ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Indian snacks | Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) | rs4916724 | 3.96690548814608 | 1.78709143111788 | 0.0264353898684998 |
| Indian snacks | Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) | All - Inverse variance weighted | 2.95255457602125 | 1.26019684588362 | 0.0191329081218845 |
| Indian snacks | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs680086 | 7.87177972755327 | 3.9350833872961 | 0.0454560212754049 |
| Indian snacks | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs76316510 | 12.7014271701137 | 3.93304872825742 | 0.0012404588742473 |
| Indian snacks | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | All - MR Egger | 3.35690327240219 | 1.50076573413583 | 0.0348539693855303 |
| Indian snacks | Osteoprotegerin levels (ebi-a-GCST90000490) | All - Inverse variance weighted | -4.50391493415874 | 1.91659222385309 | 0.0187754319962675 |
| Indian snacks | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | rs12784972 | -2.10499248358256 | 0.934965681620381 | 0.0243594867120192 |
| Indian snacks | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | rs143452328 | -2.10847132615048 | 1.02183781525433 | 0.0390736014919803 |
| Indian snacks | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | rs12784972 | -2.1035337051982 | 0.933613220982673 | 0.0242521856928163 |
| Indian snacks | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | rs143452328 | -2.07883467375847 | 0.993633984932604 | 0.0364247997103661 |
| Indian snacks | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | rs11649662 | 4.29685819138538 | 2.07773686507619 | 0.0386355720221448 |
| Indian snacks | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | rs146057934 | -4.28486897142741 | 2.09142414081576 | 0.040483584585415 |
| Indian snacks | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | rs146431609 | -4.0594608802313 | 2.02973044011565 | 0.0455002638963584 |
| Indian snacks | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | All - MR Egger | -1.57788037730472 | 0.723605628723442 | 0.0455507042640398 |
| Indian snacks | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | rs148210187 | 0.0479517982497628 | 0.0228467868844001 | 0.0358308219163174 |
| Indian snacks | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | rs4649395 | 0.0453533624528087 | 0.0230121195926801 | 0.0487414008226743 |
| Indian snacks | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | All - Inverse variance weighted | 0.0108920500753407 | 0.0048237799886466 | 0.0239462428398174 |
| Indian snacks | Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) | rs117616173 | 51.2019754521025 | 23.4699611254878 | 0.0291393556246894 |
| Indian snacks | Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) | All - MR Egger | -10.874043102609 | 4.790929507981 | 0.0333732761521617 |
| Indian snacks | Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) | rs117616173 | 51.8823749765874 | 23.6305048335124 | 0.0281228947131628 |
| Indian snacks | Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) | All - MR Egger | -10.9603512502486 | 4.77660400549262 | 0.0316686361862353 |
| Indian snacks | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | rs143452328 | 50.4540840785347 | 15.536076317192 | 0.0011640585767873 |
| Indian snacks | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | rs4916724 | -35.8232219127016 | 14.1929550037543 | 0.0116023196732953 |
| Indian snacks | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | rs680086 | 16.6655992713248 | 7.80858992331357 | 0.0328211040271815 |
| Indian snacks | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | All - MR Egger | 12.8475593434599 | 4.7912978265148 | 0.0136342845257946 |
| Indian snacks | Achilles tendinitis (finn-b-M13_ACHILLESTEND) | rs117616173 | 14.3954191528644 | 6.51731005194736 | 0.027188718308588 |
| Indian snacks | Achilles tendinitis (finn-b-M13_ACHILLESTEND) | rs138151469 | 5.35298472306346 | 1.92206743387846 | 0.0053525411051003 |
| Indian snacks | Achilles tendinitis (finn-b-M13_ACHILLESTEND) | rs146431609 | -5.32402675155515 | 2.6780759907713 | 0.0468112075458164 |
| Indian snacks | Achilles tendinitis (finn-b-M13_ACHILLESTEND) | All - MR Egger | 3.4321834804208 | 1.51997482711911 | 0.0342009501785172 |
| Indian snacks | Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) | rs72696787 | 18.3957479032419 | 7.78693794739173 | 0.0181577583239123 |
| Indian snacks | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | rs138151469 | 2.96251430109698 | 1.1817753550037 | 0.0121818005518599 |
| Indian snacks | Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) | All - MR Egger | 1.98715440893558 | 0.857937111983662 | 0.0302529732408199 |
| Indian snacks | Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) | rs11649662 | 19.9106204318988 | 7.2597847267899 | 0.0060956552749899 |
| Indian snacks | Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) | rs139904006 | 20.5026184436625 | 8.02409786433189 | 0.0106147945449949 |
| Indian snacks | Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) | rs143452328 | 12.0999815206126 | 5.97232376958079 | 0.0427638655874577 |
| Indian snacks | Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) | All - Inverse variance weighted | 3.81547870258439 | 1.36772648981102 | 0.0052764988445292 |
| Indian snacks | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs72696787 | 46.2787009387189 | 17.0526797068111 | 0.0066502904337563 |
| Indian snacks | Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) | rs148210187 | 27.3141340396197 | 12.2711520436155 | 0.026022099525491 |
| Indian snacks | Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) | All - MR Egger | 4.25094439650325 | 1.94156057864991 | 0.0394608431396747 |
| Indian snacks | Otherdisorders of bone (finn-b-M13_OTHERBONE) | rs112720655 | -12.1109115072024 | 4.88510160877782 | 0.0131695013320457 |
| Indian snacks | Otherdisorders of bone (finn-b-M13_OTHERBONE) | rs72696787 | 8.88711083170212 | 3.32195059223592 | 0.0074669351575275 |
| Indian snacks | Otherdisorders of bone (finn-b-M13_OTHERBONE) | All - MR Egger | -2.09006343476166 | 0.998885829447255 | 0.0481567359079452 |
| Indian snacks | Patellar tendinitis (finn-b-M13_PATELLARTEND) | rs12784972 | -24.1687435714851 | 12.3007160376612 | 0.0494345974487612 |
| Indian snacks | Patellar tendinitis (finn-b-M13_PATELLARTEND) | rs138398208 | 71.4480481400274 | 26.4867267545449 | 0.0069861471004516 |
| Indian snacks | Patellar tendinitis (finn-b-M13_PATELLARTEND) | rs4916724 | -28.2434717494063 | 12.0462069709284 | 0.0190477780541578 |
| Indian snacks | Patellar tendinitis (finn-b-M13_PATELLARTEND) | rs76316510 | 37.59273842583 | 15.3769635677871 | 0.0144955017950063 |
| Indian snacks | Patellar tendinitis (finn-b-M13_PATELLARTEND) | All - MR Egger | 9.10237627520501 | 4.08242715249138 | 0.0362959021821034 |
| Indian snacks | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | rs138151469 | 22.0216703681271 | 7.89555151759876 | 0.0052850863914967 |
| Indian snacks | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | rs149617817 | 82.4712541450016 | 37.8653265353123 | 0.0294049102534809 |
| Indian snacks | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | All - MR Egger | 11.294328642336 | 5.24830899436265 | 0.0426326300760859 |
| Indian snacks | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs138151469 | 2.60852008883505 | 1.07813446396124 | 0.0155429010810174 |
| Indian snacks | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | All - Inverse variance weighted | 0.908824414978726 | 0.46156213243403 | 0.0489509574165638 |
| Indian snacks | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | All - MR Egger | 1.69635219637919 | 0.785608342651618 | 0.0419976744516582 |
| Indian snacks | Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) | rs72696787 | 7.84408978553773 | 2.57183271656975 | 0.0022884136620454 |
| Indian snacks | Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) | All - MR Egger | -1.83268372488609 | 0.768305002656274 | 0.0261040911436286 |
| Indian snacks | Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) | rs148210187 | 42.0045461450925 | 19.7754445103721 | 0.0336637929359416 |
| Indian snacks | Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) | All - Inverse variance weighted | -3.81739693967186 | 1.83755286283946 | 0.0377614131897657 |
| Indian snacks | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs138151469 | 14.0413217578572 | 4.96937882764654 | 0.0047196751553046 |
| Indian snacks | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs680086 | 18.1457208120744 | 6.41860398921219 | 0.0046978845598341 |
| Indian snacks | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | All - MR Egger | 8.84269236462442 | 3.82648861672332 | 0.0305937201624577 |
| Indian snacks | Femoral neck bone mineral density (ieu-a-980) | rs138151469 | 1.93416784440406 | 0.792718217915068 | 0.0146905758018653 |
| Indian snacks | Femoral neck bone mineral density (ieu-a-980) | All - MR Egger | 0.868369042134554 | 0.369673282453623 | 0.027783477481195 |
| Indian snacks | Osteomodulin (prot-a-2147) | rs139904006 | 7.80418950986008 | 3.3855658293102 | 0.0211589605554152 |
| Indian snacks | Osteomodulin (prot-a-2147) | All - Inverse variance weighted | 1.24800653575252 | 0.630582899118549 | 0.0478011926166294 |
| Indian snacks | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs112720655 | 1.12348655344896 | 0.549862763037511 | 0.0410313919899051 |
| Indian snacks | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | All - MR Egger | 0.468300468495027 | 0.195136503183589 | 0.0253036308214255 |
| Indian snacks | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | rs12784972 | -0.290017505340612 | 0.129737320990585 | 0.0253897361024047 |
| Indian snacks | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | rs143153761 | 0.260741627817459 | 0.121747358966682 | 0.0322207333216857 |
| Indian snacks | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | All - MR Egger | 0.104319274555897 | 0.0481645594886064 | 0.0414296034315624 |
| Indian snacks | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs138398208 | 1.04395280125804 | 0.413474575954639 | 0.0115754438439532 |
| Indian snacks | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs146057934 | 0.883648803977447 | 0.391381972263975 | 0.0239602688930021 |
| Indian snacks | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs146431609 | 0.807783067083321 | 0.371726877135598 | 0.0297761541156608 |
| Indian snacks | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | All - Inverse variance weighted | 0.249916144093137 | 0.0939314830639538 | 0.0077996529840093 |
| Indian snacks | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | All - MR Egger | 0.406533679589655 | 0.174411583996263 | 0.0293242807811829 |
| Indian snacks | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | rs73994640 | -0.112803452102553 | 0.0437018656023319 | 0.0098456240382559 |
| Indian snacks | Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) | All - Inverse variance weighted | -0.0195661825141079 | 0.0090842410319937 | 0.0312511602251156 |
| Indian snacks | Non-cancer illness code self-reported: bone disorder (ukb-a-84) | All - Inverse variance weighted | -0.006878223518851 | 0.0029297988336205 | 0.0188908574201757 |
| Indian snacks | Heel bone mineral density (BMD) (left) (ukb-b-1096) | rs146431609 | 1.10152156771122 | 0.405005694927134 | 0.0065327713985324 |
| Indian snacks | Heel bone mineral density (BMD) (left) (ukb-b-1096) | rs727971 | 0.918045735536918 | 0.441506453329238 | 0.0375853399108115 |
| Indian snacks | Operative procedures - main OPCS: W20.5 Primary open reduction of fracture of ankle and extramedullary fixation NEC (ukb-b-13151) | rs12784972 | 0.0333328388321861 | 0.0140042724899122 | 0.017303681656888 |
| Indian snacks | Non-cancer illness code, self-reported: fracture lower leg / ankle (ukb-b-13979) | All - Inverse variance weighted | 0.023762880599423 | 0.0118183535237643 | 0.0443596834127457 |
| Indian snacks | Fractured heel (ukb-b-18389) | All - Inverse variance weighted | -0.0072266562786028 | 0.003603445346817 | 0.0449112023840815 |
| Indian snacks | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs12784972 | -0.273119164886463 | 0.111159036513965 | 0.0140097732268056 |
| Indian snacks | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | All - MR Egger | 0.0940025480305613 | 0.0388924158933298 | 0.0236137184653637 |
| Indian snacks | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs138151469 | 0.573104515781681 | 0.239943468604886 | 0.016917396394634 |
| Indian snacks | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs138398208 | 0.826870711454921 | 0.341734430503625 | 0.0155363273815126 |
| Indian snacks | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs141364295 | -0.716143840856924 | 0.278219774584993 | 0.0100523859943342 |
| Indian snacks | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs146431609 | 0.756698110452382 | 0.300204433281738 | 0.0117151821709659 |
| Indian snacks | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs148210187 | 0.782705156979594 | 0.323484307773449 | 0.0155372543456166 |
| Indian snacks | Ankle spacing width (ukb-b-4080) | rs4916724 | 0.643719185008984 | 0.284082931623532 | 0.0234541287493132 |
| Indian snacks | Ankle spacing width (ukb-b-4080) | All - Inverse variance weighted | 0.138592933166395 | 0.0546466226036064 | 0.011207343689552 |
| Indian snacks | Operative procedures - secondary OPCS: Z81.5 Elbow joint (ukb-b-7443) | rs12784972 | -0.0343035445842234 | 0.0136709787166706 | 0.0120996812483206 |
| Indian snacks | Non-cancer illness code, self-reported: fracture wrist / colles fracture (ukb-b-7831) | rs12784972 | -0.0265751097792547 | 0.0126176912730438 | 0.0351888520664114 |
| Indian snacks | Heel bone mineral density (BMD) (ukb-b-8875) | rs138151469 | 0.551345312605155 | 0.239858671512215 | 0.0215262014996269 |
| Indian snacks | Heel bone mineral density (BMD) (ukb-b-8875) | rs138398208 | 0.849958351853996 | 0.341705295477721 | 0.0128679989584676 |
| Indian snacks | Heel bone mineral density (BMD) (ukb-b-8875) | rs141364295 | -0.714783195014465 | 0.278165268000799 | 0.0101805730649561 |
| Indian snacks | Heel bone mineral density (BMD) (ukb-b-8875) | rs146431609 | 0.747294179492421 | 0.30011973949359 | 0.0127747852050941 |
| Indian snacks | Heel bone mineral density (BMD) (ukb-b-8875) | rs148210187 | 0.79062794703999 | 0.323398315117222 | 0.0144952684857588 |
| Indian snacks | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | rs138151469 | 0.0567240056531395 | 0.0211140722794266 | 0.0072194195645982 |
| Indian snacks | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | All - MR Egger | 0.0320769910129027 | 0.0107646645143603 | 0.0069097155553856 |
| Indian snacks | Disorders of synovium and tendon (ukb-d-M13_SYNOTEND) | rs4916724 | 0.0770931810736182 | 0.0374954470628214 | 0.0397759821749195 |
| Indian snacks | Disorders of synovium and tendon (ukb-d-M13_SYNOTEND) | All - MR Egger | -0.0300418575088693 | 0.014079349786945 | 0.044259324802103 |
| Indian snacks | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | rs138151469 | 0.0737915068308769 | 0.0253117975637661 | 0.0035534572923846 |
| Indian snacks | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | rs143452328 | 0.081809587320462 | 0.0369485978430002 | 0.0268187423513942 |
| Indian snacks | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | rs61966187 | 0.0806299527518489 | 0.0286588168303744 | 0.0049014047546946 |
| Indian snacks | Diagnoses - main ICD10: M51 Other intervertebral disk disorders (ukb-d-M51) | All - MR Egger | 0.0353331282999174 | 0.0146307572792837 | 0.0244927742313429 |