ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Lettuce (ukb-b-2867)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Lettuce (👉 📊) Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) MR Egger 12 -1.583688852 0.705178627 0.048524482
Lettuce (👉 📊) Heel bone mineral density (ebi-a-GCST006288) MR Egger 12 -0.205944344 0.074953513 0.020561796
Lettuce (👉 📊) Rheumatoid arthritis (ebi-a-GCST90038685) MR Egger 11 0.012331675 0.005353764 0.046741287
Lettuce (👉 📊) Cervical root disorders (finn-b-G6_CERVROOT) MR Egger 12 -5.719248196 2.195790789 0.026281338
Lettuce (👉 📊) Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) Weighted median 12 0.540144931 0.270225849 0.045622987
Lettuce (👉 📊) Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) Inverse variance weighted 12 0.455790531 0.205103242 0.026266464
Lettuce (👉 📊) Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) MR Egger 12 5.822005672 2.098846793 0.019655085
Lettuce (👉 📊) Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) MR Egger 12 2.737216716 0.949556307 0.016311932
Lettuce (👉 📊) Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) Weighted median 12 1.346438586 0.669350177 0.044266254
Lettuce (👉 📊) Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) Inverse variance weighted 12 1.151621085 0.501237128 0.021586991
Lettuce (👉 📊) Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) Weighted median 12 -1.026174892 0.453690792 0.023707439
Lettuce (👉 📊) Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) Inverse variance weighted 12 -0.855402163 0.343625986 0.012798025
Lettuce (👉 📊) Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) MR Egger 12 -0.936393283 0.387287026 0.036195788
Lettuce (👉 📊) Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) Weighted median 12 -2.528011733 1.235027824 0.040665258
Lettuce (👉 📊) Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) Weighted median 12 -2.488760012 1.134131478 0.028205279
Lettuce (👉 📊) Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) Inverse variance weighted 12 -0.756953026 0.38268276 0.047926783
Lettuce (👉 📊) Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) Weighted median 12 1.686695183 0.680261131 0.01315734
Lettuce (👉 📊) Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) Inverse variance weighted 12 1.701463988 0.532351101 0.001392837
Lettuce (👉 📊) Bone morphogenetic protein 7 (prot-a-257) Weighted median 12 0.63271192 0.322122072 0.049506994
Lettuce (👉 📊) Bone morphogenetic protein receptor type-1A (prot-a-259) Weighted median 12 0.682898388 0.331373511 0.039321014
Lettuce (👉 📊) Knee pain for 3+ months (ukb-a-353) Inverse variance weighted 12 -0.042999903 0.021323449 0.043741999
Lettuce (👉 📊) Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) Inverse variance weighted 5 -0.005917426 0.002945029 0.044506063
Lettuce (👉 📊) Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) Weighted median 11 0.017493765 0.0076393 0.022023084
Lettuce (👉 📊) Operation code: knee surgery (not replacement) (ukb-b-1508) Inverse variance weighted 8 0.009322125 0.004583549 0.041969483
Lettuce (👉 📊) Operative procedures - secondary OPCS: Z84.1 Sacroiliac joint (ukb-b-16715) Weighted median 3 0.004705313 0.002241187 0.035775138
Lettuce (👉 📊) Operative procedures - secondary OPCS: Z84.1 Sacroiliac joint (ukb-b-16715) Inverse variance weighted 3 0.004192361 0.001833727 0.022239523
Lettuce (👉 📊) Non-cancer illness code, self-reported: ankylosing spondylitis (ukb-b-18194) Inverse variance weighted 3 -0.004156943 0.002106403 0.048440998
Lettuce (👉 📊) Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) Weighted median 3 -0.00514255 0.002437858 0.034905401
Lettuce (👉 📊) Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) Inverse variance weighted 3 -0.004485467 0.001926267 0.019881292
Lettuce (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) Inverse variance weighted 4 -0.004920893 0.002257934 0.029303548
Lettuce (👉 📊) Fractured bone site(s): Spine (ukb-b-873) Weighted median 3 0.004991569 0.002483906 0.04447736
Lettuce (👉 📊) Fractured bone site(s): Spine (ukb-b-873) Inverse variance weighted 3 0.005428366 0.001894734 0.004170416
Lettuce (👉 📊) Knee pain for 3+ months (ukb-b-8906) Weighted median 12 -0.05496005 0.026632361 0.039050274
Lettuce (👉 📊) M51 Other intervertebral disk disorders (ukb-e-M51_CSA) Inverse variance weighted 10 -2.561950143 1.182693043 0.030295877

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Lettuce Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) All - MR Egger -1.58368885191174 0.705178626552945 0.0485244822391743
Lettuce Heel bone mineral density (ebi-a-GCST006288) rs4274598 0.23946353028683 0.112943377806704 0.0339884505079466
Lettuce Heel bone mineral density (ebi-a-GCST006288) All - MR Egger -0.205944343753259 0.0749535128940568 0.0205617957244366
Lettuce Rheumatoid arthritis (ebi-a-GCST90038685) All - MR Egger 0.0123316748002433 0.0053537644009813 0.0467412866170349
Lettuce Cervical root disorders (finn-b-G6_CERVROOT) All - MR Egger -5.71924819564006 2.19579078864558 0.026281337971272
Lettuce Ohter specific/unspecified arthritis (finn-b-M13_ARTHRITISNAS) All - Inverse variance weighted 0.455790530984771 0.205103241713231 0.0262664638355167
Lettuce Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) rs140432390 11.2689136309057 3.62368496953159 0.0018721788915725
Lettuce Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) All - MR Egger 5.82200567173529 2.09884679275709 0.0196550845238601
Lettuce Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) All - Inverse variance weighted 1.15162108527018 0.501237127834734 0.0215869911117282
Lettuce Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) All - MR Egger 2.73721671611718 0.94955630730411 0.0163119317420123
Lettuce Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) rs4274598 -2.25175491608944 1.14476314443773 0.0491826255693789
Lettuce Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) rs4794701 -2.43692379964376 1.14179829969922 0.0328193999498792
Lettuce Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) All - Inverse variance weighted -0.855402162880788 0.343625986361745 0.0127980247353205
Lettuce Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) rs56169733 -1.21881516953734 0.528307716073222 0.0210538420946188
Lettuce Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) All - MR Egger -0.936393283039896 0.387287025601553 0.0361957883303006
Lettuce Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) rs117121492 5.61869594048559 2.85812595001707 0.0493139575591851
Lettuce Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs78486026 -3.30867277603302 1.16102050403058 0.0043747137440298
Lettuce Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) All - Inverse variance weighted -0.75695302622087 0.382682759908915 0.0479267825465694
Lettuce Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) All - Inverse variance weighted 1.70146398837797 0.532351100947642 0.0013928373828029
Lettuce Knee pain for 3+ months (ukb-a-353) All - Inverse variance weighted -0.0429999028933385 0.0213234492845699 0.0437419994511583
Lettuce Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) All - Inverse variance weighted -0.0059174259173563 0.0029450287869034 0.0445060629584787
Lettuce Operation code: knee surgery (not replacement) (ukb-b-1508) rs4794701 0.0251839926402944 0.0127751570788232 0.0486866588941547
Lettuce Operation code: knee surgery (not replacement) (ukb-b-1508) rs78486026 0.0244136375133737 0.0123172649561907 0.0474718049414004
Lettuce Operation code: knee surgery (not replacement) (ukb-b-1508) All - Inverse variance weighted 0.0093221253538315 0.0045835488685935 0.0419694833398499
Lettuce Operative procedures - secondary OPCS: Z84.1 Sacroiliac joint (ukb-b-16715) All - Inverse variance weighted 0.0041923609852406 0.0018337265831638 0.0222395228729726
Lettuce Non-cancer illness code, self-reported: ankylosing spondylitis (ukb-b-18194) All - Inverse variance weighted -0.0041569430068741 0.0021064033073718 0.0484409978391612
Lettuce Diagnoses - main ICD10: M75.0 Adhesive capsulitis of shoulder (ukb-b-4921) All - Inverse variance weighted -0.0044854670853922 0.0019262665829789 0.0198812923161343
Lettuce Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) All - Inverse variance weighted -0.0049208925705405 0.0022579336979213 0.029303548331344
Lettuce Fractured bone site(s): Spine (ukb-b-873) rs783448 0.008676497959768 0.0035403393227861 0.0142557656423204
Lettuce Fractured bone site(s): Spine (ukb-b-873) All - Inverse variance weighted 0.0054283664342146 0.0018947340375067 0.004170416197157
Lettuce Knee pain for 3+ months (ukb-b-8906) rs8123963 -0.159779782274797 0.0637742178868799 0.0122313756699744
Lettuce M51 Other intervertebral disk disorders (ukb-e-M51_CSA) rs4274598 -6.48214866812329 3.15536237273953 0.0399439750055694
Lettuce M51 Other intervertebral disk disorders (ukb-e-M51_CSA) All - Inverse variance weighted -2.56195014283423 1.18269304263609 0.0302958765383637