ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Orange juice (ukb-b-2763)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Orange juice (👉 📊) Rheumatoid Arthritis (bbj-a-73) Weighted median 9 -0.786836495 0.389839442 0.043553739
Orange juice (👉 📊) Rheumatoid Arthritis (bbj-a-74) Weighted median 9 -0.625702195 0.313564843 0.04599409
Orange juice (👉 📊) Rheumatoid Arthritis (bbj-a-74) Inverse variance weighted 9 -0.499215282 0.24904586 0.0450153
Orange juice (👉 📊) Shoulder impingement (ebi-a-GCST90014054) Weighted median 10 -1.112618807 0.448584808 0.013127688
Orange juice (👉 📊) Shoulder impingement (ebi-a-GCST90014054) Inverse variance weighted 10 -1.150016485 0.396545459 0.003730586
Orange juice (👉 📊) Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) Inverse variance weighted 12 -3.681060182 1.799377911 0.040781913
Orange juice (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) Inverse variance weighted 12 -3.749230853 1.79830441 0.037081106
Orange juice (👉 📊) Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) Weighted median 12 -2.125587856 0.955764966 0.026150798
Orange juice (👉 📊) Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) Inverse variance weighted 12 -1.542493706 0.696661338 0.026820337
Orange juice (👉 📊) Pathological/recurrent dislocation and subluxation of joint, not elsewhere classified (finn-b-M13_PATHODISLOCATIO) Weighted median 12 -1.437435207 0.694482673 0.038471756
Orange juice (👉 📊) Pathological/recurrent dislocation and subluxation of joint, not elsewhere classified (finn-b-M13_PATHODISLOCATIO) Inverse variance weighted 12 -1.335276882 0.524086263 0.010839873
Orange juice (👉 📊) Recurrent dislocation and subluxation of joint (finn-b-M13_RECUDISLOCATIO) Inverse variance weighted 12 -1.463809302 0.566369585 0.009750677
Orange juice (👉 📊) Disorders of synovium and tendon (finn-b-M13_SYNOTEND) Inverse variance weighted 12 0.488067621 0.22483618 0.029948567
Orange juice (👉 📊) Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) MR Egger 12 11.44846114 4.65384127 0.033676318
Orange juice (👉 📊) Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) Weighted median 12 -1.954761524 0.89444685 0.02885647
Orange juice (👉 📊) Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) Inverse variance weighted 12 -1.268155187 0.630513808 0.044293316
Orange juice (👉 📊) Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) Weighted median 12 -3.27404483 1.394459635 0.018879842
Orange juice (👉 📊) Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) Weighted mode 12 -4.362541562 1.957380433 0.047629192
Orange juice (👉 📊) Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) Inverse variance weighted 12 -4.526097691 2.177977493 0.037698346
Orange juice (👉 📊) Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) Inverse variance weighted 12 4.895401209 1.72731489 0.004595344
Orange juice (👉 📊) Rheumatoid arthritis (ieu-a-832) Inverse variance weighted 7 -0.68093185 0.322569855 0.034775807
Orange juice (👉 📊) Rheumatoid arthritis (ieu-a-833) Inverse variance weighted 7 -0.625465594 0.261700207 0.016848005
Orange juice (👉 📊) Osteomyelitis (ieu-b-4975) MR Egger 12 -1.400637235 0.624754998 0.048846657
Orange juice (👉 📊) Bone morphogenetic protein 10 (prot-a-254) MR Egger 10 -1.971048299 0.823702011 0.043656822
Orange juice (👉 📊) Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) Inverse variance weighted 11 0.133599711 0.063072479 0.034158691
Orange juice (👉 📊) Pain type(s) experienced in last month: Knee pain (ukb-a-476) Inverse variance weighted 11 0.025011574 0.012684673 0.04863302
Orange juice (👉 📊) Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) Weighted median 5 -0.008248801 0.004177233 0.048301691
Orange juice (👉 📊) Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) Inverse variance weighted 5 -0.007581063 0.003434964 0.027312075
Orange juice (👉 📊) Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) Inverse variance weighted 5 0.006127363 0.00309012 0.047379924
Orange juice (👉 📊) Fracture resulting from simple fall (ukb-b-15251) Inverse variance weighted 12 -0.076723898 0.039038651 0.049375858
Orange juice (👉 📊) Fractured bone site(s): Arm (ukb-b-19255) Inverse variance weighted 5 -0.009738903 0.003953472 0.013763406
Orange juice (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) Inverse variance weighted 12 0.094446359 0.045584067 0.038273273
Orange juice (👉 📊) Fractured bone site(s): Leg (ukb-b-3798) Inverse variance weighted 5 -0.006822212 0.003153783 0.030527046
Orange juice (👉 📊) Heel bone mineral density (BMD) (right) (ukb-b-4657) Inverse variance weighted 12 0.09292768 0.046089084 0.043772561
Orange juice (👉 📊) Operative procedures - secondary OPCS: Z81.5 Elbow joint (ukb-b-7443) Inverse variance weighted 3 0.006192886 0.002651609 0.019516277
Orange juice (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_EAS) Weighted median 6 1.476305531 0.690868202 0.032607389
Orange juice (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_EAS) Inverse variance weighted 6 1.106360066 0.516301186 0.032124512
Orange juice (👉 📊) Pain in joint (ukb-e-745_AFR) Weighted median 7 -2.722601572 1.252900667 0.029777409
Orange juice (👉 📊) Pain in joint (ukb-e-745_AFR) Inverse variance weighted 7 -2.047571328 0.953500075 0.031759343
Orange juice (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) Weighted median 6 1.575878695 0.707939945 0.026013767
Orange juice (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) Inverse variance weighted 6 1.239927369 0.524289479 0.018031673

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Orange juice Rheumatoid Arthritis (bbj-a-74) All - Inverse variance weighted -0.49921528226795 0.249045859861051 0.0450152996494667
Orange juice Shoulder impingement (ebi-a-GCST90014054) rs4961673 -3.83429161493553 1.04130053077149 0.0002312169985517
Orange juice Shoulder impingement (ebi-a-GCST90014054) rs62352893 -1.92471216340319 0.968952921478708 0.046990749556256
Orange juice Shoulder impingement (ebi-a-GCST90014054) All - Inverse variance weighted -1.15001648541973 0.3965454586503 0.0037305863121702
Orange juice Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) All - Inverse variance weighted -3.68106018225844 1.79937791081066 0.0407819134424072
Orange juice Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) All - Inverse variance weighted -3.74923085330876 1.79830441047127 0.0370811056777089
Orange juice Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) All - Inverse variance weighted -1.54249370601172 0.696661338382987 0.0268203372641996
Orange juice Pathological/recurrent dislocation and subluxation of joint, not elsewhere classified (finn-b-M13_PATHODISLOCATIO) rs6576250 -3.16125208162804 1.59121059019447 0.0469560697946107
Orange juice Pathological/recurrent dislocation and subluxation of joint, not elsewhere classified (finn-b-M13_PATHODISLOCATIO) All - Inverse variance weighted -1.3352768820884 0.524086262857955 0.0108398729747202
Orange juice Recurrent dislocation and subluxation of joint (finn-b-M13_RECUDISLOCATIO) rs55690725 -4.00956318175026 2.00063090435158 0.0450540613895147
Orange juice Recurrent dislocation and subluxation of joint (finn-b-M13_RECUDISLOCATIO) rs6576250 -4.14561517400999 1.71822518275989 0.0158335002620307
Orange juice Recurrent dislocation and subluxation of joint (finn-b-M13_RECUDISLOCATIO) All - Inverse variance weighted -1.46380930222693 0.566369584691794 0.0097506768628387
Orange juice Disorders of synovium and tendon (finn-b-M13_SYNOTEND) rs117787888 1.64055977534256 0.640265914694784 0.0103978453669104
Orange juice Disorders of synovium and tendon (finn-b-M13_SYNOTEND) rs4961673 1.47057050903437 0.709168565149086 0.0381114198903487
Orange juice Disorders of synovium and tendon (finn-b-M13_SYNOTEND) All - Inverse variance weighted 0.488067621021484 0.224836179954169 0.0299485672430803
Orange juice Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) rs13216626 11.3277339562226 4.87933886644563 0.020256021028359
Orange juice Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) All - MR Egger 11.4484611396647 4.65384126965637 0.0336763181390697
Orange juice Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) All - Inverse variance weighted -1.26815518659745 0.63051380811015 0.0442933156988488
Orange juice Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) rs10084140 6.45140869184884 2.86601385240029 0.0243852830149439
Orange juice Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) rs76481326 7.79895819300373 3.79114464053168 0.0396716726761551
Orange juice Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs12534433 -17.8609144733704 5.70949697832708 0.0017583161732213
Orange juice Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) All - Inverse variance weighted -4.52609769133059 2.1779774932405 0.0376983459252015
Orange juice Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) All - Inverse variance weighted 4.89540120946514 1.72731489001479 0.0045953443818425
Orange juice Rheumatoid arthritis (ieu-a-832) All - Inverse variance weighted -0.680931850046817 0.322569855231126 0.0347758065127483
Orange juice Rheumatoid arthritis (ieu-a-833) All - Inverse variance weighted -0.62546559445345 0.261700206854539 0.0168480046705022
Orange juice Osteomyelitis (ieu-b-4975) rs6576250 1.7008206553953 0.829871009624884 0.0404132453505947
Orange juice Osteomyelitis (ieu-b-4975) All - MR Egger -1.40063723490449 0.624754998480372 0.0488466566805745
Orange juice Bone morphogenetic protein 10 (prot-a-254) rs76481326 -2.52817818492074 1.11814630203422 0.0237565216126146
Orange juice Bone morphogenetic protein 10 (prot-a-254) All - MR Egger -1.97104829902634 0.823702011414228 0.0436568222905535
Orange juice Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) rs10084140 0.552850043594488 0.172062983244178 0.0013132525121956
Orange juice Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) All - Inverse variance weighted 0.133599710652377 0.0630724794329098 0.0341586905843037
Orange juice Pain type(s) experienced in last month: Knee pain (ukb-a-476) All - Inverse variance weighted 0.0250115735345471 0.0126846727266985 0.048633019893175
Orange juice Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) All - Inverse variance weighted -0.0075810627865609 0.0034349638599751 0.0273120753981664
Orange juice Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) All - Inverse variance weighted 0.0061273632726942 0.0030901204691367 0.0473799241565149
Orange juice Fracture resulting from simple fall (ukb-b-15251) All - Inverse variance weighted -0.0767238981638216 0.0390386507477396 0.0493758579393974
Orange juice Fractured bone site(s): Arm (ukb-b-19255) All - Inverse variance weighted -0.0097389030018595 0.0039534720821012 0.0137634061310719
Orange juice Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) rs10084140 0.417914313091871 0.143845407903407 0.0036689921387117
Orange juice Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) rs117044389 0.326972685587122 0.155553266557474 0.0355534338873427
Orange juice Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) All - Inverse variance weighted 0.094446358828819 0.0455840668276056 0.0382732726523556
Orange juice Fractured bone site(s): Leg (ukb-b-3798) All - Inverse variance weighted -0.006822211949706 0.0031537828504587 0.0305270462677851
Orange juice Heel bone mineral density (BMD) (right) (ukb-b-4657) rs10084140 0.4143634485398 0.143851450703698 0.0039705068915632
Orange juice Heel bone mineral density (BMD) (right) (ukb-b-4657) rs117044389 0.344093007777437 0.155598543442605 0.0270070876774848
Orange juice Heel bone mineral density (BMD) (right) (ukb-b-4657) All - Inverse variance weighted 0.0929276795189382 0.0460890839595551 0.0437725614994078
Orange juice Operative procedures - secondary OPCS: Z81.5 Elbow joint (ukb-b-7443) All - Inverse variance weighted 0.0061928858743543 0.0026516091198968 0.0195162774076157
Orange juice Heel bone mineral density (BMD) (ukb-e-3148_EAS) rs76481326 1.49535228344335 0.719497956800934 0.0376792188485117
Orange juice Heel bone mineral density (BMD) (ukb-e-3148_EAS) All - Inverse variance weighted 1.10636006565694 0.516301185621827 0.0321245117508346
Orange juice Pain in joint (ukb-e-745_AFR) rs79774500 -3.42592457113235 1.67533773261902 0.0408631616304291
Orange juice Pain in joint (ukb-e-745_AFR) All - Inverse variance weighted -2.04757132811493 0.953500074630871 0.0317593428148463
Orange juice Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) rs76481326 1.61210651578427 0.730724325295253 0.0273716745381046
Orange juice Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) All - Inverse variance weighted 1.23992736879963 0.524289479052423 0.0180316727017552