ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Latte (ukb-b-3000)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Latte (👉 📊) Bone disorder (ebi-a-GCST90038652) Weighted median 6 0.027639658 0.011375242 0.015106807
Latte (👉 📊) Bone disorder (ebi-a-GCST90038652) Inverse variance weighted 6 0.020418895 0.010298736 0.047405393
Latte (👉 📊) Fracture of upper limb or shoulder (ebi-a-GCST90038704) Inverse variance weighted 6 0.01202599 0.005740585 0.036179284
Latte (👉 📊) Benign neoplasm of bone and articular cartilage (finn-b-CD2_BENIGN_BONE_CARTILAGE) Inverse variance weighted 9 2.350044075 0.949263768 0.013299419
Latte (👉 📊) Benign neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_EXALLC) Inverse variance weighted 9 2.403551978 0.952479563 0.011620354
Latte (👉 📊) Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) MR Egger 9 6.191152344 2.523499144 0.043887928
Latte (👉 📊) Cervical root disorders (finn-b-G6_CERVROOT) MR Egger 9 -17.72947175 6.630283795 0.031814037
Latte (👉 📊) Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) Weighted median 9 3.479994311 1.584685276 0.028090794
Latte (👉 📊) Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) Inverse variance weighted 9 2.744214717 1.191163149 0.021233258
Latte (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) Weighted median 9 1.682770358 0.703293384 0.016724892
Latte (👉 📊) Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) Weighted median 9 -1.127292833 0.427623749 0.008384544
Latte (👉 📊) Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) Inverse variance weighted 9 -0.013405322 0.006199506 0.030593442
Latte (👉 📊) Fractured bone site(s): Wrist (ukb-a-439) Inverse variance weighted 9 0.018711842 0.008283481 0.023887458
Latte (👉 📊) Heel bone mineral density (BMD) T-score automated (ukb-a-500) Weighted median 9 -0.289617176 0.120599582 0.016329015
Latte (👉 📊) Non-cancer illness code self-reported: osteoporosis (ukb-a-87) MR Egger 9 -0.042620339 0.017896777 0.048777772
Latte (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) Weighted median 9 -0.198479799 0.092625663 0.032127836
Latte (👉 📊) Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) Wald ratio 1 0.026232108 0.012663456 0.038313871
Latte (👉 📊) Heel bone mineral density (BMD) (ukb-b-8875) Weighted median 9 -0.187323515 0.089450598 0.036246076
Latte (👉 📊) Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) Inverse variance weighted 6 0.008462071 0.003914494 0.030639155
Latte (👉 📊) Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) Inverse variance weighted 8 -0.00854845 0.003903946 0.028546396
Latte (👉 📊) Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) MR Egger 9 -0.029762404 0.010089549 0.021412197
Latte (👉 📊) Osteoarthrosis (ukb-e-740_CSA) Inverse variance weighted 3 -4.922117858 2.494376622 0.048463015

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Latte Bone disorder (ebi-a-GCST90038652) All - Inverse variance weighted 0.0204188953355644 0.0102987364660738 0.0474053933820614
Latte Fracture of upper limb or shoulder (ebi-a-GCST90038704) rs72773940 0.0337723863666693 0.0144825046040516 0.0197036495210303
Latte Fracture of upper limb or shoulder (ebi-a-GCST90038704) All - Inverse variance weighted 0.0120259901411097 0.0057405849818195 0.0361792840476745
Latte Benign neoplasm of bone and articular cartilage (finn-b-CD2_BENIGN_BONE_CARTILAGE) rs56364544 6.53007780696821 2.93937435475613 0.0263111842972841
Latte Benign neoplasm of bone and articular cartilage (finn-b-CD2_BENIGN_BONE_CARTILAGE) All - Inverse variance weighted 2.35004407525583 0.949263768485337 0.0132994185845421
Latte Benign neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_EXALLC) rs56364544 6.64254958410623 2.95112513744219 0.0243948340461622
Latte Benign neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_EXALLC) All - Inverse variance weighted 2.40355197756822 0.952479562522355 0.0116203538654802
Latte Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) rs17623187 -7.5899017777417 3.2425070577518 0.0192449952275164
Latte Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) rs6846368 7.64955977369355 3.6025279070373 0.0337214624226448
Latte Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) All - MR Egger 6.19115234383651 2.52349914407464 0.0438879283227003
Latte Cervical root disorders (finn-b-G6_CERVROOT) All - MR Egger -17.7294717476188 6.63028379496457 0.0318140366347567
Latte Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) All - Inverse variance weighted 2.74421471684963 1.19116314948077 0.0212332577184672
Latte Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) rs72773940 -5.58891824805829 2.51688152240638 0.0263799206024216
Latte Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) rs72773940 -2.98129020204447 1.38521899271359 0.0313803618193655
Latte Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) rs76297148 -1.74531737681613 0.819876912899514 0.0332745055804316
Latte Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) rs72773940 -0.0393960018149305 0.0190183628259535 0.0383147294002633
Latte Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) All - Inverse variance weighted -0.0134053218030704 0.0061995058909047 0.0305934418265546
Latte Fractured bone site(s): Wrist (ukb-a-439) All - Inverse variance weighted 0.0187118415578719 0.0082834811602732 0.0238874581682432
Latte Heel bone mineral density (BMD) T-score automated (ukb-a-500) rs145819906 -0.486092820625037 0.212939717652364 0.022443803359403
Latte Heel bone mineral density (BMD) T-score automated (ukb-a-500) rs149925197 -0.533071458722477 0.242903116290658 0.0281934031982133
Latte Heel bone mineral density (BMD) T-score automated (ukb-a-500) rs181247093 0.448352739870086 0.225274136272289 0.0465629678365951
Latte Non-cancer illness code self-reported: osteoporosis (ukb-a-87) rs17623187 0.045389236139297 0.0230297823596793 0.0487361194789012
Latte Non-cancer illness code self-reported: osteoporosis (ukb-a-87) rs80345046 0.0441 0.0195959102902375 0.0244191524433443
Latte Non-cancer illness code self-reported: osteoporosis (ukb-a-87) All - MR Egger -0.0426203389043001 0.0178967765054238 0.0487777724230765
Latte Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) rs17623187 0.0262321075844901 0.0126634557278278 0.038313870810301
Latte Diagnoses - main ICD10: M84 Disorders of continuity of bone (ukb-d-M84) All - Inverse variance weighted 0.0084620712277954 0.0039144941240544 0.030639154500847
Latte Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) rs56364544 -0.023301634198135 0.0109198344818325 0.0328524716122767
Latte Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) rs6846368 -0.0262147605072181 0.0109816470080606 0.0169798905153427
Latte Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) All - Inverse variance weighted -0.0085484500576816 0.0039039463429498 0.0285463961051079
Latte Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) rs17623187 0.0262050491111291 0.0129654733879914 0.0432651770536228
Latte Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) All - MR Egger -0.0297624040027752 0.0100895492947418 0.0214121966492856
Latte Osteoarthrosis (ukb-e-740_CSA) rs17623187 -10.3047686049553 5.19973663085929 0.0475031249732938
Latte Osteoarthrosis (ukb-e-740_CSA) All - Inverse variance weighted -4.92211785829382 2.49437662193989 0.0484630148329035