna (👉 📊) Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) Inverse variance weighted 13 -0.685223726 0.30411243 0.024247039
Tinned tuna (👉 📊) Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) Inverse variance weighted 13 -4.99530506 1.992337258 0.01216716
Tinned tuna (👉 📊) Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) Inverse variance weighted 13 -3.233253686 1.591976493 0.042258217
Tinned tuna (👉 📊) Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) MR Egger 13 -2.604966228 1.122052339 0.040463
Tinned tuna (👉 📊) Forearm bone mineral density (ieu-a-977) MR Egger 13 1.750426599 0.699087202 0.02930386
Tinned tuna (👉 📊) Non-cancer illness code, self-reported: fracture lower leg / ankle (ukb-b-13979) Inverse variance weighted 3 0.014905367 0.007075367 0.035147374
Tinned tuna (👉 📊) Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) Weighted median 4 0.023187076 0.009839067 0.018441429
Tinned tuna (👉 📊) Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) Inverse variance weighted 4 0.019186941 0.008276816 0.020440914
Tinned tuna (👉 📊) Knee pain for 3+ months (ukb-e-3773_AFR) Inverse variance weighted 4 10.1548672 4.963480391 0.040764571

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Tinned tuna Fracture of lower leg or ankle (ebi-a-GCST90038707) rs12596114 0.0304437148684276 0.0137108060156859 0.026390434014426
Tinned tuna Fracture of lower leg or ankle (ebi-a-GCST90038707) All - Inverse variance weighted 0.0113092505168034 0.0040083475890549 0.0047810874353574
Tinned tuna Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) rs12596114 25.2366976736474 11.7478319985408 0.0316978370929985
Tinned tuna Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) rs881564 22.6857721535137 10.7328820100631 0.034543451099754
Tinned tuna Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) All - MR Egger -11.3130151563698 5.08197104287382 0.0478512573444221
Tinned tuna Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) rs139138366 16.2914802891619 8.28767946946235 0.0493278534189083
Tinned tuna Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) All - Inverse variance weighted 3.65972970202364 1.82414423696671 0.0448272242722908
Tinned tuna Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) All - MR Egger 9.98376181351257 4.48331428751663 0.0477873931642042
Tinned tuna Impingement syndrome of shoulder (finn-b-M13_IMPINGEMENT) All - Inverse variance weighted -1.04069503993177 0.473891301865026 0.0280874516595358
Tinned tuna Infective bursitis (finn-b-M13_INFBURSA) rs881564 -14.9670278847611 6.06814502946359 0.0136443982554917
Tinned tuna Infective bursitis (finn-b-M13_INFBURSA) All - Inverse variance weighted -4.82306444234837 1.61897019801737 0.0028910205068863
Tinned tuna Peroneal tendinitis (finn-b-M13_PERONEALTEND) All - MR Egger -12.8037551734693 4.88063652318947 0.0236854448995083
Tinned tuna Fracture of femur (finn-b-ST19_FRACT_FEMUR) rs117244731 5.80838154896426 1.49663819053067 0.0001040482139429
Tinned tuna Fracture of femur (finn-b-ST19_FRACT_FEMUR) All - Inverse variance weighted 1.52987788650178 0.617715653467074 0.0132614417888779
Tinned tuna Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) All - Inverse variance weighted -0.685223725622428 0.304112429697196 0.0242470389890938
Tinned tuna Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) All - Inverse variance weighted -4.99530506032992 1.99233725764421 0.0121671600824464
Tinned tuna Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) rs117244731 -9.36993032567822 4.45240484250603 0.0353379012842343
Tinned tuna Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) All - Inverse variance weighted -3.23325368586649 1.59197649291455 0.0422582171333461
Tinned tuna Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) All - MR Egger -2.60496622830825 1.12205233884464 0.0404629995761158
Tinned tuna Forearm bone mineral density (ieu-a-977) All - MR Egger 1.75042659941824 0.699087201758244 0.0293038601746813
Tinned tuna Non-cancer illness code, self-reported: fracture lower leg / ankle (ukb-b-13979) All - Inverse variance weighted 0.0149053667197011 0.0070753667831059 0.0351473740413921
Tinned tuna Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) All - Inverse variance weighted 0.0191869409917805 0.0082768163714361 0.0204409135400445
Tinned tuna Knee pain for 3+ months (ukb-e-3773_AFR) rs71512799 36.8346064509949 18.0251909676492 0.0410022612492369
Tinned tuna Knee pain for 3+ months (ukb-e-3773_AFR) All - Inverse variance weighted 10.1548671970718 4.96348039078207 0.0407645714390821