ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Standard tea (ukb-b-3291)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Standard tea (👉 📊) Osteoporosis (bbj-a-137) Weighted median 8 0.002907646 0.001382607 0.035464231
Standard tea (👉 📊) Total body bone mineral density (ebi-a-GCST005348) Weighted median 15 0.000862872 0.000437535 0.048595983
Standard tea (👉 📊) Total body bone mineral density (ebi-a-GCST005348) Inverse variance weighted 15 0.00069663 0.000333167 0.036533826
Standard tea (👉 📊) Osteoarthritis of the hip or knee (ebi-a-GCST007092) Inverse variance weighted 15 0.001197633 0.000605983 0.048115537
Standard tea (👉 📊) Osteoarthritis (Firth correction) (ebi-a-GCST90013881) Weighted median 14 0.001821077 0.000731984 0.012851185
Standard tea (👉 📊) Osteoarthritis (Firth correction) (ebi-a-GCST90013881) Inverse variance weighted 14 0.001423121 0.000720925 0.048379504
Standard tea (👉 📊) Osteoarthritis (SPA correction) (ebi-a-GCST90013931) Weighted median 14 0.001804414 0.00070525 0.010511135
Standard tea (👉 📊) Neck circumference (ebi-a-GCST90017134) Weighted median 14 0.01173809 0.004759499 0.013653791
Standard tea (👉 📊) Neck circumference (ebi-a-GCST90017134) Weighted mode 14 0.012972214 0.005645199 0.038808337
Standard tea (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017136) Weighted median 14 0.004444361 0.001948428 0.022548546
Standard tea (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017136) Inverse variance weighted 14 0.003153418 0.001464642 0.031316329
Standard tea (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017137) Weighted median 14 0.01173809 0.00484349 0.015372683
Standard tea (👉 📊) Rheumatoid arthritis (ebi-a-GCST90018910) Inverse variance weighted 15 0.001451565 0.00069938 0.037940128
Standard tea (👉 📊) Bone disorder (ebi-a-GCST90038652) MR Egger 15 -8.46e-05 3.88e-05 0.04816113
Standard tea (👉 📊) Osteoporosis (ebi-a-GCST90038656) MR Egger 15 -8.02e-05 3.31e-05 0.030696353
Standard tea (👉 📊) Rheumatoid arthritis (ebi-a-GCST90038685) Weighted median 15 4.13e-05 1.68e-05 0.013740705
Standard tea (👉 📊) Rheumatoid arthritis (ebi-a-GCST90038685) Inverse variance weighted 15 2.82e-05 1.14e-05 0.013325208
Standard tea (👉 📊) Rheumatoid arthritis (ebi-a-GCST90038685) Weighted mode 15 5.36e-05 2.41e-05 0.043361681
Standard tea (👉 📊) Fracture of forearm or wrist (ebi-a-GCST90038705) MR Egger 15 5.36e-05 2.05e-05 0.021193907
Standard tea (👉 📊) Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) Weighted median 14 0.018672896 0.009158835 0.041471472
Standard tea (👉 📊) Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) Inverse variance weighted 14 -0.009647313 0.004899084 0.048929277
Standard tea (👉 📊) Calcific tendinitis (finn-b-M13_CALCTENDINITIS) Inverse variance weighted 14 -0.014621354 0.006799322 0.031522513
Standard tea (👉 📊) Osteomyelitis (finn-b-M13_OSTEOMYELITIS) MR Egger 14 0.022285801 0.007130993 0.008769647
Standard tea (👉 📊) Osteonecrosis (finn-b-M13_OSTEONECROSIS) Weighted median 14 0.008785781 0.004269049 0.039588381
Standard tea (👉 📊) Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) Inverse variance weighted 14 0.01316854 0.006535001 0.043896422
Standard tea (👉 📊) Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) Inverse variance weighted 14 -0.008209059 0.003596467 0.022457805
Standard tea (👉 📊) Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) Weighted median 14 0.007809768 0.003624311 0.031175286
Standard tea (👉 📊) Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) Inverse variance weighted 14 0.005793776 0.002666852 0.02981686
Standard tea (👉 📊) Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) Weighted median 14 0.003224371 0.00163155 0.048125064
Standard tea (👉 📊) Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) Inverse variance weighted 14 0.003215031 0.001170549 0.00602164
Standard tea (👉 📊) Fracture of femur (finn-b-ST19_FRACT_FEMUR) Inverse variance weighted 14 0.002636138 0.001261366 0.036626136
Standard tea (👉 📊) Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) MR Egger 14 0.005127946 0.002111838 0.03183758
Standard tea (👉 📊) Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) Weighted median 14 0.001928615 0.000880051 0.028416996
Standard tea (👉 📊) Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) Weighted median 14 0.021298621 0.009324112 0.022356725
Standard tea (👉 📊) Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) Inverse variance weighted 14 0.015646252 0.006914073 0.023638331
Standard tea (👉 📊) Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) Weighted mode 14 0.031685316 0.014432986 0.046897052
Standard tea (👉 📊) Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) Weighted median 14 0.007427897 0.002883431 0.009993286
Standard tea (👉 📊) Knee osteoarthritis (ieu-a-1171) Weighted median 6 0.005312547 0.00267997 0.047443928
Standard tea (👉 📊) Osteomyelitis (ieu-b-4975) MR Egger 15 -0.006238285 0.002740983 0.04042247
Standard tea (👉 📊) Osteomyelitis (ieu-b-4975) Inverse variance weighted 15 -0.002895793 0.001122012 0.009854545
Standard tea (👉 📊) Psoriatic arthritis (ieu-b-5116) Inverse variance weighted 15 0.003407603 0.001342458 0.011138227
Standard tea (👉 📊) Bone morphogenetic protein 7 (prot-a-257) Weighted median 15 0.003555738 0.001780043 0.045764659
Standard tea (👉 📊) Alkaline phosphatase, bone (prot-c-2795_23_3) Wald ratio 1 0.024340631 0.010120843 0.01617245
Standard tea (👉 📊) Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) Weighted median 15 5.16e-05 1.89e-05 0.006281194
Standard tea (👉 📊) Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) Inverse variance weighted 15 3.32e-05 1.33e-05 0.012640654
Standard tea (👉 📊) Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) Weighted median 15 0.000168347 6.21e-05 0.006712633
Standard tea (👉 📊) Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) Weighted mode 15 0.000231723 7.45e-05 0.007696301
Standard tea (👉 📊) Pain type(s) experienced in last month: Knee pain (ukb-a-476) MR Egger 15 0.00034451 0.000157812 0.047967008
Standard tea (👉 📊) Pain type(s) experienced in last month: Knee pain (ukb-a-476) Inverse variance weighted 15 0.00015697 6.53e-05 0.016242502
Standard tea (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC (ukb-b-10298) Weighted median 7 2.12e-05 1.01e-05 0.036773878
Standard tea (👉 📊) Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC (ukb-b-10298) Weighted mode 7 2.68e-05 1.08e-05 0.047665683
Standard tea (👉 📊) Operation code: knee replacement/revision (ukb-b-11120) MR Egger 8 0.000218855 6.87e-05 0.018901996
Standard tea (👉 📊) Operation code: knee replacement/revision (ukb-b-11120) Weighted median 8 8.89e-05 2.47e-05 0.000313537
Standard tea (👉 📊) Operation code: knee replacement/revision (ukb-b-11120) Inverse variance weighted 8 6.72e-05 2.55e-05 0.008507113
Standard tea (👉 📊) Operation code: knee replacement/revision (ukb-b-11120) Weighted mode 8 0.000110257 2.64e-05 0.004145472
Standard tea (👉 📊) Non-cancer illness code, self-reported: fracture lower leg / ankle (ukb-b-13979) Inverse variance weighted 8 -2.24e-05 9.01e-06 0.013011874
Standard tea (👉 📊) Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) Weighted median 15 0.000103735 5.26e-05 0.048418872
Standard tea (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) MR Egger 8 0.000217695 4.96e-05 0.004622942
Standard tea (👉 📊) Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) Inverse variance weighted 8 5.05e-05 2.26e-05 0.025421966
Standard tea (👉 📊) Pain type(s) experienced in last month: Knee pain (ukb-b-16254) MR Egger 15 0.000341881 0.000143043 0.032687202
Standard tea (👉 📊) Pain type(s) experienced in last month: Knee pain (ukb-b-16254) Weighted median 15 0.000217062 7.01e-05 0.001968347
Standard tea (👉 📊) Pain type(s) experienced in last month: Knee pain (ukb-b-16254) Inverse variance weighted 15 0.000173745 5.91e-05 0.003264862
Standard tea (👉 📊) Pain type(s) experienced in last month: Knee pain (ukb-b-16254) Weighted mode 15 0.00027899 0.000117162 0.031998359
Standard tea (👉 📊) Operative procedures - secondary OPCS: Z86.4 Metatarsophalangeal joint of great toe (ukb-b-17501) Weighted median 7 2.32e-05 1.11e-05 0.036366023
Standard tea (👉 📊) Fractured heel (ukb-b-18389) MR Egger 15 -4.24e-05 1.92e-05 0.045698671
Standard tea (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) Weighted mode 8 7.13e-05 2.7e-05 0.033401948
Standard tea (👉 📊) Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) Inverse variance weighted 8 2.47e-05 1.24e-05 0.045734557
Standard tea (👉 📊) Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) Inverse variance weighted 8 2.85e-05 9.02e-06 0.00156141
Standard tea (👉 📊) Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) Inverse variance weighted 8 3.16e-05 1.28e-05 0.013508673
Standard tea (👉 📊) Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) Weighted median 8 3.49e-05 1.23e-05 0.004655188
Standard tea (👉 📊) Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) Inverse variance weighted 8 2.02e-05 1e-05 0.04412411
Standard tea (👉 📊) Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) Inverse variance weighted 8 2.02e-05 9.93e-06 0.042122713
Standard tea (👉 📊) Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint (ukb-b-7012) Inverse variance weighted 4 2.34e-05 1.1e-05 0.033743033
Standard tea (👉 📊) Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) Weighted median 8 2.78e-05 1.19e-05 0.01969549
Standard tea (👉 📊) Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) Weighted median 8 5.59e-05 1.89e-05 0.003119367
Standard tea (👉 📊) Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) Inverse variance weighted 8 4.25e-05 1.45e-05 0.003355674
Standard tea (👉 📊) Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) Weighted mode 8 6.32e-05 2.64e-05 0.047549043
Standard tea (👉 📊) Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) Inverse variance weighted 15 1.83e-05 7.87e-06 0.019957033
Standard tea (👉 📊) Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) Inverse variance weighted 15 3.79e-05 1.81e-05 0.035921981
Standard tea (👉 📊) Other joint disorders (ukb-d-M13_OTHERJOINT) Inverse variance weighted 15 6.75e-05 3.26e-05 0.037979465
Standard tea (👉 📊) Rheumatoid arthritis (ukb-d-M13_RHEUMA) Inverse variance weighted 15 1.79e-05 8.19e-06 0.028585227
Standard tea (👉 📊) Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) Inverse variance weighted 15 4.27e-05 1.77e-05 0.015720624
Standard tea (👉 📊) Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) Weighted median 15 2.49e-05 1.03e-05 0.015431485
Standard tea (👉 📊) Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) Inverse variance weighted 15 1.68e-05 7.32e-06 0.021558913
Standard tea (👉 📊) Ankle spacing width (ukb-e-3143_CSA) Inverse variance weighted 12 0.003943798 0.001558132 0.011370352
Standard tea (👉 📊) Knee pain for 3+ months (ukb-e-3773_CSA) Weighted median 12 0.012318272 0.005893399 0.036601522
Standard tea (👉 📊) Ankle spacing width (left) (ukb-e-4100_AFR) Inverse variance weighted 11 -0.00322131 0.001339745 0.01619813

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Standard tea Total body bone mineral density (ebi-a-GCST005348) rs140745793 0.0033204695288631 0.0015275767808329 0.0297288592598556
Standard tea Total body bone mineral density (ebi-a-GCST005348) All - Inverse variance weighted 0.0006966298847727 0.0003331665705468 0.0365338260928515
Standard tea Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs10493552 0.0048861355902626 0.0018032167059302 0.0067348674336015
Standard tea Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs2389763 0.0029594397266682 0.0013645320895416 0.0300955039586234
Standard tea Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs2472297 0.0037227528777859 0.0008425177565515 9.93401756138994e-06
Standard tea Osteoarthritis of the hip or knee (ebi-a-GCST007092) All - Inverse variance weighted 0.001197632926672 0.0006059832500356 0.0481155368418978
Standard tea Osteoarthritis (Firth correction) (ebi-a-GCST90013881) rs10493552 0.0039888704689332 0.001903760579356 0.0361480225704506
Standard tea Osteoarthritis (Firth correction) (ebi-a-GCST90013881) rs2472297 0.0046081998530492 0.0008876923830516 2.08928933450344e-07
Standard tea Osteoarthritis (Firth correction) (ebi-a-GCST90013881) All - Inverse variance weighted 0.0014231209993007 0.0007209254331139 0.0483795042038273
Standard tea Osteoarthritis (SPA correction) (ebi-a-GCST90013931) rs10493552 0.0039976151004857 0.0019124993940804 0.0365947265394231
Standard tea Osteoarthritis (SPA correction) (ebi-a-GCST90013931) rs2472297 0.0046288611315209 0.0008954347293656 2.34845576651612e-07
Standard tea Neck circumference (ebi-a-GCST90017134) rs2472297 0.0151457261817291 0.0076414401175606 0.047473501351992
Standard tea Neck circumference (ebi-a-GCST90017134) rs729009 0.0363452844432004 0.0135075532032198 0.007129419674339
Standard tea Neck circumference (BMI adjusted) (ebi-a-GCST90017136) rs2389763 0.0107744871485887 0.0044125777960503 0.01461557342188
Standard tea Neck circumference (BMI adjusted) (ebi-a-GCST90017136) All - Inverse variance weighted 0.0031534176923882 0.0014646418523264 0.0313163291909626
Standard tea Neck circumference (BMI adjusted) (ebi-a-GCST90017137) rs2472297 0.0151457261817291 0.0076414401175606 0.047473501351992
Standard tea Neck circumference (BMI adjusted) (ebi-a-GCST90017137) rs729009 0.0363452844432004 0.0135075532032198 0.007129419674339
Standard tea Rheumatoid arthritis (ebi-a-GCST90018910) rs10801677 0.0042416354031084 0.0017150294770691 0.0133903826529816
Standard tea Rheumatoid arthritis (ebi-a-GCST90018910) All - Inverse variance weighted 0.0014515647715161 0.0006993804294822 0.0379401275044166
Standard tea Bone disorder (ebi-a-GCST90038652) rs2472297 -8.01586088660299e-05 3.37237325495959e-05 0.0174578816866364
Standard tea Bone disorder (ebi-a-GCST90038652) All - MR Egger -8.46434666221837e-05 3.88123430513347e-05 0.0481611302782788
Standard tea Osteoporosis (ebi-a-GCST90038656) rs2472297 -6.25768307616948e-05 2.87625765368602e-05 0.0295826614804904
Standard tea Osteoporosis (ebi-a-GCST90038656) All - MR Egger -8.0228066573077e-05 3.31026437275174e-05 0.0306963525998412
Standard tea Rheumatoid arthritis (ebi-a-GCST90038685) rs2472297 5.56734753857458e-05 2.43118295371051e-05 0.0220227813238916
Standard tea Rheumatoid arthritis (ebi-a-GCST90038685) All - Inverse variance weighted 2.82471884475273e-05 1.14132020178674e-05 0.0133252080244668
Standard tea Fracture of forearm or wrist (ebi-a-GCST90038705) rs115709030 9.70086192327193e-05 3.25749957748859e-05 0.0029012779537201
Standard tea Fracture of forearm or wrist (ebi-a-GCST90038705) rs2472297 4.46295371050698e-05 1.58331618907666e-05 0.0048212834416284
Standard tea Fracture of forearm or wrist (ebi-a-GCST90038705) All - MR Egger 5.36233405602459e-05 2.0468434199637e-05 0.0211939067486756
Standard tea Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) rs10493552 -0.0541352800317987 0.0200486674616332 0.0069299173491802
Standard tea Other bursitis of hip (finn-b-M13_BURSITISHIPOTH) All - Inverse variance weighted -0.009647312727158 0.0048990840883894 0.0489292774319569
Standard tea Calcific tendinitis (finn-b-M13_CALCTENDINITIS) rs10493552 -0.0557639918952195 0.0278238276667733 0.0450506553227658
Standard tea Calcific tendinitis (finn-b-M13_CALCTENDINITIS) rs729009 -0.0582075879793379 0.0279269192600321 0.037134481838394
Standard tea Calcific tendinitis (finn-b-M13_CALCTENDINITIS) All - Inverse variance weighted -0.0146213540007328 0.0067993217414293 0.0315225128657945
Standard tea Osteomyelitis (finn-b-M13_OSTEOMYELITIS) rs10969132 0.0201906826127904 0.0102996133882073 0.0499567611077259
Standard tea Osteomyelitis (finn-b-M13_OSTEOMYELITIS) rs2472297 0.0113641929953466 0.0055547391623806 0.0407706015481048
Standard tea Osteomyelitis (finn-b-M13_OSTEOMYELITIS) rs7233417 -0.0332433502181386 0.0115851407783614 0.004111450375504
Standard tea Osteomyelitis (finn-b-M13_OSTEOMYELITIS) All - MR Egger 0.0222858013548596 0.0071309928183647 0.0087696465961615
Standard tea Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) rs729009 0.0594374750841836 0.0266970321551863 0.0259893991950995
Standard tea Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) All - Inverse variance weighted 0.0131685395429026 0.0065350006943247 0.043896422245227
Standard tea Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) rs2389763 -0.0319335951344684 0.0082935197130583 0.0001179119031977
Standard tea Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) rs7233417 -0.0288405519952681 0.0107623956559058 0.0073676708567898
Standard tea Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) rs908817 -0.0212127917712681 0.0090230670034261 0.0187254807485332
Standard tea Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) All - Inverse variance weighted -0.0082090590054217 0.0035964666151556 0.0224578050293331
Standard tea Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) All - Inverse variance weighted 0.0057937759807593 0.002666852336257 0.0298168598869828
Standard tea Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) rs10493552 0.0096559346188523 0.0048085778824806 0.0446364363348544
Standard tea Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) rs2472297 0.0049767327945138 0.0024491795248591 0.0421536559466274
Standard tea Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) rs908817 0.0089658382486474 0.0043112328599879 0.0375580128435583
Standard tea Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) All - Inverse variance weighted 0.0032150311181756 0.001170549167691 0.006021640420796
Standard tea Fracture of femur (finn-b-ST19_FRACT_FEMUR) All - Inverse variance weighted 0.0026361379606339 0.0012613660316237 0.0366261360305044
Standard tea Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) All - MR Egger 0.0051279462560341 0.0021118382028151 0.0318375798484006
Standard tea Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) rs2472297 0.0363360274308107 0.0144893460690669 0.0121493821812877
Standard tea Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) All - Inverse variance weighted 0.0156462520500958 0.0069140734932395 0.023638330843637
Standard tea Superficial injury of ankle and foot (finn-b-ST19_SUPERF_INJURY_ANKLE_FOOT) rs10493552 0.0185750710137762 0.0082986747326682 0.0252003409555089
Standard tea Knee osteoarthritis (ieu-a-1171) rs10969132 0.0140870328082466 0.0064975938898995 0.0301557679516915
Standard tea Knee osteoarthritis (ieu-a-1171) rs2472297 0.0066283223120254 0.0030259319128092 0.0284875529203928
Standard tea Osteomyelitis (ieu-b-4975) rs184776680 -0.0126014939040813 0.0047234841003357 0.0076340888218332
Standard tea Osteomyelitis (ieu-b-4975) All - Inverse variance weighted -0.0028957926204514 0.0011220123818252 0.0098545446105652
Standard tea Osteomyelitis (ieu-b-4975) All - MR Egger -0.006238285070838 0.0027409833404352 0.0404224704740413
Standard tea Psoriatic arthritis (ieu-b-5116) rs10801677 0.0095439859122578 0.0046376234591532 0.0395951669513112
Standard tea Psoriatic arthritis (ieu-b-5116) All - Inverse variance weighted 0.0034076028541525 0.0013424575176082 0.0111382270441554
Standard tea Bone morphogenetic protein 7 (prot-a-257) rs2472297 0.0061425422483468 0.0027724712221405 0.0267224938749803
Standard tea Alkaline phosphatase, bone (prot-c-2795_23_3) rs10969132 0.0243406312222351 0.0101208430631351 0.0161724498006834
Standard tea Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) rs2472297 7.34881214793044e-05 2.81855498408033e-05 0.0091259957766149
Standard tea Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) All - Inverse variance weighted 3.32462444507393e-05 1.33319024856431e-05 0.0126406541227315
Standard tea Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) rs10493552 0.0003960174117053 0.0001592011556098 0.0128634146706028
Standard tea Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) rs115709030 -0.0003082593938369 0.0001552088614725 0.0470228835778974
Standard tea Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) rs149011033 -0.0003568984656025 0.000150515681205 0.017731810151217
Standard tea Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) rs2472297 0.0002724526083761 7.45325495958854e-05 0.0002566963348095
Standard tea Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs2472297 0.0004293832965956 0.0001103482733284 9.9764217268069e-05
Standard tea Pain type(s) experienced in last month: Knee pain (ukb-a-476) rs4791937 0.0004899662459872 0.0002234177314785 0.0283037800989287
Standard tea Pain type(s) experienced in last month: Knee pain (ukb-a-476) All - Inverse variance weighted 0.00015696997247 6.53110754655063e-05 0.0162425017996993
Standard tea Pain type(s) experienced in last month: Knee pain (ukb-a-476) All - MR Egger 0.0003445100638201 0.0001578118950424 0.0479670076742466
Standard tea Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC (ukb-b-10298) rs2472297 2.77290227773696e-05 1.26037717364683e-05 0.0278028143545181
Standard tea Operative procedures - secondary OPCS: W28.1 Application of internal fixation to bone NEC (ukb-b-10298) rs4791937 -7.07532101718386e-05 2.54095329514698e-05 0.005360794213561
Standard tea Operation code: knee replacement/revision (ukb-b-11120) rs2389763 0.0001063415299771 4.12264130881665e-05 0.0098957374844332
Standard tea Operation code: knee replacement/revision (ukb-b-11120) rs2472297 0.0001272387950036 2.53806514817536e-05 5.35265779301043e-07
Standard tea Operation code: knee replacement/revision (ukb-b-11120) All - Inverse variance weighted 6.7195437114442e-05 2.55374465205354e-05 0.00850711275184
Standard tea Operation code: knee replacement/revision (ukb-b-11120) All - MR Egger 0.0002188549154944 6.86658622338258e-05 0.0189019964274658
Standard tea Non-cancer illness code, self-reported: fracture lower leg / ankle (ukb-b-13979) rs908817 -6.16880193509496e-05 2.67611195470535e-05 0.0211589593496688
Standard tea Non-cancer illness code, self-reported: fracture lower leg / ankle (ukb-b-13979) All - Inverse variance weighted -2.23766920433291e-05 9.01034641358909e-06 0.0130118738605553
Standard tea Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) rs10493552 0.0003120185362921 0.000135615662779 0.0214054324285121
Standard tea Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) rs115709030 -0.0002742599008506 0.0001329037800687 0.0390559001470491
Standard tea Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) rs2472297 0.0003416713201077 6.3599510164095e-05 7.77679859928333e-08
Standard tea Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) rs2472297 0.0001183570903747 2.4329757531227e-05 1.14627710302124e-06
Standard tea Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) All - Inverse variance weighted 5.0450914783162e-05 2.25738265829325e-05 0.0254219663721955
Standard tea Operative procedures - main OPCS: W40.1 Primary total prosthetic replacement of knee joint using cement (ukb-b-16240) All - MR Egger 0.0002176954020795 4.96001485496545e-05 0.0046229423193972
Standard tea Pain type(s) experienced in last month: Knee pain (ukb-b-16254) rs2472297 0.000425680137154 9.46654910604947e-05 6.90237193148396e-06
Standard tea Pain type(s) experienced in last month: Knee pain (ukb-b-16254) All - Inverse variance weighted 0.0001737445748453 5.90639803154155e-05 0.0032648622835564
Standard tea Pain type(s) experienced in last month: Knee pain (ukb-b-16254) All - MR Egger 0.0003418805425213 0.00014304253436 0.0326872017603204
Standard tea Operative procedures - secondary OPCS: Z86.4 Metatarsophalangeal joint of great toe (ukb-b-17501) rs4791937 6.11282023037704e-05 2.64174324919746e-05 0.0206713280691161
Standard tea Fractured heel (ukb-b-18389) rs149011033 -7.19515793615108e-05 3.31840152877698e-05 0.0301388953915686
Standard tea Fractured heel (ukb-b-18389) rs908817 6.19728277872311e-05 2.99699358274896e-05 0.0386557122321335
Standard tea Fractured heel (ukb-b-18389) All - MR Egger -4.23913382897013e-05 1.91865397307912e-05 0.0456986714812828
Standard tea Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) rs10493552 0.0001411015133447 5.42696487605309e-05 0.0093221625213616
Standard tea Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) rs2472297 7.50042615723732e-05 2.54467793289248e-05 0.0032035965885905
Standard tea Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) rs4791937 8.18534808333858e-05 3.91365581922326e-05 0.0364847093853743
Standard tea Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) All - Inverse variance weighted 2.46935354961509e-05 1.23601479341499e-05 0.0457345571847086
Standard tea Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) rs2389763 5.94328154018458e-05 2.44596807349334e-05 0.0151059925819723
Standard tea Operative procedures - main OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-4944) All - Inverse variance weighted 2.85329400915759e-05 9.02078719546378e-06 0.0015614102300789
Standard tea Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) rs4791937 8.62149477560269e-05 4.32820466419085e-05 0.0463783823810603
Standard tea Non-cancer illness code, self-reported: spine arthritis/spondylitis (ukb-b-5389) All - Inverse variance weighted 3.1598095331119e-05 1.27923902035476e-05 0.0135086731739319
Standard tea Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) rs2389763 5.76679614953854e-05 2.52364007542141e-05 0.0223063559042028
Standard tea Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) rs2472297 3.49663482733284e-05 1.55362233651727e-05 0.0244087455230745
Standard tea Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) All - Inverse variance weighted 2.02207288316087e-05 1.00455211333432e-05 0.0441241100216528
Standard tea Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) All - Inverse variance weighted 2.01860964090157e-05 9.93260803327442e-06 0.042122712827511
Standard tea Operative procedures - secondary OPCS: Z67.6 Lumbosacral joint (ukb-b-7012) All - Inverse variance weighted 2.33874521495779e-05 1.10155580781378e-05 0.0337430332894097
Standard tea Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) rs2472297 3.02554004408523e-05 1.49675238795004e-05 0.0432380452811996
Standard tea Operative procedures - main OPCS: W84.8 Other specified therapeutic endoscopic operations on other joint structure (ukb-b-8566) rs7233417 6.78426733435028e-05 3.12200643075377e-05 0.0297767649759698
Standard tea Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) rs2472297 6.62469752632868e-05 2.43369091354396e-05 0.0064872745438317
Standard tea Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) rs702841 0.0001093591076395 5.21981572696641e-05 0.0361642351558999
Standard tea Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) All - Inverse variance weighted 4.25341604757057e-05 1.45013056867767e-05 0.003355673992495
Standard tea Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) rs908817 6.88444751360137e-05 3.0439593141706e-05 0.0237174735350706
Standard tea Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) All - Inverse variance weighted 1.83106863328612e-05 7.86827205004253e-06 0.0199570327174476
Standard tea Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) All - Inverse variance weighted 3.79046936295443e-05 1.80687018903402e-05 0.0359219811328986
Standard tea Other joint disorders (ukb-d-M13_OTHERJOINT) rs10493552 0.0004180185944604 0.0001468638571387 0.0044230505626179
Standard tea Other joint disorders (ukb-d-M13_OTHERJOINT) All - Inverse variance weighted 6.75441824442443e-05 3.25502165816167e-05 0.0379794654053108
Standard tea Rheumatoid arthritis (ukb-d-M13_RHEUMA) rs2472297 3.67403379867744e-05 1.73167768797453e-05 0.0338661778652481
Standard tea Rheumatoid arthritis (ukb-d-M13_RHEUMA) rs908817 6.91119241833457e-05 3.16923305838096e-05 0.0292045414243581
Standard tea Rheumatoid arthritis (ukb-d-M13_RHEUMA) All - Inverse variance weighted 1.79337452130696e-05 8.19206765570096e-06 0.0285852271558748
Standard tea Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) rs10801677 0.0001556105964321 7.59654697190108e-05 0.0405170477443582
Standard tea Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) All - Inverse variance weighted 4.27249376789204e-05 1.76890115943218e-05 0.0157206241546099
Standard tea Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) rs908817 6.39748803919025e-05 2.83280428528916e-05 0.0239233089763709
Standard tea Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) All - Inverse variance weighted 1.68273969438023e-05 7.32246599192744e-06 0.0215589126701187
Standard tea Ankle spacing width (ukb-e-3143_CSA) All - Inverse variance weighted 0.0039437976685941 0.0015581322447055 0.0113703523464333
Standard tea Ankle spacing width (left) (ukb-e-4100_AFR) rs10801677 -0.0058226782022816 0.0024102289258096 0.0156998389849544
Standard tea Ankle spacing width (left) (ukb-e-4100_AFR) All - Inverse variance weighted -0.0032213099244136 0.0013397448400346 0.0161981301161105