ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Whole-wheat cereal | Total body bone mineral density (ebi-a-GCST005348) | rs17523284 | 1.21936762240249 | 0.32177756702288 | 0.0001509668025007 |
| Whole-wheat cereal | Total body bone mineral density (ebi-a-GCST005348) | rs72708587 | -0.631994997542242 | 0.297606109953754 | 0.0337039816965856 |
| Whole-wheat cereal | Total body bone mineral density (ebi-a-GCST005348) | All - MR Egger | -0.931736247941866 | 0.370956001193424 | 0.0332170787005673 |
| Whole-wheat cereal | Osteoarthritis of the hip or knee (hospital diagnosed) (ebi-a-GCST005812) | All - MR Egger | -2.0277589111877 | 0.878114174603109 | 0.0462955573511134 |
| Whole-wheat cereal | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | All - MR Egger | -1.89115583409139 | 0.710944704525003 | 0.0260432189485005 |
| Whole-wheat cereal | Knee osteoarthritis (ebi-a-GCST007090) | rs1712999 | -1.05512867904349 | 0.531153212579718 | 0.046979331868729 |
| Whole-wheat cereal | Knee osteoarthritis (ebi-a-GCST007090) | rs17523284 | -1.20807718145432 | 0.525005504089962 | 0.021387376961429 |
| Whole-wheat cereal | Knee osteoarthritis (ebi-a-GCST007090) | rs72971737 | -1.19130325312047 | 0.533871712259466 | 0.0256519283939456 |
| Whole-wheat cereal | Knee osteoarthritis (ebi-a-GCST007090) | All - Inverse variance weighted | -0.470418987514026 | 0.199695387512702 | 0.0184886982723552 |
| Whole-wheat cereal | Neck circumference (ebi-a-GCST90017135) | All - MR Egger | 5.87491406570846 | 2.48531720937129 | 0.0456829446356368 |
| Whole-wheat cereal | Benign neoplasm: Skin of upper limb, including shoulder (finn-b-CD2_BENIGN_SKIN_UPPERLIMB) | All - MR Egger | 8.31089853347233 | 3.44670220467381 | 0.0424246420609346 |
| Whole-wheat cereal | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | rs143775824 | 3.62599529585493 | 1.01662112614213 | 0.0003614876709568 |
| Whole-wheat cereal | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | All - Inverse variance weighted | 1.28260280470408 | 0.516001916727001 | 0.0129313217840306 |
| Whole-wheat cereal | Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) | All - Inverse variance weighted | 4.06027241804957 | 1.9735279529121 | 0.0396508817282246 |
| Whole-wheat cereal | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | All - Inverse variance weighted | 3.31919178782182 | 1.57766795960525 | 0.0353907012364916 |
| Whole-wheat cereal | Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) | rs17523284 | 12.3517423972993 | 4.93392269435083 | 0.0122995141271682 |
| Whole-wheat cereal | Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) | rs57726102 | 14.8643484906381 | 5.06577869971068 | 0.003343362082252 |
| Whole-wheat cereal | Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) | rs80156415 | 17.380702924088 | 7.90551481093437 | 0.0279096354349387 |
| Whole-wheat cereal | Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) | All - Inverse variance weighted | 4.24601041862801 | 2.13574931258149 | 0.0468044000788413 |
| Whole-wheat cereal | Temporomandibular joint disorders (finn-b-TEMPOROMANDIB) | All - Inverse variance weighted | 1.30911737329862 | 0.487157098747558 | 0.0072041034789666 |
| Whole-wheat cereal | Bone morphogenetic protein 10 (prot-a-254) | rs10236127 | -3.99558952699546 | 1.46517408286456 | 0.0063905133607278 |
| Whole-wheat cereal | Bone morphogenetic protein 10 (prot-a-254) | rs143775824 | -4.19094018576059 | 1.39278492659912 | 0.0026207793483643 |
| Whole-wheat cereal | Bone morphogenetic protein 10 (prot-a-254) | rs72708587 | -2.80385082242947 | 1.21550360638415 | 0.0210693173704585 |
| Whole-wheat cereal | Bone morphogenetic protein 10 (prot-a-254) | All - Inverse variance weighted | -1.55286901318308 | 0.551632352482103 | 0.0048770646985894 |
| Whole-wheat cereal | Bone morphogenetic protein 10 (prot-a-254) | All - MR Egger | -3.93903519366871 | 1.11262131234844 | 0.00761630096759 |
| Whole-wheat cereal | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs143775824 | 0.0060256126995136 | 0.0029201497942985 | 0.0390689312667656 |
| Whole-wheat cereal | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | All - MR Egger | 0.0053779996873384 | 0.0023092688289473 | 0.0448295943542842 |
| Whole-wheat cereal | Operation code: knee replacement/revision (ukb-b-11120) | rs57726102 | -0.0359873901413833 | 0.0130781156176647 | 0.0059282107673298 |
| Whole-wheat cereal | Operation code: knee replacement/revision (ukb-b-11120) | All - Inverse variance weighted | -0.0142085674708906 | 0.0048767509276498 | 0.0035736577486905 |
| Whole-wheat cereal | Diagnoses - main ICD10: M51.2 Other specified intervertebral disk displacement (ukb-b-12872) | rs17523284 | -0.0138470483964751 | 0.0065481170367108 | 0.0344588417865767 |
| Whole-wheat cereal | Diagnoses - main ICD10: M51.2 Other specified intervertebral disk displacement (ukb-b-12872) | All - Inverse variance weighted | -0.0075996188690949 | 0.0037308093778269 | 0.041651111963627 |
| Whole-wheat cereal | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | rs1712999 | -0.0402596190770136 | 0.012519532441618 | 0.0013010655744857 |
| Whole-wheat cereal | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | All - Inverse variance weighted | -0.0113507176223611 | 0.0049453573232197 | 0.0217201189769003 |
| Whole-wheat cereal | Heel bone ultrasound T-score, manual entry (ukb-b-17612) | rs17523284 | 1.09550019476011 | 0.390009088804963 | 0.0049709634022092 |
| Whole-wheat cereal | Heel bone ultrasound T-score, manual entry (ukb-b-17612) | All - Inverse variance weighted | 0.233593022479579 | 0.115961096117263 | 0.0439666583438003 |
| Whole-wheat cereal | Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) | rs17523284 | 0.0162533236235541 | 0.007554942108264 | 0.0314485958101817 |
| Whole-wheat cereal | Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint (ukb-b-19054) | All - Inverse variance weighted | 0.0086440237121995 | 0.004223495636439 | 0.0406923136676064 |
| Whole-wheat cereal | Fractured bone site(s): Wrist (ukb-b-9571) | All - MR Egger | 0.0619653283795745 | 0.0236452083321355 | 0.0395528666249928 |
| Whole-wheat cereal | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs17523284 | -0.0553433140831315 | 0.0236888693187912 | 0.0194777910948343 |
| Whole-wheat cereal | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs72971737 | -0.0650034270367555 | 0.0238559059266754 | 0.0064333468508744 |
| Whole-wheat cereal | Pain in joint (ukb-e-745_CSA) | All - Inverse variance weighted | 4.03188336158209 | 1.80070987108846 | 0.0251525212375771 |