ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Other cheese (ukb-b-4088)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Other cheese (👉 📊) Frozen shoulder (ebi-a-GCST90000513) MR Egger 14 3.2261047 1.268423719 0.025776818
Other cheese (👉 📊) Frozen shoulder (ebi-a-GCST90000513) Weighted median 14 1.331968242 0.642095757 0.038041483
Other cheese (👉 📊) Benign neoplasm of bone and articular cartilage (finn-b-CD2_BENIGN_BONE_CARTILAGE) Inverse variance weighted 17 3.081512015 1.449411197 0.033499594
Other cheese (👉 📊) Benign neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_EXALLC) Inverse variance weighted 17 3.091822056 1.452179941 0.0332468
Other cheese (👉 📊) Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) Weighted median 17 6.957583898 3.45065397 0.043767697
Other cheese (👉 📊) Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) Inverse variance weighted 17 5.383417202 2.366653506 0.022924174
Other cheese (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) Weighted median 17 6.771234371 3.209202226 0.03486325
Other cheese (👉 📊) Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) Inverse variance weighted 17 5.376545145 2.369557871 0.023267855
Other cheese (👉 📊) Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) MR Egger 17 -24.50065994 10.16975783 0.029294978
Other cheese (👉 📊) Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) Weighted median 17 -13.01949219 5.168079258 0.01176175
Other cheese (👉 📊) Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) Inverse variance weighted 17 -10.1012179 3.846795868 0.00864257
Other cheese (👉 📊) Pain in joint (finn-b-JOINTPAIN) Weighted median 17 1.380986183 0.679106837 0.0419987
Other cheese (👉 📊) Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) MR Egger 17 -10.37932249 4.771272339 0.04600383
Other cheese (👉 📊) Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) MR Egger 17 -33.87146686 11.57406664 0.01041917
Other cheese (👉 📊) Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) Weighted median 17 -14.5355113 5.908248407 0.013885708
Other cheese (👉 📊) Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) Weighted mode 17 -15.4261326 7.090895345 0.044928775
Other cheese (👉 📊) Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) Inverse variance weighted 17 0.906547634 0.392203102 0.020809451
Other cheese (👉 📊) Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) MR Egger 17 23.91306678 9.601669841 0.024968884
Other cheese (👉 📊) Transient synovitis (finn-b-M13_TRANSSYNOVITIS) Inverse variance weighted 17 13.89801079 5.227736328 0.007848606
Other cheese (👉 📊) Pain (limb, back, neck, head abdominally) (finn-b-PAIN) MR Egger 17 1.846420964 0.647917798 0.01217199
Other cheese (👉 📊) Pain (limb, back, neck, head abdominally) (finn-b-PAIN) Weighted median 17 0.896381738 0.364259072 0.013861382
Other cheese (👉 📊) Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) Inverse variance weighted 17 3.325317844 1.584997092 0.035905483
Other cheese (👉 📊) Crushing injury of wrist and hand (finn-b-ST19_CRUSHI_INJURY_WRIST_HAND) Inverse variance weighted 17 -10.39000756 3.674382126 0.004688542
Other cheese (👉 📊) Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) Inverse variance weighted 17 5.747072882 2.853037422 0.043970706
Other cheese (👉 📊) Fracture of femur (finn-b-ST19_FRACT_FEMUR) Weighted median 17 3.174576714 1.174016801 0.006850409
Other cheese (👉 📊) Fracture of femur (finn-b-ST19_FRACT_FEMUR) Inverse variance weighted 17 2.025168047 0.81681803 0.013162648
Other cheese (👉 📊) Fracture of femur (finn-b-ST19_FRACT_FEMUR) Weighted mode 17 3.884984666 1.71099544 0.037338646
Other cheese (👉 📊) Bone proteoglycan II (prot-c-2666_53_2) Wald ratio 1 -16.13667446 6.763081098 0.017033005
Other cheese (👉 📊) Fractured bone site(s): Ankle (ukb-a-438) Inverse variance weighted 16 0.029490509 0.010841662 0.006526026
Other cheese (👉 📊) Fractured bone site(s): Wrist (ukb-a-439) Weighted median 16 -0.038629126 0.01703873 0.023381894
Other cheese (👉 📊) Fractured bone site(s): Wrist (ukb-a-439) Inverse variance weighted 16 -0.026154511 0.01287062 0.042142563
Other cheese (👉 📊) Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) Wald ratio 1 0.075387542 0.026209848 0.004023595
Other cheese (👉 📊) Fractured heel (ukb-b-18389) Inverse variance weighted 18 0.010479109 0.005257447 0.046240265
Other cheese (👉 📊) Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) MR Egger 15 -0.030346759 0.013906289 0.048038246
Other cheese (👉 📊) Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) MR Egger 16 -0.067742449 0.02375185 0.012797025
Other cheese (👉 📊) Shoulder lesions (ukb-d-M13_SHOULDER) MR Egger 16 -0.072203703 0.032680706 0.04431483
Other cheese (👉 📊) Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) MR Egger 16 -0.07219415 0.032682951 0.044351773
Other cheese (👉 📊) Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) Inverse variance weighted 16 0.024311641 0.009970899 0.014758166

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Other cheese Frozen shoulder (ebi-a-GCST90000513) rs559085581 -4.23635948729883 2.02215559527064 0.0361734756424471
Other cheese Frozen shoulder (ebi-a-GCST90000513) All - MR Egger 3.22610470021339 1.26842371916112 0.0257768181478931
Other cheese Benign neoplasm of bone and articular cartilage (finn-b-CD2_BENIGN_BONE_CARTILAGE) All - Inverse variance weighted 3.08151201514505 1.44941119671869 0.0334995939391216
Other cheese Benign neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_EXALLC) All - Inverse variance weighted 3.09182205585805 1.45217994060369 0.0332467998016484
Other cheese Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) All - Inverse variance weighted 5.38341720219601 2.36665350622583 0.0229241741847168
Other cheese Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) All - Inverse variance weighted 5.37654514495101 2.36955787137944 0.0232678553335509
Other cheese Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) rs17704421 -30.4525813054355 15.5162610871048 0.0496899180793944
Other cheese Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) All - Inverse variance weighted -10.1012179019904 3.84679586841262 0.008642570474029
Other cheese Carcinoma in situ of skin of upper limb, including shoulder (finn-b-CD2_INSITU_SKIN_UPPERLIMB) All - MR Egger -24.5006599404743 10.169757827492 0.0292949781320456
Other cheese Pain in joint (finn-b-JOINTPAIN) rs77581553 4.71169967887692 2.31890647645571 0.0421675529869877
Other cheese Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) rs34747577 21.7798686917664 8.30832536135973 0.008755632110269
Other cheese Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) rs559085581 19.7809745660273 9.01497298897191 0.0282184772894644
Other cheese Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) rs77581553 20.2847480746824 8.69021569240388 0.0195849712288606
Other cheese Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) All - MR Egger -10.379322493788 4.77127233895458 0.046003830040893
Other cheese Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) rs116592084 -20.3616663006077 10.0593015594114 0.0429533803389947
Other cheese Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) All - MR Egger -33.8714668597894 11.574066643181 0.0104191702873704
Other cheese Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) rs559085581 4.41711082542358 1.97696776073945 0.025464279697161
Other cheese Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) rs78178165 2.67682323832067 1.02465934048477 0.0089908175367739
Other cheese Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) All - Inverse variance weighted 0.906547633886005 0.392203101991181 0.0208094506405902
Other cheese Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) All - MR Egger 23.9130667766096 9.6016698405883 0.0249688841835847
Other cheese Transient synovitis (finn-b-M13_TRANSSYNOVITIS) rs113253175 41.0444621066904 19.4398990135116 0.0347421009414439
Other cheese Transient synovitis (finn-b-M13_TRANSSYNOVITIS) rs130866 63.0275262197086 23.0053334287862 0.0061496798055037
Other cheese Transient synovitis (finn-b-M13_TRANSSYNOVITIS) rs77581553 55.6082866804968 23.2004319531672 0.0165360472781103
Other cheese Transient synovitis (finn-b-M13_TRANSSYNOVITIS) All - Inverse variance weighted 13.898010794569 5.22773632793148 0.0078486063879934
Other cheese Pain (limb, back, neck, head abdominally) (finn-b-PAIN) rs78178165 1.84279819374005 0.639419200845145 0.0039517531265412
Other cheese Pain (limb, back, neck, head abdominally) (finn-b-PAIN) All - MR Egger 1.84642096386521 0.647917797879988 0.0121719903046872
Other cheese Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) rs7214411 14.785221239891 7.47337475636152 0.0478851590399018
Other cheese Congenital malformations of eye, ear, face and neck (finn-b-Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK) All - Inverse variance weighted 3.32531784391786 1.58499709188801 0.0359054828312711
Other cheese Crushing injury of wrist and hand (finn-b-ST19_CRUSHI_INJURY_WRIST_HAND) All - Inverse variance weighted -10.3900075614177 3.67438212643932 0.0046885424328831
Other cheese Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) rs559085581 33.0436040009309 14.2680587532225 0.0205629380467148
Other cheese Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) All - Inverse variance weighted 5.74707288170276 2.85303742157483 0.0439707056442898
Other cheese Fracture of femur (finn-b-ST19_FRACT_FEMUR) rs78178165 4.34884487531326 2.16052202024695 0.0441285549631043
Other cheese Fracture of femur (finn-b-ST19_FRACT_FEMUR) All - Inverse variance weighted 2.02516804711212 0.816818029748654 0.013162647745344
Other cheese Bone proteoglycan II (prot-c-2666_53_2) rs7214411 -16.1366744559189 6.76308109796151 0.0170330047468179
Other cheese Fractured bone site(s): Ankle (ukb-a-438) rs4888942 0.100588092054784 0.0473271675556965 0.0335551350049811
Other cheese Fractured bone site(s): Ankle (ukb-a-438) All - Inverse variance weighted 0.0294905088555787 0.010841661575828 0.0065260261526315
Other cheese Fractured bone site(s): Wrist (ukb-a-439) rs78178165 -0.104880237975146 0.049995432719994 0.035923136095018
Other cheese Fractured bone site(s): Wrist (ukb-a-439) All - Inverse variance weighted -0.0261545105801273 0.0128706201171826 0.0421425626717632
Other cheese Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) rs559085581 0.0753875421658981 0.0262098477847794 0.0040235945641434
Other cheese Fractured heel (ukb-b-18389) All - Inverse variance weighted 0.0104791092145578 0.0052574470778661 0.046240265260142
Other cheese Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) All - MR Egger -0.0303467591225672 0.0139062885430368 0.0480382462307509
Other cheese Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) All - MR Egger -0.0677424489600502 0.0237518501837487 0.012797024835575
Other cheese Shoulder lesions (ukb-d-M13_SHOULDER) All - MR Egger -0.0722037026702757 0.0326807057616602 0.0443148304752274
Other cheese Diagnoses - main ICD10: M75 Shoulder lesions (ukb-d-M75) All - MR Egger -0.0721941503338645 0.0326829511370231 0.0443517726421316
Other cheese Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) rs113253175 0.0737444480807892 0.0366557576324279 0.0442398879396256
Other cheese Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) rs17704421 0.0820707300432113 0.0386614168751421 0.0337700200687205
Other cheese Diagnoses - main ICD10: S82 Fracture of lower leg, including ankle (ukb-d-S82) All - Inverse variance weighted 0.0243116412210723 0.0099708988606961 0.014758165728208