ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Sweet biscuits | Osteoarthritis (hip) (ebi-a-GCST007091) | rs73197294 | -0.628457754772815 | 0.225980872451117 | 0.0054188081892598 |
| Sweet biscuits | Osteoarthritis (hip) (ebi-a-GCST007091) | All - MR Egger | 0.547358770847102 | 0.229327888964595 | 0.0407710040564472 |
| Sweet biscuits | Achilles tendon injury (ebi-a-GCST90018787) | rs17693321 | -0.769737765690396 | 0.367618191032971 | 0.036273243564577 |
| Sweet biscuits | Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) | rs60129519 | -5.35836959010762 | 2.25374519421981 | 0.0174285475250299 |
| Sweet biscuits | Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) | All - Inverse variance weighted | -1.39214166423106 | 0.70035913385954 | 0.0468389043346388 |
| Sweet biscuits | Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) | rs60129519 | -5.40778325479373 | 2.25856603955504 | 0.0166501404908345 |
| Sweet biscuits | Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) | All - Inverse variance weighted | -1.41488202508962 | 0.701006477791325 | 0.0435539913194534 |
| Sweet biscuits | Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) | rs116443327 | -7.9669866936163 | 3.89590702374937 | 0.0408584812398121 |
| Sweet biscuits | Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) | All - Inverse variance weighted | -1.61956440926376 | 0.755639394634722 | 0.032088751907912 |
| Sweet biscuits | Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) | rs117635565 | -3.35356073567151 | 1.49165953806672 | 0.0245629371098194 |
| Sweet biscuits | Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) | All - MR Egger | -3.85607882127888 | 1.60463750598808 | 0.0396966456358105 |
| Sweet biscuits | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs60129519 | 6.25384161112651 | 2.74667662974703 | 0.0227936420339338 |
| Sweet biscuits | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | All - Inverse variance weighted | 2.1784906458627 | 0.844582149915064 | 0.0098980439446118 |
| Sweet biscuits | Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) | rs117635565 | -5.35781116338751 | 2.29964178785287 | 0.0198142932577007 |
| Sweet biscuits | Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) | rs62174398 | 5.52963166005499 | 2.2518536424632 | 0.014065311527419 |
| Sweet biscuits | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | rs9530870 | -4.91691257592011 | 2.24086000160334 | 0.0282204714649677 |
| Sweet biscuits | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | All - Inverse variance weighted | -1.31853804483623 | 0.622400707514608 | 0.0341351718235272 |
| Sweet biscuits | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | rs117635565 | -0.612168520102652 | 0.292718135158255 | 0.0364990118262732 |
| Sweet biscuits | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | All - Inverse variance weighted | -0.204602875250405 | 0.0934703363808133 | 0.0285997103386671 |
| Sweet biscuits | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | rs9530870 | 0.645153901654113 | 0.328303168889076 | 0.0494007808738652 |
| Sweet biscuits | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | All - Inverse variance weighted | 0.186593835997872 | 0.0913361890483538 | 0.0410589395578931 |
| Sweet biscuits | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | All - Inverse variance weighted | -2.11520551213675 | 0.992292282953248 | 0.0330368184037977 |
| Sweet biscuits | Shoulder region (finn-b-Z21_SHOUL_REGION) | All - Inverse variance weighted | -1.92528969530038 | 0.868688166663887 | 0.0266696936914127 |
| Sweet biscuits | Knee and hip osteoarthritis (ieu-a-1170) | All - Inverse variance weighted | -0.736938386046737 | 0.324953433846516 | 0.0233397127276488 |
| Sweet biscuits | Femoral neck bone mineral density (ieu-a-980) | rs62174398 | -0.318885497918654 | 0.162450016763 | 0.049648952926518 |
| Sweet biscuits | Femoral neck bone mineral density (ieu-a-980) | All - Inverse variance weighted | -0.112254277010836 | 0.0520605312870561 | 0.031066013471946 |
| Sweet biscuits | Bone sialoprotein 2 (prot-a-1396) | All - Inverse variance weighted | -0.35676333068117 | 0.165558945691254 | 0.0311694908574111 |
| Sweet biscuits | Osteoclast-associated immunoglobulin-like receptor (prot-a-2153) | All - MR Egger | -1.23124901367236 | 0.50207773498341 | 0.0366178425765298 |
| Sweet biscuits | Bone morphogenetic protein 10 (prot-a-254) | All - Inverse variance weighted | -0.372059236414874 | 0.165550392435046 | 0.0246139796149817 |
| Sweet biscuits | Bone morphogenetic protein 7 (prot-a-257) | rs73197294 | -1.09196596761051 | 0.4734051853538 | 0.0210760019262207 |
| Sweet biscuits | Bone morphogenetic protein 7 (prot-a-257) | All - Inverse variance weighted | -0.423159917055652 | 0.165562883146325 | 0.010591769917172 |
| Sweet biscuits | Knee pain for 3+ months (ukb-a-353) | rs116443327 | -0.150941552972882 | 0.0488932120599629 | 0.0020207345036851 |
| Sweet biscuits | Knee pain for 3+ months (ukb-a-353) | All - Inverse variance weighted | -0.045615455000699 | 0.0143830496438705 | 0.0015166791562016 |
| Sweet biscuits | Knee pain for 3+ months (ukb-a-353) | All - MR Egger | -0.11399832304657 | 0.0425674678223655 | 0.0252862208197634 |
| Sweet biscuits | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs72702359 | -0.179931159899945 | 0.090501738421555 | 0.0467949457361566 |
| Sweet biscuits | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | rs73197294 | -0.248478340475648 | 0.0800755798801147 | 0.0019153879409982 |
| Sweet biscuits | Heel bone mineral density (BMD) T-score automated (right) (ukb-a-362) | All - Inverse variance weighted | -0.0683725842239701 | 0.0309365568425568 | 0.0270988958593972 |
| Sweet biscuits | Diagnoses - secondary ICD10: M06.99 Rheumatoid arthritis, unspecified (Site unspecified) (ukb-b-11874) | rs73197294 | -0.0053131896952722 | 0.0023052193334059 | 0.0211748562616281 |
| Sweet biscuits | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs116443327 | -0.157642748863062 | 0.0789041603503453 | 0.0457273282619809 |
| Sweet biscuits | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs72702359 | -0.155042816033891 | 0.0758390758146891 | 0.0409174192103059 |
| Sweet biscuits | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs73197294 | -0.243739340135852 | 0.0665678618910475 | 0.0002507264826916 |
| Sweet biscuits | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | All - Inverse variance weighted | -0.0643765728929939 | 0.0301090656280136 | 0.0325076047339853 |
| Sweet biscuits | Ankle spacing width (ukb-b-4080) | rs117635565 | -0.119270610564585 | 0.0538713644140291 | 0.0268295326548698 |
| Sweet biscuits | Ankle spacing width (ukb-b-4080) | rs73197294 | -0.106948169554933 | 0.0438010312645362 | 0.0146190360386968 |
| Sweet biscuits | Ankle spacing width (ukb-b-4080) | All - Inverse variance weighted | -0.0352847536706064 | 0.0166682250594273 | 0.0342694151529118 |
| Sweet biscuits | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs116443327 | -0.16466144517433 | 0.0789034023917804 | 0.0368995415064294 |
| Sweet biscuits | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs72702359 | -0.153185248151838 | 0.0758530110576153 | 0.0434351509356299 |
| Sweet biscuits | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs73197294 | -0.247523282627844 | 0.0665736351250153 | 0.0002007763433674 |
| Sweet biscuits | Heel bone mineral density (BMD) (right) (ukb-b-4657) | All - Inverse variance weighted | -0.0644832696165655 | 0.0308683181834755 | 0.0367096101776752 |
| Sweet biscuits | Diagnoses - main ICD10: S82.80 Fractures of other parts of lower leg (closed) (ukb-b-5946) | rs73197294 | 0.0047643365894372 | 0.0022716850915305 | 0.0359696966435136 |
| Sweet biscuits | Operative procedures - main OPCS: A52.1 Therapeutic lumbar epidural injection (ukb-b-6798) | All - Inverse variance weighted | -0.0044130259517846 | 0.0020959603402263 | 0.0352485766905263 |
| Sweet biscuits | Ankle spacing width (right) (ukb-b-8607) | rs73197294 | -0.193015706495383 | 0.0605114095598157 | 0.0014240049444331 |
| Sweet biscuits | Ankle spacing width (right) (ukb-b-8607) | All - MR Egger | 0.154206529982849 | 0.0613563011461354 | 0.0331311083935089 |
| Sweet biscuits | Knee pain for 3+ months (ukb-b-8906) | rs116443327 | -0.127802762337881 | 0.0419802930773118 | 0.0023318262686759 |
| Sweet biscuits | Knee pain for 3+ months (ukb-b-8906) | All - Inverse variance weighted | -0.0409215296668892 | 0.0128306294749911 | 0.0014258690807593 |