ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Prune | Menstruation quality of life impact (stiff neck) (ebi-a-GCST006652) | rs1568143 | 13.3673423287754 | 4.7553159448226 | 0.0049382969796971 |
| Prune | Menstruation quality of life impact (stiff neck) (ebi-a-GCST006652) | rs4712683 | 4.29188770735406 | 1.27381208028781 | 0.0007535234716826 |
| Prune | Rheumatoid arthritis (ebi-a-GCST90013534) | All - MR Egger | 1.24418943361154 | 0.544988199135129 | 0.0414554575258345 |
| Prune | Shoulder impingement (ebi-a-GCST90014054) | rs75904026 | -4.26246402121877 | 2.16472421723054 | 0.0489466176396457 |
| Prune | Shoulder impingement (ebi-a-GCST90014054) | All - Inverse variance weighted | -1.57140092490655 | 0.615860534686965 | 0.0107243946463574 |
| Prune | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | rs71427295 | -0.0444622723195859 | 0.0183237073152565 | 0.0152457168909149 |
| Prune | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | All - Inverse variance weighted | 3.00724800573318 | 1.52489234315274 | 0.0485976069864466 |
| Prune | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | rs4712683 | 6.45027876975448 | 3.29009287022824 | 0.0499355432278634 |
| Prune | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | All - Inverse variance weighted | 3.01721458916846 | 1.52755152530288 | 0.0482458408713523 |
| Prune | Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) | rs150958066 | 44.5676727063029 | 22.4566780620064 | 0.0471882514694855 |
| Prune | Benign neoplasm: Scapula and long bones of upper limb (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER) | All - Inverse variance weighted | -5.65138029613145 | 2.8545788698691 | 0.0477305332166934 |
| Prune | Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) | rs150958066 | 44.8193684666631 | 22.5458866859315 | 0.0468207866519643 |
| Prune | Benign neoplasm: Scapula and long bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SCAPULA_LONG_UPPER_EXALLC) | All - Inverse variance weighted | -5.64084917121134 | 2.85723825206074 | 0.0483554491926045 |
| Prune | Pain in joint (finn-b-JOINTPAIN) | rs4712683 | -1.36269761103732 | 0.670744154849109 | 0.0421920843227273 |
| Prune | Pain in joint (finn-b-JOINTPAIN) | All - MR Egger | -1.43767683408043 | 0.560706481815565 | 0.0235579669575737 |
| Prune | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | All - Inverse variance weighted | 2.13828170960819 | 0.965515115243996 | 0.0267838368950025 |
| Prune | Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) | rs75904026 | -7.02787286476624 | 3.31120933051486 | 0.033800052832936 |
| Prune | Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) | All - MR Egger | -4.82715441010949 | 2.06173209380169 | 0.0358010769948019 |
| Prune | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | rs118054480 | 3.91157128994263 | 1.88548339138071 | 0.0380262075853743 |
| Prune | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | All - Inverse variance weighted | 1.27065271444036 | 0.506150470684155 | 0.0120585988994132 |
| Prune | Seropositive rheumatoid arthritis (finn-b-RHEUMA_SEROPOS) | All - MR Egger | 2.30223470333868 | 0.912855367787945 | 0.0255067834151345 |
| Prune | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | All - Inverse variance weighted | 1.27911083716737 | 0.505571093366214 | 0.0114052257533304 |
| Prune | Other/unspecified seropositiverheumatoid arthritis (finn-b-RHEUMA_SEROPOS_OTH) | All - MR Egger | 2.17168845517238 | 0.911437334873483 | 0.0331398069015646 |
| Prune | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | rs118054480 | 7.26533453500245 | 3.36759319658585 | 0.0309724544901188 |
| Prune | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | All - Inverse variance weighted | 1.94776131361627 | 0.906980795322912 | 0.0317517387062275 |
| Prune | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | All - MR Egger | 4.80843560439825 | 1.63513338425452 | 0.011475086870204 |
| Prune | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | rs118054480 | 3.90235132225862 | 1.8739584317757 | 0.0373049606007774 |
| Prune | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | All - Inverse variance weighted | 1.31273723424547 | 0.502692547001537 | 0.00901692513225 |
| Prune | Seropositive rheumatoid arthritis, wide (finn-b-RHEUMA_SEROPOS_WIDE) | All - MR Egger | 2.15070297909349 | 0.906382803975112 | 0.0337563383346987 |
| Prune | Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) | rs115727444 | 27.7348092065886 | 10.6687291580837 | 0.0093322772523193 |
| Prune | Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) | rs1568143 | -40.2611288476598 | 13.7190530690922 | 0.0033388413037931 |
| Prune | Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) | rs973572 | -23.6754075669025 | 10.2756844047985 | 0.0212213833435677 |
| Prune | Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) | All - MR Egger | 15.2014487839963 | 4.75753070101527 | 0.0070317429328732 |
| Prune | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | rs11247295 | 18.5420649658339 | 8.15960628984898 | 0.0230610628666561 |
| Prune | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | All - Inverse variance weighted | 7.07636886813402 | 1.93300083944117 | 0.0002514089684284 |
| Prune | Crushing injury of wrist and hand (finn-b-ST19_CRUSHI_INJURY_WRIST_HAND) | rs41460851 | 29.2370697061687 | 8.64597055959677 | 0.0007206937664528 |
| Prune | Crushing injury of wrist and hand (finn-b-ST19_CRUSHI_INJURY_WRIST_HAND) | All - Inverse variance weighted | 6.80417541549063 | 2.53756577298227 | 0.0073319438281309 |
| Prune | Crushing injury of wrist and hand (finn-b-ST19_CRUSHI_INJURY_WRIST_HAND) | All - MR Egger | 11.7426799986605 | 4.44939379027397 | 0.0204284364481276 |
| Prune | Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) | rs118054480 | -15.8790893437918 | 6.50929718491337 | 0.014709736142292 |
| Prune | Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) | All - MR Egger | -6.97738396434052 | 3.15995948876441 | 0.045813902781649 |
| Prune | Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) | rs75904026 | -21.0350485594761 | 8.53354394426694 | 0.0137019402429491 |
| Prune | Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) | All - Inverse variance weighted | -7.40448094157935 | 2.90205408964003 | 0.0107271999082883 |
| Prune | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | rs143812192 | 12.7288954544056 | 6.42189599811241 | 0.0474670842991537 |
| Prune | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | rs4712683 | 9.85967396001517 | 2.87120916878097 | 0.0005947887690124 |
| Prune | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | All - Inverse variance weighted | 3.1460813954595 | 1.41442309624945 | 0.0261292125786485 |
| Prune | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | All - MR Egger | 7.46135036786529 | 2.36783036284939 | 0.0076549082782161 |
| Prune | Knee and hip osteoarthritis (ieu-a-1170) | rs973572 | -4.93053099046447 | 2.06619117194709 | 0.0170193320005322 |
| Prune | Knee and hip osteoarthritis (ieu-a-1170) | All - Inverse variance weighted | -2.96131715622398 | 1.07288081041471 | 0.0057773972565422 |
| Prune | Knee osteoarthritis (ieu-a-1171) | rs11247295 | -7.62736578270932 | 2.53897309708285 | 0.0026635510339768 |
| Prune | Knee osteoarthritis (ieu-a-1171) | rs973572 | -6.97580552137804 | 2.6392648415872 | 0.0082154021310112 |
| Prune | Knee osteoarthritis (ieu-a-1171) | All - Inverse variance weighted | -5.22495775452636 | 1.47325034751798 | 0.0003903089241449 |
| Prune | Rheumatoid arthritis (ieu-a-832) | rs4712683 | 3.08950590281368 | 1.46535858300658 | 0.0349997153096257 |
| Prune | Psoriatic arthritis (ieu-b-5116) | rs4712683 | -6.53787318428497 | 1.82121619436204 | 0.0003308820822376 |
| Prune | Psoriatic arthritis (ieu-b-5116) | All - Inverse variance weighted | -1.7004913186516 | 0.73914128257931 | 0.0214124995051093 |
| Prune | Bone morphogenetic protein 7 (prot-a-257) | All - Inverse variance weighted | 1.38253863231762 | 0.612357370147005 | 0.0239623930653503 |
| Prune | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs115727444 | 0.0294616275544708 | 0.0115469268618779 | 0.0107269823293794 |
| Prune | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs143812192 | 0.025839411565568 | 0.0116796233034808 | 0.0269425088413975 |
| Prune | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | All - MR Egger | 0.014593667902051 | 0.0057581326173255 | 0.02491478107626 |
| Prune | Fractured heel (right) (ukb-b-3499) | rs71427295 | 0.0890052356020943 | 0.0424198599080744 | 0.0358877198789942 |
| Prune | Fractured heel (right) (ukb-b-3499) | rs8004411 | 0.083628422074353 | 0.0401825496135 | 0.0374144655173003 |
| Prune | Fractured heel (right) (ukb-b-3499) | All - Inverse variance weighted | 0.0293275352301924 | 0.010481993642102 | 0.0051436563043626 |
| Prune | Ankle spacing width (ukb-b-4080) | rs8004411 | 0.663973056098046 | 0.218318695840301 | 0.0023555754353439 |
| Prune | Ankle spacing width (ukb-b-4080) | All - Inverse variance weighted | 0.146496305517643 | 0.0577366820454527 | 0.0111705528494375 |
| Prune | Non-cancer illness code, self-reported: joint pain (ukb-b-4122) | rs11677443 | 0.0279816334323687 | 0.0122431986886345 | 0.0222844696716456 |
| Prune | Non-cancer illness code, self-reported: joint pain (ukb-b-4122) | All - Inverse variance weighted | 0.0168623954253435 | 0.0053528296485037 | 0.0016316796500243 |
| Prune | Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) | All - Inverse variance weighted | -0.0159226919669337 | 0.0061096561138649 | 0.0091565840699515 |
| Prune | Operation code: shoulder surgery (ukb-b-5935) | rs11247295 | 0.0541442018313376 | 0.0246108178816125 | 0.0278057347262232 |
| Prune | Operation code: shoulder surgery (ukb-b-5935) | All - Inverse variance weighted | 0.0194578356109731 | 0.0096654169421526 | 0.0440999233435124 |
| Prune | Ankle spacing width (right) (ukb-b-8607) | rs11677443 | 0.756782684014939 | 0.316841918989652 | 0.0169164713018166 |
| Prune | Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) | rs11247295 | 0.0471868568135457 | 0.0146869254201008 | 0.001314258907342 |
| Prune | Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) | All - Inverse variance weighted | 0.0112164657559988 | 0.0042297538684792 | 0.0080063702156519 |
| Prune | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | rs13096896 | -0.0844416502879507 | 0.0352392436895454 | 0.0165642853617626 |
| Prune | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | rs41460851 | 0.0683733318059454 | 0.0314932126696833 | 0.0299274111546003 |
| Prune | Other joint disorders (ukb-d-M13_OTHERJOINT) | rs13096896 | -0.214089414915074 | 0.0634818432277943 | 0.0007450230248967 |
| Prune | Other joint disorders (ukb-d-M13_OTHERJOINT) | rs150958066 | 0.232557324505928 | 0.0610048395678479 | 0.0001377840156178 |
| Prune | Other joint disorders (ukb-d-M13_OTHERJOINT) | All - MR Egger | 0.0942595793368316 | 0.0429765267828217 | 0.0470746780282145 |
| Prune | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | rs11247295 | 0.0425192327042875 | 0.0152913949084789 | 0.0054258764243565 |
| Prune | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | All - Inverse variance weighted | 0.0105381198313574 | 0.0041309807866793 | 0.0107415232699061 |
| Prune | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | rs11247295 | 0.0372703738599877 | 0.0136681638141586 | 0.0063951437406069 |
| Prune | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | All - Inverse variance weighted | 0.0079954919777446 | 0.0037958507794892 | 0.0351716358284901 |
| Prune | Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) | All - Inverse variance weighted | 3.82327452374423 | 1.57604994845242 | 0.0152722139491088 |