ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Parsnip | Menstruation quality of life impact (stiff neck) (ebi-a-GCST006652) | rs4001121 | 2.47998347270233 | 1.10751391487961 | 0.0251406559844751 |
| Parsnip | Menstruation quality of life impact (stiff neck) (ebi-a-GCST006652) | All - Inverse variance weighted | 2.18595659190565 | 1.04213531381733 | 0.0359427384477453 |
| Parsnip | Osteoprotegerin levels (ebi-a-GCST90010243) | All - Inverse variance weighted | -1.46644773790223 | 0.688044139596092 | 0.0330621301301443 |
| Parsnip | Neck circumference (ebi-a-GCST90017134) | rs142276527 | -14.244950913625 | 6.7071913863415 | 0.0336841540211137 |
| Parsnip | Neck circumference (ebi-a-GCST90017134) | All - Inverse variance weighted | -3.8194991288478 | 1.83488195860236 | 0.0373785808049572 |
| Parsnip | Neck circumference (BMI adjusted) (ebi-a-GCST90017137) | rs142276527 | -14.244950913625 | 6.7071913863415 | 0.0336841540211137 |
| Parsnip | Neck circumference (BMI adjusted) (ebi-a-GCST90017137) | All - Inverse variance weighted | -3.8194991288478 | 1.83488195860236 | 0.0373785808049572 |
| Parsnip | Juvenile rheumatoid arthritis (ebi-a-GCST90018873) | All - MR Egger | 8.34118882058276 | 2.97921162561423 | 0.0118418648711269 |
| Parsnip | Heel bone mineral density (ebi-a-GCST90029004) | rs149187565 | -0.327639050200026 | 0.143365893365893 | 0.0222932100317221 |
| Parsnip | Other joint disorder (ebi-a-GCST90038688) | rs34516999 | 0.0349484447561054 | 0.0165840804848554 | 0.0350873423780488 |
| Parsnip | Other joint disorder (ebi-a-GCST90038688) | All - Inverse variance weighted | 0.0104023595369742 | 0.0041341765496647 | 0.0118632363063275 |
| Parsnip | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | All - Inverse variance weighted | -0.0072191287545147 | 0.0036665621225519 | 0.0489634919879935 |
| Parsnip | Fractures (ebi-a-GCST90038703) | rs118084928 | 0.0506186252474214 | 0.0203495802699072 | 0.0128661439424665 |
| Parsnip | Fractures (ebi-a-GCST90038703) | rs4001121 | 0.0488460919427022 | 0.0220704524107514 | 0.0268845886719891 |
| Parsnip | Fractures (ebi-a-GCST90038703) | rs62136768 | 0.048638200238379 | 0.0225212753277712 | 0.0307993343789698 |
| Parsnip | Fractures (ebi-a-GCST90038703) | All - Inverse variance weighted | 0.0127885236507483 | 0.0056694590149218 | 0.0240902551755521 |
| Parsnip | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | rs118084928 | 0.0394645926385799 | 0.0144714236715892 | 0.0063899384222484 |
| Parsnip | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | rs75565820 | 0.0297607180444409 | 0.0149796064258623 | 0.0469502191434366 |
| Parsnip | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | All - Inverse variance weighted | 0.0091312009803796 | 0.0040910552177462 | 0.0256155165101176 |
| Parsnip | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | All - Inverse variance weighted | -1.37558326288189 | 0.666764204525611 | 0.039105687981013 |
| Parsnip | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | rs151325351 | -3.04307331962413 | 1.3688706919252 | 0.0262121662042563 |
| Parsnip | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | All - MR Egger | -2.02611380979541 | 0.843003699879492 | 0.0272335243131279 |
| Parsnip | Spondylosis (finn-b-M13_SPONDYLOSIS) | rs139335049 | 1.47313183430565 | 0.742673428903677 | 0.0473057342381736 |
| Parsnip | Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) | rs9398444 | -3.84354083840773 | 1.7487796286045 | 0.0279603867633428 |
| Parsnip | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | rs185294054 | -14.3906673360594 | 6.94431137495066 | 0.0382378633389349 |
| Parsnip | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | All - Inverse variance weighted | -1.07642702313006 | 0.484603316185356 | 0.0263337669601247 |
| Parsnip | Fracture of neck (finn-b-ST19_FRACT_NECK) | rs12502490 | 13.2740159656731 | 4.76469388158025 | 0.0053377425712197 |
| Parsnip | Fracture of neck (finn-b-ST19_FRACT_NECK) | rs36101522 | 7.14408452097664 | 3.20234109358647 | 0.0256881308079059 |
| Parsnip | Fracture of neck (finn-b-ST19_FRACT_NECK) | rs76557054 | 12.7948358857751 | 4.21391319188238 | 0.0023947619491729 |
| Parsnip | Fracture of neck (finn-b-ST19_FRACT_NECK) | All - Inverse variance weighted | 2.95707481098557 | 1.22075905706179 | 0.0154215644441325 |
| Parsnip | Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) | rs185294054 | -11.3464631406019 | 4.92719076033567 | 0.0212886333139258 |
| Parsnip | Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) | All - Inverse variance weighted | -0.788286264290661 | 0.352075301950738 | 0.0251578265322387 |
| Parsnip | Knee osteoarthritis (ieu-a-1171) | rs9398444 | -4.5651137335816 | 2.25903326455639 | 0.043297753873017 |
| Parsnip | Bone sialoprotein 2 (prot-a-1395) | rs12502490 | -5.06084198195471 | 2.09277990931287 | 0.0155958297132826 |
| Parsnip | Bone sialoprotein 2 (prot-a-1395) | All - Inverse variance weighted | -1.23487372829351 | 0.459764109798173 | 0.0072337886472343 |
| Parsnip | Bone morphogenetic protein 7 (prot-a-257) | rs142276527 | 4.1609240929428 | 1.90970047004903 | 0.0293438551246817 |
| Parsnip | Bone morphogenetic protein 7 (prot-a-257) | All - Inverse variance weighted | 1.03837403386371 | 0.4597486208671 | 0.0239102010611563 |
| Parsnip | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | rs142276527 | 0.0668627561928858 | 0.0277155132345274 | 0.015844979386887 |
| Parsnip | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | rs185294054 | 0.0520709658545808 | 0.026288613041151 | 0.0476201890186089 |
| Parsnip | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | All - Inverse variance weighted | 0.0166742209661783 | 0.0061640496703872 | 0.0068288825876202 |
| Parsnip | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | All - MR Egger | 0.0255210274100819 | 0.0117280877665816 | 0.0439424693632597 |
| Parsnip | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | All - Inverse variance weighted | 0.0170344787573037 | 0.0082939389222765 | 0.0399905352243542 |
| Parsnip | Cervicalgia (ukb-d-M13_CERVICALGIA) | rs192562474 | -0.0182598732559771 | 0.0092584440620129 | 0.0485822210770176 |
| Parsnip | Cervicalgia (ukb-d-M13_CERVICALGIA) | rs75565820 | -0.0213592803669652 | 0.0100048054965349 | 0.0327690069316759 |
| Parsnip | Cervicalgia (ukb-d-M13_CERVICALGIA) | All - MR Egger | -0.0158829150462393 | 0.006127286757442 | 0.0235638825063185 |
| Parsnip | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | rs4001121 | 2.92110377365289 | 1.48481434415695 | 0.049146422447701 |
| Parsnip | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | All - Inverse variance weighted | 3.22405451436575 | 1.17207131275266 | 0.0059462199471789 |
| Parsnip | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | All - Inverse variance weighted | 3.13609615861928 | 1.16369150334186 | 0.0070398151757439 |
| Parsnip | Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS) | rs9398444 | 4.98213476926174 | 2.5149715666046 | 0.0475923394977764 |
| Parsnip | Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS) | All - Inverse variance weighted | 2.72214605504175 | 1.14642420120764 | 0.0175743228087416 |
| Parsnip | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_EAS) | rs9398444 | 5.47091238488249 | 2.52126214080821 | 0.0300136510164283 |
| Parsnip | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_EAS) | All - Inverse variance weighted | 2.72283750160285 | 1.15071831267423 | 0.0179714025750982 |
| Parsnip | Osteoarthrosis (ukb-e-740_CSA) | rs4001121 | 10.5121300275535 | 4.41288456595425 | 0.017212127887722 |
| Parsnip | Osteoarthrosis (ukb-e-740_CSA) | All - Inverse variance weighted | 2.76731117502556 | 1.32029410099389 | 0.0360838882032912 |
| Parsnip | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | rs149187565 | 7.53943436870266 | 3.10213724847871 | 0.0150821673873323 |
| Parsnip | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | All - Inverse variance weighted | 2.64583159613974 | 1.31592391707072 | 0.0443649150517745 |
| Parsnip | M51 Other intervertebral disk disorders (ukb-e-M51_CSA) | rs9398444 | 13.9587841578179 | 7.02657138543606 | 0.0469699384052999 |
| Parsnip | M51 Other intervertebral disk disorders (ukb-e-M51_CSA) | All - Inverse variance weighted | 5.59695308812933 | 1.95681061453919 | 0.004233170340428 |