ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Pure fruit/vegetable juice (ukb-b-337)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Pure fruit/vegetable juice (👉 📊) Knee osteoarthritis (ebi-a-GCST007090) Inverse variance weighted 8 0.406135492 0.20063941 0.042948963
Pure fruit/vegetable juice (👉 📊) Osteoarthritis of the hip or knee (ebi-a-GCST007092) Inverse variance weighted 8 0.317227739 0.145139656 0.028839582
Pure fruit/vegetable juice (👉 📊) Rheumatoid arthritis (ebi-a-GCST90018910) Inverse variance weighted 8 0.514874847 0.257180845 0.045285235
Pure fruit/vegetable juice (👉 📊) Fracture of upper limb or shoulder (ebi-a-GCST90038704) Weighted median 8 0.009460393 0.00459723 0.039604911
Pure fruit/vegetable juice (👉 📊) Fracture of upper limb or shoulder (ebi-a-GCST90038704) Inverse variance weighted 8 0.008892147 0.003569634 0.012736527
Pure fruit/vegetable juice (👉 📊) Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) Weighted median 8 -6.411220021 3.08221339 0.0375191
Pure fruit/vegetable juice (👉 📊) Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) Weighted median 8 2.697841298 1.311488791 0.039678243
Pure fruit/vegetable juice (👉 📊) Bicipital tendinitis (finn-b-M13_BICIPITALTEND) MR Egger 8 6.773465346 2.646411215 0.042938114
Pure fruit/vegetable juice (👉 📊) Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) Weighted median 8 6.251949355 2.3049167 0.006678978
Pure fruit/vegetable juice (👉 📊) Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) Inverse variance weighted 8 5.375393826 1.929202671 0.00533087
Pure fruit/vegetable juice (👉 📊) Other juvenile arthritis (finn-b-M13_JUVEARTH) Weighted median 8 3.60954293 1.438487768 0.012098366
Pure fruit/vegetable juice (👉 📊) Other juvenile arthritis (finn-b-M13_JUVEARTH) Inverse variance weighted 8 2.379249938 1.148094455 0.038233105
Pure fruit/vegetable juice (👉 📊) Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) Weighted median 8 -6.144175465 2.139803686 0.004086924
Pure fruit/vegetable juice (👉 📊) Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) Inverse variance weighted 8 -5.337217197 2.221494282 0.016281888
Pure fruit/vegetable juice (👉 📊) Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) Inverse variance weighted 8 -5.864902035 2.446018271 0.016496824
Pure fruit/vegetable juice (👉 📊) Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) Inverse variance weighted 8 0.009047649 0.004504436 0.044578668
Pure fruit/vegetable juice (👉 📊) Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) Weighted median 8 0.005129097 0.002472876 0.038066084
Pure fruit/vegetable juice (👉 📊) Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) Inverse variance weighted 8 0.005195426 0.001982167 0.008765067
Pure fruit/vegetable juice (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) Weighted median 8 -0.207450422 0.094526268 0.028189968
Pure fruit/vegetable juice (👉 📊) Heel bone mineral density (BMD) (right) (ukb-b-4657) Weighted median 8 -0.207400171 0.093758903 0.026962629
Pure fruit/vegetable juice (👉 📊) Other joint disorders (ukb-d-M13_OTHERJOINT) MR Egger 8 0.068853802 0.028011062 0.04924673
Pure fruit/vegetable juice (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_AFR) Weighted median 6 1.622698699 0.789090166 0.039742306
Pure fruit/vegetable juice (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_AFR) Inverse variance weighted 6 1.592848139 0.614481687 0.009536941
Pure fruit/vegetable juice (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_AFR) Weighted median 6 1.547975426 0.771861124 0.044908522
Pure fruit/vegetable juice (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_AFR) Inverse variance weighted 6 1.603006217 0.61549384 0.009202914
Pure fruit/vegetable juice (👉 📊) M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) Inverse variance weighted 6 2.818408817 1.365482896 0.039014098
Pure fruit/vegetable juice (👉 📊) M75 Shoulder lesions (ukb-e-M75_CSA) Inverse variance weighted 6 3.677194836 1.829129452 0.044393902

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Pure fruit/vegetable juice Knee osteoarthritis (ebi-a-GCST007090) rs79620739 1.00775697310745 0.501910211215627 0.0446599632470269
Pure fruit/vegetable juice Knee osteoarthritis (ebi-a-GCST007090) All - Inverse variance weighted 0.406135492383063 0.200639409715123 0.0429489628545081
Pure fruit/vegetable juice Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs67447337 0.920384272871549 0.41292916026129 0.0258195167837651
Pure fruit/vegetable juice Osteoarthritis of the hip or knee (ebi-a-GCST007092) All - Inverse variance weighted 0.317227739015071 0.1451396560283 0.0288395821992144
Pure fruit/vegetable juice Rheumatoid arthritis (ebi-a-GCST90018910) All - Inverse variance weighted 0.514874846936008 0.257180845000263 0.0452852353458235
Pure fruit/vegetable juice Fracture of upper limb or shoulder (ebi-a-GCST90038704) All - Inverse variance weighted 0.0088921469838646 0.0035696344097812 0.0127365271845961
Pure fruit/vegetable juice Bicipital tendinitis (finn-b-M13_BICIPITALTEND) rs144173039 8.79760115787068 4.29215459512614 0.0403943546478503
Pure fruit/vegetable juice Bicipital tendinitis (finn-b-M13_BICIPITALTEND) All - MR Egger 6.77346534600488 2.64641121513285 0.0429381137157928
Pure fruit/vegetable juice Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) rs143987628 14.279350887675 5.19988690679413 0.0060310447846877
Pure fruit/vegetable juice Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) rs7628760 11.232497307278 3.5639578646195 0.0016232742990487
Pure fruit/vegetable juice Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) rs9599935 6.78091255364415 3.42518332224505 0.0477347167945431
Pure fruit/vegetable juice Other disorders of bone density and structure (finn-b-M13_BONEDENSOTH) All - Inverse variance weighted 5.37539382647384 1.92920267083819 0.0053308695201756
Pure fruit/vegetable juice Other juvenile arthritis (finn-b-M13_JUVEARTH) All - Inverse variance weighted 2.37924993761506 1.14809445470192 0.0382331053262834
Pure fruit/vegetable juice Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) rs67447337 -17.2634239289961 5.04967587548445 0.0006291661550502
Pure fruit/vegetable juice Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) rs79620739 -7.69398829663484 3.41889426228056 0.0244215495948349
Pure fruit/vegetable juice Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) rs9599935 -7.01851865390661 3.55312506854022 0.0482331331225099
Pure fruit/vegetable juice Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) All - Inverse variance weighted -5.33721719690271 2.22149428164193 0.0162818877549017
Pure fruit/vegetable juice Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) rs79620739 -12.6737249020291 5.42653510714307 0.0195168143677771
Pure fruit/vegetable juice Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) All - Inverse variance weighted -5.86490203526211 2.44601827098942 0.0164968243758798
Pure fruit/vegetable juice Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) All - Inverse variance weighted 0.0090476490440429 0.0045044362711674 0.0445786677083971
Pure fruit/vegetable juice Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) rs12404769 0.0129695575700176 0.0055228318224868 0.0188566509782076
Pure fruit/vegetable juice Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) rs7628760 0.0098748664035631 0.0047561163255885 0.0378712260657285
Pure fruit/vegetable juice Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) All - Inverse variance weighted 0.0051954261496942 0.0019821670146465 0.0087650674926513
Pure fruit/vegetable juice Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) rs144173039 -0.426520224649072 0.181850792573561 0.019004608618239
Pure fruit/vegetable juice Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) rs79620739 0.430701946033827 0.184891715332274 0.019833538839294
Pure fruit/vegetable juice Heel bone mineral density (BMD) (right) (ukb-b-4657) rs144173039 -0.402761715476825 0.181839712471348 0.0267650654647262
Pure fruit/vegetable juice Heel bone mineral density (BMD) (right) (ukb-b-4657) rs79620739 0.472779736211739 0.184970249518265 0.0105890063848217
Pure fruit/vegetable juice Other joint disorders (ukb-d-M13_OTHERJOINT) All - MR Egger 0.068853801695736 0.0280110619689125 0.0492467295626663
Pure fruit/vegetable juice Heel bone mineral density (BMD) (ukb-e-3148_AFR) All - Inverse variance weighted 1.59284813883793 0.614481687367265 0.0095369407926969
Pure fruit/vegetable juice Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_AFR) All - Inverse variance weighted 1.60300621700758 0.615493839926536 0.0092029139192566
Pure fruit/vegetable juice M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) All - Inverse variance weighted 2.81840881678199 1.36548289622781 0.03901409759021
Pure fruit/vegetable juice M75 Shoulder lesions (ukb-e-M75_CSA) All - Inverse variance weighted 3.67719483612568 1.82912945210163 0.0443939015768831