ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Hard cheese (ukb-b-3542)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Hard cheese (👉 📊) Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) MR Egger 13 -1.202323012 0.499530483 0.034804551
Hard cheese (👉 📊) Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) Inverse variance weighted 12 3.464097051 1.569564096 0.027310984
Hard cheese (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) Inverse variance weighted 12 3.449863864 1.569636657 0.027958074
Hard cheese (👉 📊) Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) Weighted median 12 2.743595961 1.396841098 0.049513486
Hard cheese (👉 📊) Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) Inverse variance weighted 12 2.238427855 1.106329228 0.043042979
Hard cheese (👉 📊) Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) MR Egger 12 -2.13354422 0.891391141 0.037732378
Hard cheese (👉 📊) Calcific tendinitis (finn-b-M13_CALCTENDINITIS) Inverse variance weighted 12 -3.551113643 1.534331293 0.020643744
Hard cheese (👉 📊) Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) Inverse variance weighted 12 -0.401183733 0.171683798 0.019451697
Hard cheese (👉 📊) Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) Weighted median 12 -3.960931014 1.982749848 0.045749651
Hard cheese (👉 📊) Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) Inverse variance weighted 12 3.183581456 1.622372463 0.049727569
Hard cheese (👉 📊) Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) MR Egger 12 -2.402218474 0.844410829 0.017403203
Hard cheese (👉 📊) Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) Inverse variance weighted 12 -2.142846285 1.079724097 0.047186327
Hard cheese (👉 📊) Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) Weighted median 12 -3.736060075 1.730876915 0.030890672
Hard cheese (👉 📊) Osteoclast-associated immunoglobulin-like receptor (prot-a-2153) Inverse variance weighted 13 -0.614727719 0.308154364 0.046057123
Hard cheese (👉 📊) Fracture resulting from simple fall (ukb-a-332) Inverse variance weighted 12 -0.116692821 0.048884336 0.016980906
Hard cheese (👉 📊) Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) Weighted median 12 -0.200060492 0.07825959 0.010577049
Hard cheese (👉 📊) Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) Inverse variance weighted 12 -0.128990756 0.062296126 0.038395597
Hard cheese (👉 📊) Heel bone mineral density (BMD) (left) (ukb-b-1096) Weighted median 13 -0.146998047 0.06742438 0.029243283
Hard cheese (👉 📊) Fractured/broken bones in last 5 years (ukb-b-13346) Inverse variance weighted 13 0.018203745 0.008680327 0.035982371
Hard cheese (👉 📊) Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) Inverse variance weighted 3 0.012585494 0.004758981 0.008179292
Hard cheese (👉 📊) Fracture resulting from simple fall (ukb-b-15251) Inverse variance weighted 13 -0.101870068 0.039637776 0.010169123
Hard cheese (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) Weighted median 13 -0.144827008 0.068438573 0.034331156
Hard cheese (👉 📊) Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) Weighted median 3 -0.00775877 0.003335984 0.020030222
Hard cheese (👉 📊) Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) Inverse variance weighted 3 -0.006925277 0.002636273 0.008616185
Hard cheese (👉 📊) Diagnoses - main ICD10: M54.56 Low back pain (Lumbar region) (ukb-b-19813) Inverse variance weighted 3 0.006587496 0.003003768 0.028301796
Hard cheese (👉 📊) Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) Inverse variance weighted 3 0.008322795 0.003649344 0.022570494
Hard cheese (👉 📊) Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) Inverse variance weighted 3 -0.008166493 0.004126304 0.047801362
Hard cheese (👉 📊) Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) Inverse variance weighted 3 0.007534683 0.003705092 0.041991693
Hard cheese (👉 📊) Operative procedures - secondary OPCS: Z81.5 Elbow joint (ukb-b-7443) Inverse variance weighted 3 0.005539635 0.002770343 0.045541258
Hard cheese (👉 📊) Fractured heel (left) (ukb-b-8221) Weighted median 13 -0.015548927 0.005902922 0.008435888
Hard cheese (👉 📊) Fractured heel (left) (ukb-b-8221) Inverse variance weighted 13 -0.012298 0.004427919 0.005479954
Hard cheese (👉 📊) Fractured bone site(s): Spine (ukb-b-873) Wald ratio 1 0.011320413 0.004404155 0.010158284
Hard cheese (👉 📊) Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) Inverse variance weighted 12 0.006045607 0.00217022 0.005341037
Hard cheese (👉 📊) Knee pain for 3+ months (ukb-e-3773_CSA) Inverse variance weighted 9 -3.035865012 1.125456963 0.006987257
Hard cheese (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) MR Egger 7 6.157232249 2.393960147 0.049914874
Hard cheese (👉 📊) Osteoarthrosis (ukb-e-740_AFR) Inverse variance weighted 7 -2.387592064 1.198527641 0.046359616
Hard cheese (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) MR Egger 7 6.717816969 2.450871615 0.040744029
Hard cheese (👉 📊) Internal derangement of knee (ukb-e-835_CSA) Weighted median 10 -3.113876262 1.519272261 0.040405034

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Hard cheese Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) rs2611129 -1.42278942340735 0.72292404261155 0.0490561167232715
Hard cheese Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) rs760916 -1.83693927592673 0.758398240300014 0.0154298214453994
Hard cheese Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) All - MR Egger -1.20232301171882 0.499530482552294 0.0348045512681853
Hard cheese Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) rs12652998 8.72035146865585 4.10356468147047 0.0335809905251633
Hard cheese Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) All - Inverse variance weighted 3.46409705099127 1.56956409556197 0.0273109841179837
Hard cheese Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) rs12652998 8.65398654119271 4.09914035297293 0.0347576101582332
Hard cheese Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) All - Inverse variance weighted 3.44986386366129 1.56963665708016 0.027958074119571
Hard cheese Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) rs12652998 5.48616733695243 2.51080642235525 0.028887231622517
Hard cheese Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) rs9650370 9.08601101263901 4.28528773480258 0.0339824169736193
Hard cheese Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) All - Inverse variance weighted 2.23842785450219 1.10632922806798 0.0430429787488819
Hard cheese Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) rs12703042 3.47206908856182 1.24689779046504 0.0053599425369006
Hard cheese Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) rs760916 -2.15635367084956 1.01507284004039 0.0336422308217058
Hard cheese Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) All - MR Egger -2.13354421992826 0.891391140583669 0.037732377732397
Hard cheese Calcific tendinitis (finn-b-M13_CALCTENDINITIS) rs760916 -11.9320640415405 4.78147987884033 0.0125788578645755
Hard cheese Calcific tendinitis (finn-b-M13_CALCTENDINITIS) All - Inverse variance weighted -3.55111364259636 1.53433129317042 0.0206437444419822
Hard cheese Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) rs148920910 -2.23123361737494 0.821072051584148 0.0065784341522019
Hard cheese Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) rs760916 -1.15750757247945 0.439924996394057 0.0085097083795499
Hard cheese Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) All - Inverse variance weighted -0.401183733038917 0.171683798113913 0.0194516967923188
Hard cheese Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) rs2611129 14.5732382066326 5.2161000785016 0.0052077314589468
Hard cheese Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) rs9650370 13.6348547856272 6.71567474515966 0.0423257463933924
Hard cheese Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) All - Inverse variance weighted 3.18358145567133 1.62237246274589 0.0497275692246618
Hard cheese Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) rs10866415 3.12803692905734 1.32757184506456 0.0184625193426128
Hard cheese Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) All - MR Egger -2.40221847413109 0.844410828984257 0.0174032028443187
Hard cheese Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) All - Inverse variance weighted -2.14284628492459 1.07972409709477 0.0471863274816283
Hard cheese Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) rs760916 -7.70950526467619 3.51759699985576 0.0284014238781897
Hard cheese Osteoclast-associated immunoglobulin-like receptor (prot-a-2153) All - Inverse variance weighted -0.614727718969717 0.308154364421461 0.0460571232683983
Hard cheese Fracture resulting from simple fall (ukb-a-332) rs760916 -0.365839102841483 0.173539232655416 0.0350218189575029
Hard cheese Fracture resulting from simple fall (ukb-a-332) All - Inverse variance weighted -0.116692820770859 0.048884336114165 0.016980905615521
Hard cheese Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) rs760916 -0.501235035338237 0.18852048175393 0.0078423476839166
Hard cheese Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) All - Inverse variance weighted -0.128990755947478 0.0622961264850913 0.0383955969667626
Hard cheese Heel bone mineral density (BMD) (left) (ukb-b-1096) rs12703042 -0.318199495627839 0.155745552664392 0.04104523631904
Hard cheese Heel bone mineral density (BMD) (left) (ukb-b-1096) rs760916 -0.427612505408914 0.159005300735612 0.0071602645512914
Hard cheese Fractured/broken bones in last 5 years (ukb-b-13346) rs76435153 0.0655682313225712 0.0282680208921818 0.0203668742545804
Hard cheese Fractured/broken bones in last 5 years (ukb-b-13346) rs8089039 0.0573381331312366 0.0279724643172919 0.0403833381731516
Hard cheese Fractured/broken bones in last 5 years (ukb-b-13346) All - Inverse variance weighted 0.018203744823185 0.0086803271493803 0.0359823712631965
Hard cheese Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) rs12703042 0.0196313432416937 0.0082595552062994 0.0174633681974079
Hard cheese Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) All - Inverse variance weighted 0.0125854939616772 0.0047589805772029 0.0081792922827361
Hard cheese Fracture resulting from simple fall (ukb-b-15251) rs760916 -0.407321866435886 0.149070207702293 0.0062871642616259
Hard cheese Fracture resulting from simple fall (ukb-b-15251) rs78213935 -0.342929900127799 0.140855398305486 0.0149072808444974
Hard cheese Fracture resulting from simple fall (ukb-b-15251) All - Inverse variance weighted -0.101870068171382 0.0396377762668833 0.0101691233699477
Hard cheese Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) rs12703042 -0.31681628103713 0.15580007938449 0.0420040938780235
Hard cheese Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) rs760916 -0.422295543054955 0.159073993942016 0.0079376289240511
Hard cheese Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) rs12703042 -0.0098555442849181 0.0044841812371952 0.027960010759429
Hard cheese Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) All - Inverse variance weighted -0.0069252766578816 0.0026362734052559 0.0086161845219269
Hard cheese Diagnoses - main ICD10: M54.56 Low back pain (Lumbar region) (ukb-b-19813) All - Inverse variance weighted 0.0065874958643178 0.0030037679270078 0.0283017956067282
Hard cheese Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) All - Inverse variance weighted 0.0083227948339522 0.0036493441126824 0.0225704938208394
Hard cheese Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) rs13287896 -0.0153529051631148 0.006866022231755 0.0253471973629797
Hard cheese Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) All - Inverse variance weighted -0.0081664930781954 0.0041263043432934 0.0478013616764438
Hard cheese Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) All - Inverse variance weighted 0.00753468323374 0.003705091504082 0.0419916926202003
Hard cheese Operative procedures - secondary OPCS: Z81.5 Elbow joint (ukb-b-7443) rs12703042 0.0100830730617956 0.004677871373071 0.0311240434705692
Hard cheese Operative procedures - secondary OPCS: Z81.5 Elbow joint (ukb-b-7443) All - Inverse variance weighted 0.0055396349034782 0.0027703431108848 0.0455412575444363
Hard cheese Fractured heel (left) (ukb-b-8221) All - Inverse variance weighted -0.0122980003969226 0.0044279186510918 0.0054799539365059
Hard cheese Fractured bone site(s): Spine (ukb-b-873) rs10866415 0.0113204133694294 0.0044041545189504 0.0101582841076033
Hard cheese Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) rs12703042 0.0152684037703623 0.0075718369490696 0.0437505525513427
Hard cheese Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) rs8089039 0.0166327901983074 0.007654389288872 0.0297822615366247
Hard cheese Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) All - Inverse variance weighted 0.0060456073764153 0.0021702201244046 0.0053410367632345
Hard cheese Knee pain for 3+ months (ukb-e-3773_CSA) All - Inverse variance weighted -3.03586501158623 1.1254569631439 0.0069872566916123
Hard cheese Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) rs10866415 -4.89379425239484 2.3171768707483 0.0346895327710832
Hard cheese Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) All - MR Egger 6.1572322486362 2.39396014727589 0.0499148742348156
Hard cheese Osteoarthrosis (ukb-e-740_AFR) All - Inverse variance weighted -2.38759206416267 1.19852764134674 0.0463596156249662
Hard cheese Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) rs10866415 -5.32330279050396 2.31977995279745 0.0217477585242495
Hard cheese Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) All - MR Egger 6.71781696895819 2.45087161543199 0.0407440291679732
Hard cheese Internal derangement of knee (ukb-e-835_CSA) rs760916 -6.30318765325256 3.15519976921967 0.0457476445387718