ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Mushroom | Total body bone mineral density (age 15-30) (ebi-a-GCST005344) | All - MR Egger | 2.16813763494038 | 0.866962837830119 | 0.0368935651519971 |
| Mushroom | Osteoarthritis (self-reported) (ebi-a-GCST005811) | rs2410501 | -2.09465562547756 | 0.645570996378275 | 0.0011759270260531 |
| Mushroom | Osteoarthritis (self-reported) (ebi-a-GCST005811) | All - Inverse variance weighted | -0.3905624627175 | 0.198168120936982 | 0.0487394065887653 |
| Mushroom | Osteoclast-associated immunoglobulin-like receptor levels (ebi-a-GCST90010135) | rs56270010 | 3.71798528421071 | 1.77646348611974 | 0.0363568330896217 |
| Mushroom | Osteoprotegerin levels (ebi-a-GCST90010243) | rs35350431 | -2.8547293725884 | 1.21070748982504 | 0.018378553854613 |
| Mushroom | Osteoprotegerin levels (ebi-a-GCST90010243) | rs61068241 | -3.32841890071679 | 1.59305313637391 | 0.0366777345150125 |
| Mushroom | Osteoprotegerin levels (ebi-a-GCST90010243) | All - MR Egger | -2.23859216494341 | 0.94155161282742 | 0.0447158896822249 |
| Mushroom | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | rs2410501 | -14.0588794394091 | 5.61292887627118 | 0.0122544401212512 |
| Mushroom | Juvenile rheumatoid arthritis (ebi-a-GCST90018653) | All - Inverse variance weighted | -6.08991952464809 | 3.04813384267635 | 0.0457256200675434 |
| Mushroom | Spine arthritis or spondylitis (ebi-a-GCST90038657) | rs182656582 | 0.0174889879189099 | 0.0083633171050033 | 0.0365142195372115 |
| Mushroom | Spine arthritis or spondylitis (ebi-a-GCST90038657) | All - Inverse variance weighted | 0.0057299236062932 | 0.0027754402502603 | 0.0389694053385911 |
| Mushroom | Fractures (ebi-a-GCST90038703) | rs182656582 | -0.0242771524003332 | 0.0119712698453586 | 0.0425652173071377 |
| Mushroom | Fracture of forearm or wrist (ebi-a-GCST90038705) | rs182656582 | -0.0199518301949976 | 0.0062305023913174 | 0.001363431092415 |
| Mushroom | Fracture of forearm or wrist (ebi-a-GCST90038705) | All - Inverse variance weighted | -0.0051537703101556 | 0.0022135981022602 | 0.0198997789046694 |
| Mushroom | Fracture of forearm or wrist (ebi-a-GCST90038705) | All - MR Egger | -0.0149199618474198 | 0.0051794146421285 | 0.0236304092232768 |
| Mushroom | Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) | All - Inverse variance weighted | 5.4953220151497 | 2.34748120099634 | 0.019235052380712 |
| Mushroom | Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) | All - Inverse variance weighted | 5.53012304582996 | 2.34621346338909 | 0.0184211765298057 |
| Mushroom | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs11130791 | 1.74703787488521 | 0.77646127772676 | 0.0244489453100894 |
| Mushroom | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs4420937 | 1.92991137703001 | 0.81425165324576 | 0.0177801126032164 |
| Mushroom | Cervical disc disorders (finn-b-M13_CERVICDISC) | All - Inverse variance weighted | 0.790529733709902 | 0.297257644341451 | 0.0078277811140345 |
| Mushroom | Olecranon bursitis (finn-b-M13_OLECRANONBURSITIS) | All - MR Egger | 5.11403730529267 | 1.90225113286869 | 0.0311572441427972 |
| Mushroom | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | rs35350431 | 7.3682541360537 | 3.3392356889899 | 0.0273441809264352 |
| Mushroom | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | rs61068241 | 2.63341410834891 | 1.00942233657389 | 0.0090851619150314 |
| Mushroom | Osteoporosis (finn-b-M13_OSTEOPOROSIS) | All - Inverse variance weighted | 1.22401631304152 | 0.425544951627474 | 0.004023030802502 |
| Mushroom | Patellar tendinitis (finn-b-M13_PATELLARTEND) | All - Inverse variance weighted | 3.30539265036347 | 1.54498729441497 | 0.032400834160144 |
| Mushroom | Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) | rs56270010 | -11.3413065731109 | 5.02716559199993 | 0.0240703695516857 |
| Mushroom | Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) | rs80060075 | -25.5531223492297 | 10.364891830341 | 0.0136878136234974 |
| Mushroom | Osteonecrosis due to drugs (finn-b-OSTEON_DRUGS) | All - MR Egger | -14.1631962582244 | 5.82087327958702 | 0.0452094898706782 |
| Mushroom | Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) | All - Inverse variance weighted | -1.44828726141111 | 0.719257310959124 | 0.0440528992244458 |
| Mushroom | Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) | All - Inverse variance weighted | 4.40473860447708 | 1.69063360294916 | 0.0091773107134342 |
| Mushroom | Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) | rs56270010 | -7.69823008075311 | 3.17850549873577 | 0.0154368237359339 |
| Mushroom | Superficial injury of neck (finn-b-ST19_SUPERF_INJURY_NECK) | All - Inverse variance weighted | -2.78681835616121 | 1.41969781454363 | 0.0496501399002772 |
| Mushroom | Bone morphogenetic protein 6 (prot-a-256) | All - Inverse variance weighted | -0.663520148499299 | 0.33031217728566 | 0.0445618664864971 |
| Mushroom | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | rs11130791 | 0.0228770503430615 | 0.0098409747575425 | 0.0200894410337354 |
| Mushroom | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | All - Inverse variance weighted | 0.0070748305225855 | 0.0031714606774331 | 0.0256957163966238 |
| Mushroom | Diagnoses - secondary ICD10: M06.99 Rheumatoid arthritis, unspecified (Site unspecified) (ukb-b-11874) | All - Inverse variance weighted | -0.006324274144521 | 0.0025854298173861 | 0.0144402532888368 |
| Mushroom | Operative procedures - main OPCS: W26.2 Manipulation of fracture of bone NEC (ukb-b-1935) | All - Inverse variance weighted | -0.0060468452428166 | 0.0025589688257641 | 0.0181276331388987 |
| Mushroom | Ankle spacing width (ukb-b-4080) | rs35350431 | -0.185107563824726 | 0.0902313811512236 | 0.0402205595832063 |
| Mushroom | Ankle spacing width (ukb-b-4080) | All - Inverse variance weighted | -0.0639960237153041 | 0.0299422225628453 | 0.0325722105265608 |
| Mushroom | Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) | rs12626372 | 0.0158023374532053 | 0.0067851302781536 | 0.0198608690750732 |
| Mushroom | Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) | All - Inverse variance weighted | 0.0069048565212491 | 0.0028328069720259 | 0.0147908095136073 |
| Mushroom | Operative procedures - main OPCS: W15.3 Osteotomy of first metatarsal bone NEC (ukb-b-8539) | All - Inverse variance weighted | -0.0053058704366104 | 0.0026322904299325 | 0.0438328415869883 |
| Mushroom | Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) | rs11130791 | 0.0172359845006383 | 0.0075532883881709 | 0.0224941837345155 |
| Mushroom | Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) | All - Inverse variance weighted | 0.0049359051976567 | 0.0024346075597378 | 0.0426222845424317 |
| Mushroom | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | All - Inverse variance weighted | 0.0044809850543166 | 0.0022159657537746 | 0.0431622605133391 |
| Mushroom | Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) | All - Inverse variance weighted | -1.49367395331567 | 0.666770706353913 | 0.0250804510409645 |
| Mushroom | Heel bone mineral density (BMD) (right) (ukb-e-4124_CSA) | All - Inverse variance weighted | -0.665607095694166 | 0.322228583455115 | 0.038862823384088 |
| Mushroom | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_CSA) | All - Inverse variance weighted | -0.638677077804909 | 0.323780156490034 | 0.0485452589299723 |