ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

White wine (ukb-b-311)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
White wine (👉 📊) Frozen shoulder (ebi-a-GCST90000512) Weighted median 12 0.398477456 0.19398395 0.039958521
White wine (👉 📊) Shoulder impingement (ebi-a-GCST90014054) Weighted median 12 -0.585547035 0.291786721 0.044774817
White wine (👉 📊) Shoulder impingement (ebi-a-GCST90014054) Inverse variance weighted 12 -0.465749206 0.227316073 0.040471333
White wine (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017136) MR Egger 15 1.320090847 0.577157492 0.03958534
White wine (👉 📊) Joint disorder (ebi-a-GCST90038654) Inverse variance weighted 15 -0.013672268 0.005912267 0.020748748
White wine (👉 📊) Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) Inverse variance weighted 13 -0.447561867 0.18186034 0.013854278
White wine (👉 📊) Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) Weighted median 13 -0.379438887 0.183589071 0.038754546
White wine (👉 📊) Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) Inverse variance weighted 13 -0.365489767 0.148127671 0.013609938
White wine (👉 📊) Loose body in joint (finn-b-M13_LOOSEJOINT) Inverse variance weighted 13 -1.666276193 0.795074528 0.036104513
White wine (👉 📊) Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) Weighted median 13 1.543915386 0.781181351 0.048111148
White wine (👉 📊) Peroneal tendinitis (finn-b-M13_PERONEALTEND) Inverse variance weighted 13 2.850740271 1.240662436 0.021575648
White wine (👉 📊) Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) MR Egger 13 9.557285429 4.131840323 0.041075219
White wine (👉 📊) Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) MR Egger 13 -8.154475141 3.56625176 0.043036588
White wine (👉 📊) Contusion of ankle (finn-b-ST19_CONTU_ANKLE) Inverse variance weighted 13 -1.380652138 0.699477089 0.048400544
White wine (👉 📊) Crushing injury of wrist and hand (finn-b-ST19_CRUSHI_INJURY_WRIST_HAND) MR Egger 13 6.402048231 2.772234503 0.041346287
White wine (👉 📊) Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) Inverse variance weighted 13 0.509215747 0.231785587 0.028025743
White wine (👉 📊) Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) MR Egger 13 4.871643743 2.182880304 0.04738094
White wine (👉 📊) Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) Inverse variance weighted 13 4.243349874 1.621431434 0.008869611
White wine (👉 📊) Ankle and foot (finn-b-Z21_ANKLE_FOOT) Weighted median 13 -3.865893363 1.876531533 0.039386397
White wine (👉 📊) Femoral neck bone mineral density (ieu-a-980) Inverse variance weighted 14 -0.178066594 0.075526794 0.018390467
White wine (👉 📊) Lumbar spine bone mineral density (ieu-a-982) Weighted median 14 -0.251152274 0.12296958 0.041112512
White wine (👉 📊) Lumbar spine bone mineral density (ieu-a-982) Inverse variance weighted 14 -0.241090394 0.099461162 0.015352077
White wine (👉 📊) Lumbar spine bone mineral density (ieu-a-982) Simple mode 14 -0.547962991 0.24890777 0.046372151
White wine (👉 📊) Fractured/broken bones in last 5 years (ukb-a-308) Weighted median 14 0.018720305 0.009021544 0.03798037
White wine (👉 📊) Fracture resulting from simple fall (ukb-b-15251) MR Egger 14 0.161275383 0.073612217 0.048930806
White wine (👉 📊) Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) Weighted median 7 -0.005954202 0.002972105 0.045138427
White wine (👉 📊) Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) Inverse variance weighted 7 -0.004797553 0.002294917 0.03657176
White wine (👉 📊) Operation code: reduction or fixation of bone fracture (ukb-b-847) Weighted median 14 0.011009955 0.005462389 0.043842505
White wine (👉 📊) Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) Inverse variance weighted 14 0.002734066 0.001335359 0.040615079
White wine (👉 📊) Ankle spacing width (left) (ukb-e-4100_CSA) Weighted median 12 0.508209345 0.227105432 0.025236166
White wine (👉 📊) Ankle spacing width (left) (ukb-e-4100_CSA) Inverse variance weighted 12 0.502738868 0.16404627 0.002179494
White wine (👉 📊) Ankle spacing width (left) (ukb-e-4100_EAS) Inverse variance weighted 9 -0.55879018 0.276522855 0.043303172

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
White wine Frozen shoulder (ebi-a-GCST90000512) rs10766353 0.959487996289988 0.412454487485611 0.0200031825226841
White wine Frozen shoulder (ebi-a-GCST90000512) rs2988328 -1.19622991631223 0.464871344975518 0.0100748574317926
White wine Frozen shoulder (ebi-a-GCST90000512) rs4920553 1.07805439158656 0.47430367266453 0.0230309901551143
White wine Shoulder impingement (ebi-a-GCST90014054) All - Inverse variance weighted -0.465749206414526 0.227316073028814 0.0404713331327138
White wine Neck circumference (BMI adjusted) (ebi-a-GCST90017136) rs4551638 -1.71351084812623 0.825936883629191 0.0380211302072903
White wine Neck circumference (BMI adjusted) (ebi-a-GCST90017136) rs59696398 2.81407499884404 1.2660100799926 0.0262299395652749
White wine Neck circumference (BMI adjusted) (ebi-a-GCST90017136) All - MR Egger 1.32009084749286 0.577157491721621 0.039585339679941
White wine Joint disorder (ebi-a-GCST90038654) rs1229984 -0.0757967205085316 0.0238981082234562 0.0015156933033287
White wine Joint disorder (ebi-a-GCST90038654) All - Inverse variance weighted -0.0136722680674506 0.0059122672429038 0.0207487481976449
White wine Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) rs1229984 -2.749751238458 1.39686887383837 0.0490093132884874
White wine Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) All - Inverse variance weighted -0.447561867038355 0.181860339807763 0.0138542783849149
White wine Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs72805122 -1.45307553031774 0.411247791599359 0.0004103547314102
White wine Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) rs7644783 -0.940693547697439 0.427587976226109 0.0278068950269972
White wine Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) All - Inverse variance weighted -0.365489766733061 0.148127671404981 0.0136099383888146
White wine Loose body in joint (finn-b-M13_LOOSEJOINT) rs72805122 -6.26083637930864 2.59579606057515 0.0158690322078888
White wine Loose body in joint (finn-b-M13_LOOSEJOINT) All - Inverse variance weighted -1.66627619308027 0.795074527658671 0.0361045132305103
White wine Peroneal tendinitis (finn-b-M13_PERONEALTEND) rs73137883 13.350391294158 5.84223077536405 0.0223038568819154
White wine Peroneal tendinitis (finn-b-M13_PERONEALTEND) All - Inverse variance weighted 2.85074027103037 1.24066243619023 0.0215756475362324
White wine Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) rs73137883 18.8676510028196 7.63621603206703 0.0134806825646896
White wine Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) All - MR Egger 9.55728542858219 4.13184032308367 0.0410752189705644
White wine Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) rs339866 10.5108395017036 4.20751128089345 0.0124856313891569
White wine Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) rs4551638 10.6971153846154 4.43786982248521 0.0159343110272432
White wine Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) All - MR Egger -8.15447514126223 3.56625176000659 0.043036587993802
White wine Contusion of ankle (finn-b-ST19_CONTU_ANKLE) All - Inverse variance weighted -1.38065213764412 0.699477088599897 0.0484005436976214
White wine Crushing injury of wrist and hand (finn-b-ST19_CRUSHI_INJURY_WRIST_HAND) All - MR Egger 6.40204823139392 2.7722345031505 0.0413462871219796
White wine Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) rs116453290 1.41383696717792 0.673834428483076 0.0358878001461724
White wine Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) rs339866 1.50517762048566 0.701781126850908 0.0319691307708373
White wine Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) All - Inverse variance weighted 0.509215746661884 0.231785587490809 0.0280257429981427
White wine Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) rs59696398 6.11642853840107 2.42659638414944 0.0117161845992634
White wine Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) All - MR Egger 4.87164374296613 2.18288030443848 0.0473809398807812
White wine Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) rs116453290 9.97788094601492 4.67362917230446 0.0327665567851102
White wine Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) All - Inverse variance weighted 4.24334987353135 1.62143143370096 0.0088696114396579
White wine Femoral neck bone mineral density (ieu-a-980) rs73234113 -0.694536978247067 0.284736416376019 0.0147186872235382
White wine Femoral neck bone mineral density (ieu-a-980) rs7644783 -0.690028319480579 0.259216987741382 0.007768437931186
White wine Femoral neck bone mineral density (ieu-a-980) All - Inverse variance weighted -0.178066594103379 0.0755267938457185 0.0183904669697538
White wine Lumbar spine bone mineral density (ieu-a-982) rs72805122 -0.666583320447569 0.302195843874985 0.0273980693503048
White wine Lumbar spine bone mineral density (ieu-a-982) rs72863217 -0.660891796375667 0.318339724791338 0.0378885684355617
White wine Lumbar spine bone mineral density (ieu-a-982) rs73234113 -0.705678724570116 0.341662825185043 0.0388828649413075
White wine Lumbar spine bone mineral density (ieu-a-982) All - Inverse variance weighted -0.241090394330298 0.0994611623345643 0.0153520773582785
White wine Fracture resulting from simple fall (ukb-b-15251) rs1229984 0.256692190730259 0.117452658033423 0.0288525759869625
White wine Fracture resulting from simple fall (ukb-b-15251) All - MR Egger 0.161275383007889 0.0736122172589629 0.0489308061440333
White wine Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) All - Inverse variance weighted -0.0047975527580027 0.0022949167070973 0.0365717595218404
White wine Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) rs339866 0.0107029560545293 0.0046760851409754 0.0220868439299962
White wine Diagnoses - main ICD10: S02 Fracture of skull and facial bones (ukb-d-S02) All - Inverse variance weighted 0.0027340658137559 0.0013353593817907 0.0406150785621086
White wine Ankle spacing width (left) (ukb-e-4100_CSA) All - Inverse variance weighted 0.502738868071009 0.164046270002169 0.0021794943885671
White wine Ankle spacing width (left) (ukb-e-4100_EAS) rs1229984 -1.48840836599629 0.471131178469911 0.0015819050010933
White wine Ankle spacing width (left) (ukb-e-4100_EAS) All - Inverse variance weighted -0.558790179711495 0.276522855393821 0.043303171775545