ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Beef (ukb-b-2862)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Beef (👉 📊) Rheumatoid arthritis (bbj-a-151) MR Egger 69 5.131303835 2.039468034 0.014272033
Beef (👉 📊) Rheumatoid Arthritis (bbj-a-72) MR Egger 69 4.774574788 1.994448115 0.019475033
Beef (👉 📊) Rheumatoid Arthritis (bbj-a-72) Inverse variance weighted 69 0.809397817 0.407562569 0.047039167
Beef (👉 📊) Total body bone mineral density (age over 60) (ebi-a-GCST005349) MR Egger 101 -1.225648669 0.445781228 0.007097072
Beef (👉 📊) Ankylosing spondylitis (ebi-a-GCST005529) Inverse variance weighted 2 0.696937102 0.355159482 0.049725061
Beef (👉 📊) Knee osteoarthritis (ebi-a-GCST007090) Weighted median 103 0.355162384 0.155943052 0.022755588
Beef (👉 📊) Knee osteoarthritis (ebi-a-GCST007090) Inverse variance weighted 103 0.420331264 0.127111931 0.000943748
Beef (👉 📊) Osteoarthritis of the hip or knee (ebi-a-GCST007092) Weighted median 103 0.374492943 0.131222532 0.004318927
Beef (👉 📊) Osteoarthritis of the hip or knee (ebi-a-GCST007092) Inverse variance weighted 103 0.283477495 0.115508423 0.014120957
Beef (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) MR Egger 90 0.771023497 0.312223586 0.015462463
Beef (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) MR Egger 90 0.771525558 0.312123908 0.015366015
Beef (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017138) MR Egger 100 -2.803337609 1.408112648 0.049282174
Beef (👉 📊) Rheumatoid arthritis (ebi-a-GCST90018690) MR Egger 74 4.295336797 1.876034063 0.024979175
Beef (👉 📊) Spine arthritis or spondylitis (ebi-a-GCST90038657) Weighted median 102 0.006605434 0.003283036 0.044221067
Beef (👉 📊) Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) Inverse variance weighted 98 3.348950239 1.488122814 0.024420213
Beef (👉 📊) Pain in joint (finn-b-JOINTPAIN) Weighted median 98 0.662704369 0.239272846 0.005611488
Beef (👉 📊) Pain in joint (finn-b-JOINTPAIN) Inverse variance weighted 98 0.501089155 0.164832506 0.002365861
Beef (👉 📊) Pain in joint (finn-b-JOINTPAIN) Weighted mode 98 1.342413613 0.596199922 0.026602384
Beef (👉 📊) Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) Weighted median 98 0.732071589 0.296563834 0.013567584
Beef (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) Weighted median 98 3.600554291 1.742712912 0.038822552
Beef (👉 📊) Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) Inverse variance weighted 98 2.313886807 1.168231471 0.047627738
Beef (👉 📊) Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) Weighted median 98 0.580974823 0.216201316 0.007205515
Beef (👉 📊) Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) Inverse variance weighted 98 0.489966638 0.152520764 0.001316041
Beef (👉 📊) Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) Simple mode 98 1.203650981 0.60078231 0.047916157
Beef (👉 📊) Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) Weighted mode 98 1.18059107 0.565782222 0.039542487
Beef (👉 📊) Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) Weighted median 98 0.413212329 0.204793261 0.043622023
Beef (👉 📊) Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) Inverse variance weighted 98 0.4540487 0.157704063 0.003987883
Beef (👉 📊) Other joint disorders (finn-b-M13_OTHERJOINT) Inverse variance weighted 98 0.285992611 0.118180671 0.015522173
Beef (👉 📊) Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) MR Egger 98 2.723356618 1.328737772 0.04313278
Beef (👉 📊) Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) Inverse variance weighted 98 -4.435945251 1.843703941 0.016128419
Beef (👉 📊) Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) MR Egger 98 -3.974081189 1.659590951 0.018579547
Beef (👉 📊) Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) Inverse variance weighted 98 -4.007192858 1.903241087 0.03525152
Beef (👉 📊) Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) MR Egger 98 3.3604246 1.532330023 0.030721572
Beef (👉 📊) Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) Inverse variance weighted 98 2.597074698 1.23908142 0.036085052
Beef (👉 📊) Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) MR Egger 98 5.693341609 2.480647729 0.023904586
Beef (👉 📊) Contusion of ankle (finn-b-ST19_CONTU_ANKLE) MR Egger 98 6.12995985 2.424823835 0.013103364
Beef (👉 📊) Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) MR Egger 98 1.215291185 0.519273575 0.02133493
Beef (👉 📊) Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) Inverse variance weighted 98 1.955877144 0.905245366 0.030725909
Beef (👉 📊) Fracture of neck (finn-b-ST19_FRACT_NECK) MR Egger 98 -4.52682534 2.135866485 0.036633906
Beef (👉 📊) Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) Inverse variance weighted 98 0.441074948 0.220290675 0.045258854
Beef (👉 📊) Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) MR Egger 98 4.254315541 1.624198682 0.010240371
Beef (👉 📊) Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) MR Egger 98 3.318872596 1.636748555 0.045359987
Beef (👉 📊) Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) Inverse variance weighted 98 2.383327714 1.071550489 0.026135925
Beef (👉 📊) Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) Weighted median 98 2.008017456 1.00915527 0.046612939
Beef (👉 📊) Rheumatoid arthritis (ieu-a-832) MR Egger 58 -3.672807941 1.696932367 0.034714302
Beef (👉 📊) Four-jointed box protein 1 (prot-a-1112) MR Egger 102 2.015298561 0.991682619 0.044784774
Beef (👉 📊) Osteocrin (prot-a-2157) Inverse variance weighted 102 0.620229651 0.291948092 0.033632382
Beef (👉 📊) Fractured/broken bones in last 5 years (ukb-a-308) MR Egger 102 0.058361469 0.027622778 0.037107574
Beef (👉 📊) Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) Inverse variance weighted 102 0.032482205 0.014365769 0.023754083
Beef (👉 📊) Pain type(s) experienced in last month: Knee pain (ukb-a-476) Inverse variance weighted 102 0.037556429 0.014245451 0.008379573
Beef (👉 📊) Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) Inverse variance weighted 102 0.01473762 0.003826397 0.000117365
Beef (👉 📊) Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) Inverse variance weighted 102 0.009284451 0.004173092 0.026092171
Beef (👉 📊) Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) MR Egger 102 0.022956537 0.009214658 0.014373073
Beef (👉 📊) Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) MR Egger 102 -0.010890511 0.00513137 0.036279136
Beef (👉 📊) Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) Weighted median 90 0.01503648 0.005461433 0.005901379
Beef (👉 📊) Operation code: knee replacement/revision (ukb-b-11120) Inverse variance weighted 84 0.005998451 0.002993373 0.045079704
Beef (👉 📊) Diagnoses - main ICD10: M25.5 Pain in joint (ukb-b-13019) MR Egger 55 -0.02222634 0.011007762 0.048542049
Beef (👉 📊) Fractured/broken bones in last 5 years (ukb-b-13346) MR Egger 102 0.060056033 0.023482414 0.012044498
Beef (👉 📊) Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) Inverse variance weighted 78 -0.005342902 0.002398153 0.025885614
Beef (👉 📊) Fracture resulting from simple fall (ukb-b-15251) MR Egger 99 0.326947786 0.13366784 0.016248056
Beef (👉 📊) Fracture resulting from simple fall (ukb-b-15251) Weighted median 99 0.128320027 0.053939778 0.017362037
Beef (👉 📊) Fracture resulting from simple fall (ukb-b-15251) Inverse variance weighted 99 0.076908232 0.038987355 0.048535962
Beef (👉 📊) Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) Inverse variance weighted 74 0.00456526 0.002143697 0.033202981
Beef (👉 📊) Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) Weighted median 83 -0.009353213 0.00405157 0.020969104
Beef (👉 📊) Neck/shoulder pain for 3+ months (ukb-b-16118) Inverse variance weighted 102 0.052339082 0.024387006 0.031858038
Beef (👉 📊) Pain type(s) experienced in last month: Knee pain (ukb-b-16254) Inverse variance weighted 102 0.046958515 0.013536623 0.000522404
Beef (👉 📊) Heel bone ultrasound T-score, manual entry (ukb-b-17612) MR Egger 102 -0.583062468 0.290996498 0.047810016
Beef (👉 📊) Fractured bone site(s): Other bones (ukb-b-17738) MR Egger 99 0.043678455 0.020433933 0.035067501
Beef (👉 📊) Non-cancer illness code, self-reported: ankylosing spondylitis (ukb-b-18194) Inverse variance weighted 44 0.004674323 0.001939767 0.015964141
Beef (👉 📊) Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) MR Egger 63 -0.031159205 0.013433916 0.023735146
Beef (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) Weighted median 59 0.005189917 0.002637308 0.049081339
Beef (👉 📊) Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) MR Egger 72 0.025418491 0.012740202 0.049921458
Beef (👉 📊) Ankle spacing width (ukb-b-4080) Weighted median 103 0.182454284 0.044707157 4.48e-05
Beef (👉 📊) Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) MR Egger 78 0.041191583 0.015161991 0.00815906
Beef (👉 📊) Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) Weighted median 80 0.008568281 0.003656004 0.019097677
Beef (👉 📊) Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) Inverse variance weighted 70 -0.005618786 0.002032426 0.005699766
Beef (👉 📊) Operation code: reduction or fixation of bone fracture (ukb-b-847) MR Egger 99 0.043858335 0.018968633 0.022884071
Beef (👉 📊) Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) Inverse variance weighted 36 0.00469993 0.002369157 0.047278281
Beef (👉 📊) Ankle spacing width (right) (ukb-b-8607) Weighted median 102 0.136562139 0.054636777 0.012438467
Beef (👉 📊) Fractured bone site(s): Wrist (ukb-b-9571) MR Egger 90 0.031157605 0.015086158 0.041835468
Beef (👉 📊) Fractured bone site(s): Wrist (ukb-b-9571) Weighted median 90 0.010267678 0.004895014 0.035942378
Beef (👉 📊) Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) Weighted median 103 0.022576116 0.006741034 0.000810867
Beef (👉 📊) Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) Inverse variance weighted 103 0.020924302 0.00529571 7.78e-05
Beef (👉 📊) Rheumatoid arthritis (ukb-d-M13_RHEUMA) Weighted median 102 0.00542091 0.00257054 0.034956599
Beef (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) MR Egger 102 0.020749833 0.009703394 0.03491946
Beef (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_CSA) MR Egger 91 -2.660819443 1.338715618 0.049930923
Beef (👉 📊) Ankle spacing width (left) (ukb-e-4100_CSA) Weighted median 92 -0.616090796 0.313288928 0.049237892
Beef (👉 📊) Ankle spacing width (left) (ukb-e-4100_CSA) Inverse variance weighted 92 -0.456504496 0.216009071 0.034570139
Beef (👉 📊) Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) Inverse variance weighted 91 -3.091932257 1.196741565 0.009776784
Beef (👉 📊) Pain in joint (ukb-e-745_CSA) Inverse variance weighted 91 -2.444600834 1.192004651 0.040283347

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Beef Rheumatoid arthritis (bbj-a-151) rs1343431 -5.88432259312493 2.84757947419583 0.0387879307861391
Beef Rheumatoid arthritis (bbj-a-151) rs2965199 5.71951715082342 2.86556047007091 0.0459392997449666
Beef Rheumatoid arthritis (bbj-a-151) rs429358 5.1179080760063 2.52143232287865 0.0423807146620954
Beef Rheumatoid arthritis (bbj-a-151) rs62396185 7.19084925933161 2.05892338679798 0.0004784699670087
Beef Rheumatoid arthritis (bbj-a-151) All - MR Egger 5.13130383484466 2.03946803374142 0.0142720328846985
Beef Rheumatoid Arthritis (bbj-a-72) rs12113634 7.0306626970854 3.01913369077227 0.0198748575181716
Beef Rheumatoid Arthritis (bbj-a-72) rs62169335 7.77284984534827 3.44611140706236 0.0240993140040259
Beef Rheumatoid Arthritis (bbj-a-72) rs62396185 8.79303724561628 2.29172701368165 0.0001246171258087
Beef Rheumatoid Arthritis (bbj-a-72) rs7791463 8.24845053547902 4.05196230596347 0.0417836912704466
Beef Rheumatoid Arthritis (bbj-a-72) All - Inverse variance weighted 0.809397816779396 0.407562569239626 0.0470391669408663
Beef Rheumatoid Arthritis (bbj-a-72) All - MR Egger 4.7745747875745 1.99444811451779 0.0194750327211424
Beef Total body bone mineral density (age over 60) (ebi-a-GCST005349) rs112094422 3.20560819534782 1.38828738763169 0.0209414781718039
Beef Total body bone mineral density (age over 60) (ebi-a-GCST005349) rs117340623 -3.36483648780975 1.56729811674568 0.0318010322240709
Beef Total body bone mineral density (age over 60) (ebi-a-GCST005349) rs1470610 2.46400183367578 0.982326312428884 0.0121302177234361
Beef Total body bone mineral density (age over 60) (ebi-a-GCST005349) rs17501421 -2.46374982723705 1.18981089217789 0.0383861790657311
Beef Total body bone mineral density (age over 60) (ebi-a-GCST005349) rs267733 -3.47225297843129 1.20465919659861 0.0039471733562835
Beef Total body bone mineral density (age over 60) (ebi-a-GCST005349) rs35800274 3.6893479077573 1.25977733435615 0.0034052358212947
Beef Total body bone mineral density (age over 60) (ebi-a-GCST005349) rs4131337 2.40178083261736 1.18136374287276 0.0420466786240023
Beef Total body bone mineral density (age over 60) (ebi-a-GCST005349) rs41476948 2.38039718627337 1.20234347674012 0.047726233482875
Beef Total body bone mineral density (age over 60) (ebi-a-GCST005349) rs61845699 2.63190086259624 1.22327786571375 0.031435561213217
Beef Total body bone mineral density (age over 60) (ebi-a-GCST005349) rs62015188 -2.18523564375535 0.928348383829859 0.018577802801841
Beef Total body bone mineral density (age over 60) (ebi-a-GCST005349) rs72779821 2.69075533346146 1.30693830482414 0.039511146777562
Beef Total body bone mineral density (age over 60) (ebi-a-GCST005349) rs9615805 3.37496030544499 1.23330059301819 0.0062091509535039
Beef Total body bone mineral density (age over 60) (ebi-a-GCST005349) All - MR Egger -1.22564866929367 0.445781227835378 0.0070970719524344
Beef Ankylosing spondylitis (ebi-a-GCST005529) All - Inverse variance weighted 0.696937102285519 0.355159481652455 0.0497250605389007
Beef Knee osteoarthritis (ebi-a-GCST007090) rs10909905 2.61981548890253 1.14995201328065 0.0227149329504993
Beef Knee osteoarthritis (ebi-a-GCST007090) rs12113634 2.18569824779857 1.07077136382051 0.0412272644025804
Beef Knee osteoarthritis (ebi-a-GCST007090) rs1421085 -3.55516695261977 0.783621486076283 5.7102825914421e-06
Beef Knee osteoarthritis (ebi-a-GCST007090) rs1442572 2.09046317767644 1.00212925527788 0.0369766750853574
Beef Knee osteoarthritis (ebi-a-GCST007090) rs62396185 3.49619729600463 0.714059563345841 9.76944993817112e-07
Beef Knee osteoarthritis (ebi-a-GCST007090) rs645040 3.64040465971796 1.06338136112814 0.0006183767190374
Beef Knee osteoarthritis (ebi-a-GCST007090) rs7174015 4.0713150706912 1.13757332857548 0.0003449809283123
Beef Knee osteoarthritis (ebi-a-GCST007090) rs7601686 2.36364303941547 1.09002955701199 0.0301266653415788
Beef Knee osteoarthritis (ebi-a-GCST007090) All - Inverse variance weighted 0.420331263943716 0.127111930636237 0.0009437478342919
Beef Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs10789340 -1.64009376111236 0.573307111185294 0.0042262752847158
Beef Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs10909905 2.3171965380392 0.942441875545795 0.0139435027445746
Beef Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs12670003 -2.23409624440318 0.960777141375462 0.020055859923205
Beef Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs1421085 -3.80262636927544 0.635145836082882 2.13729723239881e-09
Beef Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs41476948 1.85816719132564 0.947300921067972 0.0498162429153154
Beef Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs429358 1.62947600899578 0.707004053489907 0.0211799117377658
Beef Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs62396185 2.36448025221123 0.586067754821586 5.47227078382e-05
Beef Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs645040 2.71114347026364 0.871781115879828 0.0018715695893897
Beef Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs6669189 -2.1140439671403 0.969973114334959 0.0292954960479384
Beef Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs71559014 3.03652410406036 0.904356091861455 0.0007860403201548
Beef Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs7174015 3.2810009687335 0.934007575040923 0.0004433768822104
Beef Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs7601686 1.82436525857796 0.894971636283527 0.0415037974173481
Beef Osteoarthritis of the hip or knee (ebi-a-GCST007092) All - Inverse variance weighted 0.283477494708498 0.115508423440111 0.0141209570374024
Beef Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) rs10123094 -1.81982733759978 0.913886008455181 0.0464471786133278
Beef Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) rs140748046 2.20859933617828 0.934846846846847 0.0181509020055198
Beef Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) rs187160427 2.35073233885685 0.824971793125322 0.0043792141561199
Beef Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) rs4714375 1.83935728393017 0.90053533202724 0.0411004334114305
Beef Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) rs61845699 -2.10690460038972 0.908823787441261 0.0204343124056678
Beef Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) rs7174015 -3.20219707320344 0.903309859407911 0.0003926730767185
Beef Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) rs803370 -2.17163603649916 0.840190745861507 0.0097465436562021
Beef Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) All - MR Egger 0.771023497265897 0.312223585923887 0.0154624627638527
Beef Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) rs10123094 -1.81925056909871 0.913158298410205 0.0463423197952456
Beef Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) rs140748046 2.18468278805121 0.916214319582741 0.0171038830535156
Beef Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) rs187160427 2.37151963562437 0.837445211070613 0.0046279481720672
Beef Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) rs4714375 1.83747414944147 0.898543293375337 0.0408600026586131
Beef Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) rs61845699 -2.10710230186297 0.908859620833287 0.0204274632029272
Beef Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) rs7174015 -3.19876040430554 0.901627448327228 0.0003885178057984
Beef Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) rs803370 -2.17589579248044 0.842978761333438 0.009845785723822
Beef Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) All - MR Egger 0.77152555762066 0.312123908257657 0.0153660151396486
Beef Neck circumference (BMI adjusted) (ebi-a-GCST90017138) rs115736207 -9.58374006414726 4.03709385023009 0.0176003370527084
Beef Neck circumference (BMI adjusted) (ebi-a-GCST90017138) rs12652806 8.87492211416032 3.98775499146642 0.0260447757596872
Beef Neck circumference (BMI adjusted) (ebi-a-GCST90017138) rs2107601 -7.26853100740341 3.46941222312142 0.0361681126233449
Beef Neck circumference (BMI adjusted) (ebi-a-GCST90017138) rs4863708 9.27212116803324 3.96056981399178 0.0192266110775893
Beef Neck circumference (BMI adjusted) (ebi-a-GCST90017138) rs62169335 -6.94797177038037 3.37590901770339 0.039580153478243
Beef Neck circumference (BMI adjusted) (ebi-a-GCST90017138) rs7018123 -11.5795855507214 3.92567694698478 0.0031807836057953
Beef Neck circumference (BMI adjusted) (ebi-a-GCST90017138) rs803370 7.9805647337808 3.67935127336647 0.0300816146242915
Beef Neck circumference (BMI adjusted) (ebi-a-GCST90017138) All - MR Egger -2.80333760891806 1.40811264778024 0.0492821742261983
Beef Rheumatoid arthritis (ebi-a-GCST90018690) rs11165829 -6.17166498367663 2.39236870226762 0.0098877628982025
Beef Rheumatoid arthritis (ebi-a-GCST90018690) rs429358 5.03481153291945 2.27918580066526 0.0271718914075852
Beef Rheumatoid arthritis (ebi-a-GCST90018690) rs4759074 4.76105462715271 2.39071835138744 0.0464287462355039
Beef Rheumatoid arthritis (ebi-a-GCST90018690) rs62396185 8.16729203015218 1.84528484913808 9.59817522494191e-06
Beef Rheumatoid arthritis (ebi-a-GCST90018690) rs67616875 -5.01117004316133 2.39381920925549 0.036315366051096
Beef Rheumatoid arthritis (ebi-a-GCST90018690) rs7220792 4.97908156011563 2.340960144069 0.0334250761958498
Beef Rheumatoid arthritis (ebi-a-GCST90018690) All - MR Egger 4.29533679747288 1.87603406260513 0.0249791749237953
Beef Spine arthritis or spondylitis (ebi-a-GCST90038657) rs10123094 -0.0530809868877204 0.0233772863655608 0.0231698545189396
Beef Spine arthritis or spondylitis (ebi-a-GCST90038657) rs112663712 -0.0640693341153984 0.0240288824728089 0.0076680544223612
Beef Spine arthritis or spondylitis (ebi-a-GCST90038657) rs11749912 -0.0464475271188879 0.0234216456858746 0.0473559670927517
Beef Spine arthritis or spondylitis (ebi-a-GCST90038657) rs12113634 0.0568019922970695 0.0216060687346905 0.008564058494682
Beef Spine arthritis or spondylitis (ebi-a-GCST90038657) rs2567950 -0.0436348760800952 0.0204053914213277 0.0324843438887321
Beef Spine arthritis or spondylitis (ebi-a-GCST90038657) rs35556085 0.0541103781313327 0.0240654507825637 0.0245464106390865
Beef Spine arthritis or spondylitis (ebi-a-GCST90038657) rs4759074 -0.0478160759776333 0.0217240570014537 0.027731375514684
Beef Spine arthritis or spondylitis (ebi-a-GCST90038657) rs74045004 0.0443149294181217 0.0224731729762588 0.0486206187578598
Beef Spine arthritis or spondylitis (ebi-a-GCST90038657) rs7902949 0.0489123082857761 0.0232451046293673 0.0353611578735522
Beef Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) rs1421085 22.1311204962386 10.5830143856408 0.0365108098054836
Beef Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) rs1555302 45.2829605900353 15.5980770461169 0.0036947478450287
Beef Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) rs61845699 34.239423897907 16.1744517799929 0.0342697688784899
Beef Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) rs6739040 41.2000440766237 20.420235809937 0.0436320369701164
Beef Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) rs7597864 33.2475911580249 16.876541607166 0.0488329095979492
Beef Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) All - Inverse variance weighted 3.34895023914366 1.4881228136494 0.0244202128365045
Beef Pain in joint (finn-b-JOINTPAIN) rs140748046 -4.18018018018018 1.99146514935989 0.0358127032251653
Beef Pain in joint (finn-b-JOINTPAIN) rs429358 3.40708620062755 1.19854020496384 0.0044733627929651
Beef Pain in joint (finn-b-JOINTPAIN) rs4714375 -4.19734795674236 1.63356244802946 0.0101861723112976
Beef Pain in joint (finn-b-JOINTPAIN) rs6739040 4.67444193774757 2.23862852105529 0.0367903571433439
Beef Pain in joint (finn-b-JOINTPAIN) rs952645 3.48044958329182 1.74022479164591 0.0455002638963584
Beef Pain in joint (finn-b-JOINTPAIN) rs9615805 2.90231816201287 1.454851597752 0.0460511849980698
Beef Pain in joint (finn-b-JOINTPAIN) All - Inverse variance weighted 0.501089154767719 0.164832506034075 0.0023658607652761
Beef Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs1421085 -7.42378249967005 1.43526461660288 2.31089124212718e-07
Beef Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs1556147 4.64999460358544 2.01735123799802 0.0211665734149196
Beef Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs2403202 3.9110460359533 1.98275871460585 0.0485494233126332
Beef Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs429358 4.20162408931145 1.5419421738018 0.006432275156939
Beef Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs6851529 -4.66363383812037 2.21239772374443 0.0350349213899708
Beef Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs7018123 4.71545810791663 2.09059719070195 0.0240984792962833
Beef Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs7174015 9.98669637928371 2.16737655233855 4.07079387762762e-06
Beef Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs77862656 3.36240892115641 1.63223734036719 0.0393985408187538
Beef Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs79809011 7.4520747131967 3.18254553748668 0.0192040925850924
Beef Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) rs71559014 34.5503633927216 14.9581817821756 0.0208993955244718
Beef Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) rs7220792 38.6616748021421 10.8620444528695 0.0003717924519387
Beef Chronic crepitant synovitis/bursitis of hand and wrist/periarhritis of wrist (finn-b-M13_CHRONSYNOVITISHANDWRIST) All - Inverse variance weighted 2.31388680667886 1.16823147075744 0.047627738032738
Beef Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) rs12113634 3.77529697347026 1.52336544543537 0.0132024577103307
Beef Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) rs140748046 -3.75912754860123 1.82456140350877 0.0393707240428742
Beef Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) rs429358 2.9963505124096 1.09080625395586 0.0060158983768699
Beef Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) rs4714375 -3.45997601839573 1.48608806036013 0.0198991364275123
Beef Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) rs61845699 3.6451209129854 1.59396812805124 0.0222062320352033
Beef Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) rs952645 3.63177347821756 1.58890089672018 0.0222709789592328
Beef Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) All - Inverse variance weighted 0.489966637924636 0.152520764057571 0.0013160412125706
Beef Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs10123094 3.47288267669671 1.47260042828129 0.0183572009376131
Beef Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs1421085 -2.83753464431833 0.981589019400818 0.0038431600856244
Beef Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs2403202 2.84340672808861 1.35089055280838 0.0353053503296361
Beef Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs429358 2.12101216046972 1.03020590651386 0.039511146777562
Beef Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs4585149 -3.23501954876099 1.33097947149023 0.0150756946410892
Beef Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs62396185 2.37795307416115 0.815105727970252 0.0035301331876338
Beef Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs67616875 2.84657560977572 1.43837566147678 0.0478136443075876
Beef Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs7174015 5.30468404798883 1.47285809910299 0.0003162330690351
Beef Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs74818437 -3.04011631749389 1.37771157531914 0.027339075616132
Beef Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs952645 4.60276847065767 1.48801830010303 0.0019799706933597
Beef Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) All - Inverse variance weighted 0.45404870031996 0.157704063113375 0.0039878834151176
Beef Other joint disorders (finn-b-M13_OTHERJOINT) rs1421085 -1.90543750824865 0.717632308301438 0.0079267882287121
Beef Other joint disorders (finn-b-M13_OTHERJOINT) rs2107601 -2.07565266912448 0.936666366933429 0.0266915021434139
Beef Other joint disorders (finn-b-M13_OTHERJOINT) rs429358 2.14121227628372 0.7541376570559 0.0045214652134513
Beef Other joint disorders (finn-b-M13_OTHERJOINT) rs4585149 -2.30148533611853 0.979748777624756 0.0188210453923122
Beef Other joint disorders (finn-b-M13_OTHERJOINT) rs61845699 2.84195867792082 1.09971444493458 0.0097585462516864
Beef Other joint disorders (finn-b-M13_OTHERJOINT) rs62396185 1.89966789493893 0.592804165796547 0.0013527592847427
Beef Other joint disorders (finn-b-M13_OTHERJOINT) rs7174015 2.7541249007617 1.07770104812414 0.0106018435684866
Beef Other joint disorders (finn-b-M13_OTHERJOINT) rs952645 3.48044958329182 1.09709823821155 0.0015117743463054
Beef Other joint disorders (finn-b-M13_OTHERJOINT) All - Inverse variance weighted 0.285992610851929 0.118180670577609 0.0155221728027718
Beef Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) rs10247400 -9.74793736610485 4.5959856783156 0.0339245171487671
Beef Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) rs12670003 -10.1518259395937 4.5839487708998 0.0267843401084954
Beef Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) rs6851529 9.62895827493316 4.67620427973255 0.039480849542122
Beef Trochanteric bursitis (finn-b-M13_TROCHANTERICBURSITIS) All - MR Egger 2.72335661781638 1.32873777207999 0.0431327802887313
Beef Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) rs117117111 -59.022393410368 22.6268487486035 0.0090936976745025
Beef Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) rs132901 -29.1420405173466 13.2209207965587 0.0275076930413993
Beef Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) rs1884 -45.7391726556974 17.7578073659845 0.0100031075811923
Beef Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) rs7597864 -48.871891080248 20.8055934993722 0.0188249955447389
Beef Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) rs784251 32.0736649675491 15.1179548686005 0.0338746119033061
Beef Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) All - Inverse variance weighted -4.43594525140268 1.84370394094669 0.0161284186948773
Beef Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) rs12829270 10.9620975071635 5.30759784365829 0.0388889997840788
Beef Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) rs13145306 -11.0132158590308 5.22903907453171 0.0351900757745684
Beef Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) rs144160011 -12.105991014553 4.26342980388223 0.0045184890163722
Beef Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) rs1470610 -11.0020546992035 4.78884077309081 0.0215939159379788
Beef Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) rs4759074 -13.6943850742596 5.21799364726363 0.0086787977099846
Beef Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) rs7791463 -9.72931760723719 4.75469342700289 0.0407312387848121
Beef Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) rs9615805 -10.4128972224889 4.83719693668811 0.0313444847581866
Beef Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) All - MR Egger -3.9740811885463 1.65959095137592 0.0185795468559233
Beef Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs117117111 -50.5602521134511 20.1298917846364 0.0120151132011273
Beef Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs17274957 53.0423705552675 18.1929935274701 0.0035507545148491
Beef Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs34465895 -37.0310849901281 18.8897561871528 0.0499514859694826
Beef Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs35556085 -36.312680550166 16.6946923640754 0.0296223758008841
Beef Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs6739040 55.2059712226043 23.0358354550041 0.0165513336541687
Beef Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs6851529 -40.3385471334994 18.2522812208916 0.0271013387307049
Beef Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs7018123 -45.7840784763728 17.2358123944539 0.0078995277648678
Beef Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs77862656 -27.3562978245541 13.4888093807944 0.0425527397111369
Beef Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs7902949 -37.5091342268759 17.0505568350152 0.0278155962846879
Beef Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs937813 34.0526534137666 15.8803566449261 0.032006816444641
Beef Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) rs952645 49.382031044097 18.0075434961621 0.0061011163667596
Beef Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) All - Inverse variance weighted -4.00719285812173 1.90324108689162 0.035251519669724
Beef Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs10247400 -15.2828878604204 5.10253248694715 0.0027430326731203
Beef Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs117340623 10.8739975533506 5.45086867151373 0.046052593966954
Beef Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs4676964 6.17824807350992 3.0179805740903 0.0406437121317468
Beef Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs4714375 -10.3005187695191 4.78724550741966 0.0314242398635857
Beef Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs62169335 -8.26942851125509 4.18117171917392 0.0479537814825985
Beef Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs67616875 -11.1247795915617 4.90858267692775 0.0234273047275417
Beef Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) rs7220792 -8.70100943083266 4.32207004407374 0.0440980211996215
Beef Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) All - MR Egger 3.36042459963608 1.53233002256111 0.0307215722108168
Beef Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) rs11904006 34.3801859911701 14.9878406446024 0.0217978598593394
Beef Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) rs1191468 28.5990809929461 12.8434287507956 0.0259641115769
Beef Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) rs645040 33.7982832618026 14.3221183323115 0.0182815264077467
Beef Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) rs74045004 24.9484988686637 11.7988247610685 0.0344734242379618
Beef Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) All - Inverse variance weighted 2.5970746980418 1.23908142025451 0.0360850517791761
Beef Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) rs11121250 21.0613990755542 8.74123978110027 0.0159774922522147
Beef Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) rs386231 -17.3605228262073 8.26799135249429 0.0357528827737705
Beef Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) All - MR Egger 5.69334160890311 2.48064772874197 0.0239045861568121
Beef Contusion of ankle (finn-b-ST19_CONTU_ANKLE) rs12257513 -16.338766786422 7.65036284726367 0.0327050807030605
Beef Contusion of ankle (finn-b-ST19_CONTU_ANKLE) rs140748046 19.7515410146989 9.67662399241347 0.0412348934300716
Beef Contusion of ankle (finn-b-ST19_CONTU_ANKLE) rs2403202 17.4962115145989 7.64778361347971 0.0221521256136835
Beef Contusion of ankle (finn-b-ST19_CONTU_ANKLE) rs4714375 -21.4291629467198 7.87286346480864 0.0064907384094095
Beef Contusion of ankle (finn-b-ST19_CONTU_ANKLE) rs7791463 -16.4948064923558 6.93305517329496 0.0173524211371577
Beef Contusion of ankle (finn-b-ST19_CONTU_ANKLE) rs80321956 20.4069291200062 9.6372162573736 0.0342163471492523
Beef Contusion of ankle (finn-b-ST19_CONTU_ANKLE) rs952645 -18.6254494004421 8.37325551922381 0.0261217058427895
Beef Contusion of ankle (finn-b-ST19_CONTU_ANKLE) All - MR Egger 6.12995985023334 2.42482383469036 0.013103364216957
Beef Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) rs11121250 -3.89343062210297 1.74607891409075 0.0257598158528189
Beef Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) rs17413652 4.20088621435207 1.93191440386054 0.0296699997021953
Beef Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) rs34962644 3.59482088033987 1.68003792743157 0.032376914361447
Beef Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) rs429358 2.41728052574168 1.18507346108784 0.0413729673838021
Beef Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) rs62169335 3.14878364036555 1.41437166796748 0.025995608166468
Beef Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) rs74818437 -3.15196006161574 1.58106383735886 0.0461991615545033
Beef Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) rs803370 5.41020102731633 1.64793479567681 0.0010270179153738
Beef Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) All - MR Egger 1.21529118475876 0.519273575203043 0.0213349299331373
Beef Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) rs1421085 12.8596410188729 6.4669394219348 0.046754164215954
Beef Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) rs62419271 23.4581483870152 11.918762724939 0.0490485082760759
Beef Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) rs7174015 -27.8046870416029 9.78313062574915 0.0044816691604716
Beef Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) rs80321956 23.2684071930027 11.2342563730422 0.0383399816167342
Beef Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) All - Inverse variance weighted 1.95587714440532 0.905245366193351 0.0307259092759302
Beef Fracture of neck (finn-b-ST19_FRACT_NECK) rs117340623 -17.8172669094823 7.48142127586389 0.0172406505046281
Beef Fracture of neck (finn-b-ST19_FRACT_NECK) rs139552257 -9.42178498096206 3.6680421824851 0.0102106083007341
Beef Fracture of neck (finn-b-ST19_FRACT_NECK) rs17413652 -15.6608380398057 7.90029677493608 0.0474445450199277
Beef Fracture of neck (finn-b-ST19_FRACT_NECK) rs62169335 16.4459420954174 5.7194299565984 0.0040345042475067
Beef Fracture of neck (finn-b-ST19_FRACT_NECK) rs74818437 -19.933605486444 6.49710477216921 0.0021544245473008
Beef Fracture of neck (finn-b-ST19_FRACT_NECK) All - MR Egger -4.5268253395957 2.1358664852396 0.0366339055820229
Beef Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) All - Inverse variance weighted 0.44107494845206 0.220290675133348 0.0452588538002293
Beef Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) rs139552257 9.27725614496741 2.98526802623448 0.0018856245891793
Beef Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) rs7974084 12.8174103156788 5.79119971294342 0.0268799678910902
Beef Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) rs80321956 21.2947844683038 6.75374795903221 0.0016158400805319
Beef Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) All - MR Egger 4.25431554131022 1.62419868229269 0.0102403713855391
Beef Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs12257513 -9.07247914315936 4.34939217503864 0.0369859740899291
Beef Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs139552257 6.90498973346889 2.52177900045851 0.0061787335893332
Beef Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs1421085 -6.31021512471955 3.12623729708328 0.0435423712031051
Beef Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs1884 8.31906709249128 4.21708684059621 0.0485292145118631
Beef Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs41476948 -9.43657455986942 4.61505576930551 0.0408808093462949
Beef Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs4759074 -8.52196342391527 4.3179467081068 0.0484255623411626
Beef Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs6851529 -10.3454734468277 4.82704957907876 0.0320947013596772
Beef Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs71559014 14.5291077239932 5.5713616170151 0.0091120881426252
Beef Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs7174015 -10.0585431158253 4.72991015565596 0.0334548062312924
Beef Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs74045004 -12.8858363446017 4.16863665529702 0.0019939010921201
Beef Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs7902949 12.4716825899284 4.52660399114751 0.0058656930767633
Beef Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs9319848 9.01020695817753 4.446595641698 0.0427324342394774
Beef Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) All - MR Egger 3.31887259597133 1.63674855454555 0.0453599868637824
Beef Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) rs10959890 24.7359029828357 9.45854190023528 0.0089177313633631
Beef Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) rs11121250 25.670613600328 11.4850780746714 0.0254089808409652
Beef Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) rs11600756 -25.7361095093195 10.9030260554821 0.0182525004043588
Beef Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) rs17274957 27.6472506410362 11.4131416519848 0.015418159330266
Beef Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) rs71559014 33.4545742595172 13.2484866888025 0.0115644987986168
Beef Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) rs7220792 28.3588455523435 9.60144069001469 0.0031408761317646
Beef Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) rs7601686 24.4166620770685 10.3265958032715 0.0180571353990283
Beef Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) rs77862656 18.3789924525345 8.48763416990938 0.0303582432304371
Beef Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) All - Inverse variance weighted 2.38332771382194 1.07155048861603 0.0261359251371539
Beef Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) rs11121250 16.5172558146597 7.49404055674973 0.0275206803719965
Beef Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) rs112663712 29.2212553155987 12.8990175307306 0.0234889951519743
Beef Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) rs1884 15.1312842965313 6.55061132062836 0.0208934610820673
Beef Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) rs2541303 -16.1340852130326 6.98034147869674 0.0208129536628217
Beef Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) rs2965199 18.0868780873949 7.79849808443518 0.0203800158306987
Beef Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) rs34465895 -17.9347077459938 7.64038752927132 0.0189071917222667
Beef Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) rs79809011 -35.0507674817262 11.2333522219015 0.0018070305895274
Beef Rheumatoid arthritis (ieu-a-832) rs10909905 -6.27464831354782 2.79943280562352 0.0250001852373417
Beef Rheumatoid arthritis (ieu-a-832) rs11878917 4.50495715341541 2.12491094435604 0.0340002532845555
Beef Rheumatoid arthritis (ieu-a-832) rs1191468 6.3276077043134 2.4885385695228 0.0109999541895444
Beef Rheumatoid arthritis (ieu-a-832) rs2812225 -5.60042206374618 2.53238975403871 0.0270000813165937
Beef Rheumatoid arthritis (ieu-a-832) rs2965199 8.52322989361627 2.00851257742711 2.20008224971781e-05
Beef Rheumatoid arthritis (ieu-a-832) rs6851529 4.93021519338996 2.47079572152449 0.0459997380087588
Beef Rheumatoid arthritis (ieu-a-832) rs71559014 -6.29155912310465 2.4190601297784 0.0092999090450125
Beef Rheumatoid arthritis (ieu-a-832) rs7601686 8.32675873400525 2.20576086357879 0.0001600043245659
Beef Rheumatoid arthritis (ieu-a-832) rs9861346 -4.69918063194568 2.33315053468604 0.0439998390682048
Beef Rheumatoid arthritis (ieu-a-832) All - MR Egger -3.67280794142583 1.69693236715729 0.0347143021823352
Beef Four-jointed box protein 1 (prot-a-1112) rs10959890 5.38457894487518 2.39226894471727 0.0243966182388822
Beef Four-jointed box protein 1 (prot-a-1112) rs13145306 -7.18097489344938 2.97267289853515 0.0157066057660377
Beef Four-jointed box protein 1 (prot-a-1112) rs62419271 8.86793884441747 2.87694272670941 0.0020532657962314
Beef Four-jointed box protein 1 (prot-a-1112) rs6851529 -6.43606610543835 3.18032172788262 0.0429994415826855
Beef Four-jointed box protein 1 (prot-a-1112) rs75191738 -5.98223615464995 3.03030303030303 0.0483660613405832
Beef Four-jointed box protein 1 (prot-a-1112) rs7597864 -9.22523002760676 3.07890616114397 0.0027330552869834
Beef Four-jointed box protein 1 (prot-a-1112) rs7974084 5.97478241277736 3.0374592154343 0.0491794102494182
Beef Four-jointed box protein 1 (prot-a-1112) All - MR Egger 2.01529856060904 0.991682619164003 0.0447847742904671
Beef Osteocrin (prot-a-2157) rs10247400 -6.18975490547342 3.15047405368408 0.0494482887344702
Beef Osteocrin (prot-a-2157) rs117117111 7.33246627649109 3.22645190335651 0.0230497033948501
Beef Osteocrin (prot-a-2157) rs11878917 5.43988494343718 2.66334636153595 0.0411019594249264
Beef Osteocrin (prot-a-2157) rs11981999 9.69664640692915 3.02878932057927 0.0013671761653011
Beef Osteocrin (prot-a-2157) rs2567950 5.41125541125541 2.69484831237819 0.0446432916694909
Beef Osteocrin (prot-a-2157) rs2812225 7.16052976277107 2.77252219473148 0.0098037012358886
Beef Osteocrin (prot-a-2157) rs4585149 5.95243596972022 2.97621798486011 0.0455002638963584
Beef Osteocrin (prot-a-2157) rs4916505 6.19831621992408 2.89791407684762 0.0324446681305199
Beef Osteocrin (prot-a-2157) rs7018123 -6.64345329489732 3.13589578605293 0.0341311782649943
Beef Osteocrin (prot-a-2157) rs75191738 7.77603622431209 3.02159526297457 0.0100679419868744
Beef Osteocrin (prot-a-2157) All - Inverse variance weighted 0.62022965088445 0.291948092063216 0.0336323820949965
Beef Fractured/broken bones in last 5 years (ukb-a-308) rs10909905 0.176460568750703 0.0888299022108476 0.0469778727835991
Beef Fractured/broken bones in last 5 years (ukb-a-308) rs117117111 -0.18410034515532 0.0899750721157854 0.0407439637951881
Beef Fractured/broken bones in last 5 years (ukb-a-308) rs140748046 0.181629587482219 0.0899106685633001 0.0433718094828273
Beef Fractured/broken bones in last 5 years (ukb-a-308) rs17413652 -0.179569388610748 0.0874113169079504 0.0399463103326753
Beef Fractured/broken bones in last 5 years (ukb-a-308) rs17501421 0.17608059466508 0.0853280693215073 0.0390583369061734
Beef Fractured/broken bones in last 5 years (ukb-a-308) rs187160427 0.237284548871985 0.0820973436143275 0.0038489527386164
Beef Fractured/broken bones in last 5 years (ukb-a-308) rs61845699 -0.220765821369305 0.0889732003296672 0.0130918103851288
Beef Fractured/broken bones in last 5 years (ukb-a-308) rs7174015 -0.221738188097151 0.0882486280266935 0.011982710144757
Beef Fractured/broken bones in last 5 years (ukb-a-308) rs7238302 -0.205259329883892 0.0912703766372597 0.0245178969441738
Beef Fractured/broken bones in last 5 years (ukb-a-308) All - MR Egger 0.0583614685017281 0.027622777843215 0.0371075736774756
Beef Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) rs10959890 0.249347850116061 0.0983964692321054 0.0112732116098148
Beef Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) rs117340623 0.258040794134699 0.127409408781863 0.0428377617904002
Beef Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) rs1191468 0.441064095074506 0.118903294997777 0.0002077219236653
Beef Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) rs12652806 0.321423888602931 0.127344837862 0.0116013628133741
Beef Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) rs1884 -0.527308514957578 0.123327291981466 1.9055144381044e-05
Beef Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) rs2107601 -0.249444744177682 0.123162635254623 0.042833686523608
Beef Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) rs2965199 0.249602441023858 0.125975105878705 0.0475505556645521
Beef Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) rs62169335 0.235075797932746 0.107094777355187 0.0281617480239558
Beef Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) rs645040 0.35967581238504 0.116867527590435 0.0020864899357429
Beef Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) rs6739040 -0.296204190758988 0.117041994583215 0.011381848930979
Beef Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) rs7597864 0.306320144203098 0.128168659722278 0.0168494296118229
Beef Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) All - Inverse variance weighted 0.0324822046916067 0.014365769234086 0.0237540829904275
Beef Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs10959890 0.24708585324259 0.0961305247201124 0.0101605702297286
Beef Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs11121250 0.444678580492069 0.126230660278115 0.0004271001254961
Beef Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs11904006 0.265169970045193 0.124443957374414 0.0331024529745021
Beef Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs1191468 0.24439222593274 0.116167199993025 0.0353961442764816
Beef Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs1421085 -0.234502441599578 0.0839134881879372 0.0051968166085657
Beef Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs1556147 0.329986211404288 0.1072171749215 0.0020857926598202
Beef Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs4131337 0.231438920565492 0.116954034210732 0.0478286313777995
Beef Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs429358 0.189678414156241 0.0924815168940302 0.0402681861501662
Beef Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs62169335 0.320318016823796 0.104628402234914 0.0022024390558677
Beef Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs645040 0.329744022072348 0.114176502145923 0.0038767521792492
Beef Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs7174015 0.483308206932971 0.122423246730075 7.88572811116674e-05
Beef Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs7601686 0.328646206238182 0.117826458115327 0.0052831986243601
Beef Pain type(s) experienced in last month: Knee pain (ukb-a-476) All - Inverse variance weighted 0.0375564290671373 0.0142454514472742 0.0083795732645161
Beef Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) rs1421085 -0.0937689718886103 0.0283098521842418 0.0009255272853861
Beef Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) rs4759074 0.0779875861880392 0.0388753059020293 0.0448460325689286
Beef Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) rs62396185 0.0965415266054551 0.0259976287833368 0.000204433225909
Beef Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) rs7174015 0.135328118058557 0.0413026531802359 0.0010510253876642
Beef Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) rs72779821 0.0855948491255045 0.040716029213915 0.0355322921909113
Beef Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) All - Inverse variance weighted 0.0147376199733195 0.003826397026249 0.0001173649783734
Beef Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) rs386231 0.0918806517707281 0.0456052011539044 0.0439364301433154
Beef Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) rs7174015 0.109649735184904 0.0440354635491569 0.0127731416208694
Beef Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) rs784251 0.0975693268979659 0.0348318453964232 0.005092037668323
Beef Diagnoses - main ICD10: M23 Internal derangement of knee (ukb-a-566) All - Inverse variance weighted 0.0092844507682132 0.0041730922625074 0.0260921713092509
Beef Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) rs10959890 0.0509756983372547 0.0230433924426408 0.026955529720576
Beef Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) rs12257513 0.0666379821311607 0.0305655351672751 0.0292450580725859
Beef Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) rs2107601 0.0866588736024938 0.0288408566375925 0.0026582013991314
Beef Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) rs4863708 -0.0715978647563557 0.0304088624389027 0.0185473185226895
Beef Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) All - MR Egger 0.0229565371276135 0.0092146577075286 0.0143730727481955
Beef Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) rs10247400 0.0359355425363416 0.0162841208694814 0.0273291313018843
Beef Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) rs12113634 0.0373434272852413 0.0150812075210097 0.0132805417835377
Beef Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) rs12257513 0.0360007183244356 0.0166645040810586 0.0307476417469681
Beef Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) rs12652806 0.0487363259556254 0.0162597458889822 0.0027232814030029
Beef Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) rs140748046 0.0390941678520626 0.0162942057847321 0.0164278825993792
Beef Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) rs17501421 -0.0344368528900987 0.0154684429702006 0.0259964376806699
Beef Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) rs2965199 0.0343656556023518 0.0160852244299697 0.0326408394012276
Beef Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) rs60255715 -0.0307598013830079 0.0154906631736071 0.0470667058453643
Beef Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) rs645040 -0.0309568516247701 0.0149217312998161 0.038022205642712
Beef Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) rs72779821 0.04053084758793 0.015774072650394 0.0101857171067896
Beef Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) All - MR Egger -0.0108905105966654 0.0051313697940993 0.0362791361693809
Beef Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) rs10789340 0.0562247363875846 0.0231194438195316 0.0150188473889808
Beef Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) rs10909905 -0.078253975116076 0.0378823590444158 0.0388558525020241
Beef Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) rs112663712 0.0834107813740412 0.0389129126699601 0.0320710065726328
Beef Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) rs41476948 0.0825181687458707 0.0382331866231394 0.0309055673259808
Beef Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) rs4714375 -0.124421872039877 0.0376037000189448 0.0009370787268562
Beef Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) rs4863708 0.084030589917059 0.0390998306076992 0.0316241550995884
Beef Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) rs6851529 -0.0913390914336212 0.0393037483799843 0.0201293395495851
Beef Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) rs74045004 -0.0791880551146533 0.0367629428253014 0.0312387293400593
Beef Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) rs74818437 -0.106831110862569 0.0376395377803084 0.0045359022627444
Beef Operation code: knee replacement/revision (ukb-b-11120) rs1421085 -0.0417962254190313 0.0192022733271743 0.0295082579510267
Beef Operation code: knee replacement/revision (ukb-b-11120) rs2403202 0.0572342912672552 0.0263290747598084 0.0297197346326468
Beef Operation code: knee replacement/revision (ukb-b-11120) rs4714375 0.0673866063761119 0.0279173553531501 0.015787600292096
Beef Operation code: knee replacement/revision (ukb-b-11120) rs61845699 0.0718375486994332 0.0282767474647875 0.0110688812517528
Beef Operation code: knee replacement/revision (ukb-b-11120) rs62396185 0.0526842576811926 0.0175591288473327 0.0026963296066449
Beef Operation code: knee replacement/revision (ukb-b-11120) rs7174015 0.079939912179339 0.0279883751980276 0.004287683715609
Beef Operation code: knee replacement/revision (ukb-b-11120) rs9861346 -0.051500750012097 0.0262501008080775 0.0497711236413086
Beef Operation code: knee replacement/revision (ukb-b-11120) All - Inverse variance weighted 0.0059984505898062 0.0029933732698636 0.0450797035619794
Beef Diagnoses - main ICD10: M25.5 Pain in joint (ukb-b-13019) rs10789340 -0.0197555099167616 0.0087327735727192 0.0236834261201583
Beef Diagnoses - main ICD10: M25.5 Pain in joint (ukb-b-13019) rs28570979 -0.0320367669784511 0.0148050910527214 0.0304718670679139
Beef Diagnoses - main ICD10: M25.5 Pain in joint (ukb-b-13019) rs7220792 -0.0271010852566229 0.0129293398417137 0.0360740343266622
Beef Diagnoses - main ICD10: M25.5 Pain in joint (ukb-b-13019) rs897509 0.0371416739728222 0.0131733087801372 0.0048103879807034
Beef Diagnoses - main ICD10: M25.5 Pain in joint (ukb-b-13019) All - MR Egger -0.0222263402641085 0.0110077620903727 0.0485420491135665
Beef Fractured/broken bones in last 5 years (ukb-b-13346) rs10909905 0.174679440068478 0.0758218698392661 0.0212331203557669
Beef Fractured/broken bones in last 5 years (ukb-b-13346) rs17501421 0.149485917566536 0.0735591570370103 0.0421347904968105
Beef Fractured/broken bones in last 5 years (ukb-b-13346) rs187160427 0.217852741916196 0.0705868589760255 0.0020265922131611
Beef Fractured/broken bones in last 5 years (ukb-b-13346) rs7174015 -0.201442682469756 0.0754532032268764 0.0075903267913186
Beef Fractured/broken bones in last 5 years (ukb-b-13346) rs7238302 -0.170501123643494 0.0781613700285527 0.0291539277264151
Beef Fractured/broken bones in last 5 years (ukb-b-13346) All - MR Egger 0.0600560327514528 0.0234824140852979 0.0120444979996306
Beef Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) rs132901 -0.040600363377834 0.0156235233287133 0.0093586006674568
Beef Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) rs35800274 0.0535424488721618 0.022018883162401 0.0150297868957982
Beef Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) rs4916505 -0.0519053210072321 0.0206662672451762 0.0120186478426491
Beef Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) rs62396185 -0.0312559364621717 0.0136678410476466 0.0222061427961155
Beef Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) rs784251 -0.0343838200160562 0.0172617447067813 0.0463810726900786
Beef Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) rs803370 -0.0404354486321105 0.0204112789217739 0.0475873998139384
Beef Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) rs9319848 0.0446040349132222 0.022717103968427 0.0495932081047413
Beef Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) All - Inverse variance weighted -0.0053429020512361 0.0023981532368752 0.0258856140661621
Beef Fracture resulting from simple fall (ukb-b-15251) rs115736207 0.925522939617905 0.377276530469948 0.0141603949357364
Beef Fracture resulting from simple fall (ukb-b-15251) rs13145306 -0.932989506106515 0.38807946229242 0.0162114611330104
Beef Fracture resulting from simple fall (ukb-b-15251) rs140748046 1.01879943100996 0.409486960644855 0.0128467373653231
Beef Fracture resulting from simple fall (ukb-b-15251) rs4714375 0.77135797819421 0.392151413088238 0.0491843430244199
Beef Fracture resulting from simple fall (ukb-b-15251) rs62015188 0.80972776485056 0.361248086034988 0.0249954644289557
Beef Fracture resulting from simple fall (ukb-b-15251) rs952645 -1.28091893957259 0.406400496342375 0.0016223202699257
Beef Fracture resulting from simple fall (ukb-b-15251) rs9861346 -0.903498443523283 0.36882691656317 0.0142993426753818
Beef Fracture resulting from simple fall (ukb-b-15251) All - Inverse variance weighted 0.0769082324842787 0.0389873554128954 0.0485359615438457
Beef Fracture resulting from simple fall (ukb-b-15251) All - MR Egger 0.326947785715439 0.133667840164525 0.016248055828716
Beef Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) rs11749912 0.0436127534692382 0.0203792156761495 0.0323498817922308
Beef Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) rs4714375 0.0438770335867246 0.0199358146088128 0.0277420411992416
Beef Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) rs62396185 0.0265878731129629 0.0125389532964627 0.0339704684058147
Beef Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) All - Inverse variance weighted 0.004565260070276 0.0021436968165754 0.0332029809427579
Beef Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) rs11878917 -0.0598596416467471 0.0230874176859515 0.0095215077706811
Beef Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) rs1555302 -0.07275013733809 0.0257578966643942 0.0047371901444628
Beef Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) rs2812225 0.0531666424101295 0.0238695240867414 0.0259214911002588
Beef Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) rs4131337 -0.050375693196907 0.0252678083261736 0.0461880357352952
Beef Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) rs41476948 -0.0603203577396914 0.0268159029963857 0.0244854810439601
Beef Operative procedures - main OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-16039) rs4863708 -0.0633834351188229 0.0274231932353929 0.0208158701759388
Beef Neck/shoulder pain for 3+ months (ukb-b-16118) rs10247400 -0.51754752273901 0.249768347496053 0.0382551719395914
Beef Neck/shoulder pain for 3+ months (ukb-b-16118) rs117340623 0.585312336161867 0.248675286343979 0.0185865370643321
Beef Neck/shoulder pain for 3+ months (ukb-b-16118) rs12113634 0.585237264168127 0.231701676474712 0.0115427845844599
Beef Neck/shoulder pain for 3+ months (ukb-b-16118) rs13145306 0.59178993111517 0.245437723099698 0.0159018154792062
Beef Neck/shoulder pain for 3+ months (ukb-b-16118) rs1421085 0.438964959746601 0.168409330869737 0.0091463246652409
Beef Neck/shoulder pain for 3+ months (ukb-b-16118) All - Inverse variance weighted 0.0523390822720616 0.0243870057635767 0.031858037699821
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs10283912 0.239144992144169 0.102861817820433 0.0200765010772189
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs10959890 0.266709564338613 0.0824685373209746 0.0012203673232789
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs11121250 0.405575088984953 0.107595768632614 0.0001636185294051
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs11904006 0.311548778323992 0.106064021876403 0.0033101392707602
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs1191468 0.295159082388023 0.0990705298677292 0.0028892439574832
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs1421085 -0.17595106902468 0.071616487396067 0.014016064068419
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs1556147 0.277506836299008 0.0915881496753578 0.0024460022099281
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs1884 -0.246702719445479 0.102749373192303 0.0163496953475755
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs2567950 -0.234339697487108 0.0929445637363964 0.011692723765328
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs62169335 0.312965348926523 0.0892962003989148 0.0004569499213918
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs62396185 0.135826254488134 0.0654897707599345 0.0380786444449279
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs645040 0.277406499080319 0.0973664546290619 0.0043843475299001
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs6851529 0.309871442093632 0.108829478188398 0.0044090174691251
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs7174015 0.501498603179697 0.10438684198867 1.55346647331128e-06
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs7601686 0.328212489214444 0.100425341007141 0.0010822475267288
Beef Pain type(s) experienced in last month: Knee pain (ukb-b-16254) All - Inverse variance weighted 0.046958514806162 0.0135366226490952 0.000522403643252
Beef Heel bone ultrasound T-score, manual entry (ukb-b-17612) rs11121250 -1.81032594196077 0.868123323059304 0.0370391123200048
Beef Heel bone ultrasound T-score, manual entry (ukb-b-17612) rs11165829 -1.65894452015176 0.702397035323183 0.0181848302988419
Beef Heel bone ultrasound T-score, manual entry (ukb-b-17612) rs139552257 -1.65665181508283 0.767948986304647 0.0309868127316458
Beef Heel bone ultrasound T-score, manual entry (ukb-b-17612) rs1421085 -1.8262752408605 0.578362148607628 0.0015903695362126
Beef Heel bone ultrasound T-score, manual entry (ukb-b-17612) rs2403202 2.3146964908439 0.788513726246387 0.003329909452871
Beef Heel bone ultrasound T-score, manual entry (ukb-b-17612) rs34962644 -2.00275710333844 0.806270914170775 0.0129924788987066
Beef Heel bone ultrasound T-score, manual entry (ukb-b-17612) rs4759074 1.63753856530239 0.791688123481883 0.0386011375022654
Beef Heel bone ultrasound T-score, manual entry (ukb-b-17612) rs74818437 -1.78928130226789 0.830810917982949 0.0312671228576255
Beef Heel bone ultrasound T-score, manual entry (ukb-b-17612) rs75191738 2.54359979101358 0.839324277255312 0.0024412263234829
Beef Heel bone ultrasound T-score, manual entry (ukb-b-17612) All - MR Egger -0.583062467849842 0.290996498125742 0.0478100156773372
Beef Fractured bone site(s): Other bones (ukb-b-17738) rs11600756 -0.113427843968737 0.0567776190771906 0.0457430914536483
Beef Fractured bone site(s): Other bones (ukb-b-17738) rs1191468 0.112794601051539 0.053961844640724 0.0365939251590395
Beef Fractured bone site(s): Other bones (ukb-b-17738) rs13145306 0.113491637119014 0.0567940498788248 0.0456839790709566
Beef Fractured bone site(s): Other bones (ukb-b-17738) rs1555302 0.147594873593801 0.0553950152340484 0.0077124158369055
Beef Fractured bone site(s): Other bones (ukb-b-17738) rs17501421 0.134816390546412 0.0554418825452338 0.0150293725824947
Beef Fractured bone site(s): Other bones (ukb-b-17738) rs187160427 0.126293486681676 0.0532036250383457 0.0176072298433502
Beef Fractured bone site(s): Other bones (ukb-b-17738) rs35800274 -0.136247168313001 0.057472954155353 0.017757748537072
Beef Fractured bone site(s): Other bones (ukb-b-17738) rs7174015 -0.157248557377403 0.0568680091628538 0.0056896681622865
Beef Fractured bone site(s): Other bones (ukb-b-17738) All - MR Egger 0.0436784546511478 0.0204339334359805 0.035067500657634
Beef Non-cancer illness code, self-reported: ankylosing spondylitis (ukb-b-18194) rs10247400 0.0312486255284766 0.0137046856815278 0.0225992847707137
Beef Non-cancer illness code, self-reported: ankylosing spondylitis (ukb-b-18194) rs11165829 0.0224260546465231 0.011209399907844 0.0454304221733485
Beef Non-cancer illness code, self-reported: ankylosing spondylitis (ukb-b-18194) rs12113634 0.0398840255263062 0.0126911796036821 0.001674218507436
Beef Non-cancer illness code, self-reported: ankylosing spondylitis (ukb-b-18194) All - Inverse variance weighted 0.0046743230229342 0.0019397669670364 0.0159641412615029
Beef Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) rs11165829 -0.0304669562063117 0.0140077058068058 0.0296290674471742
Beef Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) rs2567950 -0.0307394879357031 0.0149752720718856 0.0401033219162201
Beef Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) rs62169335 0.0414616343942153 0.0143889088483917 0.003957877978345
Beef Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) rs6851529 0.0574656481256843 0.0175341318915875 0.0010478298294227
Beef Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) rs7597864 0.0361215432672479 0.0172187827061977 0.0359229145277337
Beef Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) All - MR Egger -0.0311592051868509 0.0134339160335601 0.0237351458915391
Beef Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) rs10959890 0.0279311216030571 0.0118157558148715 0.0180842861782017
Beef Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) rs4863708 0.0319844302264222 0.015620117847159 0.0405949597411375
Beef Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) rs62396185 0.0243185783478278 0.0094485573975897 0.0100592051866508
Beef Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) rs10789340 0.0235760575339086 0.0118786330616777 0.0471728498525125
Beef Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) rs10909905 -0.0483169198578556 0.0194637592190702 0.013049911093854
Beef Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) rs1421085 0.0262490101623334 0.0132885706744094 0.0482332895661417
Beef Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) rs17413652 -0.0433054644404436 0.0191516840538963 0.0237479207827121
Beef Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) rs4863708 -0.0393775323687094 0.0200888645635233 0.0499762568603859
Beef Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) rs7791463 -0.0388189299635753 0.0165651843333899 0.0191086459223009
Beef Diagnoses - main ICD10: S52.50 Fracture of lower end of radius (closed) (ukb-b-2804) All - MR Egger 0.0254184909584979 0.0127402017466978 0.0499214578924998
Beef Ankle spacing width (ukb-b-4080) rs10123094 -1.30168060523878 0.281185688778171 3.66981428048828e-06
Beef Ankle spacing width (ukb-b-4080) rs10789340 -0.516235476824604 0.169217762360574 0.0022829576689562
Beef Ankle spacing width (ukb-b-4080) rs10959890 0.500631622163622 0.219008669014196 0.022260188099117
Beef Ankle spacing width (ukb-b-4080) rs112094422 0.569740191931743 0.257804158386187 0.0271070462654385
Beef Ankle spacing width (ukb-b-4080) rs112663712 -0.628992703534968 0.286738940268093 0.02826363535874
Beef Ankle spacing width (ukb-b-4080) rs12670003 1.02122159919619 0.284920197619125 0.0003380646293933
Beef Ankle spacing width (ukb-b-4080) rs12829270 0.742295888750899 0.262154861597737 0.0046327803134736
Beef Ankle spacing width (ukb-b-4080) rs132901 0.434897916681628 0.199238055569519 0.0290501390039115
Beef Ankle spacing width (ukb-b-4080) rs1343431 1.55918296388616 0.288467518602949 6.47883087775671e-08
Beef Ankle spacing width (ukb-b-4080) rs1421085 -3.02542233073776 0.190249274119044 6.0971363443889e-57
Beef Ankle spacing width (ukb-b-4080) rs1470610 0.48554752412839 0.232657438256698 0.036891456406923
Beef Ankle spacing width (ukb-b-4080) rs187160427 0.675862714411243 0.259278631927582 0.0091418280317744
Beef Ankle spacing width (ukb-b-4080) rs2107601 0.674899589365465 0.269471420435812 0.0122613778441708
Beef Ankle spacing width (ukb-b-4080) rs267733 1.08173081181629 0.271678107976438 6.84346149230468e-05
Beef Ankle spacing width (ukb-b-4080) rs28570979 0.783487440292154 0.287210219595443 0.0063734432065059
Beef Ankle spacing width (ukb-b-4080) rs2965199 -1.29378727482424 0.279343610751592 3.62979910273128e-06
Beef Ankle spacing width (ukb-b-4080) rs34465895 0.612544193948299 0.277727168373204 0.0274147566547601
Beef Ankle spacing width (ukb-b-4080) rs34953822 -0.552195997650543 0.281522017885654 0.0498246330835014
Beef Ankle spacing width (ukb-b-4080) rs35556085 1.11430172896995 0.285504246971069 9.50370679499698e-05
Beef Ankle spacing width (ukb-b-4080) rs429358 0.567914136041047 0.210536380408581 0.006987000923022
Beef Ankle spacing width (ukb-b-4080) rs4759074 -1.36391290279949 0.26107855245109 1.74959147944496e-07
Beef Ankle spacing width (ukb-b-4080) rs4916505 0.825703117902554 0.262013981285455 0.0016250623569641
Beef Ankle spacing width (ukb-b-4080) rs60255715 1.13080695768727 0.266428245042191 2.19256442924337e-05
Beef Ankle spacing width (ukb-b-4080) rs62169335 1.08231436629955 0.236316728403474 4.65128825347718e-06
Beef Ankle spacing width (ukb-b-4080) rs62396185 1.90957041907213 0.173226808221116 2.94296590396655e-28
Beef Ankle spacing width (ukb-b-4080) rs6669189 -1.57618143968881 0.286230361153323 3.6564640267929e-08
Beef Ankle spacing width (ukb-b-4080) rs67616875 0.632675066914644 0.282719274334449 0.0252327447692468
Beef Ankle spacing width (ukb-b-4080) rs71559014 0.610723550884883 0.26937533418268 0.0233789644247244
Beef Ankle spacing width (ukb-b-4080) rs75191738 -3.29214559386973 0.276665795889934 1.19259836078074e-32
Beef Ankle spacing width (ukb-b-4080) rs7597864 -0.735646036080644 0.282888289702093 0.0093092777314333
Beef Ankle spacing width (ukb-b-4080) rs7601686 0.575916542747517 0.265585127866204 0.0301220402782739
Beef Ankle spacing width (ukb-b-4080) rs7791463 0.899802690695672 0.236357485919195 0.0001406874232443
Beef Ankle spacing width (ukb-b-4080) rs79809011 0.546920272423047 0.238494545480465 0.021835387908828
Beef Ankle spacing width (ukb-b-4080) rs803370 0.871662154711021 0.258453179995937 0.0007445894481616
Beef Ankle spacing width (ukb-b-4080) rs9861346 -0.880433555379925 0.258734818303521 0.0006668897634099
Beef Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) rs12113634 0.0739144641341268 0.0214243687692421 0.000560548571735
Beef Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) rs132901 0.0333104726066255 0.0162933306522848 0.0409117002775694
Beef Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) rs429358 0.0367800342055294 0.0172949351576282 0.0334503269779663
Beef Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) rs62396185 0.0581005341973903 0.014253706710139 4.5783517904198e-05
Beef Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) rs7791463 -0.0436815989175218 0.0194313009637156 0.0245760771925272
Beef Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) All - MR Egger 0.0411915826129786 0.0151619908183458 0.0081590602234696
Beef Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) rs12113634 0.0596974905314007 0.0223246998252545 0.0074940006363632
Beef Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) rs2567950 -0.0424751211603801 0.0210808282023421 0.0439183076983135
Beef Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) rs35556085 0.0584971327555728 0.0244879058336567 0.0169027061960695
Beef Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) rs7902949 0.0533737835405152 0.0237811883537693 0.0248086109341631
Beef Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) rs10247400 -0.0383541182255542 0.0187185107029634 0.0404626906303284
Beef Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) rs11904006 0.0391176378495162 0.0186801097995011 0.0362528852617064
Beef Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) rs267733 0.0381453563045308 0.0180816688072988 0.0348915476424866
Beef Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) rs4759074 -0.0486868429087694 0.017347322417321 0.0050068733000557
Beef Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) rs62169335 -0.0326992405753292 0.0157273999925668 0.0376058040106872
Beef Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) rs7791463 -0.0370082714909001 0.0157219069881426 0.0185760994109792
Beef Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) rs7902949 0.0388291672198602 0.018464989906614 0.0354785844502147
Beef Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) All - Inverse variance weighted -0.0056187855024432 0.0020324256414093 0.0056997657370065
Beef Operation code: reduction or fixation of bone fracture (ukb-b-847) rs1105388 -0.118961091478102 0.0418633190920759 0.0044880091880161
Beef Operation code: reduction or fixation of bone fracture (ukb-b-847) rs12652806 -0.126475767344838 0.0541213122748083 0.0194446988914229
Beef Operation code: reduction or fixation of bone fracture (ukb-b-847) rs1555302 0.113954211811738 0.0517820858181048 0.0277608593746724
Beef Operation code: reduction or fixation of bone fracture (ukb-b-847) rs35800274 0.131765960366505 0.0537259039464775 0.014184403450457
Beef Operation code: reduction or fixation of bone fracture (ukb-b-847) rs4759074 -0.105264818874098 0.0501616666590713 0.0358600123166091
Beef Operation code: reduction or fixation of bone fracture (ukb-b-847) rs62419271 -0.124760044007739 0.0552976845353263 0.0240610427646785
Beef Operation code: reduction or fixation of bone fracture (ukb-b-847) rs75191738 0.157182166492511 0.0533059038662487 0.0031913202721177
Beef Operation code: reduction or fixation of bone fracture (ukb-b-847) All - MR Egger 0.0438583351386875 0.018968632521227 0.0228840712031882
Beef Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) rs2965199 -0.0262825828061909 0.0126851262440601 0.0382727845376895
Beef Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) rs35800274 0.0360028614942309 0.012733311887124 0.0046919665324377
Beef Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) rs4676964 0.0188547400268099 0.0077684167958482 0.015219975652816
Beef Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) rs4759074 -0.0259400363664535 0.0118888225563156 0.0291180660963941
Beef Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) rs7601686 0.03676348423932 0.0121219318536469 0.0024229021053125
Beef Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) All - Inverse variance weighted 0.0046999302320593 0.0023691567774525 0.0472782805698872
Beef Ankle spacing width (right) (ukb-b-8607) rs10123094 -1.57940077434239 0.38846340281144 4.7875229244937e-05
Beef Ankle spacing width (right) (ukb-b-8607) rs10789340 -0.65875091620282 0.234557356110801 0.0049775135325649
Beef Ankle spacing width (right) (ukb-b-8607) rs11749912 0.988177480411575 0.390288223093502 0.0113440762749512
Beef Ankle spacing width (right) (ukb-b-8607) rs12257513 0.841765168115945 0.397557281702553 0.0342307393248828
Beef Ankle spacing width (right) (ukb-b-8607) rs12829270 0.905691271256409 0.362528590491652 0.0124804042052922
Beef Ankle spacing width (right) (ukb-b-8607) rs1343431 0.982922505466414 0.398895208899053 0.013735315107251
Beef Ankle spacing width (right) (ukb-b-8607) rs1421085 -2.4446350798469 0.26242081298667 1.21144422647456e-20
Beef Ankle spacing width (right) (ukb-b-8607) rs267733 0.958704991363657 0.375631338854688 0.0107029765898458
Beef Ankle spacing width (right) (ukb-b-8607) rs2812225 -1.27407218745452 0.346631494687818 0.0002373085924766
Beef Ankle spacing width (right) (ukb-b-8607) rs2965199 -1.57115072476704 0.38607850644668 4.71119175534642e-05
Beef Ankle spacing width (right) (ukb-b-8607) rs429358 0.886434948893707 0.293751430841537 0.0025475454058567
Beef Ankle spacing width (right) (ukb-b-8607) rs4759074 -1.5475680503844 0.361240105180169 1.83527632595468e-05
Beef Ankle spacing width (right) (ukb-b-8607) rs4916505 1.12178943894314 0.362553200297611 0.001973860088303
Beef Ankle spacing width (right) (ukb-b-8607) rs60255715 0.74665976178146 0.369726140067627 0.0434358889954233
Beef Ankle spacing width (right) (ukb-b-8607) rs62169335 1.05485284340325 0.326991373365213 0.001255619666852
Beef Ankle spacing width (right) (ukb-b-8607) rs62396185 1.36043166921528 0.239389815893888 1.32419082272374e-08
Beef Ankle spacing width (right) (ukb-b-8607) rs6669189 -0.784218288718715 0.396784912192562 0.0481059013027532
Beef Ankle spacing width (right) (ukb-b-8607) rs74045004 0.776541023606092 0.373885549289116 0.0378063144804258
Beef Ankle spacing width (right) (ukb-b-8607) rs75191738 -2.91201671891327 0.383893242772553 3.31243751790153e-14
Beef Ankle spacing width (right) (ukb-b-8607) rs784251 0.599173977385938 0.303690986294215 0.0484986906947483
Beef Ankle spacing width (right) (ukb-b-8607) rs80321956 -0.764459947553313 0.375128505379359 0.0415637834501988
Beef Fractured bone site(s): Wrist (ukb-b-9571) rs10959890 0.0676449967629364 0.0280836583555717 0.0160096253437447
Beef Fractured bone site(s): Wrist (ukb-b-9571) rs4759074 -0.0839768858831625 0.0335528384518281 0.0123206416831528
Beef Fractured bone site(s): Wrist (ukb-b-9571) rs6669189 0.0787835791013075 0.0369329698835784 0.0329123912842767
Beef Fractured bone site(s): Wrist (ukb-b-9571) rs7597864 -0.0984112614439381 0.0364026657812897 0.0068632424279703
Beef Fractured bone site(s): Wrist (ukb-b-9571) rs897509 0.0745929709705847 0.0328888708350682 0.0233273314509903
Beef Fractured bone site(s): Wrist (ukb-b-9571) All - MR Egger 0.0311576051052408 0.0150861582866565 0.0418354684785518
Beef Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) rs11904006 0.107507488701715 0.0521996430472493 0.0394421049032518
Beef Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) rs1421085 -0.1407458426818 0.0351716543486868 6.28932869324866e-05
Beef Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) rs1442572 0.115312750532314 0.0451363326810513 0.0106259324158805
Beef Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) rs62396185 0.142299945435071 0.0322606047949773 1.02917630787063e-05
Beef Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) rs7174015 0.18050774088714 0.0513035991622671 0.0004341204922069
Beef Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) rs72779821 0.1038064578128 0.0505897559100519 0.0401768117211574
Beef Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) rs7597864 0.111505458739785 0.0524365291536799 0.033462950785712
Beef Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) All - Inverse variance weighted 0.0209243015484004 0.005295710362641 7.77670085586853e-05
Beef Rheumatoid arthritis (ukb-d-M13_RHEUMA) rs11165829 0.040262350369114 0.0159768041489789 0.0117338059396615
Beef Rheumatoid arthritis (ukb-d-M13_RHEUMA) rs11878917 -0.034276002583446 0.016783476599173 0.0411270491877705
Beef Rheumatoid arthritis (ukb-d-M13_RHEUMA) rs1343431 -0.0430866080807438 0.0200555578680862 0.0316849708084842
Beef Rheumatoid arthritis (ukb-d-M13_RHEUMA) rs1470610 -0.0369648572761729 0.0162045367103529 0.0225400163330479
Beef Rheumatoid arthritis (ukb-d-M13_RHEUMA) rs2403202 0.0382463261768817 0.0180667448875874 0.0342644176208125
Beef Rheumatoid arthritis (ukb-d-M13_RHEUMA) rs62396185 0.0254236192041604 0.0120789237909826 0.0353094391992376
Beef Rheumatoid arthritis (ukb-d-M13_RHEUMA) rs7791463 -0.0328392222410734 0.0164035875942299 0.0452897155256919
Beef Rheumatoid arthritis (ukb-d-M13_RHEUMA) rs937813 0.0358099661989839 0.017181661758605 0.0371422604953984
Beef Rheumatoid arthritis (ukb-d-M13_RHEUMA) rs9861346 -0.0368225293956354 0.0178516588977242 0.0391416054395031
Beef Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) rs11600756 -0.0899166969774931 0.0323940525722802 0.0055080262126057
Beef Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) rs4863708 0.0844690238407828 0.0335753553254653 0.0118761100896128
Beef Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) rs6669189 -0.08088419267148 0.0335685310876383 0.0159733306079115
Beef Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) rs7791463 -0.0765808308355484 0.0276519983327154 0.0056150996735207
Beef Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) All - MR Egger 0.0207498327260767 0.0097033936539213 0.0349194595585705
Beef Heel bone mineral density (BMD) (ukb-e-3148_CSA) rs2107601 -5.85004346131943 2.36189791085933 0.0132551270636052
Beef Heel bone mineral density (BMD) (ukb-e-3148_CSA) rs2965199 -6.93408624857008 3.31788510369419 0.036625749955734
Beef Heel bone mineral density (BMD) (ukb-e-3148_CSA) rs7238302 8.49924190179017 3.92804159427991 0.0304846771391211
Beef Heel bone mineral density (BMD) (ukb-e-3148_CSA) rs77862656 -12.5290538246585 5.51435063069651 0.0230815907662988
Beef Heel bone mineral density (BMD) (ukb-e-3148_CSA) rs7974084 -9.32933901883392 2.58184033311915 0.0003021550312592
Beef Heel bone mineral density (BMD) (ukb-e-3148_CSA) All - MR Egger -2.66081944301474 1.33871561840665 0.0499309230562099
Beef Ankle spacing width (left) (ukb-e-4100_CSA) rs132901 -3.10163807280483 1.31778325158529 0.0185886819367393
Beef Ankle spacing width (left) (ukb-e-4100_CSA) rs1421085 4.21340900092385 1.51362676521051 0.0053750798700663
Beef Ankle spacing width (left) (ukb-e-4100_CSA) rs784251 -4.4270556259491 1.84742762629731 0.0165599438992948
Beef Ankle spacing width (left) (ukb-e-4100_CSA) All - Inverse variance weighted -0.456504496289841 0.216009070789212 0.0345701385198706
Beef Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) rs11749912 29.3718794683309 11.886451682705 0.0134721322370543
Beef Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) rs11878917 -20.8540020108265 8.94218540885696 0.0196958344328388
Beef Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) rs11904006 24.1934642160086 12.1906670424064 0.0471902125985663
Beef Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) rs645040 26.0863733905579 10.6338136112814 0.0141610032161395
Beef Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) rs897509 -26.4375636820316 10.8661433315392 0.0149733990697342
Beef Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) All - Inverse variance weighted -3.0919322565995 1.19674156514218 0.009776783509649
Beef Pain in joint (ukb-e-745_CSA) rs1556147 -22.8263292579476 9.33932755631184 0.0145210613588452
Beef Pain in joint (ukb-e-745_CSA) rs17413652 54.6690671730749 19.2040512656095 0.0044168508579104
Beef Pain in joint (ukb-e-745_CSA) rs2567950 -26.4741898208034 9.41687794277436 0.0049333273499398
Beef Pain in joint (ukb-e-745_CSA) rs2965199 -26.8954226104768 10.1251283111319 0.0079002273071125
Beef Pain in joint (ukb-e-745_CSA) rs61845699 21.0799195849258 10.6585806764109 0.0479578521666817
Beef Pain in joint (ukb-e-745_CSA) rs62169335 23.9720511899305 9.53100674355893 0.0118976807087275
Beef Pain in joint (ukb-e-745_CSA) rs62396185 -16.5244161215787 6.01089951295749 0.0059763632594488
Beef Pain in joint (ukb-e-745_CSA) rs7018123 22.0790292195801 10.6515926866265 0.0381873312178355
Beef Pain in joint (ukb-e-745_CSA) rs74818437 -35.7950819255426 16.1309181863012 0.0264843017942889
Beef Pain in joint (ukb-e-745_CSA) rs7601686 -26.5164032237337 10.9989719300178 0.0159172503003949
Beef Pain in joint (ukb-e-745_CSA) All - Inverse variance weighted -2.44460083366955 1.19200465051027 0.0402833466937193