ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Bacon | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs6590783 | 3.62825497529325 | 1.35386811821387 | 0.0073640288838867 |
| Bacon | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs66799945 | 4.03109036164958 | 1.56013058628506 | 0.0097713910329369 |
| Bacon | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs74871396 | 2.74437111221131 | 1.23470256264318 | 0.0262361601701733 |
| Bacon | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | All - Inverse variance weighted | 1.83365443280673 | 0.425730751191811 | 1.65427254859524e-05 |
| Bacon | Osteoarthritis of the hip or knee (hospital diagnosed) (ebi-a-GCST005812) | All - Inverse variance weighted | 0.654186475783144 | 0.257492984466141 | 0.0110662689247272 |
| Bacon | Heel bone mineral density (ebi-a-GCST006979) | rs8116059 | -0.311562243909707 | 0.0902213496588384 | 0.000553753266263 |
| Bacon | Heel bone mineral density (ebi-a-GCST006979) | All - MR Egger | 0.173329092793278 | 0.0532223255932077 | 0.0086221676369449 |
| Bacon | Osteoarthritis (hip) (ebi-a-GCST007091) | rs116340177 | 1.44703358115862 | 0.55087071503418 | 0.0086189040881457 |
| Bacon | Osteoarthritis (hip) (ebi-a-GCST007091) | rs117334069 | 1.21195454679382 | 0.535263555917854 | 0.0235605758020121 |
| Bacon | Osteoarthritis (hip) (ebi-a-GCST007091) | rs8116059 | 1.19198390821724 | 0.565315897647147 | 0.0349854184285916 |
| Bacon | Osteoarthritis (hip) (ebi-a-GCST007091) | All - Inverse variance weighted | 0.482192279498477 | 0.200637494418287 | 0.016247810083048 |
| Bacon | Frozen shoulder (ebi-a-GCST90000513) | rs6693446 | -1.25231646922654 | 0.600858912002631 | 0.0371410216834129 |
| Bacon | Frozen shoulder (ebi-a-GCST90000513) | rs74871396 | -1.39300922478777 | 0.530175152717732 | 0.0086027235692 |
| Bacon | Frozen shoulder (ebi-a-GCST90000513) | All - Inverse variance weighted | -0.40037876914985 | 0.197193578786686 | 0.0423174795661672 |
| Bacon | Bone mineral density (ebi-a-GCST90014022) | rs8116059 | -0.367648592626353 | 0.0999018366193233 | 0.0002331439380938 |
| Bacon | Bone mineral density (ebi-a-GCST90014022) | All - MR Egger | 0.181361769299209 | 0.0763960422341089 | 0.0416373023351789 |
| Bacon | Shoulder impingement (ebi-a-GCST90014054) | All - Inverse variance weighted | -0.639401068379372 | 0.313411956303979 | 0.0413374004060534 |
| Bacon | Fracture of pelvis or lower limb (ebi-a-GCST90038706) | rs66626876 | 0.0204548494782653 | 0.0088105528678162 | 0.0202528326875031 |
| Bacon | Fracture of pelvis or lower limb (ebi-a-GCST90038706) | All - Inverse variance weighted | 0.0051840619424307 | 0.0024666033456727 | 0.0355795035046602 |
| Bacon | Benign neoplasm: Short bones of lower limb (finn-b-CD2_BENIGN_BONE_SHORT_LOWER) | All - Inverse variance weighted | -4.62578210272182 | 1.87890790010321 | 0.013818294533496 |
| Bacon | Benign neoplasm: Short bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_LOWER_EXALLC) | All - Inverse variance weighted | -4.59590679828204 | 1.87643676446855 | 0.0143144717295 |
| Bacon | Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) | rs143523506 | -5.6168018884397 | 2.55915036207979 | 0.0281785455418328 |
| Bacon | Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) | rs8116059 | -7.69092558426932 | 3.0237827083452 | 0.0109754886390082 |
| Bacon | Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder (finn-b-CD2_BENIGN_CONNSOFT_UPPERLIMB) | All - Inverse variance weighted | -2.23408337692556 | 0.88199008965714 | 0.0113090045768845 |
| Bacon | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | rs6693446 | 3.07386769719241 | 1.07522121095208 | 0.0042521526026636 |
| Bacon | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | All - Inverse variance weighted | 0.93554673048453 | 0.412476079055528 | 0.0233216741579558 |
| Bacon | Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) | rs141192377 | 9.76814737201199 | 3.65099864356669 | 0.0074623939975523 |
| Bacon | Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) | rs6590783 | -5.13472481084217 | 2.42335970639907 | 0.0341035259882066 |
| Bacon | Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) | All - MR Egger | 6.02284893129772 | 2.16994355819088 | 0.0195987844529448 |
| Bacon | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | rs6590783 | -6.76401249120555 | 3.33674825448157 | 0.0426494258988808 |
| Bacon | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | All - Inverse variance weighted | -2.45088151082218 | 1.19617365927357 | 0.0404685175773757 |
| Bacon | Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) | rs145150281 | 22.6186774885045 | 10.9022925496228 | 0.0380169747436872 |
| Bacon | Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) | rs8116059 | 19.9744950501992 | 8.07656743692784 | 0.0133931058756653 |
| Bacon | Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) | All - Inverse variance weighted | 5.04869521713259 | 2.31910160944098 | 0.0294802131116121 |
| Bacon | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | rs8116059 | -13.8173722890035 | 6.72243865884281 | 0.0398393537473735 |
| Bacon | Villonodular synovitis (pigmented) (finn-b-M13_VILLONODULAR) | All - Inverse variance weighted | -5.11511804846288 | 1.96539245468762 | 0.0092521524944463 |
| Bacon | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | rs8116059 | -1.36727565942566 | 0.587227366548199 | 0.0198930907961119 |
| Bacon | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | All - MR Egger | 1.00872192853721 | 0.426438509957797 | 0.0395829578422178 |
| Bacon | Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) | All - Inverse variance weighted | -0.716500027954314 | 0.291653787009051 | 0.0140227529638722 |
| Bacon | Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) | rs117334069 | 7.03012207937615 | 2.40328425932292 | 0.0034421881330674 |
| Bacon | Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) | rs66799945 | -2.40874183835718 | 1.12317737406543 | 0.03198657778205 |
| Bacon | Fracture of foot, except ankle (finn-b-ST19_FRACT_FOOT_ANKLE) | All - MR Egger | 2.52272277433988 | 1.07349963965956 | 0.0406407251821299 |
| Bacon | Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) | rs143523506 | 2.71909725970978 | 1.31956190544739 | 0.0393406380965116 |
| Bacon | Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) | rs35073044 | 3.48603307668678 | 1.65284342578555 | 0.034934854045092 |
| Bacon | Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) | All - MR Egger | 3.11293381747327 | 1.13873933725515 | 0.0210604445761395 |
| Bacon | Four-jointed box protein 1 (prot-a-1112) | All - Inverse variance weighted | 0.677680921771135 | 0.324822065914672 | 0.0369501619799285 |
| Bacon | Non-cancer illness code, self-reported: osteoporosis (ukb-b-12141) | All - Inverse variance weighted | -0.0098755925846979 | 0.0046507460198917 | 0.0337167740864195 |
| Bacon | Diagnoses - main ICD10: N32.0 Bladder-neck obstruction (ukb-b-123) | rs6590783 | -0.0131582260513226 | 0.0047026755701478 | 0.0051415380048158 |
| Bacon | Diagnoses - main ICD10: N32.0 Bladder-neck obstruction (ukb-b-123) | rs8116059 | -0.0235020224285796 | 0.0055163437646533 | 2.04029681975349e-05 |
| Bacon | Diagnoses - main ICD10: N32.0 Bladder-neck obstruction (ukb-b-123) | All - Inverse variance weighted | -0.0175117095262817 | 0.0051067336165095 | 0.0006054949185036 |
| Bacon | Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) | All - Inverse variance weighted | -0.0085442636525965 | 0.0043004455510748 | 0.0469409961232246 |
| Bacon | Diagnoses - main ICD10: M51.3 Other specified intervertebral disk degeneration (ukb-b-19807) | rs6590783 | 0.0081832619491382 | 0.0040939761613817 | 0.0456241181105783 |
| Bacon | Fractured heel (right) (ukb-b-3499) | All - Inverse variance weighted | -0.0107840637366486 | 0.0054924965211195 | 0.0495976831218189 |
| Bacon | Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement (ukb-b-898) | rs66626876 | 0.0213969112826065 | 0.0088195808726271 | 0.0152633702282294 |
| Bacon | Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement (ukb-b-898) | rs8116059 | 0.0192980880052237 | 0.0088339154480238 | 0.0289222062437119 |
| Bacon | Operative procedures - main OPCS: W37.1 Primary total prosthetic replacement of hip joint using cement (ukb-b-898) | All - Inverse variance weighted | 0.0097366857903164 | 0.0049033992174204 | 0.0470665098771509 |
| Bacon | Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) | All - Inverse variance weighted | -0.004122288384812 | 0.0019883154394024 | 0.0381483924400443 |
| Bacon | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | rs143523506 | -0.013663597019123 | 0.0065814682858624 | 0.037887362741632 |
| Bacon | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | rs66799945 | -0.015719983761291 | 0.0073518048648465 | 0.0324966016023299 |
| Bacon | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | All - Inverse variance weighted | -0.004901347341652 | 0.0020701367406695 | 0.0179017401856151 |
| Bacon | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | rs66626876 | -0.0143317626804476 | 0.0068013269067536 | 0.0351001625753981 |
| Bacon | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | rs66799945 | -0.0151017964071856 | 0.0065713995737338 | 0.0215555523447514 |
| Bacon | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | All - Inverse variance weighted | -0.0051279346792657 | 0.0022617107107386 | 0.0233730395481845 |