ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Spirits | Heel bone mineral density (ebi-a-GCST006288) | rs62204569 | 0.332795404495298 | 0.169048506810529 | 0.0489946143551833 |
| Spirits | Heel bone mineral density (ebi-a-GCST006288) | rs7746271 | -0.619301947658202 | 0.172523223944311 | 0.0003310931197275 |
| Spirits | Heel bone mineral density (ebi-a-GCST006288) | All - MR Egger | 0.153309876339488 | 0.0694415733952207 | 0.0375068370174869 |
| Spirits | Osteoarthritis (hip) (ebi-a-GCST007091) | rs62001190 | 1.31615975754952 | 0.554172529494534 | 0.0175489501914767 |
| Spirits | Osteoarthritis (hip) (ebi-a-GCST007091) | rs72689525 | 1.25187556716253 | 0.540582631274727 | 0.0205697662542228 |
| Spirits | Osteoarthritis (hip) (ebi-a-GCST007091) | All - Inverse variance weighted | 0.306346582473743 | 0.115223950168695 | 0.0078441431054663 |
| Spirits | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | rs10416487 | 1.09146255983017 | 0.39052330122364 | 0.0051920300801086 |
| Spirits | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | rs62001190 | 0.74466933650828 | 0.363675722480788 | 0.0405973414877944 |
| Spirits | Osteoarthritis of the hip or knee (ebi-a-GCST007092) | All - Inverse variance weighted | 0.215108074855524 | 0.0751390600004175 | 0.0041991598895336 |
| Spirits | Osteoprotegerin levels (ebi-a-GCST90012002) | rs139164359 | 1.05263157894737 | 0.519852262234534 | 0.042881045047485 |
| Spirits | Osteoprotegerin levels (ebi-a-GCST90012002) | rs150981413 | 1.45648949197089 | 0.463926249664002 | 0.001692450913842 |
| Spirits | Osteoprotegerin levels (ebi-a-GCST90012002) | All - Inverse variance weighted | 0.278142035687923 | 0.123585069075294 | 0.0244101246601377 |
| Spirits | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | rs141415334 | -0.829972306996073 | 0.352818748083256 | 0.0186524934948279 |
| Spirits | Fractured bones in last 5 years (UKB data field 2463) (Firth correction) (ebi-a-GCST90013913) | All - Inverse variance weighted | -0.198918402274693 | 0.0922911744199054 | 0.031135625545341 |
| Spirits | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | rs141415334 | -0.818365595893487 | 0.343763101340773 | 0.0172840381639097 |
| Spirits | Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) | All - Inverse variance weighted | -0.200190246590111 | 0.0922573889843602 | 0.0300136517671945 |
| Spirits | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | rs62001190 | 28.5358588591839 | 12.7726377313562 | 0.0254738731234992 |
| Spirits | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | rs74878100 | 5.77844054413595 | 1.91566751062095 | 0.0025578629799688 |
| Spirits | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | All - Inverse variance weighted | 4.61341766491409 | 1.78040871401143 | 0.0095638361153882 |
| Spirits | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | All - MR Egger | 7.19437045245789 | 2.76989826185113 | 0.048404880865469 |
| Spirits | Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) | rs139164359 | 11.0286241920591 | 3.98799630655586 | 0.0056843453146647 |
| Spirits | Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) | rs78876987 | -9.41875 | 4.546875 | 0.0383141797466315 |
| Spirits | Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) | All - Inverse variance weighted | 2.08192697842751 | 0.937599417881655 | 0.0263857517790035 |
| Spirits | Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) | rs139164359 | 11.0156971375808 | 3.98522622345337 | 0.0057074190634366 |
| Spirits | Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) | rs78876987 | -9.496875 | 4.54375 | 0.0366091512363853 |
| Spirits | Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) | All - Inverse variance weighted | 2.06822509960602 | 0.937578902983881 | 0.0273895234831636 |
| Spirits | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | rs140480689 | 14.1917198393048 | 5.09960089444104 | 0.0053874089684067 |
| Spirits | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | rs4608967 | 10.3218813414751 | 5.23176503555075 | 0.0485040793462266 |
| Spirits | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | rs74878100 | 10.2999613783633 | 3.701669312964 | 0.0053938878329296 |
| Spirits | Carcinoma in situ of skin of scalp and neck (finn-b-CD2_INSITU_SKIN_SCALPNECK) | All - Inverse variance weighted | 2.5151113408167 | 1.18932192152477 | 0.034451776129971 |
| Spirits | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs117203543 | 4.6832332837361 | 1.77438388260847 | 0.0083063352921214 |
| Spirits | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs7746271 | -5.65621285988018 | 2.70683256930801 | 0.036653230964683 |
| Spirits | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | All - MR Egger | 2.06140335013946 | 0.864887716444868 | 0.025794694421474 |
| Spirits | Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) | rs12480712 | 5.18235506882958 | 2.00607292986951 | 0.0097850732044699 |
| Spirits | Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) | rs76296599 | 4.28432427423382 | 1.585642725864 | 0.0068934531754451 |
| Spirits | Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) | All - Inverse variance weighted | 1.01225879563266 | 0.479332945879616 | 0.0347029842440303 |
| Spirits | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | rs76296599 | -1.07906076409446 | 0.488048475363334 | 0.0270378824441949 |
| Spirits | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | rs7746271 | 1.70268500327439 | 0.839215115573989 | 0.042468300116272 |
| Spirits | Osteopathies and chondropathies (finn-b-M13_OSTEOCHONDRO) | All - Inverse variance weighted | -0.301552887070061 | 0.149644546853008 | 0.0438912596574874 |
| Spirits | Other joint disorders (finn-b-M13_OTHERJOINT) | rs139045461 | -0.965362844644856 | 0.442987226407755 | 0.0293159622805589 |
| Spirits | Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) | rs7746271 | 28.6109292003202 | 7.88765189551044 | 0.0002863935062624 |
| Spirits | Other osteochondrodysplasias (finn-b-Q17_OTHER_OSTEOCHONDROD) | All - MR Egger | -5.83265083852594 | 2.47704596353174 | 0.0274468674965025 |
| Spirits | Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) | All - MR Egger | -8.52955870848695 | 2.59674800593975 | 0.0032475248083245 |
| Spirits | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | rs72689525 | -5.57503915854794 | 2.83019715542724 | 0.0488565650839417 |
| Spirits | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | rs76296599 | -4.46657022389481 | 1.8976230803684 | 0.0185840546874739 |
| Spirits | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | All - Inverse variance weighted | -1.44451953454006 | 0.576015317784794 | 0.0121492377900772 |
| Spirits | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | All - MR Egger | -3.61586734805769 | 1.05819669806397 | 0.0023592011068523 |
| Spirits | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | rs4608967 | 5.73369422966186 | 2.64513605976345 | 0.0301863325067158 |
| Spirits | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | All - Inverse variance weighted | 1.47700934242781 | 0.551121766873115 | 0.0073620960091815 |
| Spirits | Bone sialoprotein 2 (prot-a-1395) | rs139164359 | 2.42197599261311 | 1.16158818097876 | 0.0370642499173537 |
| Spirits | Bone sialoprotein 2 (prot-a-1395) | rs143539446 | 2.20312017255368 | 1.10156008627684 | 0.0455002638963584 |
| Spirits | Bone sialoprotein 2 (prot-a-1395) | All - Inverse variance weighted | 0.56028006245986 | 0.254493714304922 | 0.0276972706740078 |
| Spirits | Bone sialoprotein 2 (prot-a-1395) | All - MR Egger | 0.992244787802198 | 0.475878198944623 | 0.0488771398546672 |
| Spirits | Osteocalcin (prot-a-246) | rs78998916 | 2.60693250941392 | 1.26027146653928 | 0.0385884855288713 |
| Spirits | Osteocalcin (prot-a-246) | All - Inverse variance weighted | 0.518425319762167 | 0.249949255400006 | 0.0380679557700021 |
| Spirits | Alkaline phosphatase, bone (prot-c-2795_23_3) | rs12480712 | 5.8875200987231 | 2.29891398506387 | 0.0104371175465087 |
| Spirits | Fracture resulting from simple fall (ukb-a-332) | rs147930370 | -0.370141504290423 | 0.177709928786519 | 0.0372657300250138 |
| Spirits | Fracture resulting from simple fall (ukb-a-332) | rs150981413 | -0.467316097046204 | 0.193836550618734 | 0.0159142109640898 |
| Spirits | Fracture resulting from simple fall (ukb-a-332) | rs76296599 | -0.382297431567676 | 0.188608083688988 | 0.0426684610680763 |
| Spirits | Fracture resulting from simple fall (ukb-a-332) | All - MR Egger | -0.159131293794123 | 0.0703979762298958 | 0.0335654034448499 |
| Spirits | Knee pain for 3+ months (ukb-a-353) | rs114112236 | 0.361791448041828 | 0.108705033980985 | 0.0008741095539332 |
| Spirits | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | rs147930370 | -0.0101917479596373 | 0.0047163791006467 | 0.0307010276993693 |
| Spirits | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | rs78876987 | 0.0116655625 | 0.0049391875 | 0.018184569048271 |
| Spirits | Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level (ukb-a-591) | All - MR Egger | -0.0051267518955975 | 0.0018458692007189 | 0.0107108492448883 |
| Spirits | Operation code: elbow surgery (ukb-b-10324) | rs62001190 | 0.019441108345059 | 0.0076602229678536 | 0.0111510341377231 |
| Spirits | Operation code: elbow surgery (ukb-b-10324) | All - Inverse variance weighted | 0.0095935219644641 | 0.0043877258029294 | 0.0287830507216396 |
| Spirits | Diagnoses - secondary ICD10: G55.1 Nerve root and plexus compressions in intervertebral disk disorders (ukb-b-1220) | All - Inverse variance weighted | 0.0091499213833864 | 0.0042257980780888 | 0.0303683260897255 |
| Spirits | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | rs139045461 | 0.0900650190929082 | 0.0428411517667887 | 0.0355268702678194 |
| Spirits | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | rs139164359 | 0.0909320406278855 | 0.0440792243767313 | 0.0391199556362068 |
| Spirits | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | All - Inverse variance weighted | 0.0193428393711966 | 0.0084617122673892 | 0.0222586482919355 |
| Spirits | Operative procedures - secondary OPCS: Z84.3 Hip joint (ukb-b-17133) | rs62001190 | 0.0150179889598441 | 0.0073968611321571 | 0.0423241067903527 |
| Spirits | Operative procedures - secondary OPCS: Z84.3 Hip joint (ukb-b-17133) | All - Inverse variance weighted | 0.0093828088828294 | 0.0044864418408105 | 0.0364949290468962 |
| Spirits | Diagnoses - main ICD10: M51.1 Lumbar and other intervertebral disk disorders with radiculopathy (ukb-b-18279) | All - Inverse variance weighted | 0.0100538172861251 | 0.0041482321133633 | 0.0153658700268293 |
| Spirits | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs143539446 | 0.373392776191287 | 0.16950454339396 | 0.0276054505008204 |
| Spirits | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs7746271 | -0.552936040165903 | 0.17632394673652 | 0.0017132172938243 |
| Spirits | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | All - MR Egger | 0.134438735870123 | 0.0644913163219155 | 0.0483994751830715 |
| Spirits | Operative procedures - secondary OPCS: W90.3 Injection of therapeutic substance into joint (ukb-b-20239) | All - Inverse variance weighted | 0.0078910873230352 | 0.0039692910027921 | 0.0468078781625494 |
| Spirits | Ankle spacing width (left) (ukb-b-2122) | rs150981413 | -0.321336625284976 | 0.156842912182544 | 0.0404836300213982 |
| Spirits | Ankle spacing width (left) (ukb-b-2122) | rs62001190 | 0.353452105206191 | 0.147457949994588 | 0.0165313313501961 |
| Spirits | Ankle spacing width (left) (ukb-b-2122) | rs72689525 | -0.323398692418965 | 0.145035175307503 | 0.0257610629630175 |
| Spirits | Ankle spacing width (left) (ukb-b-2122) | All - MR Egger | -0.204020637196186 | 0.0578832992323025 | 0.0018153849523637 |
| Spirits | Ankle spacing width (ukb-b-4080) | rs141415334 | -0.39656473512463 | 0.106888333216558 | 0.0002071901822566 |
| Spirits | Ankle spacing width (ukb-b-4080) | rs72689525 | -0.232673652811179 | 0.10552697073067 | 0.0274629515868013 |
| Spirits | Ankle spacing width (ukb-b-4080) | All - Inverse variance weighted | -0.0560847687176828 | 0.0283477707603847 | 0.0478774801782443 |
| Spirits | Ankle spacing width (ukb-b-4080) | All - MR Egger | -0.178532471993173 | 0.0457810633938436 | 0.0007214331577108 |
| Spirits | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs143539446 | 0.381672523366645 | 0.16952186806111 | 0.0243561122045134 |
| Spirits | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs62001190 | -0.356337265937872 | 0.164303928996645 | 0.0301002267331518 |
| Spirits | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs7746271 | -0.568866574498533 | 0.176357418322055 | 0.0012568877732356 |
| Spirits | Heel bone mineral density (BMD) (right) (ukb-b-4657) | All - MR Egger | 0.139981709917943 | 0.0644979536933074 | 0.0405560020577011 |
| Spirits | Fractured heel (left) (ukb-b-8221) | rs138008081 | 0.042375902719576 | 0.0170832936027984 | 0.0131181183248325 |
| Spirits | Fractured heel (left) (ukb-b-8221) | rs143539446 | 0.06059028028424 | 0.0174938713989957 | 0.0005331675148429 |
| Spirits | Fractured heel (left) (ukb-b-8221) | All - Inverse variance weighted | 0.0098006649950431 | 0.0039296096714627 | 0.0126292761213902 |
| Spirits | Ankle spacing width (right) (ukb-b-8607) | rs62001190 | 0.350697261608399 | 0.14926723671393 | 0.0188007115217315 |
| Spirits | Ankle spacing width (right) (ukb-b-8607) | rs72689525 | -0.339608684063145 | 0.146644943530828 | 0.0205660908089731 |
| Spirits | Ankle spacing width (right) (ukb-b-8607) | rs74878100 | -0.388608333690941 | 0.152512552031927 | 0.0108329538779584 |
| Spirits | Ankle spacing width (right) (ukb-b-8607) | All - MR Egger | -0.230970795734448 | 0.0586049855116628 | 0.000651005719271 |
| Spirits | Knee pain for 3+ months (ukb-b-8906) | rs114112236 | 0.278032007598462 | 0.094868502346855 | 0.003381890263689 |
| Spirits | Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement (ukb-b-898) | rs62001190 | 0.0187619006385972 | 0.0086524082692932 | 0.0301281027516211 |
| Spirits | Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement (ukb-b-898) | All - Inverse variance weighted | 0.0091645458200539 | 0.0033673848137289 | 0.0064974238280045 |
| Spirits | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | rs74878100 | -0.669012573488392 | 0.314980903746299 | 0.0336719663825017 |
| Spirits | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | All - MR Egger | -1.05606769042984 | 0.354136856366708 | 0.0105976542467973 |
| Spirits | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | rs74878100 | -0.665751190833798 | 0.316783246792258 | 0.0355884628861317 |
| Spirits | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_CSA) | All - MR Egger | -1.06156280379434 | 0.356179245410355 | 0.0106317710886513 |
| Spirits | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | rs9310159 | 1.55364539367589 | 0.738851421880531 | 0.0354846025627776 |
| Spirits | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | All - MR Egger | -0.788070222786621 | 0.360440061308762 | 0.0476716466284711 |
| Spirits | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) | All - MR Egger | -0.792476338175854 | 0.362226540638576 | 0.0475510868061788 |
| Spirits | Fractured bone site(s) (ukb-e-6151_p7_CSA) | rs139045461 | -16.5445408572359 | 7.78165016711256 | 0.0334952074106965 |
| Spirits | Fractured bone site(s) (ukb-e-6151_p7_CSA) | All - Inverse variance weighted | -2.93848543023806 | 1.01779813993778 | 0.0038881012377752 |
| Spirits | Fractured bone site(s) (ukb-e-6151_p7_CSA) | All - MR Egger | -4.08131304690535 | 1.81584392354815 | 0.0441869393521624 |