ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Fizzy drink | Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) | rs35421650 | -1.74147094369294 | 0.820813372744878 | 0.0338679336265162 |
| Fizzy drink | Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) | All - Inverse variance weighted | -0.68882360088334 | 0.344277951850467 | 0.0454163665940113 |
| Fizzy drink | Osteoprotegerin levels (ebi-a-GCST90010243) | rs2212808 | 5.1234296096401 | 2.50030726480883 | 0.0404503827593612 |
| Fizzy drink | Osteoprotegerin levels (ebi-a-GCST90010243) | All - Inverse variance weighted | 1.75174741472204 | 0.700770093875775 | 0.0124282290639094 |
| Fizzy drink | Achilles tendon injury (ebi-a-GCST90018567) | All - Inverse variance weighted | -3.66847597181211 | 1.80955909536647 | 0.0426341805656588 |
| Fizzy drink | Benign neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_EXALLC) | rs6819167 | 5.03586943421142 | 2.25330266046921 | 0.025424983563186 |
| Fizzy drink | Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) | rs35421650 | 12.7444413704734 | 6.23935233047454 | 0.0410929990823006 |
| Fizzy drink | Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) | rs7829588 | 9.25686730388358 | 4.49926806165504 | 0.039646201632675 |
| Fizzy drink | Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) | All - Inverse variance weighted | 4.23690104847216 | 1.901924092297 | 0.0259010621453468 |
| Fizzy drink | Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) | rs35421650 | 12.6934781659071 | 6.23571210157695 | 0.0417895287343688 |
| Fizzy drink | Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) | rs7829588 | 9.21073673592402 | 4.50234343285234 | 0.0407794944251813 |
| Fizzy drink | Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) | All - Inverse variance weighted | 4.2441772456652 | 1.90447378650978 | 0.0258451833685804 |
| Fizzy drink | Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) | rs6819167 | -11.3555973610158 | 4.74765630322118 | 0.0167645036167221 |
| Fizzy drink | Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) | All - Inverse variance weighted | -3.02380959342373 | 1.31389482829667 | 0.021368514634705 |
| Fizzy drink | Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) | rs6819167 | -11.4027595097233 | 4.74765630322118 | 0.0163161415990813 |
| Fizzy drink | Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) | All - Inverse variance weighted | -3.02963746171979 | 1.31431438027413 | 0.0211604885339056 |
| Fizzy drink | Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) | All - Inverse variance weighted | -1.76417953659158 | 0.871363376456646 | 0.0429064205139356 |
| Fizzy drink | Pain in joint (finn-b-JOINTPAIN) | rs7829588 | 0.962591184756 | 0.488984020371259 | 0.0490043914905164 |
| Fizzy drink | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | rs7829588 | 0.950289699966786 | 0.412099740438671 | 0.0211123003516535 |
| Fizzy drink | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | All - Inverse variance weighted | 0.355577212365511 | 0.173657295440934 | 0.0406011665381895 |
| Fizzy drink | Juvenile osteochondrosis (finn-b-M13_JUVOSTEOCHONRHIP) | All - MR Egger | 6.48086248074588 | 2.51170257287911 | 0.0274037656701565 |
| Fizzy drink | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | rs7829588 | 0.550491444317329 | 0.246029695784281 | 0.0252536793235391 |
| Fizzy drink | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | All - Inverse variance weighted | 0.255591749728919 | 0.103930369372911 | 0.0139223937828302 |
| Fizzy drink | Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) | All - Inverse variance weighted | 2.53501851489265 | 1.2401703774513 | 0.0409447645451875 |
| Fizzy drink | Knee and hip osteoarthritis (ieu-a-1170) | rs949734 | -2.742625744984 | 1.13553890167534 | 0.0157238268329055 |
| Fizzy drink | Knee and hip osteoarthritis (ieu-a-1170) | All - Inverse variance weighted | -1.07316147916748 | 0.513424652231985 | 0.036599615253686 |
| Fizzy drink | Psoriatic arthritis (ieu-b-5116) | rs9587497 | 3.57818007411463 | 1.51966661991141 | 0.018543538563999 |
| Fizzy drink | Psoriatic arthritis (ieu-b-5116) | All - Inverse variance weighted | 1.16244649717333 | 0.425834931686549 | 0.0063371720722786 |
| Fizzy drink | Pain type(s) experienced in last month: Knee pain (ukb-a-476) | rs78236863 | -0.142085354870573 | 0.0575201185322913 | 0.0135043056686519 |
| Fizzy drink | Pain type(s) experienced in last month: Knee pain (ukb-a-476) | All - Inverse variance weighted | -0.0421087357064098 | 0.0163718899599621 | 0.0101108704469746 |
| Fizzy drink | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | All - MR Egger | 0.335075172461664 | 0.141192040101918 | 0.0390641221000098 |
| Fizzy drink | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | rs6819167 | -0.0401910067022654 | 0.0132107466816188 | 0.0023478060687955 |
| Fizzy drink | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | rs7829588 | -0.0283830620855937 | 0.0137215989469929 | 0.0385934778966192 |
| Fizzy drink | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | All - Inverse variance weighted | -0.01317146286692 | 0.0056955434824209 | 0.020745134221715 |
| Fizzy drink | Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis (ukb-b-14753) | rs2212808 | -0.0120313677291795 | 0.0060308867929569 | 0.0460474269182132 |
| Fizzy drink | Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis (ukb-b-14753) | All - Inverse variance weighted | -0.0075778415461926 | 0.0034115821538549 | 0.0263367183815261 |
| Fizzy drink | Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026) | rs2212808 | -0.0250764421407006 | 0.0092563657252785 | 0.0067465523902341 |
| Fizzy drink | Diagnoses - secondary ICD10: M13.99 Arthritis, unspecified (Site unspecified) (ukb-b-15026) | All - Inverse variance weighted | -0.0079242005456538 | 0.0040079391953758 | 0.0480273964100167 |
| Fizzy drink | Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) | All - Inverse variance weighted | -0.0092627193302794 | 0.0041382721068593 | 0.0252011064266619 |
| Fizzy drink | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | rs6920614 | -0.101893872951582 | 0.0500390149521881 | 0.0417213894056259 |
| Fizzy drink | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | rs78236863 | -0.107738589814358 | 0.0494369716161645 | 0.0293084918778937 |
| Fizzy drink | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | All - Inverse variance weighted | -0.0440424241218375 | 0.0140093319074226 | 0.0016677399447956 |
| Fizzy drink | Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) | All - Inverse variance weighted | -0.0066349795735682 | 0.0033349902604907 | 0.0466454979038487 |
| Fizzy drink | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | rs2212808 | 0.0196980789269778 | 0.0090096454431292 | 0.0287913019982178 |
| Fizzy drink | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | All - MR Egger | -0.0170746014630516 | 0.0071130670925751 | 0.0372866109900815 |
| Fizzy drink | Fractured/broken bones in last 5 years (ukb-e-2463_AFR) | rs9587497 | -14.0446769136099 | 6.43865181960916 | 0.0291607098026901 |
| Fizzy drink | Fractured/broken bones in last 5 years (ukb-e-2463_AFR) | All - Inverse variance weighted | -2.79852606942963 | 1.38156895486111 | 0.0428043073073352 |
| Fizzy drink | Pain in joint (ukb-e-745_CSA) | rs2212808 | 12.0394367702461 | 5.20426430117295 | 0.0207017998215489 |
| Fizzy drink | Pain in joint (ukb-e-745_CSA) | All - Inverse variance weighted | 3.72108148437643 | 1.77094804795378 | 0.0356251255077248 |