ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Porridge | Osteoarthritis (self-reported) (ebi-a-GCST005811) | rs138894584 | -1.59624074391421 | 0.727850784230606 | 0.0283010470337598 |
| Porridge | Osteoarthritis (self-reported) (ebi-a-GCST005811) | rs718911 | -1.91131452334059 | 0.77160835861509 | 0.0132472361674408 |
| Porridge | Osteoarthritis (self-reported) (ebi-a-GCST005811) | All - Inverse variance weighted | -0.524919355637658 | 0.200589961909002 | 0.0088738184336921 |
| Porridge | Osteoarthritis of the knee (hospital diagnosed) (ebi-a-GCST005813) | rs4906184 | -3.56948115175963 | 1.28128364837226 | 0.0053385372238448 |
| Porridge | Osteoarthritis of the knee (hospital diagnosed) (ebi-a-GCST005813) | All - Inverse variance weighted | -0.913380931190329 | 0.358111994368469 | 0.0107554487802052 |
| Porridge | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | All - Inverse variance weighted | -0.523776608895899 | 0.225928384640491 | 0.0204313794972165 |
| Porridge | Juvenile rheumatoid arthritis (ebi-a-GCST90018873) | rs6026835 | -5.0349380921525 | 2.56562932347945 | 0.049709262858911 |
| Porridge | Juvenile rheumatoid arthritis (ebi-a-GCST90018873) | rs718911 | -7.17855594994487 | 3.06672737945677 | 0.0192431358215241 |
| Porridge | Juvenile rheumatoid arthritis (ebi-a-GCST90018873) | All - Inverse variance weighted | -2.35440387133453 | 1.11196484667302 | 0.0342312904918216 |
| Porridge | Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) | rs117679919 | -11.6144914801756 | 4.10340531613147 | 0.0046482295999905 |
| Porridge | Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) | All - MR Egger | -9.13289930164968 | 2.87582299491399 | 0.0079839156419975 |
| Porridge | Cervical root disorders (finn-b-G6_CERVROOT) | rs6026835 | 12.5341812877933 | 6.00690005428977 | 0.036921541675323 |
| Porridge | Cervical root disorders (finn-b-G6_CERVROOT) | rs911784 | -14.6437757337765 | 6.69475110344317 | 0.0287168535173877 |
| Porridge | Cervical root disorders (finn-b-G6_CERVROOT) | All - MR Egger | 8.98832933792651 | 3.84792612747766 | 0.0376656884643931 |
| Porridge | Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) | rs4906184 | -9.77316167189585 | 3.92059885730772 | 0.0126749969219827 |
| Porridge | Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) | rs78787695 | 6.6956792545167 | 3.11224716783485 | 0.0314448769150584 |
| Porridge | Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) | All - MR Egger | 5.87233252515963 | 2.42456679042462 | 0.0321988643813197 |
| Porridge | Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) | rs911784 | -6.59419752955746 | 2.88429988251109 | 0.0222403076881995 |
| Porridge | Other specified/unspecified disorders of synovium and tendon +Other specified/unspecified bursopathies (finn-b-M13_DISSYNOTENDNAS) | All - Inverse variance weighted | -1.84567430602038 | 0.754436770401929 | 0.0144280106687209 |
| Porridge | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | rs911784 | -1.19605829990368 | 0.603321443314246 | 0.047428211594277 |
| Porridge | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | All - MR Egger | 0.781322950034356 | 0.345367298175283 | 0.0430322860286472 |
| Porridge | Other joint disorders (finn-b-M13_OTHERJOINT) | rs4906184 | -1.12311504716568 | 0.484278965291624 | 0.0203869621317624 |
| Porridge | Other joint disorders (finn-b-M13_OTHERJOINT) | All - MR Egger | 0.635493071631269 | 0.262912053157031 | 0.0324871270535 |
| Porridge | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | rs10945577 | -13.1596683965761 | 5.91707667767518 | 0.0261474224346875 |
| Porridge | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | rs718911 | -9.29893185720791 | 3.82929465270273 | 0.0151669968121461 |
| Porridge | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | All - Inverse variance weighted | -3.25518495083038 | 1.5113572577508 | 0.0312546300177475 |
| Porridge | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs117679919 | 3.141339101582 | 1.47608089321563 | 0.0333236634815523 |
| Porridge | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | rs78787695 | 3.36300652378776 | 1.46208882543509 | 0.0214403853179172 |
| Porridge | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | All - MR Egger | 2.71551358309635 | 0.993084312122258 | 0.0181174729971916 |
| Porridge | Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) | rs138894584 | 14.1051022340877 | 6.6957239363957 | 0.0351536895534898 |
| Porridge | Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) | All - Inverse variance weighted | 5.2847262535181 | 2.19096469332663 | 0.0158629100366156 |
| Porridge | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | rs1186256 | 12.1454782362953 | 5.5549922661564 | 0.0287857858778987 |
| Porridge | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | rs139125030 | -14.8779524144511 | 6.41990536855191 | 0.0204780216536532 |
| Porridge | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | All - Inverse variance weighted | 2.71302990390925 | 1.2101719090747 | 0.0249707474162526 |
| Porridge | Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) | rs138894584 | 1.91322504126343 | 0.938010155763802 | 0.0413838565301032 |
| Porridge | Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) | rs4906184 | -3.31782610263623 | 1.2261531248873 | 0.0068123175199169 |
| Porridge | Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) | rs911784 | -2.9001767625983 | 1.16959683309165 | 0.0131515824031249 |
| Porridge | Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) | All - MR Egger | 2.03498493261028 | 0.660436457490466 | 0.0095153833475 |
| Porridge | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | rs4912340 | -10.828014578806 | 4.15119522253213 | 0.0090964220024097 |
| Porridge | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | rs76126926 | -7.82611058608269 | 3.43600071256254 | 0.0227456418037257 |
| Porridge | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | All - Inverse variance weighted | -2.5858716524451 | 1.09755729390618 | 0.0184717094269315 |
| Porridge | Fracture of femur (finn-b-ST19_FRACT_FEMUR) | rs911784 | 2.60910062766599 | 1.25427352689014 | 0.0375100550548144 |
| Porridge | Fracture of femur (finn-b-ST19_FRACT_FEMUR) | All - Inverse variance weighted | 0.645542184269614 | 0.329038065075404 | 0.0497732769179876 |
| Porridge | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | rs4906184 | -1.75164732126757 | 0.674899409076624 | 0.0094475435497598 |
| Porridge | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | rs718911 | -1.13836481437796 | 0.504720785169987 | 0.0241060515575081 |
| Porridge | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -0.426323900413685 | 0.190866220397883 | 0.025507640642192 |
| Porridge | Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) | rs6026835 | -2.39925745608658 | 0.953198217694461 | 0.011833855143951 |
| Porridge | Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) | rs718911 | -1.64857169503892 | 0.833886514628674 | 0.0480446048837718 |
| Porridge | Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) | rs911784 | -2.75728484181335 | 1.06375096584354 | 0.0095408732949942 |
| Porridge | Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) | All - Inverse variance weighted | -0.833362708135121 | 0.281942780125297 | 0.0031187273244886 |
| Porridge | Hip osteoarthritis (ieu-a-1169) | All - Inverse variance weighted | -2.12409422076378 | 1.07399838889635 | 0.0479575569213795 |
| Porridge | Fracture resulting from simple fall (ukb-a-332) | All - Inverse variance weighted | -0.110453734863979 | 0.0538653079001332 | 0.0403103777085496 |
| Porridge | Knee pain for 3+ months (ukb-a-353) | All - Inverse variance weighted | 0.0645141351405374 | 0.0309376447966499 | 0.0370424749061809 |
| Porridge | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | rs6026835 | 0.0383133145028734 | 0.014501997713325 | 0.0082434223961792 |
| Porridge | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | rs78787695 | 0.0300015369121816 | 0.0152511233614696 | 0.0491637319716456 |
| Porridge | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | rs911784 | -0.0351564401917927 | 0.0159909290091768 | 0.0279117907238929 |
| Porridge | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | All - MR Egger | 0.0285876100390888 | 0.0103569165072353 | 0.0172713720013699 |
| Porridge | Diagnoses - secondary ICD10: M13.9 Arthritis, unspecified (ukb-b-11045) | All - Inverse variance weighted | 0.0101755496535754 | 0.0045406221783245 | 0.0250258560023667 |
| Porridge | Fractured bone site(s): Ankle (ukb-b-15582) | rs911784 | 0.0268261587476317 | 0.0134506281952221 | 0.0461065248312184 |
| Porridge | Fractured bone site(s): Ankle (ukb-b-15582) | All - Inverse variance weighted | 0.0105758999445009 | 0.005229446254115 | 0.0431376538732441 |
| Porridge | Fractured bone site(s): Arm (ukb-b-19255) | rs76126926 | 0.0347685228518202 | 0.0116241896865631 | 0.0027802072771656 |
| Porridge | Fractured bone site(s): Arm (ukb-b-19255) | All - Inverse variance weighted | 0.0139543288110348 | 0.0056120214943721 | 0.0129004155648061 |
| Porridge | Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) | rs4906184 | -0.0138705738705739 | 0.0067314776175535 | 0.0393455986074331 |
| Porridge | Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) | All - Inverse variance weighted | -0.013530427908349 | 0.00476073465453 | 0.0044819086736968 |
| Porridge | Fractured heel (right) (ukb-b-3499) | rs1186256 | -0.0462145154644513 | 0.0230453438378417 | 0.0449231620452899 |
| Porridge | Fractured heel (right) (ukb-b-3499) | All - MR Egger | -0.0314967675157373 | 0.0123400829676363 | 0.025353769176071 |
| Porridge | Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement (ukb-b-898) | rs4726021 | 0.0229511642725547 | 0.0096664057846546 | 0.0175811893885888 |
| Porridge | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | rs6026835 | 0.0473646946388229 | 0.0171640726832405 | 0.0057885386034333 |
| Porridge | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | rs911784 | -0.0400596441461943 | 0.0189130158662955 | 0.0341666656250069 |
| Porridge | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | All - MR Egger | 0.0290915109319356 | 0.0110314462923282 | 0.0216878057926001 |
| Porridge | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | rs6026835 | 0.0470861155796621 | 0.0168034335150498 | 0.0050759759291937 |
| Porridge | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | rs911784 | -0.0411794404987457 | 0.0185155646347788 | 0.0261454474559983 |
| Porridge | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | All - MR Egger | 0.0324687936866241 | 0.011166944631572 | 0.0131399866183396 |
| Porridge | Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) | All - Inverse variance weighted | -0.006811065901983 | 0.0026220310999604 | 0.0093869657920974 |
| Porridge | Knee pain for 3+ months (ukb-e-3773_CSA) | rs4906184 | 9.74225024857936 | 4.42960696125253 | 0.0278531383629705 |
| Porridge | Knee pain for 3+ months (ukb-e-3773_CSA) | All - Inverse variance weighted | 1.82745444661713 | 0.854776814110513 | 0.0325222870409091 |
| Porridge | Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS) | All - MR Egger | 2.52131806489585 | 0.999090446763247 | 0.0356078220372305 |
| Porridge | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_EAS) | All - MR Egger | 2.68561408966199 | 1.00200825437089 | 0.0279159869103605 |
| Porridge | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | rs718911 | 4.08439809303321 | 1.2782602493979 | 0.0013969573927578 |
| Porridge | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | All - Inverse variance weighted | 1.20701398502953 | 0.59653446113858 | 0.0430343149375147 |