ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Ham | Heel bone mineral density (ebi-a-GCST006979) | rs12231846 | -0.158009726554011 | 0.0754560671503557 | 0.036254406044679 |
| Ham | Heel bone mineral density (ebi-a-GCST006979) | rs150704396 | -0.165030858135109 | 0.0805209982222941 | 0.0404095208515103 |
| Ham | Heel bone mineral density (ebi-a-GCST006979) | rs7426620 | 0.21321842337492 | 0.0756697458649417 | 0.0048361455041307 |
| Ham | Heel bone mineral density (ebi-a-GCST006979) | rs77635552 | -0.181543634385591 | 0.0786284620471984 | 0.0209502757397787 |
| Ham | Heel bone mineral density (ebi-a-GCST006979) | All - MR Egger | -0.23678734212316 | 0.0669656710645047 | 0.0095214471804104 |
| Ham | Bone mineral density (ebi-a-GCST90014022) | rs12231846 | -0.217542051730069 | 0.0838207884582448 | 0.0094501959671765 |
| Ham | Bone mineral density (ebi-a-GCST90014022) | rs140758254 | -0.207068806756843 | 0.0906109100146059 | 0.0222980276190942 |
| Ham | Bone mineral density (ebi-a-GCST90014022) | rs150704396 | -0.20470522599313 | 0.0901514763872131 | 0.0231663085017688 |
| Ham | Bone mineral density (ebi-a-GCST90014022) | rs7426620 | 0.309836702640122 | 0.0841301197406025 | 0.0002306614210266 |
| Ham | Bone mineral density (ebi-a-GCST90014022) | All - MR Egger | -0.296628775240184 | 0.0881821210820833 | 0.0120213889233058 |
| Ham | Heel bone mineral density T score (ebi-a-GCST90025982) | rs12231846 | -0.180085175712688 | 0.0762280889868869 | 0.0181545086874454 |
| Ham | Heel bone mineral density T score (ebi-a-GCST90025982) | All - Inverse variance weighted | -0.0889598161652421 | 0.0380446352398384 | 0.0193716289121324 |
| Ham | Heel bone mineral density (ebi-a-GCST90029004) | rs12231846 | -0.180210391782372 | 0.0763304207403868 | 0.0182294213022564 |
| Ham | Heel bone mineral density (ebi-a-GCST90029004) | rs7426620 | 0.278425641814487 | 0.0765671931798862 | 0.0002765211352323 |
| Ham | Heel bone mineral density (ebi-a-GCST90029004) | All - MR Egger | -0.252430345253626 | 0.075340669697359 | 0.0122420634044861 |
| Ham | Benign neoplasm: Bones of skull and face (finn-b-CD2_BENIGN_BONE_SKULL_FACE) | All - MR Egger | -6.96315779389679 | 2.84215342747534 | 0.0441099517400888 |
| Ham | Benign neoplasm: Bones of skull and face (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SKULL_FACE_EXALLC) | All - MR Egger | -6.99207434045864 | 2.84824694409411 | 0.0437934656851454 |
| Ham | Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) | rs140758254 | 3.70149869816473 | 1.72413793103448 | 0.0318036926925282 |
| Ham | Benign neoplasm: Connective and other soft tissue of head, face and neck (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK) | All - Inverse variance weighted | 2.27580315124877 | 1.02045485863415 | 0.0257351615562542 |
| Ham | Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) | rs140758254 | 3.7888169175081 | 1.73048834698673 | 0.0285641822152264 |
| Ham | Benign neoplasm: Connective and other soft tissue of head, face and neck (all cancers excluded) (finn-b-CD2_BENIGN_CONNSOFT_HEADFACETRUNK_EXALLC) | All - Inverse variance weighted | 2.30281573635442 | 1.0214374908118 | 0.0241656588230594 |
| Ham | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | rs80300216 | -0.992256482633553 | 0.458265822900496 | 0.03036914483158 |
| Ham | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | All - Inverse variance weighted | -0.300060289459746 | 0.13088968071917 | 0.0218787027363438 |
| Ham | Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) | rs140758254 | -2.58620689655172 | 1.13672445545183 | 0.0228975528931944 |
| Ham | Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) | All - Inverse variance weighted | -1.73000556163429 | 0.675476395140502 | 0.0104322214877501 |
| Ham | Panniculitis affecting regions of neck and back (finn-b-M13_PANNICULITIS) | All - MR Egger | -3.53887761719845 | 1.28067273721176 | 0.0279628577699835 |
| Ham | Prepatellar bursitis (finn-b-M13_PREPATELLARBURSITIS) | rs140758254 | -2.38458119006795 | 1.11687940560107 | 0.0327578172272376 |
| Ham | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | rs10075595 | -8.19231160074361 | 3.78681459253636 | 0.0305121137653116 |
| Ham | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | rs140758254 | 3.2053724518956 | 1.50584238267607 | 0.0332853693652123 |
| Ham | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | rs80300216 | 7.75526777216224 | 3.12430231966065 | 0.0130559356373434 |
| Ham | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | rs8095065 | -9.10174367850121 | 3.51468500679405 | 0.0096078348244964 |
| Ham | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | rs140758254 | -5.4303994411634 | 2.34092208039627 | 0.0203533545351992 |
| Ham | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | All - Inverse variance weighted | -3.85594522444635 | 1.40074965614737 | 0.0059092932871294 |
| Ham | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | rs140758254 | -0.477868800406427 | 0.137327744967295 | 0.0005018466837042 |
| Ham | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | All - MR Egger | -0.511966408877129 | 0.166629383175406 | 0.018004482535205 |
| Ham | Seropositive rheumatoid arthritis, strict definition (finn-b-RHEUMA_SEROPOS_STRICT) | All - Inverse variance weighted | 0.926102954431821 | 0.46553872389061 | 0.0466664952973524 |
| Ham | Burn and corrosion of hip and lower limb, except ankle and foot (finn-b-ST19_BURN_CORROSION_HIP_LOWER_LIMB_ANKLE_FOOT) | All - Inverse variance weighted | 2.40125735701227 | 0.99349510508 | 0.0156498961211177 |
| Ham | Burn and corrosion of shoulder and upper limb, except wrist and hand (finn-b-ST19_BURN_CORROSION_SHOUL_UPPER_LIMB_WRIST_HAND) | All - Inverse variance weighted | -2.03514138883112 | 1.00227818720544 | 0.0423041678202365 |
| Ham | Fracture of neck (finn-b-ST19_FRACT_NECK) | rs140758254 | -2.54096018289198 | 1.08750873182193 | 0.0194653875958314 |
| Ham | Fracture of skull and facial bones (finn-b-ST19_FRACT_SKULL_FACIAL_BONES) | All - Inverse variance weighted | -0.727782039729069 | 0.285282238732447 | 0.0107385107714221 |
| Ham | Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) | rs10075595 | 1.80523758002523 | 0.887674770310417 | 0.0419848754599143 |
| Ham | Injuries to the abdomen, lower back, lumbar spine and pelvis (finn-b-ST19_INJURI_ABDOMEN_LOWER_BACK_LUMBAR_SPINE_PELVIS) | rs17151445 | -1.06414829642176 | 0.494435462485351 | 0.0313777376241878 |
| Ham | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs17151445 | -0.780147304129135 | 0.359278363743681 | 0.0298987911015437 |
| Ham | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | All - Inverse variance weighted | -0.342464538725015 | 0.159322063766794 | 0.0315939100340568 |
| Ham | Injuries to the neck (finn-b-ST19_INJURI_NECK) | All - Inverse variance weighted | -0.681210767863998 | 0.29105987531042 | 0.0192605734324758 |
| Ham | Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) | rs140758254 | 6.31866387248365 | 3.07915793484473 | 0.0401623472045016 |
| Ham | Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) | All - Inverse variance weighted | 4.15582778773951 | 1.79047710836312 | 0.0202829129222066 |
| Ham | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs10075595 | 3.68220645462099 | 1.86501365883401 | 0.0483409394676693 |
| Ham | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs17151445 | -2.33359851498276 | 1.04361810420783 | 0.0253474761085867 |
| Ham | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | All - Inverse variance weighted | -1.16018961818134 | 0.578230998375882 | 0.0448086211666032 |
| Ham | Osteomyelitis (ieu-b-4975) | rs12231846 | -1.98132121663963 | 0.866187199463442 | 0.0221721754936074 |
| Ham | Osteomyelitis (ieu-b-4975) | rs140758254 | -2.40128278402235 | 0.943108211087826 | 0.0108922406874716 |
| Ham | Osteomyelitis (ieu-b-4975) | All - MR Egger | -1.96975270731577 | 0.668285678726294 | 0.0214839198908221 |
| Ham | Four-jointed box protein 1 (prot-a-1112) | rs77635552 | -2.48770931797693 | 1.0377404143434 | 0.0165192524516053 |
| Ham | Four-jointed box protein 1 (prot-a-1112) | All - Inverse variance weighted | -0.751508745627503 | 0.345483345047171 | 0.029612232790377 |
| Ham | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs10075595 | -0.243932429120515 | 0.122752867757381 | 0.0469021055947763 |
| Ham | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs12231846 | -0.265325655333413 | 0.126393820371071 | 0.0357994499717362 |
| Ham | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs7426620 | 0.297111328804942 | 0.127376798335452 | 0.0196723623884946 |
| Ham | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | All - MR Egger | -0.373325267435486 | 0.0993695202895926 | 0.0071032895152721 |
| Ham | Operative procedures - secondary OPCS: Z81.2 Acromioclavicular joint (ukb-b-17708) | All - Inverse variance weighted | -0.0082918554277729 | 0.0039822549360958 | 0.0373241089940839 |
| Ham | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs17151445 | -0.202295959829257 | 0.102103660362187 | 0.0475598604400771 |
| Ham | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | rs7426620 | 0.280596193236559 | 0.104499785454634 | 0.0072500179446602 |
| Ham | Heel bone mineral density (BMD) T-score, automated (ukb-b-20124) | All - MR Egger | -0.293833188889852 | 0.0890037638292296 | 0.013096250143803 |
| Ham | Operative procedures - main OPCS: W91.9 Unspecified other manipulation of joint (ukb-b-4663) | rs7426620 | -0.0093506561849785 | 0.0040379097614093 | 0.0205737268591366 |
| Ham | Fractured heel (left) (ukb-b-8221) | rs17151445 | 0.031408798898213 | 0.0141892028297448 | 0.0268583477537441 |
| Ham | Fractured heel (left) (ukb-b-8221) | rs7426620 | 0.0356614878923549 | 0.0145411157978254 | 0.014188361300621 |
| Ham | Fractured heel (left) (ukb-b-8221) | All - Inverse variance weighted | 0.0149621753465927 | 0.0055960874401207 | 0.0075022871675635 |
| Ham | Heel bone mineral density (BMD) (ukb-b-8875) | rs17151445 | -0.204362665845459 | 0.102081419320622 | 0.0452892996459119 |
| Ham | Heel bone mineral density (BMD) (ukb-b-8875) | rs7426620 | 0.293303350955739 | 0.104477521312856 | 0.004995333943545 |
| Ham | Heel bone mineral density (BMD) (ukb-b-8875) | All - MR Egger | -0.308568280409336 | 0.0882121512366235 | 0.0100196736359114 |
| Ham | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | rs77635552 | 0.0169357084863508 | 0.0057475046734164 | 0.0032126841251288 |
| Ham | Adhesive capsulitis of shoulder (ukb-d-M13_ADHCAPSULITIS) | All - Inverse variance weighted | 0.0053117198464407 | 0.0018548679828597 | 0.0041877112618991 |
| Ham | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | rs17151445 | -0.0156033395779335 | 0.0068233120332589 | 0.0222093000390984 |
| Ham | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | All - Inverse variance weighted | -0.0059735229891178 | 0.002364224305436 | 0.0115162351571828 |
| Ham | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | rs8095065 | -0.0149631451496588 | 0.0073753349578313 | 0.0424777591816429 |
| Ham | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | All - Inverse variance weighted | -0.0052536380144319 | 0.0024817603903146 | 0.0342683546930053 |
| Ham | Fractured/broken bones in last 5 years (ukb-e-2463_AFR) | All - Inverse variance weighted | -2.98080736387897 | 1.25520570902304 | 0.0175605513930801 |
| Ham | Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) | rs7426620 | 5.48102690317932 | 2.50370394358671 | 0.0285846794978639 |
| Ham | Neck/shoulder pain for 3+ months (ukb-e-3404_CSA) | All - Inverse variance weighted | 2.31977501052424 | 0.864638969984544 | 0.0072977947620167 |
| Ham | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | rs17151445 | -6.67573416822782 | 3.00767315933995 | 0.0264481275249157 |
| Ham | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | All - Inverse variance weighted | -3.57735376556738 | 1.40915951715505 | 0.0111283128710098 |