ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Croissant | Bone mineral density (paediatric, total body less head) (ebi-a-GCST004772) | rs3791299 | 3.33346311306174 | 1.68258238063215 | 0.047573453072034 |
| Croissant | Osteoprotegerin levels (ebi-a-GCST90000490) | rs11577949 | 14.0998155724276 | 5.90542703876724 | 0.0169586479258608 |
| Croissant | Osteoprotegerin levels (ebi-a-GCST90000490) | rs6446355 | 21.3773058022908 | 8.28762846405225 | 0.009896530030821 |
| Croissant | Osteoprotegerin levels (ebi-a-GCST90000490) | All - Inverse variance weighted | 3.2065956529697 | 1.51230908037986 | 0.0339781506948066 |
| Croissant | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | All - MR Egger | -4.9796509574529 | 1.82856072551292 | 0.0134939883110581 |
| Croissant | Rheumatoid arthritis (ebi-a-GCST90038685) | rs111997347 | 0.0593849246035037 | 0.0267863676500002 | 0.0266242458675269 |
| Croissant | Rheumatoid arthritis (ebi-a-GCST90038685) | rs117892082 | 0.0536094016840367 | 0.0270562811440226 | 0.0475460766654506 |
| Croissant | Rheumatoid arthritis (ebi-a-GCST90038685) | All - Inverse variance weighted | 0.0196363788640264 | 0.005536743233965 | 0.000390299391801 |
| Croissant | Rheumatoid arthritis (ebi-a-GCST90038685) | All - MR Egger | 0.0295811351136433 | 0.0106643806894637 | 0.0117150585959688 |
| Croissant | Sciatica (ebi-a-GCST90038692) | rs12572321 | -0.0704497004204045 | 0.0250148962229799 | 0.0048578779290669 |
| Croissant | Sciatica (ebi-a-GCST90038692) | rs2350305 | -0.0512973831103158 | 0.025477113155438 | 0.0440652900970029 |
| Croissant | Sciatica (ebi-a-GCST90038692) | All - Inverse variance weighted | -0.0123441476274475 | 0.0050971895286626 | 0.0154457317185348 |
| Croissant | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | All - Inverse variance weighted | -1.13702397029139 | 0.463925151078258 | 0.0142508224832707 |
| Croissant | Gluteal tendinitis (finn-b-M13_GLUTEALTEND) | rs59535896 | 10.183607634895 | 3.7361515908914 | 0.0064166369226864 |
| Croissant | Gluteal tendinitis (finn-b-M13_GLUTEALTEND) | All - Inverse variance weighted | 4.50996124726478 | 1.33500779304462 | 0.0007295445785922 |
| Croissant | Gluteal tendinitis (finn-b-M13_GLUTEALTEND) | All - MR Egger | 5.24087830144381 | 2.10203620774934 | 0.0196388235905297 |
| Croissant | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | rs114278508 | -21.0503472222222 | 8.00095942982456 | 0.0085139579035103 |
| Croissant | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | rs1189976 | -30.353776518885 | 11.4735744155558 | 0.0081561138129656 |
| Croissant | Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) | All - Inverse variance weighted | -3.63957747849089 | 1.6563232115757 | 0.0279930608093815 |
| Croissant | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs62010408 | 7.27738806451074 | 3.03602414498447 | 0.0165293562688912 |
| Croissant | Other arthritis (FG) (finn-b-RHEU_ARTHRITIS_OTH) | rs6446355 | -4.63828263095224 | 2.25046514895861 | 0.0392999049014497 |
| Croissant | Burn and corrosion of shoulder and upper limb, except wrist and hand (finn-b-ST19_BURN_CORROSION_SHOUL_UPPER_LIMB_WRIST_HAND) | rs149682269 | 6.50079448263185 | 2.7643400138217 | 0.0186897289291253 |
| Croissant | Burn and corrosion of shoulder and upper limb, except wrist and hand (finn-b-ST19_BURN_CORROSION_SHOUL_UPPER_LIMB_WRIST_HAND) | rs71322578 | 48.9983166064843 | 20.0593685346766 | 0.0145792651006693 |
| Croissant | Burn and corrosion of shoulder and upper limb, except wrist and hand (finn-b-ST19_BURN_CORROSION_SHOUL_UPPER_LIMB_WRIST_HAND) | All - MR Egger | 6.09415745640907 | 2.31698362629372 | 0.0143957855660415 |
| Croissant | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | rs145083515 | -13.7201499742533 | 6.29586122554068 | 0.0293143467666792 |
| Croissant | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | rs76127800 | 10.1940735363396 | 5.10475955115185 | 0.0458279769084771 |
| Croissant | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | All - Inverse variance weighted | 2.55056831423613 | 1.17658810470414 | 0.0301764545315811 |
| Croissant | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | All - MR Egger | 5.06412465774732 | 1.78817107185782 | 0.0090057699674005 |
| Croissant | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | rs3776992 | 3.73909985622271 | 1.65811273386067 | 0.0241312225404774 |
| Croissant | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | rs117892082 | -3.75549362348478 | 1.78871571290978 | 0.0357686642010021 |
| Croissant | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | rs3791299 | -8.92530586722354 | 4.09985960193018 | 0.0294821778060591 |
| Croissant | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | All - Inverse variance weighted | -0.814632231897235 | 0.335646130159793 | 0.0152218713314395 |
| Croissant | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | All - MR Egger | -1.41099817572624 | 0.528354928105087 | 0.0131211578393159 |
| Croissant | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | rs17582361 | 36.9129825501606 | 14.676115192839 | 0.0118973668336521 |
| Croissant | Injury of nerves at wrist and hand level (finn-b-ST19_INJURY_NERVES_WRIST_HAND_LEVEL) | rs62010408 | 18.9178674317193 | 8.85984404574085 | 0.0327416504102785 |
| Croissant | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | All - MR Egger | -1.83539070411384 | 0.775007362711892 | 0.0259166758246544 |
| Croissant | Osteomyelitis (ieu-b-4975) | rs2350305 | 5.51196368834604 | 2.73382799128676 | 0.0437783135264672 |
| Croissant | Osteocrin (prot-a-2157) | rs145336632 | 7.90540470488217 | 3.00664572382404 | 0.0085558240674557 |
| Croissant | Osteocrin (prot-a-2157) | rs149682269 | 6.18441541455379 | 2.96760030895565 | 0.0371621176432611 |
| Croissant | Osteocrin (prot-a-2157) | All - Inverse variance weighted | 1.22106064409658 | 0.604246067182593 | 0.0433004400082357 |
| Croissant | Bone morphogenetic protein receptor type-1A (prot-a-259) | rs17582361 | 6.52875294662935 | 2.31385087792354 | 0.0047785296622269 |
| Croissant | Bone morphogenetic protein receptor type-1A (prot-a-259) | All - Inverse variance weighted | 1.22109716867377 | 0.606269181312755 | 0.0439972330882953 |
| Croissant | Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) | rs111997347 | 0.064093607762595 | 0.0311230687422859 | 0.0394597494955882 |
| Croissant | Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) | rs117892082 | 0.0857531356483218 | 0.0316662035250919 | 0.0067683217898826 |
| Croissant | Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) | All - Inverse variance weighted | 0.0204937887034685 | 0.0061851300326521 | 0.0009217018664975 |
| Croissant | Non-cancer illness code self-reported: rheumatoid arthritis (ukb-a-105) | All - MR Egger | 0.0299960786163044 | 0.011208270687718 | 0.0132055598231192 |
| Croissant | Fractured bone site(s): Wrist (ukb-a-439) | rs10147965 | 0.0875789520670748 | 0.0428120699018725 | 0.0407898035544377 |
| Croissant | Fractured bone site(s): Wrist (ukb-a-439) | rs117892082 | 0.105166501644377 | 0.0422873438246141 | 0.0128843575153162 |
| Croissant | Fractured bone site(s): Wrist (ukb-a-439) | rs139115181 | 0.108033035217264 | 0.0386550058090932 | 0.0051931728149942 |
| Croissant | Fractured bone site(s): Wrist (ukb-a-439) | rs1689216 | 0.088603282227732 | 0.0438349440874361 | 0.0432494042102934 |
| Croissant | Fractured bone site(s): Wrist (ukb-a-439) | rs6446355 | 0.0828332827947185 | 0.0392148306709873 | 0.0346611718488485 |
| Croissant | Fractured bone site(s): Wrist (ukb-a-439) | All - Inverse variance weighted | 0.0255283997056357 | 0.0087167113069874 | 0.0034041200483273 |
| Croissant | Non-cancer illness code self-reported: joint disorder (ukb-a-86) | rs2350305 | 0.0476556422125408 | 0.021816652403921 | 0.0289350667851104 |
| Croissant | Non-cancer illness code self-reported: joint disorder (ukb-a-86) | All - Inverse variance weighted | 0.0084746159817895 | 0.004092378865098 | 0.0383747985467822 |
| Croissant | Heel bone mineral density (BMD), manual entry (ukb-b-11364) | rs115844331 | -2.56324819532191 | 0.815466738741174 | 0.001670604142006 |
| Croissant | Heel bone mineral density (BMD), manual entry (ukb-b-11364) | rs59535896 | -1.75693393411573 | 0.787815562109196 | 0.0257385765979052 |
| Croissant | Heel bone mineral density (BMD), manual entry (ukb-b-11364) | rs62010408 | -1.70303769491299 | 0.868546360231903 | 0.0499034340686624 |
| Croissant | Heel bone mineral density (BMD), manual entry (ukb-b-11364) | rs6446355 | -2.08516689893298 | 0.774381888087432 | 0.0070879089204608 |
| Croissant | Heel bone mineral density (BMD), manual entry (ukb-b-11364) | All - Inverse variance weighted | -0.566976133014086 | 0.203369159586366 | 0.0053048297513521 |
| Croissant | Heel bone ultrasound T-score, manual entry (ukb-b-17612) | rs115844331 | -2.20622318321565 | 0.827176030721759 | 0.0076491843458869 |
| Croissant | Heel bone ultrasound T-score, manual entry (ukb-b-17612) | rs12572321 | -2.12511999735178 | 0.852899798073422 | 0.0127154531856323 |
| Croissant | Heel bone ultrasound T-score, manual entry (ukb-b-17612) | rs6446355 | -2.28954717048911 | 0.785740926029429 | 0.0035697815238059 |
| Croissant | Heel bone ultrasound T-score, manual entry (ukb-b-17612) | rs76127800 | -1.9579069713562 | 0.91776394541537 | 0.0328964489336681 |
| Croissant | Heel bone ultrasound T-score, manual entry (ukb-b-17612) | All - Inverse variance weighted | -0.654794737306969 | 0.20784882920074 | 0.0016307986519032 |
| Croissant | Fractured bone site(s): Other bones (ukb-b-17738) | All - Inverse variance weighted | -0.0320589483207613 | 0.0153345950946772 | 0.0365613392384382 |
| Croissant | Fractured bone site(s): Wrist (ukb-b-9571) | rs10147965 | 0.0790227426590387 | 0.0362878207369604 | 0.0294309340740942 |
| Croissant | Fractured bone site(s): Wrist (ukb-b-9571) | rs1689216 | 0.0877279090556427 | 0.0373761574659718 | 0.0189170108304329 |
| Croissant | Fractured bone site(s): Wrist (ukb-b-9571) | rs6446355 | 0.0739441567676136 | 0.0333954236315746 | 0.0268150037752633 |
| Croissant | Fractured bone site(s): Wrist (ukb-b-9571) | All - Inverse variance weighted | 0.0287641980131016 | 0.0116335764063241 | 0.0134165894563078 |
| Croissant | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | rs115844331 | 0.0436095814047772 | 0.0212503800804081 | 0.0401522802617625 |
| Croissant | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | rs17582361 | 0.0355780462987439 | 0.0174475219345097 | 0.0414354484797205 |
| Croissant | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | All - Inverse variance weighted | 0.0100645445709105 | 0.0041600056686351 | 0.0155479136747425 |
| Croissant | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | All - MR Egger | 0.0190544424786281 | 0.0076541568757051 | 0.0204656183135749 |
| Croissant | M51 Other intervertebral disk disorders (ukb-e-M51_CSA) | All - Inverse variance weighted | -6.07158283167664 | 2.18849837453715 | 0.0055318167172702 |
| Croissant | M51 Other intervertebral disk disorders (ukb-e-M51_CSA) | All - MR Egger | -10.0530048965398 | 3.94870549059048 | 0.0215814270385897 |