ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Wholemeal pasta | Osteoarthritis (self-reported) (ebi-a-GCST005811) | rs184803792 | 3.57614162975847 | 1.7982674930194 | 0.0467388054999227 |
| Wholemeal pasta | Osteoarthritis (self-reported) (ebi-a-GCST005811) | rs189429947 | 3.88692466370585 | 1.72009028829134 | 0.0238385534364081 |
| Wholemeal pasta | Osteoarthritis (self-reported) (ebi-a-GCST005811) | All - MR Egger | 1.64862801883009 | 0.736395611810083 | 0.0367001040701151 |
| Wholemeal pasta | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | rs115069064 | -4.28622141524889 | 2.14720182965685 | 0.0459133167273044 |
| Wholemeal pasta | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | rs3821340 | -4.27055488588346 | 2.10461897129535 | 0.0424445965585884 |
| Wholemeal pasta | Osteoarthritis (hospital diagnosed) (ebi-a-GCST005814) | All - MR Egger | 1.69832303360797 | 0.794479685403869 | 0.0450781048976844 |
| Wholemeal pasta | Knee osteoarthritis (ebi-a-GCST007090) | All - MR Egger | 1.04680373416032 | 0.475385890182704 | 0.0395663036273978 |
| Wholemeal pasta | Shoulder impingement (ebi-a-GCST90014054) | rs78662557 | -5.5831415369904 | 2.8115763046184 | 0.0470589608301998 |
| Wholemeal pasta | Shoulder impingement (ebi-a-GCST90014054) | All - MR Egger | -3.25375004799763 | 1.23403952286612 | 0.016754097182403 |
| Wholemeal pasta | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | All - Inverse variance weighted | 1.04425062123663 | 0.526540329577324 | 0.0473417351227619 |
| Wholemeal pasta | Ankylosis of joint (finn-b-M13_ANKYLOSISJOINT) | All - MR Egger | -16.3479008873285 | 6.23159057024494 | 0.0162808081200655 |
| Wholemeal pasta | Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) | All - MR Egger | 3.74639972550251 | 1.77095309570287 | 0.0471339844455406 |
| Wholemeal pasta | Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) | rs184803792 | 1.90057872377849 | 0.901431297010619 | 0.0349963107619624 |
| Wholemeal pasta | Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) | All - MR Egger | 1.36535245992742 | 0.481969408068657 | 0.0102808671891684 |
| Wholemeal pasta | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | rs141836859 | 4.02325143303103 | 1.93223714308781 | 0.0373266977550423 |
| Wholemeal pasta | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | rs78986965 | 3.53451367830709 | 1.70204440966448 | 0.0378358739934711 |
| Wholemeal pasta | Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) | rs141836859 | 22.3687397400361 | 9.87916790010495 | 0.0235597769269128 |
| Wholemeal pasta | Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) | rs55814537 | 33.7801905606027 | 16.0462367974001 | 0.0352757847066963 |
| Wholemeal pasta | Monoarthritis, not elsewhere classified (finn-b-M13_MONOARTHRITIS) | All - Inverse variance weighted | 3.0734838244372 | 1.54511573880915 | 0.0466834453466327 |
| Wholemeal pasta | Other joint disorders (finn-b-M13_OTHERJOINT) | rs114324039 | 2.55598890080455 | 0.776655141072313 | 0.0009982422254584 |
| Wholemeal pasta | Other joint disorders (finn-b-M13_OTHERJOINT) | rs3821340 | 2.30484945624098 | 1.15242472812049 | 0.0455002638963584 |
| Wholemeal pasta | Other joint disorders (finn-b-M13_OTHERJOINT) | All - Inverse variance weighted | 0.587285195042644 | 0.245235216589154 | 0.0166301918101136 |
| Wholemeal pasta | Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) | rs140000171 | 12.6501946183787 | 5.44649404862639 | 0.0201989967313389 |
| Wholemeal pasta | Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) | rs6901655 | 18.0132509977652 | 8.55629422393848 | 0.0352684072267446 |
| Wholemeal pasta | Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) | All - Inverse variance weighted | 3.2470785584697 | 1.62192899905282 | 0.0452862764223517 |
| Wholemeal pasta | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | All - Inverse variance weighted | -4.36113072501179 | 2.04505469618985 | 0.03296369310372 |
| Wholemeal pasta | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | rs141836859 | 19.3008423262198 | 7.6482144298824 | 0.0116168294939303 |
| Wholemeal pasta | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | rs3821340 | 12.6899182705681 | 5.76212364060244 | 0.0276442053401498 |
| Wholemeal pasta | Spontaneous rupture of synovium and tendon (finn-b-M13_SPONTRUPTSYNOTEND) | All - Inverse variance weighted | 2.450659887487 | 1.10339590845406 | 0.0263498825973988 |
| Wholemeal pasta | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs114324039 | 26.4904324742838 | 11.0775549068735 | 0.0167860400365052 |
| Wholemeal pasta | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs142419548 | 50.4468536155304 | 21.958677186735 | 0.0215985868845815 |
| Wholemeal pasta | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | All - Inverse variance weighted | 6.56947523493595 | 3.10751466449536 | 0.0345100665405716 |
| Wholemeal pasta | Transient synovitis (finn-b-M13_TRANSSYNOVITIS) | rs189429947 | 75.1739215946358 | 36.0993079727214 | 0.0373041214540253 |
| Wholemeal pasta | Transient synovitis (finn-b-M13_TRANSSYNOVITIS) | All - Inverse variance weighted | 8.98468354207506 | 3.52352910426235 | 0.0107750604455842 |
| Wholemeal pasta | Transient synovitis (finn-b-M13_TRANSSYNOVITIS) | All - MR Egger | 12.1321856137362 | 5.67331750383731 | 0.0450046343339235 |
| Wholemeal pasta | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | rs114324039 | 2.63293306338756 | 1.03153267962855 | 0.0106969013195493 |
| Wholemeal pasta | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | rs2590760 | -4.72864383730993 | 1.51440227469403 | 0.0017935318912837 |
| Wholemeal pasta | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | All - MR Egger | 1.12681666468818 | 0.521316642917639 | 0.0429607306293695 |
| Wholemeal pasta | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | rs115069064 | 1.44615053350443 | 0.730349665814107 | 0.0476945759005309 |
| Wholemeal pasta | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | rs55649517 | 2.51466081038685 | 1.04737312064097 | 0.0163538372367727 |
| Wholemeal pasta | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | rs77944049 | -3.6736092557529 | 1.49558005273735 | 0.014037174340388 |
| Wholemeal pasta | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | rs78986965 | 2.14548893019009 | 1.04339887182497 | 0.0397584250516796 |
| Wholemeal pasta | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | All - Inverse variance weighted | 0.551909686262298 | 0.192676486394808 | 0.0041775104198292 |
| Wholemeal pasta | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | All - Inverse variance weighted | -1.30442132693946 | 0.627952716890075 | 0.0377775296598711 |
| Wholemeal pasta | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs115069064 | 20.7931422785164 | 9.80007041618292 | 0.0338600845548268 |
| Wholemeal pasta | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs141836859 | 34.8959875131193 | 15.6193654296402 | 0.0254732798459325 |
| Wholemeal pasta | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs2590760 | -26.9810854246508 | 12.2491449293279 | 0.0276165112521186 |
| Wholemeal pasta | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs55814537 | 56.4775832779378 | 26.135608242854 | 0.0306996729992504 |
| Wholemeal pasta | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | rs78662557 | -10.9793324519412 | 4.85475419419404 | 0.0237244162841712 |
| Wholemeal pasta | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | rs1761938 | -41.4756953659551 | 19.6886113418745 | 0.035153735346921 |
| Wholemeal pasta | Other and unspecified injuries of neck (finn-b-ST19_OTHER_UNSPE_INJURI_NECK) | All - Inverse variance weighted | -8.00295173619518 | 3.71214049971626 | 0.0310925678621489 |
| Wholemeal pasta | Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) | rs728864 | 24.2592536083733 | 10.0111965785885 | 0.0153839378763649 |
| Wholemeal pasta | Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) | All - MR Egger | -8.56748195972909 | 3.06845587653835 | 0.0112514823235341 |
| Wholemeal pasta | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | rs76962427 | 21.660870095796 | 6.73335415073956 | 0.00129560742599 |
| Wholemeal pasta | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | rs78662557 | 3.80753648324548 | 1.50404466064145 | 0.0113565606134583 |
| Wholemeal pasta | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | All - MR Egger | 2.67697809262275 | 1.22088919532957 | 0.0403279916060391 |
| Wholemeal pasta | Shoulder region (finn-b-Z21_SHOUL_REGION) | rs141836859 | 55.6850291988482 | 24.640060281493 | 0.0238250470544653 |
| Wholemeal pasta | Shoulder region (finn-b-Z21_SHOUL_REGION) | All - Inverse variance weighted | 9.47687140364234 | 3.22241154519253 | 0.00327233515119 |
| Wholemeal pasta | Osteomyelitis (ieu-b-4975) | rs1761938 | 5.66090162730385 | 2.85672492602884 | 0.047523418897821 |
| Wholemeal pasta | Osteomyelitis (ieu-b-4975) | All - Inverse variance weighted | 1.20619449229107 | 0.596349476802975 | 0.0431112828421569 |
| Wholemeal pasta | Bone morphogenetic protein 7 (prot-a-257) | rs728864 | -8.70845001326219 | 3.16884299673961 | 0.0059932922165719 |
| Wholemeal pasta | Bone morphogenetic protein 7 (prot-a-257) | All - Inverse variance weighted | -1.43144000145255 | 0.691184891405284 | 0.0383593245274733 |
| Wholemeal pasta | Bone proteoglycan II (prot-c-2666_53_2) | rs1761938 | -12.6278679640988 | 5.99613881026474 | 0.0352043577136519 |
| Wholemeal pasta | Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) | rs13122391 | 0.19538780455273 | 0.0915903432331496 | 0.0329018022325339 |
| Wholemeal pasta | Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) | rs141836859 | 0.200200489787131 | 0.0933235555316343 | 0.031934463172958 |
| Wholemeal pasta | Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) | rs1761938 | 0.20959051391596 | 0.091033349668503 | 0.0213155157134168 |
| Wholemeal pasta | Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) | rs189429947 | 0.206448477585726 | 0.0930852158640278 | 0.0265654781353908 |
| Wholemeal pasta | Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) | All - Inverse variance weighted | 0.045357860375217 | 0.0228307994674295 | 0.0469560837251703 |
| Wholemeal pasta | Operative procedures - secondary OPCS: Y81.1 Epidural anaesthetic using lumbar approach (ukb-b-13920) | All - Inverse variance weighted | 0.0192812354116638 | 0.0088105021231693 | 0.0286377312814815 |
| Wholemeal pasta | Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) | rs6901655 | 0.0426034776832708 | 0.0208523645206505 | 0.0410424842468583 |
| Wholemeal pasta | Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) | All - Inverse variance weighted | 0.0162281596078489 | 0.0081287244852038 | 0.0458907480901068 |
| Wholemeal pasta | Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) | rs13122391 | 0.193388760448159 | 0.0771474301974035 | 0.0121849360659235 |
| Wholemeal pasta | Non-cancer illness code, self-reported: osteoarthritis (ukb-b-14486) | rs2590760 | -0.157283553797338 | 0.0778790126509251 | 0.0434260950595689 |
| Wholemeal pasta | Operative procedures - secondary OPCS: Z66.5 Lumbar vertebra (ukb-b-17671) | rs55723826 | -0.0433385096543919 | 0.0140042181104101 | 0.0019702837976232 |
| Wholemeal pasta | Operative procedures - secondary OPCS: Z66.5 Lumbar vertebra (ukb-b-17671) | All - Inverse variance weighted | -0.0225907595505897 | 0.0079560215367556 | 0.0045190767927001 |
| Wholemeal pasta | Gonarthrosis [arthrosis of knee](FG) (ukb-d-KNEE_ARTHROSIS) | All - MR Egger | 0.0708192294351825 | 0.0221064358603782 | 0.0046767438167627 |
| Wholemeal pasta | Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) | rs78986965 | 0.0384153379634158 | 0.0168986272783593 | 0.0230092173890037 |
| Wholemeal pasta | Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) | All - MR Egger | 0.0264757967835668 | 0.0108457127485701 | 0.0297037994392044 |
| Wholemeal pasta | Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) | All - Inverse variance weighted | -0.0122995749723906 | 0.0060781068281744 | 0.0430127143915793 |
| Wholemeal pasta | Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) | rs78986965 | 0.0384153379634158 | 0.0168986272783593 | 0.0230092173890037 |
| Wholemeal pasta | Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) | All - MR Egger | 0.0264757967835668 | 0.0108457127485701 | 0.0297037994392044 |
| Wholemeal pasta | Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) | All - MR Egger | -0.0194881183366621 | 0.0091566149858738 | 0.0473813446165398 |
| Wholemeal pasta | Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) | All - Inverse variance weighted | -5.88596588792894 | 2.34787428167559 | 0.0121783445540692 |
| Wholemeal pasta | Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) | All - Inverse variance weighted | -5.7812864617006 | 2.32946909837126 | 0.0130719038926848 |
| Wholemeal pasta | Osteoarthrosis (ukb-e-740_CSA) | rs145584824 | -15.7458259556036 | 7.08011964426838 | 0.0261518667067502 |
| Wholemeal pasta | Osteoarthrosis (ukb-e-740_CSA) | rs3821340 | 20.9820778085385 | 8.50542434397891 | 0.013628633245597 |
| Wholemeal pasta | Osteoarthrosis (ukb-e-740_CSA) | All - MR Egger | -15.7572827945835 | 4.87761326981154 | 0.0080076548110934 |
| Wholemeal pasta | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | rs3821340 | 17.9089452002172 | 8.22327897950803 | 0.0294183192994566 |
| Wholemeal pasta | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | rs76962427 | -11.5285359979613 | 5.08590769274944 | 0.0234048443003443 |
| Wholemeal pasta | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_CSA) | All - MR Egger | -13.4933165455929 | 4.70101964115436 | 0.0152334621437485 |