ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Milk (ukb-b-2966)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Milk (👉 📊) Rheumatoid Arthritis (bbj-a-74) Inverse variance weighted 18 0.726631948 0.344841744 0.035104914
Milk (👉 📊) Rheumatoid arthritis (ebi-a-GCST000679) Inverse variance weighted 8 1.666482364 0.787050991 0.034228005
Milk (👉 📊) Total body bone mineral density (age 15-30) (ebi-a-GCST005344) Weighted median 20 -1.445995449 0.608173319 0.017425518
Milk (👉 📊) Total body bone mineral density (age 15-30) (ebi-a-GCST005344) Inverse variance weighted 20 -1.231649861 0.461880199 0.007662275
Milk (👉 📊) Osteoprotegerin levels (ebi-a-GCST90012002) Inverse variance weighted 21 0.386863362 0.190911423 0.042723567
Milk (👉 📊) Osteoarthritis (Firth correction) (ebi-a-GCST90013881) Weighted median 20 0.469465934 0.208212629 0.024149475
Milk (👉 📊) Osteoarthritis (Firth correction) (ebi-a-GCST90013881) Inverse variance weighted 20 0.389499299 0.155723361 0.012376421
Milk (👉 📊) Osteoarthritis (SPA correction) (ebi-a-GCST90013931) Weighted median 20 0.466919067 0.216103843 0.030724426
Milk (👉 📊) Osteoarthritis (SPA correction) (ebi-a-GCST90013931) Inverse variance weighted 20 0.387783056 0.155795142 0.012808227
Milk (👉 📊) Shoulder impingement (ebi-a-GCST90014054) MR Egger 19 2.451205893 1.05781787 0.033223123
Milk (👉 📊) Cervical spondylosis (ebi-a-GCST90038693) Inverse variance weighted 21 0.00781636 0.003112509 0.012029651
Milk (👉 📊) Neck injury (ebi-a-GCST90038700) Inverse variance weighted 21 0.007593276 0.003298481 0.021332221
Milk (👉 📊) Fracture of lower leg or ankle (ebi-a-GCST90038707) MR Egger 21 -0.018249231 0.006087783 0.007399621
Milk (👉 📊) Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) MR Egger 20 13.51640492 5.886083149 0.033878605
Milk (👉 📊) Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) MR Egger 20 13.43857713 5.863439502 0.03418175
Milk (👉 📊) Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) Inverse variance weighted 20 -2.208576706 1.041192064 0.033904967
Milk (👉 📊) Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) Weighted median 20 0.848192437 0.289685358 0.003411739
Milk (👉 📊) Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) Inverse variance weighted 20 0.573099811 0.22940317 0.012481836
Milk (👉 📊) Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) Simple mode 20 0.958008305 0.455133448 0.048838371
Milk (👉 📊) Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) Weighted mode 20 0.916122972 0.373448224 0.023990167
Milk (👉 📊) Osteomalacia (finn-b-M13_OSTEOMALACIA) MR Egger 20 -12.84647154 5.134127567 0.022207507
Milk (👉 📊) Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) Weighted median 20 -4.279240025 1.923419014 0.02609406
Milk (👉 📊) Pain (limb, back, neck, head abdominally) (finn-b-PAIN) Inverse variance weighted 20 -0.255955702 0.126497228 0.043030938
Milk (👉 📊) Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) Inverse variance weighted 20 1.288071135 0.601644859 0.032280809
Milk (👉 📊) Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) MR Egger 20 -2.633895134 1.07072406 0.024241253
Milk (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) MR Egger 20 -1.939538367 0.866560909 0.038086335
Milk (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) Weighted median 20 -1.206234652 0.542766151 0.026257385
Milk (👉 📊) Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) MR Egger 20 -1.956179999 0.768460517 0.020286204
Milk (👉 📊) Ankle and foot (finn-b-Z21_ANKLE_FOOT) Weighted median 20 -7.527327517 3.285859736 0.021973574
Milk (👉 📊) Rheumatoid arthritis (ieu-a-832) Weighted median 11 1.535732332 0.662750332 0.020492243
Milk (👉 📊) Rheumatoid arthritis (ieu-a-834) Inverse variance weighted 8 1.635993951 0.78290036 0.036648538
Milk (👉 📊) Femoral neck bone mineral density (ieu-a-980) MR Egger 19 -0.897370801 0.361216741 0.023696485
Milk (👉 📊) Lumbar spine bone mineral density (ieu-a-982) MR Egger 19 -1.125229392 0.506023651 0.040013882
Milk (👉 📊) Osteomyelitis (ieu-b-4975) MR Egger 18 -2.368596217 0.928883748 0.021405928
Milk (👉 📊) Osteoclast-associated immunoglobulin-like receptor (prot-a-2153) MR Egger 21 -2.494351953 1.001494032 0.022173804
Milk (👉 📊) Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) Inverse variance weighted 20 0.028214085 0.012830338 0.027876967
Milk (👉 📊) Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) Inverse variance weighted 13 0.015203071 0.007062058 0.031335824
Milk (👉 📊) Diagnoses - main ICD10: M51.2 Other specified intervertebral disk displacement (ukb-b-12872) Weighted median 6 -0.011997687 0.005322066 0.024175503
Milk (👉 📊) Operation code: bone surgery/joint surgery (ukb-b-12974) Inverse variance weighted 11 0.009426116 0.004758912 0.047621665
Milk (👉 📊) Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) MR Egger 11 0.078921593 0.032294984 0.037134134
Milk (👉 📊) Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) Weighted median 21 0.029255016 0.014777004 0.047729776
Milk (👉 📊) Operative procedures - secondary OPCS: Z85.6 Ankle joint (ukb-b-15453) Weighted median 8 -0.01169036 0.005485725 0.033084953
Milk (👉 📊) Operative procedures - secondary OPCS: Z85.6 Ankle joint (ukb-b-15453) Inverse variance weighted 8 -0.010637165 0.004250188 0.012323197
Milk (👉 📊) Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) Weighted median 10 -0.015174957 0.005948555 0.010740428
Milk (👉 📊) Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) Inverse variance weighted 10 -0.012607194 0.004325625 0.003562164
Milk (👉 📊) Heel bone ultrasound T-score, manual entry (ukb-b-17612) Weighted median 21 0.388283159 0.187278086 0.038144615
Milk (👉 📊) Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint (ukb-b-19054) MR Egger 8 0.13755615 0.046742702 0.025852223
Milk (👉 📊) Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) Weighted median 10 -0.011555246 0.0058764 0.049254535
Milk (👉 📊) Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) MR Egger 11 0.101746034 0.034874133 0.017100643
Milk (👉 📊) Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) MR Egger 8 0.140177412 0.051877803 0.03547822
Milk (👉 📊) Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) Inverse variance weighted 20 -0.006335564 0.003211155 0.048497128
Milk (👉 📊) Ankle spacing width (ukb-e-3143_CSA) MR Egger 18 2.522691253 1.158842701 0.044805547
Milk (👉 📊) Fractured bone site(s) (ukb-e-6151_p7_CSA) MR Egger 18 -9.521523247 4.372779403 0.044758142

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Milk Rheumatoid Arthritis (bbj-a-74) rs191749866 4.83298856358362 2.17795088739385 0.0264831154997304
Milk Rheumatoid Arthritis (bbj-a-74) rs2807888 2.00444764995793 1.02175742276716 0.0497898845480362
Milk Rheumatoid Arthritis (bbj-a-74) rs9342975 2.77363827134211 1.38529850065387 0.0452637213481001
Milk Rheumatoid Arthritis (bbj-a-74) All - Inverse variance weighted 0.726631948196233 0.344841744069233 0.0351049143357115
Milk Rheumatoid arthritis (ebi-a-GCST000679) rs2807888 4.06651039788436 1.96084865969467 0.0380930351800966
Milk Rheumatoid arthritis (ebi-a-GCST000679) All - Inverse variance weighted 1.66648236374765 0.787050990655407 0.0342280048622334
Milk Total body bone mineral density (age 15-30) (ebi-a-GCST005344) rs2807888 -3.73241976199062 1.88724606322875 0.0479617694093487
Milk Total body bone mineral density (age 15-30) (ebi-a-GCST005344) All - Inverse variance weighted -1.23164986051901 0.461880199341132 0.0076622747652934
Milk Osteoprotegerin levels (ebi-a-GCST90012002) rs1549862 1.75576582374018 0.818298098847232 0.0319024247218399
Milk Osteoprotegerin levels (ebi-a-GCST90012002) All - Inverse variance weighted 0.386863362364488 0.190911423123822 0.0427235671712999
Milk Osteoarthritis (Firth correction) (ebi-a-GCST90013881) rs13072001 1.41712767069408 0.661716599629132 0.0322262435089061
Milk Osteoarthritis (Firth correction) (ebi-a-GCST90013881) All - Inverse variance weighted 0.389499299334738 0.155723360637749 0.0123764213547618
Milk Osteoarthritis (SPA correction) (ebi-a-GCST90013931) rs13072001 1.43626337040722 0.678775361673629 0.0343479771153704
Milk Osteoarthritis (SPA correction) (ebi-a-GCST90013931) All - Inverse variance weighted 0.387783055664564 0.155795141911987 0.0128082273832917
Milk Shoulder impingement (ebi-a-GCST90014054) All - MR Egger 2.45120589269404 1.05781786998864 0.0332231234970543
Milk Cervical spondylosis (ebi-a-GCST90038693) rs13072001 0.0292221065141901 0.0143957911525939 0.04236606910982
Milk Cervical spondylosis (ebi-a-GCST90038693) rs1549862 0.032512175163461 0.0145317825392664 0.0252657590287351
Milk Cervical spondylosis (ebi-a-GCST90038693) rs9342975 0.040464782093002 0.0144201058361972 0.0050139482429568
Milk Cervical spondylosis (ebi-a-GCST90038693) All - Inverse variance weighted 0.0078163603530663 0.0031125087906466 0.0120296509410738
Milk Neck injury (ebi-a-GCST90038700) rs1549862 0.0334645788148183 0.0154001318810528 0.0297798665038414
Milk Neck injury (ebi-a-GCST90038700) rs9342975 0.0336027645144612 0.0152816216051823 0.0278850021321193
Milk Neck injury (ebi-a-GCST90038700) All - Inverse variance weighted 0.0075932757411581 0.0032984809298913 0.0213322207288374
Milk Fracture of lower leg or ankle (ebi-a-GCST90038707) rs117951732 -0.0254722411746831 0.0126968459919845 0.0448363523811812
Milk Fracture of lower leg or ankle (ebi-a-GCST90038707) rs191749866 -0.0235569367052436 0.011217161457848 0.0357218022177182
Milk Fracture of lower leg or ankle (ebi-a-GCST90038707) All - MR Egger -0.0182492312105182 0.0060877833176295 0.0073996207899256
Milk Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) All - MR Egger 13.5164049215773 5.88608314918062 0.0338786045537459
Milk Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) All - MR Egger 13.438577127365 5.86343950197062 0.0341817496579869
Milk Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs13072001 31.9457402453612 15.4289563436606 0.0384050237910048
Milk Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs3744761 -8.13276074436566 4.11797995938613 0.0482750289478643
Milk Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) All - Inverse variance weighted -2.20857670587884 1.04119206398636 0.0339049672195226
Milk Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs191749866 1.32161737391056 0.642948992713245 0.0398253754995507
Milk Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) All - Inverse variance weighted 0.573099811129976 0.229403170095982 0.0124818361043308
Milk Osteomalacia (finn-b-M13_OSTEOMALACIA) All - MR Egger -12.8464715444621 5.13412756650629 0.022207506512079
Milk Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) rs781770 14.576976152067 6.25838176128744 0.0198488675957463
Milk Pain (limb, back, neck, head abdominally) (finn-b-PAIN) rs62435191 -1.50449110169018 0.643183928231859 0.0193286839874062
Milk Pain (limb, back, neck, head abdominally) (finn-b-PAIN) rs73164589 -2.2652769733231 1.00072476733149 0.0235964893839543
Milk Pain (limb, back, neck, head abdominally) (finn-b-PAIN) All - Inverse variance weighted -0.255955702373907 0.12649722787426 0.0430309375946024
Milk Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) rs191821864 5.16747256014009 2.39677828407397 0.0310830598520252
Milk Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) rs6025776 8.14270594324828 3.15201520383804 0.0097850732044699
Milk Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) rs9342975 5.42106383625802 2.71433350567197 0.045803582740203
Milk Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) All - Inverse variance weighted 1.28807113512661 0.601644859109889 0.0322808086096477
Milk Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) rs191749866 -3.20232082844133 1.46915397851867 0.0292794086206474
Milk Spondyloarthritis (finn-b-SPONDYLOARTHRITIS) All - MR Egger -2.63389513383674 1.07072405994384 0.0242412530622668
Milk Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) All - MR Egger -1.93953836724728 0.866560908686429 0.0380863353670624
Milk Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) rs56674454 2.93881024727229 1.46275623167399 0.0445274935839779
Milk Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) All - MR Egger -1.95617999925329 0.768460517141619 0.0202862035913379
Milk Ankle and foot (finn-b-Z21_ANKLE_FOOT) rs71413244 28.9420696789448 11.993386780951 0.0158144830647945
Milk Rheumatoid arthritis (ieu-a-834) rs2807888 4.06651039788436 2.00899146532035 0.0429541917976696
Milk Rheumatoid arthritis (ieu-a-834) All - Inverse variance weighted 1.63599395103853 0.782900360391228 0.0366485381596939
Milk Femoral neck bone mineral density (ieu-a-980) rs71413244 -1.44234676912846 0.676469501607123 0.0329930205030361
Milk Femoral neck bone mineral density (ieu-a-980) rs73164589 -1.67575911038601 0.825506958069632 0.0423590038067219
Milk Femoral neck bone mineral density (ieu-a-980) All - MR Egger -0.897370801129556 0.361216740548209 0.0236964848850555
Milk Lumbar spine bone mineral density (ieu-a-982) rs71413244 -2.24558502974101 0.797465548453837 0.0048640464026688
Milk Lumbar spine bone mineral density (ieu-a-982) rs73164589 -2.48440537237575 0.953902978217557 0.0092018254471785
Milk Lumbar spine bone mineral density (ieu-a-982) All - MR Egger -1.12522939192182 0.506023651132609 0.0400138815493841
Milk Osteomyelitis (ieu-b-4975) rs12947049 4.75610292314587 1.83025967546908 0.009360624676927
Milk Osteomyelitis (ieu-b-4975) All - MR Egger -2.36859621700982 0.928883748161446 0.0214059281238301
Milk Osteoclast-associated immunoglobulin-like receptor (prot-a-2153) rs6025776 4.65076753115319 2.17087321636885 0.0321654283123552
Milk Osteoclast-associated immunoglobulin-like receptor (prot-a-2153) All - MR Egger -2.4943519525825 1.00149403238681 0.0221738043889325
Milk Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) rs6489968 0.146662217018809 0.0580673574562603 0.0115459590888276
Milk Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) All - Inverse variance weighted 0.0282140847266249 0.012830337584144 0.0278769669957045
Milk Operative procedures - main OPCS: S06.5 Excision of lesion of skin of head or neck NEC (ukb-b-10810) All - Inverse variance weighted 0.0152030712620763 0.0070620582996846 0.0313358235452778
Milk Operation code: bone surgery/joint surgery (ukb-b-12974) All - Inverse variance weighted 0.0094261158890587 0.0047589122788811 0.0476216649833641
Milk Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) All - MR Egger 0.0789215934409642 0.0322949840515033 0.0371341336607048
Milk Operative procedures - secondary OPCS: Z85.6 Ankle joint (ukb-b-15453) All - Inverse variance weighted -0.0106371648336689 0.0042501878689763 0.0123231972297809
Milk Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) All - Inverse variance weighted -0.0126071941627522 0.0043256247914831 0.0035621640650927
Milk Heel bone ultrasound T-score, manual entry (ukb-b-17612) rs191749866 -1.40906620200401 0.518993396572181 0.0066276105812997
Milk Heel bone ultrasound T-score, manual entry (ukb-b-17612) rs3744761 1.11972768733979 0.551130197410034 0.0421846856166383
Milk Heel bone ultrasound T-score, manual entry (ukb-b-17612) rs781770 1.13651824065616 0.563225852429172 0.0436044896455135
Milk Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint (ukb-b-19054) rs56674454 0.0223948643958484 0.0105352358029534 0.0335273481557915
Milk Operative procedures - secondary OPCS: Z67.5 Lumbar intervertebral joint (ukb-b-19054) All - MR Egger 0.13755614989036 0.0467427019358117 0.0258522226909396
Milk Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) rs2807888 0.0371561485755499 0.0152963096526025 0.0151366767198514
Milk Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) rs56674454 0.0334500435502424 0.0149428527735853 0.0251864290502579
Milk Operative procedures - secondary OPCS: Y76.7 Arthroscopic approach to joint (ukb-b-4455) All - MR Egger 0.101746034412114 0.0348741333733848 0.0171006431930586
Milk Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) rs56674454 0.0286917640175265 0.0114407483992793 0.0121465720757427
Milk Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) All - MR Egger 0.140177412052965 0.0518778032131433 0.0354782200966071
Milk Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) rs1549862 -0.0313768858593322 0.0145612571601084 0.0311759348859385
Milk Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) rs3744761 0.027355937281534 0.0137150038283565 0.0460865980463874
Milk Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) rs9400375 -0.0330675303694525 0.0146580348670332 0.0240748881444665
Milk Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) All - Inverse variance weighted -0.0063355638089343 0.0032111545478234 0.0484971275207067
Milk Ankle spacing width (ukb-e-3143_CSA) rs191749866 3.87943619274803 1.39507507283649 0.005422376380807
Milk Ankle spacing width (ukb-e-3143_CSA) All - MR Egger 2.52269125286661 1.15884270116568 0.0448055469792837
Milk Fractured bone site(s) (ukb-e-6151_p7_CSA) rs3744761 -22.350943773095 10.416458603815 0.0318942499496785
Milk Fractured bone site(s) (ukb-e-6151_p7_CSA) All - MR Egger -9.52152324663208 4.37277940344069 0.0447581421401259