ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Apple | Osteoclast-associated immunoglobulin-like receptor levels (ebi-a-GCST90010135) | All - Inverse variance weighted | 0.856166393451241 | 0.331135097460817 | 0.0097223734437017 |
| Apple | Osteopontin levels (ebi-a-GCST90010244) | rs2030733 | -2.80815122235912 | 1.43151870825498 | 0.0498022255410654 |
| Apple | Osteopontin levels (ebi-a-GCST90010244) | All - Inverse variance weighted | 0.709241344514378 | 0.352721671936193 | 0.0443499994928215 |
| Apple | Rheumatoid arthritis (ebi-a-GCST90013534) | rs2030733 | -1.22884378444978 | 0.444199468257571 | 0.005667490516749 |
| Apple | Rheumatoid arthritis (ebi-a-GCST90013534) | rs7195117 | -1.24667790700997 | 0.475095019003801 | 0.0086888438850168 |
| Apple | Rheumatoid arthritis (ebi-a-GCST90013534) | All - Inverse variance weighted | -0.322262783852668 | 0.137522808797578 | 0.0191119259552563 |
| Apple | Neck circumference (ebi-a-GCST90017135) | rs116587918 | 3.34451225099419 | 1.44959407700625 | 0.0210433349685859 |
| Apple | Neck circumference (ebi-a-GCST90017135) | All - Inverse variance weighted | 0.788856981828007 | 0.353440856926295 | 0.0256192661954703 |
| Apple | Neck circumference (ebi-a-GCST90017135) | All - MR Egger | 2.29726201566376 | 1.03466204900642 | 0.0411899358714288 |
| Apple | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | rs17767097 | 2.33951012154103 | 1.19167990755453 | 0.0496225371213353 |
| Apple | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | rs7195117 | 2.54336581602035 | 1.13951361700912 | 0.0256166204659583 |
| Apple | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | All - Inverse variance weighted | 0.663324519440896 | 0.274456436403133 | 0.0156547649430573 |
| Apple | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018773) | All - Inverse variance weighted | -0.581098467749022 | 0.219054034721942 | 0.007983587336429 |
| Apple | Achilles tendon injury (ebi-a-GCST90018787) | All - Inverse variance weighted | 0.307047108997688 | 0.133534040679763 | 0.0214826880596852 |
| Apple | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | rs7195117 | 0.0139917626382419 | 0.0069432457920155 | 0.0438877144671358 |
| Apple | Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) | rs17767097 | -6.03062256247292 | 2.30597800293019 | 0.0089171950272932 |
| Apple | Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) | rs57320778 | -4.1498893478646 | 1.91079040713732 | 0.0298693797159431 |
| Apple | Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) | All - Inverse variance weighted | -1.00921641727263 | 0.506951747630546 | 0.046507895874108 |
| Apple | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | rs12127789 | 8.84542087663155 | 3.54705184364206 | 0.01264055178966 |
| Apple | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | rs57320778 | 7.27663728681659 | 3.53843641758066 | 0.0397386244721038 |
| Apple | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | All - Inverse variance weighted | 2.48819842153436 | 0.926678295518245 | 0.0072514071366726 |
| Apple | Other bursitis of knee (finn-b-M13_BURSITISKNEEOTH) | All - MR Egger | 7.42901554804334 | 2.94732871342184 | 0.0227124685570516 |
| Apple | Contracture of joint (finn-b-M13_CONTRACTUREJOINT) | rs7853153 | -13.070793211386 | 4.2315330940394 | 0.0020089734838054 |
| Apple | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | All - Inverse variance weighted | -0.200626097673942 | 0.100837581075413 | 0.0466354027912554 |
| Apple | Other intervertebral disc disorders (finn-b-M13_INTERVERTEB) | All - MR Egger | -0.817264880112864 | 0.319895631549595 | 0.0211971043379109 |
| Apple | Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) | All - Inverse variance weighted | -1.02269919477046 | 0.502257064231328 | 0.0417296046741907 |
| Apple | Patellar tendinitis (finn-b-M13_PATELLARTEND) | rs2963826 | 6.87012768033637 | 3.47632048159057 | 0.0481248631685514 |
| Apple | Patellar tendinitis (finn-b-M13_PATELLARTEND) | All - Inverse variance weighted | 1.99817357865103 | 0.841433331208375 | 0.0175619831421026 |
| Apple | Rheumatoid arthritis (M13_RHEUMA) (finn-b-M13_RHEUMA) | rs38618 | 2.06464074337507 | 1.04145595019805 | 0.047428211594277 |
| Apple | Rheumatoid arthritis (M13_RHEUMA_INCLAVO) (finn-b-M13_RHEUMA_INCLAVO) | All - Inverse variance weighted | -0.325434976536086 | 0.164879441111914 | 0.0484072929476149 |
| Apple | Spondylosis (finn-b-M13_SPONDYLOSIS) | All - MR Egger | -1.12964406711881 | 0.440969795703601 | 0.0209015030085766 |
| Apple | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | rs12127789 | -0.505513053446901 | 0.230547794249842 | 0.028331845024594 |
| Apple | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | All - Inverse variance weighted | -0.122979205031298 | 0.0602171749394766 | 0.0411256202905159 |
| Apple | Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) | rs1347300 | -3.3748880776913 | 1.4013467763726 | 0.0160262331758464 |
| Apple | Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) | All - Inverse variance weighted | -0.901630679451481 | 0.39317952615571 | 0.0218377533385981 |
| Apple | Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) | rs10938443 | 7.26076472247803 | 2.9649896997216 | 0.0143319867409316 |
| Apple | Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) | All - Inverse variance weighted | 1.33840890047553 | 0.672312382441421 | 0.0465078838544828 |
| Apple | Fracture of lumbar spine and pelvis (finn-b-ST19_FRACT_LUMBAR_SPINE_PELVIS) | All - MR Egger | 1.67223909725615 | 0.744996669330414 | 0.0392835085292966 |
| Apple | Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) | rs1347300 | -0.972200882663036 | 0.339078237005091 | 0.0041413757457232 |
| Apple | Injuries to the wrist and hand (finn-b-ST19_INJURI_WRIST_HAND) | All - Inverse variance weighted | -0.191385664668135 | 0.0948874584158113 | 0.0436980857610086 |
| Apple | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | rs111964094 | -3.02848148821906 | 1.1373612901695 | 0.0077510498414987 |
| Apple | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | rs1347300 | -2.78150116293239 | 0.882133225958558 | 0.0016151704280877 |
| Apple | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | All - Inverse variance weighted | -0.723755605314431 | 0.273946862548242 | 0.0082428720779244 |
| Apple | Psoriatic arthritis (ieu-b-5116) | rs2030733 | 1.51830296349134 | 0.772550418260813 | 0.0493780842639116 |
| Apple | Psoriatic arthritis (ieu-b-5116) | rs7853153 | 2.27848987973469 | 0.775076244131699 | 0.0032853256845105 |
| Apple | Psoriatic arthritis (ieu-b-5116) | All - Inverse variance weighted | 0.622820919591067 | 0.209267926246026 | 0.0029185484559375 |
| Apple | Psoriatic arthritis (ieu-b-5116) | All - MR Egger | 1.59735426659499 | 0.611354622773771 | 0.0188437445214403 |
| Apple | Fractured bone site(s): Wrist (ukb-a-439) | All - Inverse variance weighted | 0.0080534787027348 | 0.0028259028416172 | 0.0043735983839868 |
| Apple | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | rs28373108 | -0.021591167291294 | 0.0100855978793142 | 0.0322908151075404 |
| Apple | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | rs62354196 | -0.0234852246500846 | 0.0101474707911199 | 0.0206462323930733 |
| Apple | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | All - Inverse variance weighted | -0.0057080239741188 | 0.0024225564948621 | 0.0184630488300116 |
| Apple | Operation code: elbow surgery (ukb-b-10324) | rs17767097 | -0.0185338983925218 | 0.0060425651554858 | 0.0021605717896637 |
| Apple | Operation code: elbow surgery (ukb-b-10324) | All - Inverse variance weighted | -0.0046876793449032 | 0.00180004012898 | 0.0092086786049527 |
| Apple | Operation code: elbow surgery (ukb-b-10324) | All - MR Egger | -0.0340950884356826 | 0.0135051906754949 | 0.0325227123831257 |
| Apple | Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) | rs2030733 | 0.0161879579793788 | 0.0059205952921341 | 0.0062536337242485 |
| Apple | Fractured bone site(s): Wrist (ukb-b-9571) | rs1347300 | 0.0225728885757125 | 0.0103319787864178 | 0.0289064866472383 |
| Apple | Fractured bone site(s): Wrist (ukb-b-9571) | rs2963826 | -0.0234272071406277 | 0.0106262399414514 | 0.0274782198014897 |
| Apple | Fractured bone site(s): Wrist (ukb-b-9571) | rs7195117 | 0.0222912796845083 | 0.0105633626725345 | 0.0348372874579814 |
| Apple | Fractured bone site(s): Wrist (ukb-b-9571) | All - Inverse variance weighted | 0.0064807706717229 | 0.0029978491879188 | 0.0306330733962687 |
| Apple | Ankle spacing width (ukb-e-3143_AFR) | rs12948969 | -9.62837152413469 | 3.80555442841326 | 0.0114035294365439 |
| Apple | Ankle spacing width (ukb-e-3143_AFR) | rs38618 | 1.01665937995524 | 0.423499318094318 | 0.0163674872894863 |
| Apple | Ankle spacing width (ukb-e-3143_AFR) | All - MR Egger | 1.65006197782516 | 0.713793351963615 | 0.0393562115805165 |
| Apple | Heel bone mineral density (BMD) (left) (ukb-e-4105_CSA) | All - Inverse variance weighted | -0.366735600424802 | 0.173412994247428 | 0.0344461117548997 |
| Apple | Ankle spacing width (right) (ukb-e-4119_AFR) | rs1401190 | -1.60969856361366 | 0.784663165817408 | 0.0402229814052486 |
| Apple | Ankle spacing width (right) (ukb-e-4119_AFR) | rs7902193 | -1.89396230577369 | 0.915492206040896 | 0.0385656757277567 |
| Apple | Ankle spacing width (right) (ukb-e-4119_AFR) | All - Inverse variance weighted | -0.433924045072476 | 0.190399839480569 | 0.0226661877287787 |