ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Whole egg | Osteoprotegerin levels (ebi-a-GCST90010243) | rs2184358 | -4.80382821099715 | 1.97587930040361 | 0.0150474239555529 |
| Whole egg | Osteoprotegerin levels (ebi-a-GCST90010243) | All - Inverse variance weighted | -1.96526644565521 | 0.816764690882829 | 0.0161212068879231 |
| Whole egg | Osteoprotegerin levels (ebi-a-GCST90012002) | rs2184358 | -1.22743871542641 | 0.484860133139972 | 0.0113565606134583 |
| Whole egg | Osteoprotegerin levels (ebi-a-GCST90012002) | All - Inverse variance weighted | -0.451314741226203 | 0.205712827270531 | 0.0282421207101383 |
| Whole egg | Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) | rs72719958 | -11.5578618277924 | 5.40989154432501 | 0.0326442720353956 |
| Whole egg | Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) | All - MR Egger | -17.3399043611109 | 5.73753344206651 | 0.0390791333407689 |
| Whole egg | Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) | rs72719958 | -11.5240197895348 | 5.40022239053712 | 0.0328436113769663 |
| Whole egg | Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) | All - MR Egger | -17.2110814167834 | 5.72362210520389 | 0.0396663470396595 |
| Whole egg | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | rs811082 | 9.8217473830599 | 4.88150946232922 | 0.0442166904723059 |
| Whole egg | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | All - Inverse variance weighted | 7.17203759542744 | 2.33819835756064 | 0.0021597667992984 |
| Whole egg | Pyogenic arthritis (finn-b-M13_PYOGARTH) | rs811082 | 4.95668188908308 | 1.71487098532258 | 0.0038473850538204 |
| Whole egg | Pyogenic arthritis (finn-b-M13_PYOGARTH) | All - Inverse variance weighted | 1.94644820403794 | 0.917094770299191 | 0.0338035891605016 |
| Whole egg | Spondylosis (finn-b-M13_SPONDYLOSIS) | rs2184358 | -1.91759998602205 | 0.733842363671309 | 0.008972629500547 |
| Whole egg | Spondylosis (finn-b-M13_SPONDYLOSIS) | All - Inverse variance weighted | -0.86217272221321 | 0.303879619646746 | 0.0045508530046256 |
| Whole egg | Other/unspecified synovitis and tenosynovitis (finn-b-M13_TENDOSYNOVITISNAS) | All - Inverse variance weighted | -1.60867501151897 | 0.619896280010498 | 0.0094571313262105 |
| Whole egg | Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) | rs2420110 | -6.12251672903002 | 2.42339740397703 | 0.0115232027362958 |
| Whole egg | Artificial joint re-operation (finn-b-OPER_ARTIF_JOINT_REOP) | All - Inverse variance weighted | -2.29423606480151 | 0.960094931053633 | 0.0168670558427193 |
| Whole egg | Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) | All - Inverse variance weighted | 2.05525141453079 | 0.860086687589615 | 0.0168673579310129 |
| Whole egg | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | All - Inverse variance weighted | 1.36516574271258 | 0.589923520967255 | 0.0206600321912935 |
| Whole egg | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | All - Inverse variance weighted | 0.920973893732042 | 0.431635712895532 | 0.032868717527552 |
| Whole egg | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | All - Inverse variance weighted | 0.99739911964089 | 0.463862797745436 | 0.0315391711380277 |
| Whole egg | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | rs2184358 | -0.0287136354900145 | 0.0114499065224608 | 0.0121498621393392 |
| Whole egg | Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis (ukb-b-14753) | All - Inverse variance weighted | -0.0080740397234611 | 0.0034759323144752 | 0.0201876704125985 |
| Whole egg | Operative procedures - secondary OPCS: Z48.2 Skin of neck (ukb-b-14873) | All - Inverse variance weighted | -0.0127220025188666 | 0.0058015674311613 | 0.0283177486563305 |
| Whole egg | Operative procedures - secondary OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-19546) | rs2420110 | -0.011942891288574 | 0.0052545041520243 | 0.0230330235574784 |
| Whole egg | Operative procedures - secondary OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-19546) | All - Inverse variance weighted | -0.0099366643151221 | 0.0036603523722082 | 0.006634099050088 |
| Whole egg | Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) | rs2184358 | -0.0235243653137176 | 0.0105937570981776 | 0.026378908586049 |
| Whole egg | Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) | rs2420110 | -0.0389173436529278 | 0.0109106472984573 | 0.0003612095717737 |
| Whole egg | Diagnoses - secondary ICD10: Z96.6 Presence of orthopaedic joint implants (ukb-b-20477) | All - Inverse variance weighted | -0.026315263652602 | 0.0065404813870673 | 5.73531122014084e-05 |
| Whole egg | Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) | rs2184358 | -0.0161340922195237 | 0.0051768210647703 | 0.0018294821909179 |
| Whole egg | Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) | rs2420110 | -0.010795737476347 | 0.0053316639871763 | 0.0428843555560729 |
| Whole egg | Operative procedures - main OPCS: W58.1 Primary resurfacing arthroplasty of joint (ukb-b-6725) | All - Inverse variance weighted | -0.0135435586305789 | 0.0037141006635809 | 0.0002658112658768 |
| Whole egg | Non-cancer illness code, self-reported: rheumatoid arthritis (ukb-b-9125) | All - Inverse variance weighted | -0.0192721013369371 | 0.0072688700845693 | 0.0080177814101315 |
| Whole egg | Fractured bone site(s): Wrist (ukb-b-9571) | All - Inverse variance weighted | 0.0155609868790495 | 0.0067360114668046 | 0.0208815766323435 |