ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Cake | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | rs35268725 | -1.75407590686166 | 0.698095700967614 | 0.0119825357287868 |
| Cake | Total body bone mineral density (age 45-60) (ebi-a-GCST005350) | All - Inverse variance weighted | -0.541138406437163 | 0.233719687981119 | 0.0205948320695517 |
| Cake | Heel bone mineral density (ebi-a-GCST006979) | rs13262758 | 0.233607510767948 | 0.106682281018638 | 0.0285423823054058 |
| Cake | Heel bone mineral density (ebi-a-GCST006979) | rs71489608 | -0.669338412683505 | 0.100817078825801 | 3.1552472383264594e-11 |
| Cake | Heel bone mineral density (ebi-a-GCST006979) | rs73090823 | 0.209116475520381 | 0.104949660745836 | 0.0463117589491822 |
| Cake | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | rs73090823 | 4.66278449780975 | 2.32930131415249 | 0.0453067481987563 |
| Cake | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | All - Inverse variance weighted | 1.65792807896442 | 0.648700572737394 | 0.01059537756313 |
| Cake | Melanocytic naevi of upper limb, including shoulder (finn-b-CD2_BENIGN_MELANOCYTIC_UPPERLIMB) | All - Inverse variance weighted | -4.01432255481697 | 1.47874966895988 | 0.0066341137790719 |
| Cake | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | rs144092251 | -0.809893477369351 | 0.382277964508943 | 0.0341244225300067 |
| Cake | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | rs73090823 | -2.41921150850488 | 0.73600903283813 | 0.0010128535362383 |
| Cake | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | rs75120634 | -2.95286845273729 | 1.28024896470235 | 0.0210838342204226 |
| Cake | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | All - Inverse variance weighted | -0.668570833518152 | 0.253662954840107 | 0.0083972333427 |
| Cake | Gonarthrosis [arthrosis of knee](FG) (finn-b-KNEE_ARTHROSIS) | All - MR Egger | -1.36182899150492 | 0.516464570660118 | 0.0298599170926176 |
| Cake | Cervical disc disorders (finn-b-M13_CERVICDISC) | All - Inverse variance weighted | 0.685470853377734 | 0.304472527274606 | 0.0243640789708465 |
| Cake | Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) | All - Inverse variance weighted | -3.57938528263098 | 1.81821505828133 | 0.0489960644117845 |
| Cake | Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) | rs13262758 | -1.40529167741807 | 0.686766836704313 | 0.0407324908103124 |
| Cake | Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) | rs144092251 | -0.845957436285289 | 0.39155155394447 | 0.0307319486616349 |
| Cake | Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) | All - Inverse variance weighted | -0.616934523110236 | 0.223873139244425 | 0.0058560838255739 |
| Cake | Other joint disorders (finn-b-M13_OTHERJOINT) | rs73090823 | -1.26292459043816 | 0.552006774628598 | 0.0221445809237508 |
| Cake | Other joint disorders (finn-b-M13_OTHERJOINT) | All - Inverse variance weighted | -0.436155311359711 | 0.165230105972145 | 0.0082983297066856 |
| Cake | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | rs1468944 | 11.8720044826448 | 5.68835613011677 | 0.036881695337264 |
| Cake | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | rs35268725 | 18.3095480051253 | 6.4949410153316 | 0.0048166371937554 |
| Cake | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | All - Inverse variance weighted | 5.80513111248677 | 2.08379300958328 | 0.0053387858092583 |
| Cake | Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) | rs144092251 | -3.30551943435226 | 1.6774892890042 | 0.0487792664756115 |
| Cake | Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) | rs75120634 | -13.338355676032 | 5.65013553598935 | 0.0182397771779541 |
| Cake | Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) | All - Inverse variance weighted | -2.38678014469109 | 0.861951172746626 | 0.0056221157921719 |
| Cake | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | rs35268725 | -1.02505191534485 | 0.428577740467459 | 0.0167681420152518 |
| Cake | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | All - Inverse variance weighted | -0.289426447148131 | 0.118088229583514 | 0.014248610927639 |
| Cake | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | rs144092251 | -3.05410212076686 | 1.03452042147434 | 0.0031552745285153 |
| Cake | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | rs71489608 | -3.29590345321461 | 1.37647259087947 | 0.0166450272663559 |
| Cake | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | All - Inverse variance weighted | -1.87517848805291 | 0.529096475868918 | 0.000393934136205 |
| Cake | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | All - MR Egger | -3.20725323211152 | 1.15084886192088 | 0.0236727320316228 |
| Cake | Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) | rs71489608 | -2.09846034643673 | 0.971455069469309 | 0.0307633156573441 |
| Cake | Dislocation, sprain and strain of joints and ligaments at wrist and hand level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_WRIST_HAND_LEVEL) | All - Inverse variance weighted | -0.797530419796122 | 0.404009649573334 | 0.0483774168413027 |
| Cake | Injuries to the neck (finn-b-ST19_INJURI_NECK) | rs144092251 | -2.62030421494944 | 0.830501453892744 | 0.0016045033545225 |
| Cake | Injuries to the neck (finn-b-ST19_INJURI_NECK) | rs71489608 | -3.1726372510463 | 1.10352600036393 | 0.004040274979892 |
| Cake | Injuries to the neck (finn-b-ST19_INJURI_NECK) | All - Inverse variance weighted | -1.64088760461552 | 0.425040132353132 | 0.0001131332616828 |
| Cake | Injuries to the neck (finn-b-ST19_INJURI_NECK) | All - MR Egger | -2.46079008802795 | 0.92499851783238 | 0.0287912805414308 |
| Cake | Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) | All - Inverse variance weighted | -0.498354913872893 | 0.192664900240204 | 0.0096916532795898 |
| Cake | Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) | All - Inverse variance weighted | -0.731629665344396 | 0.335898530602373 | 0.0293965815075294 |
| Cake | Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) | rs1468944 | -8.43997958795689 | 3.76722266137021 | 0.0250667924867639 |
| Cake | Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) | rs4233064 | -7.29896812446855 | 3.69085101004298 | 0.0479756489767085 |
| Cake | Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) | All - Inverse variance weighted | -3.6938580605669 | 1.18488451801156 | 0.0018240209073872 |
| Cake | Psoriatic arthritis (ieu-b-5116) | rs13262758 | -3.14288719953951 | 1.31779837637205 | 0.0170813031832041 |
| Cake | Psoriatic arthritis (ieu-b-5116) | rs16863585 | -2.99638772496462 | 1.05403617299838 | 0.0044722624630711 |
| Cake | Psoriatic arthritis (ieu-b-5116) | rs4233064 | -2.57039965067911 | 1.20630616137706 | 0.0331054527873674 |
| Cake | Psoriatic arthritis (ieu-b-5116) | All - Inverse variance weighted | -1.48450500186855 | 0.515982875262439 | 0.0040142068712038 |
| Cake | Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) | All - Inverse variance weighted | -0.0076002374519495 | 0.0037590013671805 | 0.0431890866766225 |
| Cake | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs4233064 | 0.715730930986142 | 0.217376875876175 | 0.0009927236310297 |
| Cake | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs71489608 | -0.751383809864818 | 0.225364075532833 | 0.0008557937310488 |
| Cake | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs75120634 | 0.476102393011769 | 0.237321387332486 | 0.0448402053446017 |
| Cake | Fractured bone site(s): Other bones (ukb-a-441) | rs16863585 | -0.0610590330604121 | 0.0284833748810099 | 0.0320591213241559 |
| Cake | Fractured bone site(s): Other bones (ukb-a-441) | All - Inverse variance weighted | -0.0223694529357173 | 0.0100180921469184 | 0.0255551776004832 |
| Cake | Diagnoses - secondary ICD10: G55.1 Nerve root and plexus compressions in intervertebral disk disorders (ukb-b-1220) | rs4233064 | -0.0162558315905591 | 0.0076973318318663 | 0.0346968497722464 |
| Cake | Fractured/broken bones in last 5 years (ukb-b-13346) | rs1468944 | -0.0794333656857546 | 0.0346342341981769 | 0.021819651203933 |
| Cake | Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) | rs4233064 | -0.0201488290855606 | 0.0096049456484269 | 0.0359267353439902 |
| Cake | Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) | All - Inverse variance weighted | -0.012491365567166 | 0.0050790193557072 | 0.0139167526501941 |
| Cake | Fractured bone site(s): Other bones (ukb-b-17738) | rs16863585 | -0.0651348461712397 | 0.0245810570510548 | 0.0080539808742197 |
| Cake | Fractured bone site(s): Other bones (ukb-b-17738) | All - Inverse variance weighted | -0.0217291592219478 | 0.0108447912725372 | 0.0451076331326448 |
| Cake | Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) | rs35268725 | -0.0219980559360226 | 0.0090342420359651 | 0.0148932631035986 |
| Cake | Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) | rs4233064 | -0.0168926987337118 | 0.0083849424309976 | 0.0439416538998395 |
| Cake | Diagnoses - main ICD10: Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device (ukb-b-19542) | All - Inverse variance weighted | -0.0127574587921143 | 0.0044338677548923 | 0.0040112529694557 |
| Cake | Operative procedures - secondary OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-19546) | All - Inverse variance weighted | -0.0091654080538579 | 0.0041693166807391 | 0.0279277481703254 |
| Cake | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | rs73090823 | -0.0529315950695759 | 0.0240802500757964 | 0.0279396214139851 |
| Cake | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | All - Inverse variance weighted | -0.016062103300286 | 0.0080269195373021 | 0.045389204010506 |
| Cake | Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) | rs71489608 | -0.0159173353368983 | 0.0074544648779371 | 0.0327385226132618 |
| Cake | Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) | All - Inverse variance weighted | -0.0057208737350803 | 0.0026839916207755 | 0.0330496406148366 |
| Cake | Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) | rs71489608 | -0.0159173353368983 | 0.0074544648779371 | 0.0327385226132618 |
| Cake | Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) | All - Inverse variance weighted | -0.0057208737350803 | 0.0026839916207755 | 0.0330496406148366 |