ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
Intake (exposure) | Outcome | SNP | b | se | P-value |
---|---|---|---|---|---|
Hard cheese | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | rs2611129 | -1.42278942340735 | 0.72292404261155 | 0.0490561167232715 |
Hard cheese | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | rs760916 | -1.83693927592673 | 0.758398240300014 | 0.0154298214453994 |
Hard cheese | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | All - MR Egger | -1.20232301171882 | 0.499530482552294 | 0.0348045512681853 |
Hard cheese | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | rs12652998 | 8.72035146865585 | 4.10356468147047 | 0.0335809905251633 |
Hard cheese | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | All - Inverse variance weighted | 3.46409705099127 | 1.56956409556197 | 0.0273109841179837 |
Hard cheese | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | rs12652998 | 8.65398654119271 | 4.09914035297293 | 0.0347576101582332 |
Hard cheese | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | All - Inverse variance weighted | 3.44986386366129 | 1.56963665708016 | 0.027958074119571 |
Hard cheese | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | rs12652998 | 5.48616733695243 | 2.51080642235525 | 0.028887231622517 |
Hard cheese | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | rs9650370 | 9.08601101263901 | 4.28528773480258 | 0.0339824169736193 |
Hard cheese | Melanocytic naevi of scalp and neck (finn-b-CD2_BENIGN_MELANOCYTIC_SCALPNECK) | All - Inverse variance weighted | 2.23842785450219 | 1.10632922806798 | 0.0430429787488819 |
Hard cheese | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | rs12703042 | 3.47206908856182 | 1.24689779046504 | 0.0053599425369006 |
Hard cheese | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | rs760916 | -2.15635367084956 | 1.01507284004039 | 0.0336422308217058 |
Hard cheese | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | All - MR Egger | -2.13354421992826 | 0.891391140583669 | 0.037732377732397 |
Hard cheese | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | rs760916 | -11.9320640415405 | 4.78147987884033 | 0.0125788578645755 |
Hard cheese | Calcific tendinitis (finn-b-M13_CALCTENDINITIS) | All - Inverse variance weighted | -3.55111364259636 | 1.53433129317042 | 0.0206437444419822 |
Hard cheese | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | rs148920910 | -2.23123361737494 | 0.821072051584148 | 0.0065784341522019 |
Hard cheese | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | rs760916 | -1.15750757247945 | 0.439924996394057 | 0.0085097083795499 |
Hard cheese | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | All - Inverse variance weighted | -0.401183733038917 | 0.171683798113913 | 0.0194516967923188 |
Hard cheese | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | rs2611129 | 14.5732382066326 | 5.2161000785016 | 0.0052077314589468 |
Hard cheese | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | rs9650370 | 13.6348547856272 | 6.71567474515966 | 0.0423257463933924 |
Hard cheese | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | All - Inverse variance weighted | 3.18358145567133 | 1.62237246274589 | 0.0497275692246618 |
Hard cheese | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | rs10866415 | 3.12803692905734 | 1.32757184506456 | 0.0184625193426128 |
Hard cheese | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | All - MR Egger | -2.40221847413109 | 0.844410828984257 | 0.0174032028443187 |
Hard cheese | Injury of nerves and spinal cord at neck level (finn-b-ST19_INJURY_NERVES_SPINAL_CORD_NECK_LEVEL) | All - Inverse variance weighted | -2.14284628492459 | 1.07972409709477 | 0.0471863274816283 |
Hard cheese | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs760916 | -7.70950526467619 | 3.51759699985576 | 0.0284014238781897 |
Hard cheese | Osteoclast-associated immunoglobulin-like receptor (prot-a-2153) | All - Inverse variance weighted | -0.614727718969717 | 0.308154364421461 | 0.0460571232683983 |
Hard cheese | Fracture resulting from simple fall (ukb-a-332) | rs760916 | -0.365839102841483 | 0.173539232655416 | 0.0350218189575029 |
Hard cheese | Fracture resulting from simple fall (ukb-a-332) | All - Inverse variance weighted | -0.116692820770859 | 0.048884336114165 | 0.016980905615521 |
Hard cheese | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs760916 | -0.501235035338237 | 0.18852048175393 | 0.0078423476839166 |
Hard cheese | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | All - Inverse variance weighted | -0.128990755947478 | 0.0622961264850913 | 0.0383955969667626 |
Hard cheese | Heel bone mineral density (BMD) (left) (ukb-b-1096) | rs12703042 | -0.318199495627839 | 0.155745552664392 | 0.04104523631904 |
Hard cheese | Heel bone mineral density (BMD) (left) (ukb-b-1096) | rs760916 | -0.427612505408914 | 0.159005300735612 | 0.0071602645512914 |
Hard cheese | Fractured/broken bones in last 5 years (ukb-b-13346) | rs76435153 | 0.0655682313225712 | 0.0282680208921818 | 0.0203668742545804 |
Hard cheese | Fractured/broken bones in last 5 years (ukb-b-13346) | rs8089039 | 0.0573381331312366 | 0.0279724643172919 | 0.0403833381731516 |
Hard cheese | Fractured/broken bones in last 5 years (ukb-b-13346) | All - Inverse variance weighted | 0.018203744823185 | 0.0086803271493803 | 0.0359823712631965 |
Hard cheese | Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) | rs12703042 | 0.0196313432416937 | 0.0082595552062994 | 0.0174633681974079 |
Hard cheese | Operative procedures - main OPCS: W28.3 Removal of internal fixation from bone NEC (ukb-b-14157) | All - Inverse variance weighted | 0.0125854939616772 | 0.0047589805772029 | 0.0081792922827361 |
Hard cheese | Fracture resulting from simple fall (ukb-b-15251) | rs760916 | -0.407321866435886 | 0.149070207702293 | 0.0062871642616259 |
Hard cheese | Fracture resulting from simple fall (ukb-b-15251) | rs78213935 | -0.342929900127799 | 0.140855398305486 | 0.0149072808444974 |
Hard cheese | Fracture resulting from simple fall (ukb-b-15251) | All - Inverse variance weighted | -0.101870068171382 | 0.0396377762668833 | 0.0101691233699477 |
Hard cheese | Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) | rs12703042 | -0.31681628103713 | 0.15580007938449 | 0.0420040938780235 |
Hard cheese | Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) | rs760916 | -0.422295543054955 | 0.159073993942016 | 0.0079376289240511 |
Hard cheese | Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) | rs12703042 | -0.0098555442849181 | 0.0044841812371952 | 0.027960010759429 |
Hard cheese | Non-cancer illness code, self-reported: osteopenia (ukb-b-19381) | All - Inverse variance weighted | -0.0069252766578816 | 0.0026362734052559 | 0.0086161845219269 |
Hard cheese | Diagnoses - main ICD10: M54.56 Low back pain (Lumbar region) (ukb-b-19813) | All - Inverse variance weighted | 0.0065874958643178 | 0.0030037679270078 | 0.0283017956067282 |
Hard cheese | Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) | All - Inverse variance weighted | 0.0083227948339522 | 0.0036493441126824 | 0.0225704938208394 |
Hard cheese | Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) | rs13287896 | -0.0153529051631148 | 0.006866022231755 | 0.0253471973629797 |
Hard cheese | Operative procedures - main OPCS: W36.5 Diagnostic extraction of bone marrow NEC (ukb-b-5602) | All - Inverse variance weighted | -0.0081664930781954 | 0.0041263043432934 | 0.0478013616764438 |
Hard cheese | Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) | All - Inverse variance weighted | 0.00753468323374 | 0.003705091504082 | 0.0419916926202003 |
Hard cheese | Operative procedures - secondary OPCS: Z81.5 Elbow joint (ukb-b-7443) | rs12703042 | 0.0100830730617956 | 0.004677871373071 | 0.0311240434705692 |
Hard cheese | Operative procedures - secondary OPCS: Z81.5 Elbow joint (ukb-b-7443) | All - Inverse variance weighted | 0.0055396349034782 | 0.0027703431108848 | 0.0455412575444363 |
Hard cheese | Fractured heel (left) (ukb-b-8221) | All - Inverse variance weighted | -0.0122980003969226 | 0.0044279186510918 | 0.0054799539365059 |
Hard cheese | Fractured bone site(s): Spine (ukb-b-873) | rs10866415 | 0.0113204133694294 | 0.0044041545189504 | 0.0101582841076033 |
Hard cheese | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | rs12703042 | 0.0152684037703623 | 0.0075718369490696 | 0.0437505525513427 |
Hard cheese | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | rs8089039 | 0.0166327901983074 | 0.007654389288872 | 0.0297822615366247 |
Hard cheese | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | All - Inverse variance weighted | 0.0060456073764153 | 0.0021702201244046 | 0.0053410367632345 |
Hard cheese | Knee pain for 3+ months (ukb-e-3773_CSA) | All - Inverse variance weighted | -3.03586501158623 | 1.1254569631439 | 0.0069872566916123 |
Hard cheese | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | rs10866415 | -4.89379425239484 | 2.3171768707483 | 0.0346895327710832 |
Hard cheese | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | All - MR Egger | 6.1572322486362 | 2.39396014727589 | 0.0499148742348156 |
Hard cheese | Osteoarthrosis (ukb-e-740_AFR) | All - Inverse variance weighted | -2.38759206416267 | 1.19852764134674 | 0.0463596156249662 |
Hard cheese | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | rs10866415 | -5.32330279050396 | 2.31977995279745 | 0.0217477585242495 |
Hard cheese | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | All - MR Egger | 6.71781696895819 | 2.45087161543199 | 0.0407440291679732 |
Hard cheese | Internal derangement of knee (ukb-e-835_CSA) | rs760916 | -6.30318765325256 | 3.15519976921967 | 0.0457476445387718 |