ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Drinking water (ukb-b-3975)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Drinking water (👉 📊) Osteoporosis (bbj-a-137) Simple mode 16 0.336417097 0.12843687 0.019340176
Drinking water (👉 📊) Rheumatoid arthritis (bbj-a-151) Simple mode 16 -0.587742716 0.192971219 0.00817396
Drinking water (👉 📊) Knee osteoarthritis (ebi-a-GCST007090) Inverse variance weighted 24 -0.132622007 0.051715058 0.010333183
Drinking water (👉 📊) Osteoarthritis of the hip or knee (ebi-a-GCST007092) Inverse variance weighted 24 -0.09998133 0.03875994 0.009894298
Drinking water (👉 📊) Osteopontin levels (ebi-a-GCST90010244) MR Egger 24 0.65011842 0.291991938 0.036535576
Drinking water (👉 📊) Osteoarthritis (Firth correction) (ebi-a-GCST90013881) MR Egger 21 -0.206886419 0.084808193 0.024687234
Drinking water (👉 📊) Osteoarthritis (Firth correction) (ebi-a-GCST90013881) Inverse variance weighted 21 -0.114950088 0.039874133 0.003941282
Drinking water (👉 📊) Osteoarthritis (SPA correction) (ebi-a-GCST90013931) MR Egger 21 -0.205673019 0.085205123 0.02604278
Drinking water (👉 📊) Osteoarthritis (SPA correction) (ebi-a-GCST90013931) Inverse variance weighted 21 -0.114048505 0.039918911 0.004276599
Drinking water (👉 📊) Fractured bones in last 5 years (UKB data field 2463) (SPA correction) (ebi-a-GCST90013963) Simple mode 21 0.149709902 0.069529056 0.043686313
Drinking water (👉 📊) Neck circumference (ebi-a-GCST90017134) Inverse variance weighted 20 -0.489086577 0.2424723 0.043686929
Drinking water (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017136) Weighted median 22 -0.310269021 0.140537158 0.027262643
Drinking water (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017136) Inverse variance weighted 22 -0.257321752 0.106849313 0.016028422
Drinking water (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017137) Inverse variance weighted 20 -0.489086577 0.2424723 0.043686929
Drinking water (👉 📊) Neck circumference (BMI adjusted) (ebi-a-GCST90017138) Inverse variance weighted 21 -0.365374783 0.13522137 0.006891358
Drinking water (👉 📊) Osteoarthritis (ebi-a-GCST90038686) Inverse variance weighted 23 -0.005259288 0.002019001 0.009190209
Drinking water (👉 📊) Fracture of lower leg or ankle (ebi-a-GCST90038707) Weighted median 23 0.001640844 0.000752935 0.029311986
Drinking water (👉 📊) Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) MR Egger 24 1.552995915 0.713799189 0.040601318
Drinking water (👉 📊) Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) MR Egger 24 1.537160357 0.712461817 0.042149396
Drinking water (👉 📊) Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) Weighted median 24 0.754974713 0.312984271 0.015857407
Drinking water (👉 📊) Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) Weighted mode 24 0.844713871 0.375730659 0.03444731
Drinking water (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) Weighted median 24 0.750350694 0.30721606 0.014589157
Drinking water (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) Weighted mode 24 0.846258222 0.386279036 0.038861784
Drinking water (👉 📊) Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) Inverse variance weighted 24 -0.298720332 0.144451236 0.038643164
Drinking water (👉 📊) Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) Inverse variance weighted 24 -0.118585147 0.052713161 0.024472397
Drinking water (👉 📊) Other bursitis of elbow (finn-b-M13_BURSELBOWOTH) MR Egger 24 -2.153896411 0.956999414 0.034734081
Drinking water (👉 📊) Other bursitis of elbow (finn-b-M13_BURSELBOWOTH) Inverse variance weighted 24 -1.248781583 0.5428889 0.021433916
Drinking water (👉 📊) Loose body in joint (finn-b-M13_LOOSEJOINT) MR Egger 24 0.879499932 0.407772261 0.042209544
Drinking water (👉 📊) Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) Weighted median 24 -0.483859202 0.231390284 0.036519496
Drinking water (👉 📊) Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) Weighted median 24 0.902567817 0.36363129 0.013061203
Drinking water (👉 📊) Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) Inverse variance weighted 24 0.5371636 0.247400179 0.029913513
Drinking water (👉 📊) Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) MR Egger 24 1.670958064 0.619873821 0.013207091
Drinking water (👉 📊) Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) Inverse variance weighted 24 0.720662007 0.347405522 0.038041111
Drinking water (👉 📊) Burn and corrosion of wrist and hand (finn-b-ST19_BURN_CORROSION_WRIST_HAND) Weighted median 24 0.636204665 0.300832835 0.034446037
Drinking water (👉 📊) Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) Inverse variance weighted 24 -0.132790178 0.066639377 0.046297774
Drinking water (👉 📊) Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) MR Egger 24 0.304216732 0.132835197 0.031964831
Drinking water (👉 📊) Fracture of neck (finn-b-ST19_FRACT_NECK) MR Egger 24 -0.671573259 0.298252952 0.034660387
Drinking water (👉 📊) Injury of muscle and tendon at shoulder and upper arm level (finn-b-ST19_INJURY_MUSCLE_TENDON_SHOUL_UPPER_ARM_LEVEL) Weighted median 24 -0.243689332 0.090679988 0.007202033
Drinking water (👉 📊) Knee and hip osteoarthritis (ieu-a-1170) MR Egger 11 -0.9863447 0.389682063 0.032174476
Drinking water (👉 📊) Knee osteoarthritis (ieu-a-1171) MR Egger 11 -1.415168153 0.513524701 0.022264804
Drinking water (👉 📊) Rheumatoid arthritis (ieu-a-834) Weighted mode 10 -0.649869406 0.259440815 0.0335915
Drinking water (👉 📊) Osteocalcin (prot-a-246) Inverse variance weighted 22 -0.205586666 0.096505014 0.033145113
Drinking water (👉 📊) Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) Weighted median 24 -0.009197595 0.003522641 0.009027951
Drinking water (👉 📊) Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) Inverse variance weighted 24 -0.008110316 0.002471263 0.001031281
Drinking water (👉 📊) Fracture resulting from simple fall (ukb-a-332) Weighted median 24 0.040759713 0.020251535 0.044149069
Drinking water (👉 📊) Neck/shoulder pain for 3+ months (ukb-a-341) MR Egger 24 -0.056149291 0.020533642 0.012102217
Drinking water (👉 📊) Operation code: knee replacement/revision (ukb-b-11120) MR Egger 14 -0.018184573 0.008343336 0.049935606
Drinking water (👉 📊) Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) Weighted median 22 -0.00713537 0.003095135 0.021146957
Drinking water (👉 📊) Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) Inverse variance weighted 22 -0.009367661 0.002604238 0.000321806
Drinking water (👉 📊) Fracture resulting from simple fall (ukb-b-15251) Weighted median 21 0.048899164 0.017995246 0.006580938
Drinking water (👉 📊) Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) Inverse variance weighted 14 -0.002383129 0.001148145 0.037927699
Drinking water (👉 📊) Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) MR Egger 11 -0.008954706 0.003703337 0.038736861
Drinking water (👉 📊) Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) MR Egger 13 -0.011030424 0.004385054 0.028706437
Drinking water (👉 📊) Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) Inverse variance weighted 12 -0.001653522 0.000692359 0.016929021
Drinking water (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_EAS) Inverse variance weighted 17 -0.185681083 0.094543886 0.049533905
Drinking water (👉 📊) Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) Inverse variance weighted 18 0.151091289 0.071395099 0.03432187
Drinking water (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) Inverse variance weighted 18 0.155575618 0.068584158 0.023305446
Drinking water (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) Inverse variance weighted 17 -0.212589824 0.096020494 0.026828457

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Drinking water Rheumatoid arthritis (bbj-a-151) rs113928962 0.961743186592714 0.398228025915042 0.015732768581809
Drinking water Rheumatoid arthritis (bbj-a-151) rs12204397 -0.956192988325479 0.436275524115805 0.0283998637442727
Drinking water Knee osteoarthritis (ebi-a-GCST007090) rs141204290 -0.407970379876352 0.174720577141519 0.0195440688875008
Drinking water Knee osteoarthritis (ebi-a-GCST007090) rs2472297 -0.566302077932113 0.10675353354196 1.12820154507138e-07
Drinking water Knee osteoarthritis (ebi-a-GCST007090) rs28444545 0.419955574061399 0.180491544596601 0.0199794977310454
Drinking water Knee osteoarthritis (ebi-a-GCST007090) rs2950835 -0.425505606127281 0.170929602461386 0.0127972696413118
Drinking water Knee osteoarthritis (ebi-a-GCST007090) rs4410790 -0.320399677332006 0.136098977981737 0.0185642853591186
Drinking water Knee osteoarthritis (ebi-a-GCST007090) rs4562414 -0.414537360824671 0.184047707918008 0.024301018481818
Drinking water Knee osteoarthritis (ebi-a-GCST007090) All - Inverse variance weighted -0.132622007403433 0.0517150582860089 0.0103331831313456
Drinking water Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs141204290 -0.307820371638905 0.143071440339209 0.031435561213217
Drinking water Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs2472297 -0.386346121389951 0.0874362274724627 9.93401756138994e-06
Drinking water Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs2950835 -0.347314405001327 0.140016802016242 0.0131191094945423
Drinking water Osteoarthritis of the hip or knee (ebi-a-GCST007092) rs4410790 -0.321817375019316 0.111998117297471 0.0040605683103052
Drinking water Osteoarthritis of the hip or knee (ebi-a-GCST007092) All - Inverse variance weighted -0.0999813303680575 0.038759940059307 0.0098942978248848
Drinking water Osteopontin levels (ebi-a-GCST90010244) rs113928962 -1.68438325790003 0.733958217191235 0.0217370951056194
Drinking water Osteopontin levels (ebi-a-GCST90010244) rs4645766 2.00557785159931 0.921426154411524 0.0295102887085489
Drinking water Osteopontin levels (ebi-a-GCST90010244) All - MR Egger 0.650118420110169 0.291991937905532 0.036535576432036
Drinking water Osteoarthritis (Firth correction) (ebi-a-GCST90013881) rs150119776 -0.307819211853328 0.14159417747166 0.0297085988175908
Drinking water Osteoarthritis (Firth correction) (ebi-a-GCST90013881) rs2472297 -0.478237529662232 0.0921244359854978 2.08928933450344e-07
Drinking water Osteoarthritis (Firth correction) (ebi-a-GCST90013881) All - Inverse variance weighted -0.114950088350915 0.0398741327071211 0.0039412815989072
Drinking water Osteoarthritis (Firth correction) (ebi-a-GCST90013881) All - MR Egger -0.206886418898664 0.0848081931665362 0.0246872344491201
Drinking water Osteoarthritis (SPA correction) (ebi-a-GCST90013931) rs150119776 -0.314186187341887 0.147170233116196 0.0327733672179118
Drinking water Osteoarthritis (SPA correction) (ebi-a-GCST90013931) rs2472297 -0.480381750635946 0.0929279342479569 2.34845576651611e-07
Drinking water Osteoarthritis (SPA correction) (ebi-a-GCST90013931) All - Inverse variance weighted -0.114048504937427 0.0399189111358724 0.0042765990369782
Drinking water Osteoarthritis (SPA correction) (ebi-a-GCST90013931) All - MR Egger -0.205673018968898 0.085205122723782 0.0260427803126701
Drinking water Neck circumference (ebi-a-GCST90017134) rs2472297 -1.57181869386543 0.793026249168847 0.047473501351992
Drinking water Neck circumference (ebi-a-GCST90017134) All - Inverse variance weighted -0.489086576614666 0.24247229994133 0.0436869288033419
Drinking water Neck circumference (BMI adjusted) (ebi-a-GCST90017136) rs12204397 -1.06940703023927 0.479589409582893 0.0257581525193845
Drinking water Neck circumference (BMI adjusted) (ebi-a-GCST90017136) rs28444545 -1.04720836765949 0.503946688873679 0.0377080527209846
Drinking water Neck circumference (BMI adjusted) (ebi-a-GCST90017136) rs2950835 -1.0273960147945 0.438234406310575 0.0190578051229123
Drinking water Neck circumference (BMI adjusted) (ebi-a-GCST90017136) All - Inverse variance weighted -0.257321752312984 0.106849313092783 0.01602842200934
Drinking water Neck circumference (BMI adjusted) (ebi-a-GCST90017137) rs2472297 -1.57181869386543 0.793026249168847 0.047473501351992
Drinking water Neck circumference (BMI adjusted) (ebi-a-GCST90017137) All - Inverse variance weighted -0.489086576614666 0.24247229994133 0.0436869288033419
Drinking water Neck circumference (BMI adjusted) (ebi-a-GCST90017138) rs12204397 -1.48131245056652 0.620758872887534 0.0170191931499697
Drinking water Neck circumference (BMI adjusted) (ebi-a-GCST90017138) rs28444545 -1.35636715196852 0.646910288554156 0.0360214618744068
Drinking water Neck circumference (BMI adjusted) (ebi-a-GCST90017138) rs2950835 -1.14377361647034 0.570977608222078 0.04515746584277
Drinking water Neck circumference (BMI adjusted) (ebi-a-GCST90017138) rs377268 -1.18818506025426 0.581158730487208 0.0409031524563302
Drinking water Neck circumference (BMI adjusted) (ebi-a-GCST90017138) All - Inverse variance weighted -0.365374782538158 0.135221369607674 0.0068913581016451
Drinking water Osteoarthritis (ebi-a-GCST90038686) rs2472297 -0.0264676577461381 0.0064294704821396 3.84476720355261e-05
Drinking water Osteoarthritis (ebi-a-GCST90038686) All - Inverse variance weighted -0.0052592879094 0.0020190009174781 0.0091902085228418
Drinking water Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) rs28444545 -5.4629965527902 2.47863140946026 0.0275217075667664
Drinking water Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) All - MR Egger 1.55299591522072 0.713799188842702 0.04060131752591
Drinking water Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) rs28444545 -5.43440383285411 2.48399254444828 0.0286863759103458
Drinking water Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) All - MR Egger 1.537160357251 0.712461816922393 0.0421493956537513
Drinking water Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) rs377268 -2.7609350964689 1.24336927205127 0.0263830118667881
Drinking water Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) rs76945478 -4.5487334858509 2.0431858309803 0.0259944581103861
Drinking water Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) rs377268 -2.78680269574875 1.24336927205127 0.0250046110230669
Drinking water Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) rs76945478 -4.58651937041846 2.04868195964468 0.0251711502385015
Drinking water Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) rs11050325 -5.45557638902313 2.18815842885586 0.0126587771453216
Drinking water Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) All - Inverse variance weighted -0.298720331869294 0.144451236187529 0.0386431638596355
Drinking water Gonarthrosis, primary, with knee surgery (finn-b-M13_ARTHROSIS_KNEE_PRIM_KNEESURG) All - Inverse variance weighted -0.118585146822028 0.0527131613519401 0.0244723970540353
Drinking water Other bursitis of elbow (finn-b-M13_BURSELBOWOTH) rs150119776 -4.32388379845268 1.91179050669806 0.023716358380096
Drinking water Other bursitis of elbow (finn-b-M13_BURSELBOWOTH) rs2472297 -7.19823826168646 1.89716279608855 0.0001481129556507
Drinking water Other bursitis of elbow (finn-b-M13_BURSELBOWOTH) rs76945478 -9.87448216162741 4.6875107346263 0.0351564858046416
Drinking water Other bursitis of elbow (finn-b-M13_BURSELBOWOTH) All - Inverse variance weighted -1.24878158261178 0.54288890038131 0.0214339156750478
Drinking water Other bursitis of elbow (finn-b-M13_BURSELBOWOTH) All - MR Egger -2.15389641069356 0.956999414220242 0.0347340811865421
Drinking water Loose body in joint (finn-b-M13_LOOSEJOINT) rs7138369 -3.38287417947307 1.31476244705762 0.0100823334079929
Drinking water Loose body in joint (finn-b-M13_LOOSEJOINT) All - MR Egger 0.87949993191996 0.407772260604277 0.0422095440962017
Drinking water Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) rs148278971 -3.18687231891857 1.17276096697461 0.0065795057071262
Drinking water Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) rs1504260 2.34965043014574 0.896406747079484 0.0087623977499331
Drinking water Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) rs28444545 2.61980796414473 0.956069072863186 0.006140425261494
Drinking water Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) rs4645766 2.72561554666948 1.13885684969637 0.0166980036646053
Drinking water Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) All - Inverse variance weighted 0.537163600294973 0.247400178698473 0.029913512684038
Drinking water Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) All - Inverse variance weighted 0.720662007386899 0.347405522318317 0.0380411110685716
Drinking water Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) All - MR Egger 1.67095806395131 0.619873821294263 0.0132070905186848
Drinking water Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) rs2472297 -0.516483762279198 0.25417507986181 0.0421536559466274
Drinking water Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) rs35294020 -0.462954064302837 0.155965544794787 0.0029944230104997
Drinking water Dislocation, sprain and strain of joints and ligaments of shoulder girdle (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_SHOUL_GIRDLE) All - Inverse variance weighted -0.132790178217536 0.0666393770570324 0.0462977741637733
Drinking water Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) rs35294020 0.391561385347476 0.176010412347638 0.0261048114037984
Drinking water Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) All - MR Egger 0.304216731798589 0.132835197031063 0.0319648312579795
Drinking water Fracture of neck (finn-b-ST19_FRACT_NECK) rs4645766 -1.76249922681444 0.789922754214316 0.0256659078027698
Drinking water Fracture of neck (finn-b-ST19_FRACT_NECK) All - MR Egger -0.671573259276803 0.298252952159949 0.0346603868249996
Drinking water Knee and hip osteoarthritis (ieu-a-1170) rs10153636 -0.957731307466105 0.423730007590185 0.0238063895426317
Drinking water Knee and hip osteoarthritis (ieu-a-1170) rs2472297 -0.496050119258947 0.247198482269763 0.0447829414196219
Drinking water Knee and hip osteoarthritis (ieu-a-1170) All - MR Egger -0.986344699614101 0.389682062759954 0.0321744761444235
Drinking water Knee osteoarthritis (ieu-a-1171) rs10153636 -1.36852845864713 0.592275282813913 0.0208533546766374
Drinking water Knee osteoarthritis (ieu-a-1171) rs2472297 -0.687885202333531 0.314030261068308 0.0284875529203928
Drinking water Knee osteoarthritis (ieu-a-1171) All - MR Egger -1.4151681530475 0.513524701243973 0.0222648040715249
Drinking water Osteocalcin (prot-a-246) rs4562414 -1.140407760277 0.505701178765367 0.0241269245824497
Drinking water Osteocalcin (prot-a-246) rs79375232 -0.995770572085776 0.504068660186491 0.0482152731023823
Drinking water Osteocalcin (prot-a-246) All - Inverse variance weighted -0.205586665868287 0.0965050135683792 0.0331451133939967
Drinking water Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) rs2472297 -0.0282750459040194 0.0077349645273258 0.0002566963348095
Drinking water Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) All - Inverse variance weighted -0.0081103159474676 0.0024712626669996 0.0010312807000109
Drinking water Fracture resulting from simple fall (ukb-a-332) rs12561532 0.145624099643069 0.0690801245028602 0.0350269862538445
Drinking water Fracture resulting from simple fall (ukb-a-332) rs13162251 -0.224294429653401 0.0729148543202268 0.0020971740016556
Drinking water Neck/shoulder pain for 3+ months (ukb-a-341) rs13438763 0.103817524325533 0.0424637447030607 0.0144912037434203
Drinking water Neck/shoulder pain for 3+ months (ukb-a-341) rs148278971 -0.115662293119836 0.0445473152725462 0.0094208516315939
Drinking water Neck/shoulder pain for 3+ months (ukb-a-341) rs2472297 -0.0573099736267937 0.027192463403872 0.0350683487819342
Drinking water Neck/shoulder pain for 3+ months (ukb-a-341) rs4645766 -0.119510109628616 0.0441912842885056 0.0068431589120077
Drinking water Neck/shoulder pain for 3+ months (ukb-a-341) All - MR Egger -0.0561492909797058 0.0205336423136508 0.0121022169858478
Drinking water Operation code: knee replacement/revision (ukb-b-11120) rs2472297 -0.0132048020789488 0.0026339960186015 5.35265779301041e-07
Drinking water Operation code: knee replacement/revision (ukb-b-11120) rs4410790 -0.0095371217050933 0.0033567536991276 0.0044947765236344
Drinking water Operation code: knee replacement/revision (ukb-b-11120) rs7138369 -0.0089371377205666 0.0040240687899067 0.0263563321420566
Drinking water Operation code: knee replacement/revision (ukb-b-11120) All - MR Egger -0.0181845732278026 0.0083433364088239 0.0499356056274309
Drinking water Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) rs2472297 -0.0354585420110739 0.0066003371378259 7.77679859928333e-08
Drinking water Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) rs4410790 -0.0187223991981502 0.0084112003788088 0.0260216109956201
Drinking water Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) All - Inverse variance weighted -0.0093676609160674 0.0026042382543354 0.0003218059329717
Drinking water Fracture resulting from simple fall (ukb-b-15251) rs12561532 0.12731977313809 0.0581738900822849 0.0286254290063038
Drinking water Fracture resulting from simple fall (ukb-b-15251) rs13162251 -0.144676821443401 0.0621076641821472 0.0198351339818485
Drinking water Fracture resulting from simple fall (ukb-b-15251) rs1504260 0.134007772695422 0.0577893141984786 0.0204003352582687
Drinking water Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) rs2472297 -0.0077839186477072 0.0026408587457578 0.0032035965885905
Drinking water Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) rs2950835 -0.0115124360377791 0.004215142180698 0.0063102359574595
Drinking water Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) All - Inverse variance weighted -0.0023831293588912 0.0011481445831063 0.0379276994642941
Drinking water Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) rs13162251 0.0072148454894415 0.0023830531594482 0.0024653366300033
Drinking water Diagnoses - main ICD10: M25.56 Pain in joint (Lower leg) (ukb-b-2083) All - MR Egger -0.008954705676805 0.0037033373220975 0.0387368608811718
Drinking water Non-cancer illness code, self-reported: cervical spondylosis (ukb-b-2349) All - MR Egger -0.0110304241170362 0.0043850543535269 0.0287064370030097
Drinking water Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) rs2472297 -0.0036287966131679 0.0016123443685986 0.0244087455230745
Drinking water Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) All - Inverse variance weighted -0.0016535222203004 0.0006923585127546 0.0169290210791151
Drinking water Heel bone mineral density (BMD) (ukb-e-3148_EAS) rs10153636 -0.71356825030338 0.247340026633821 0.0039145250231772
Drinking water Heel bone mineral density (BMD) (ukb-e-3148_EAS) All - Inverse variance weighted -0.185681082707533 0.0945438855801372 0.0495339050281548
Drinking water Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) rs113928962 0.766774068579744 0.338426262759883 0.0234694524905301
Drinking water Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) All - Inverse variance weighted 0.151091289002779 0.0713950986551575 0.0343218702671396
Drinking water Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) rs113928962 0.709608534200108 0.339843590058551 0.036793822015024
Drinking water Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) rs28444545 -0.786121093743019 0.399583261106931 0.0491425961979819
Drinking water Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) All - Inverse variance weighted 0.155575617678691 0.068584157664098 0.0233054464883741
Drinking water Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) rs10153636 -0.746292399361879 0.251294194645057 0.0029799793352188
Drinking water Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) All - Inverse variance weighted -0.212589823918451 0.0960204942349752 0.0268284567767487