ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Seeds (ukb-b-4548)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Seeds (👉 📊) Rheumatoid arthritis (ebi-a-GCST005569) Wald ratio 1 6.584815383 2.566579399 0.010299761
Seeds (👉 📊) Rheumatoid arthritis (ebi-a-GCST90013534) MR Egger 14 -3.480981775 1.500859251 0.038814616
Seeds (👉 📊) Ulcerative colitis vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016625) Weighted median 8 0.509013914 0.212682714 0.016697502
Seeds (👉 📊) Rheumatoid arthritis (ebi-a-GCST90018910) MR Egger 15 -2.860320559 1.288360386 0.044808525
Seeds (👉 📊) Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) Inverse variance weighted 15 -4.887447646 2.228250472 0.028278473
Seeds (👉 📊) Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) MR Egger 15 6.463944108 2.760049432 0.035757321
Seeds (👉 📊) Loose body in joint (finn-b-M13_LOOSEJOINT) Weighted median 15 -7.922552273 3.495681351 0.023427953
Seeds (👉 📊) Loose body in joint (finn-b-M13_LOOSEJOINT) Inverse variance weighted 15 -5.55178271 2.514459188 0.027248243
Seeds (👉 📊) Otherdisorders of bone (finn-b-M13_OTHERBONE) Weighted median 15 -2.34676643 1.160192629 0.043100104
Seeds (👉 📊) Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) Inverse variance weighted 15 7.101307277 3.013735943 0.018457324
Seeds (👉 📊) Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) MR Egger 15 -16.89152959 7.728746687 0.047747368
Seeds (👉 📊) Burn and corrosion of shoulder and upper limb, except wrist and hand (finn-b-ST19_BURN_CORROSION_SHOUL_UPPER_LIMB_WRIST_HAND) MR Egger 15 -13.09329059 5.553815092 0.034734894
Seeds (👉 📊) Burn and corrosion of shoulder and upper limb, except wrist and hand (finn-b-ST19_BURN_CORROSION_SHOUL_UPPER_LIMB_WRIST_HAND) Weighted median 15 -8.674082039 4.170034861 0.037516526
Seeds (👉 📊) Burn and corrosion of shoulder and upper limb, except wrist and hand (finn-b-ST19_BURN_CORROSION_SHOUL_UPPER_LIMB_WRIST_HAND) Weighted mode 15 -10.48554241 4.887104323 0.04992871
Seeds (👉 📊) Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) Inverse variance weighted 15 1.259656589 0.639990278 0.049040048
Seeds (👉 📊) Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) Inverse variance weighted 15 -5.87473915 2.617001596 0.024778669
Seeds (👉 📊) Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) Inverse variance weighted 15 1.317657955 0.595796697 0.026995014
Seeds (👉 📊) Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) Inverse variance weighted 15 0.985430907 0.455864195 0.030643122
Seeds (👉 📊) Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) Inverse variance weighted 15 0.724217904 0.315322453 0.021632844
Seeds (👉 📊) Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) MR Egger 15 9.87557475 4.438865004 0.044424708
Seeds (👉 📊) Osteomodulin (prot-a-2147) Inverse variance weighted 15 -1.813641221 0.859076673 0.034759271
Seeds (👉 📊) Osteocalcin (prot-a-246) MR Egger 15 5.72628936 1.830915359 0.00801039
Seeds (👉 📊) Bone morphogenetic protein receptor type-1A (prot-a-259) Inverse variance weighted 15 -2.138391905 0.85904321 0.012800512
Seeds (👉 📊) Neck/shoulder pain for 3+ months (ukb-a-341) Inverse variance weighted 15 0.168235344 0.083188951 0.04314248
Seeds (👉 📊) Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) MR Egger 15 0.024966733 0.009673952 0.022821097
Seeds (👉 📊) Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) Inverse variance weighted 6 -0.029754894 0.013508565 0.027618101
Seeds (👉 📊) Operation code: elbow surgery (ukb-b-10324) Weighted median 4 0.029935717 0.013007124 0.021364158
Seeds (👉 📊) Diagnoses - secondary ICD10: G55.1 Nerve root and plexus compressions in intervertebral disk disorders (ukb-b-1220) Weighted median 4 -0.027536254 0.01185315 0.020172868
Seeds (👉 📊) Diagnoses - secondary ICD10: G55.1 Nerve root and plexus compressions in intervertebral disk disorders (ukb-b-1220) Inverse variance weighted 4 -0.024569135 0.009692242 0.011247043
Seeds (👉 📊) Diagnoses - main ICD10: N32.0 Bladder-neck obstruction (ukb-b-123) Wald ratio 1 0.034001384 0.015637507 0.029679001
Seeds (👉 📊) Diagnoses - main ICD10: M51.1 Lumbar and other intervertebral disk disorders with radiculopathy (ukb-b-18279) Inverse variance weighted 4 -0.023402011 0.009514401 0.013907604
Seeds (👉 📊) Diagnoses - main ICD10: M54.56 Low back pain (Lumbar region) (ukb-b-19813) Wald ratio 1 -0.031353665 0.015881529 0.048356499
Seeds (👉 📊) Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) Inverse variance weighted 15 -0.01962153 0.007472819 0.008646593
Seeds (👉 📊) Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) Weighted median 15 -0.017452552 0.008433958 0.038516134
Seeds (👉 📊) Heel bone mineral density (BMD) (ukb-e-3148_CSA) Inverse variance weighted 10 -3.925022839 1.665587127 0.018446076
Seeds (👉 📊) Ankle spacing width (right) (ukb-e-4119_EAS) Weighted median 8 -3.774360134 1.852664671 0.041623967
Seeds (👉 📊) Ankle spacing width (right) (ukb-e-4119_EAS) Inverse variance weighted 8 -3.027753101 1.45778039 0.037805154
Seeds (👉 📊) Fractured bone site(s) (ukb-e-6151_p7_CSA) Inverse variance weighted 10 8.927015905 3.903360579 0.022195371
Seeds (👉 📊) Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) Inverse variance weighted 10 -3.638776082 1.677124863 0.030033275

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Seeds Rheumatoid arthritis (ebi-a-GCST005569) rs12778642 6.58481538322651 2.56657939875418 0.0102997611042457
Seeds Rheumatoid arthritis (ebi-a-GCST90013534) rs12073612 -3.77805950286035 1.70927232934083 0.027082122155294
Seeds Rheumatoid arthritis (ebi-a-GCST90013534) rs12778642 3.81626137697276 1.65508109897385 0.0211226418556953
Seeds Rheumatoid arthritis (ebi-a-GCST90013534) All - MR Egger -3.48098177520202 1.50085925056348 0.0388146161051834
Seeds Ulcerative colitis vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016625) rs12778642 -2.46210411417597 1.14898191994879 0.0321245712076566
Seeds Ulcerative colitis vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016625) rs143824001 0.816708368290926 0.337820279611247 0.0156239953109404
Seeds Ulcerative colitis vs rheumatoid arthritis (ordinary least squares (OLS)) (ebi-a-GCST90016625) rs181802580 0.532610274536387 0.215465065607902 0.0134393303230719
Seeds Rheumatoid arthritis (ebi-a-GCST90018910) rs12778642 6.31940055971833 1.83289972944211 0.0005652535710083
Seeds Rheumatoid arthritis (ebi-a-GCST90018910) All - MR Egger -2.86032055922271 1.28836038556707 0.0448085245119639
Seeds Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) rs12778642 -24.3748307303422 7.82401974060365 0.0018370520434806
Seeds Ankylosing spondylitis, strict definition (finn-b-M13_ANKYLOSPON_STRICT) All - Inverse variance weighted -4.8874476464278 2.22825047234725 0.0282784734631213
Seeds Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) rs1441393 -13.4335695623595 5.57890841199962 0.0160436614260102
Seeds Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) rs1713456 -11.3396026890249 5.24019941083163 0.030467115173737
Seeds Disorders of continuity of bone (finn-b-M13_BONECONTINUITY) All - MR Egger 6.46394410782556 2.7600494319847 0.0357573214748203
Seeds Loose body in joint (finn-b-M13_LOOSEJOINT) All - Inverse variance weighted -5.55178270995117 2.51445918770028 0.0272482427427475
Seeds Otherdisorders of bone (finn-b-M13_OTHERBONE) rs78954735 9.9068170671898 4.2504495667811 0.0197655314031897
Seeds Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) rs181802580 13.9568101486467 6.37679755967656 0.0286196405203871
Seeds Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) rs183161766 25.219602093114 11.756951263805 0.0319464439014406
Seeds Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) rs6571334 24.038435320358 12.1282849710699 0.0474776302833968
Seeds Disorders of synovium and tendon in diseases classified elsewhere (finn-b-M13_SYNOTENDINOTH) All - Inverse variance weighted 7.10130727675322 3.01373594251722 0.0184573235642974
Seeds Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) All - MR Egger -16.8915295898307 7.7287466868431 0.0477473679319101
Seeds Burn and corrosion of shoulder and upper limb, except wrist and hand (finn-b-ST19_BURN_CORROSION_SHOUL_UPPER_LIMB_WRIST_HAND) All - MR Egger -13.0932905878991 5.55381509180107 0.0347348936113963
Seeds Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) rs1441393 6.20860698523523 2.48565226277211 0.0124974509449828
Seeds Dislocation, sprain and strain of joints and ligaments at ankle and foot level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ANKLE_FOOT_LEVEL) All - Inverse variance weighted 1.25965658894737 0.639990277980965 0.0490400481634434
Seeds Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) rs6571334 -31.9130951666821 10.3613945346371 0.0020700059496056
Seeds Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) All - Inverse variance weighted -5.87473914998267 2.61700159615991 0.0247786687727695
Seeds Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) rs143824001 4.94851024969002 1.98237394848798 0.0125512450881023
Seeds Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) rs1441393 5.20329873673628 1.8890957197068 0.0058802377607469
Seeds Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) rs183161766 5.80045467385894 1.93707206177108 0.0027494512125227
Seeds Fracture of lower leg, including ankle (finn-b-ST19_FRACT_LOWER_LEG_INCLU_ANKLE) All - Inverse variance weighted 1.31765795470947 0.595796696922743 0.0269950142284954
Seeds Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) rs1441393 3.54619722822154 1.76757494241572 0.0448295816915875
Seeds Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) rs1870059 2.65579255541614 1.32092569357312 0.0443725775071921
Seeds Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) All - Inverse variance weighted 0.985430907369015 0.455864194668676 0.0306431218429806
Seeds Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) rs183161766 3.13967096678729 1.24564495083334 0.0117182125360903
Seeds Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) All - Inverse variance weighted 0.724217903751003 0.315322453303876 0.0216328436312132
Seeds Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) rs181802580 11.1944995884375 4.93148695104827 0.0232072851862696
Seeds Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) rs183161766 18.3456866516902 8.96433904141837 0.0407053736471728
Seeds Other and unspecified injuries of wrist and hand (finn-b-ST19_OTHER_UNSPE_INJURI_WRIST_HAND) All - MR Egger 9.87557475004532 4.43886500417633 0.0444247075759848
Seeds Osteomodulin (prot-a-2147) rs183161766 -7.48194083859078 3.63201011582077 0.0393985408187538
Seeds Osteomodulin (prot-a-2147) All - Inverse variance weighted -1.81364122096259 0.859076672610393 0.0347592705273999
Seeds Osteocalcin (prot-a-246) All - MR Egger 5.72628936037854 1.83091535938449 0.0080103895234732
Seeds Bone morphogenetic protein receptor type-1A (prot-a-259) rs143824001 -7.35779993614825 3.24084729780899 0.0231874355024171
Seeds Bone morphogenetic protein receptor type-1A (prot-a-259) All - Inverse variance weighted -2.13839190475921 0.85904320956567 0.0128005119530301
Seeds Neck/shoulder pain for 3+ months (ukb-a-341) All - Inverse variance weighted 0.168235343922798 0.0831889514756036 0.043142480234075
Seeds Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) rs1713456 -0.0386886282951885 0.0161548266485384 0.0166264874630779
Seeds Non-cancer illness code self-reported: ankylosing spondylitis (ukb-a-88) All - MR Egger 0.0249667332712427 0.0096739518907301 0.0228210970459466
Seeds Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) All - Inverse variance weighted -0.0297548935010901 0.0135085645192557 0.0276181013593829
Seeds Diagnoses - secondary ICD10: G55.1 Nerve root and plexus compressions in intervertebral disk disorders (ukb-b-1220) All - Inverse variance weighted -0.0245691347289232 0.0096922415342604 0.0112470430742995
Seeds Diagnoses - main ICD10: N32.0 Bladder-neck obstruction (ukb-b-123) rs12778642 0.0340013842496464 0.0156375071469411 0.0296790012201413
Seeds Diagnoses - main ICD10: M51.1 Lumbar and other intervertebral disk disorders with radiculopathy (ukb-b-18279) rs1441393 -0.0448542026856092 0.0204107402272439 0.0279791609671172
Seeds Diagnoses - main ICD10: M51.1 Lumbar and other intervertebral disk disorders with radiculopathy (ukb-b-18279) All - Inverse variance weighted -0.0234020112527743 0.0095144010045878 0.0139076036838098
Seeds Diagnoses - main ICD10: M54.56 Low back pain (Lumbar region) (ukb-b-19813) rs12778642 -0.031353664841974 0.0158815290213683 0.0483564993827903
Seeds Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) rs74847895 -0.0748891713826636 0.0288116332944008 0.0093422663409838
Seeds Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) All - Inverse variance weighted -0.0196215295169416 0.0074728188743062 0.0086465927660097
Seeds Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) rs181802580 0.0478325182782162 0.0219397908294195 0.0292447121865084
Seeds Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) rs74847895 -0.0457612167594809 0.0229242622718092 0.045913085786139
Seeds Heel bone mineral density (BMD) (ukb-e-3148_CSA) rs12073612 -9.99072830138697 3.1984206575968 0.0017862628226702
Seeds Heel bone mineral density (BMD) (ukb-e-3148_CSA) rs1441393 -8.80473268190832 3.85883704616132 0.0225066876768636
Seeds Heel bone mineral density (BMD) (ukb-e-3148_CSA) rs6571334 -9.31325767697534 4.03330915674609 0.0209388098981972
Seeds Heel bone mineral density (BMD) (ukb-e-3148_CSA) All - Inverse variance weighted -3.92502283881178 1.66558712715007 0.0184460764285248
Seeds Ankle spacing width (right) (ukb-e-4119_EAS) All - Inverse variance weighted -3.02775310141314 1.45778039032318 0.0378051535775007
Seeds Fractured bone site(s) (ukb-e-6151_p7_CSA) rs1713456 22.8680413928544 11.4434624971675 0.045678746186944
Seeds Fractured bone site(s) (ukb-e-6151_p7_CSA) All - Inverse variance weighted 8.92701590530895 3.90336057857239 0.0221953705757291
Seeds Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) rs12073612 -10.0538010810674 3.18769828505112 0.0016108359350899
Seeds Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) rs1441393 -8.12200686040025 3.84558023409321 0.0346832954952258
Seeds Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) rs6571334 -8.80173198889695 4.01913040633027 0.0285271890725097
Seeds Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) All - Inverse variance weighted -3.63877608220983 1.67712486331768 0.0300332745730587