ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Sliced bread | Osteopontin levels (ebi-a-GCST90010244) | rs117466345 | 7.83031005722407 | 3.7564797845682 | 0.037116453188092 |
| Sliced bread | Osteopontin levels (ebi-a-GCST90010244) | rs7209025 | -2.37710449740176 | 0.875131500073442 | 0.0066019530975165 |
| Sliced bread | Osteopontin levels (ebi-a-GCST90010244) | rs74184761 | -3.52668409071748 | 1.09691737939778 | 0.0013040528970714 |
| Sliced bread | Bone disorder (ebi-a-GCST90038652) | All - MR Egger | 0.0108493035344833 | 0.0048364169166537 | 0.0445354224998009 |
| Sliced bread | Osteoporosis (ebi-a-GCST90038656) | rs7965336 | -0.0102206409389005 | 0.0047140459937969 | 0.0301491777007969 |
| Sliced bread | Osteoporosis (ebi-a-GCST90038656) | All - MR Egger | 0.0098742167110062 | 0.0041249207152538 | 0.0338999577083423 |
| Sliced bread | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | rs79885987 | 5.88803292900388 | 2.35690473002023 | 0.0124823725036299 |
| Sliced bread | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | rs79885987 | 5.8986051691206 | 2.35831436203579 | 0.0123774845559527 |
| Sliced bread | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | rs896961 | -1.48605290225518 | 0.52810144460308 | 0.0048936308295836 |
| Sliced bread | Adhesive capsulitis of shoulder (finn-b-M13_ADHCAPSULITIS) | All - Inverse variance weighted | -0.319535196977811 | 0.13656175738192 | 0.0192910440925769 |
| Sliced bread | Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) | rs117466345 | 2.73291693159292 | 1.06743464113401 | 0.0104591985219469 |
| Sliced bread | Other specified/unspecified disorders of bone/cartilage (finn-b-M13_BONEDISNAS) | All - MR Egger | 2.80707197732734 | 0.944507677962292 | 0.0108053107748925 |
| Sliced bread | Radial styloid tenosynovitis [de Quervain] (finn-b-M13_DEQUERVAIN) | All - Inverse variance weighted | -0.533761303433559 | 0.262258529500108 | 0.041825865767322 |
| Sliced bread | Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) | rs896961 | 0.482046086062113 | 0.228741614086799 | 0.0350844329311964 |
| Sliced bread | Internar derangement of knee (finn-b-M13_KNEEDERANGEMENTS) | All - MR Egger | 0.435719073705461 | 0.167543886415375 | 0.0219798409765443 |
| Sliced bread | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | rs2826965 | -0.524094193677313 | 0.256391404101131 | 0.0409419261984763 |
| Sliced bread | Articial joint operation, menisceal resection (finn-b-OPER_ARTIF_JOINT_MENISC_RESECT) | All - MR Egger | 0.440958836903378 | 0.155816325766949 | 0.0141908278367403 |
| Sliced bread | Pain (limb, back, neck, head abdominally) (finn-b-PAIN) | rs79885987 | 0.260781922879032 | 0.124047617369486 | 0.035529392197537 |
| Sliced bread | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | rs117638730 | -4.42394344313238 | 1.77089807333748 | 0.0124848442459238 |
| Sliced bread | Other/unspecified rheumatoid arthritis (finn-b-RHEUMA_NOS) | All - MR Egger | -1.10365334896178 | 0.449871082663103 | 0.0290342370606963 |
| Sliced bread | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | rs117466345 | 0.481355425066387 | 0.209821595541759 | 0.0217837419717068 |
| Sliced bread | Dislocation, sprain and strain of joints and ligaments of knee (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_KNEE) | All - Inverse variance weighted | 0.145995604537227 | 0.0688911703098572 | 0.0340718069869474 |
| Sliced bread | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | rs117466345 | -0.369525376818641 | 0.185136701948611 | 0.0459383208888935 |
| Sliced bread | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | rs7675682 | 0.594974940812389 | 0.258235651394266 | 0.0212226435871005 |
| Sliced bread | Injuries to the shoulder and upper arm (finn-b-ST19_INJURI_SHOUL_UPPER_ARM) | All - MR Egger | -0.443455156567311 | 0.163328066723403 | 0.0176767803658545 |
| Sliced bread | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | All - Inverse variance weighted | 0.410220040425096 | 0.20140021796591 | 0.0416660682171887 |
| Sliced bread | Traumatic amputation of wrist and hand (finn-b-ST19_TRAUMAT_AMPUT_WRIST_HAND) | All - Inverse variance weighted | -0.583967316718276 | 0.294656094814098 | 0.0474948402217409 |
| Sliced bread | Shoulder region (finn-b-Z21_SHOUL_REGION) | rs2826965 | 5.47282533901165 | 2.78071559594977 | 0.049052438464021 |
| Sliced bread | Shoulder region (finn-b-Z21_SHOUL_REGION) | All - MR Egger | -4.66010602024042 | 1.82947859166846 | 0.0243196227649754 |
| Sliced bread | Bone sialoprotein 2 (prot-a-1396) | rs74952756 | -1.1764606843255 | 0.517726884336447 | 0.0230649129760628 |
| Sliced bread | Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] (ukb-a-563) | rs117466345 | -0.0150149979429255 | 0.006959382129633 | 0.0309652620966146 |
| Sliced bread | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | rs61937025 | -0.0110092453979884 | 0.0048962845385952 | 0.02454498056548 |
| Sliced bread | Diagnoses - main ICD10: S52 Fracture of forearm (ukb-a-590) | All - Inverse variance weighted | -0.0029722098400612 | 0.0012775913542482 | 0.0199963325028498 |
| Sliced bread | Heel bone mineral density (BMD) (left) (ukb-b-1096) | rs12191202 | 0.15610336723251 | 0.0655765844949151 | 0.0172903719701705 |
| Sliced bread | Heel bone mineral density (BMD) (left) (ukb-b-1096) | rs7209025 | -0.145767980277966 | 0.0690358513860604 | 0.0347308752115169 |
| Sliced bread | Heel bone mineral density (BMD) (left) (ukb-b-1096) | All - MR Egger | 0.130307252378255 | 0.0515982695108962 | 0.0253433075036562 |
| Sliced bread | Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) | rs12191202 | 0.156854182107737 | 0.0656034485133866 | 0.0168051085674641 |
| Sliced bread | Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) | rs7209025 | -0.149885470879433 | 0.0690572883791648 | 0.0299726855891642 |
| Sliced bread | Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) | All - MR Egger | 0.124784653358023 | 0.0530649355252883 | 0.0351246875423752 |
| Sliced bread | Neck/shoulder pain for 3+ months (ukb-b-16118) | All - Inverse variance weighted | -0.0226617167914744 | 0.0103729432380939 | 0.0289112201306941 |
| Sliced bread | Operative procedures - main OPCS: W26.2 Manipulation of fracture of bone NEC (ukb-b-1935) | rs7209025 | 0.0045430546127248 | 0.0019980468517393 | 0.0229811550243068 |
| Sliced bread | Operative procedures - main OPCS: W26.2 Manipulation of fracture of bone NEC (ukb-b-1935) | All - Inverse variance weighted | 0.0020037281345612 | 0.0009966549874181 | 0.0443832525840302 |
| Sliced bread | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs12191202 | 0.138008039918554 | 0.0652696458633544 | 0.0344786326309465 |
| Sliced bread | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | rs7209025 | -0.155480129098336 | 0.0687537961341956 | 0.0237342337479782 |
| Sliced bread | Heel bone mineral density (BMD) T-score, automated (right) (ukb-b-20032) | All - MR Egger | 0.151764400480589 | 0.0481352407516252 | 0.0076292900667794 |
| Sliced bread | Ankle spacing width (ukb-b-4080) | rs7209025 | -0.105688742799751 | 0.0451782644769175 | 0.0193162169578488 |
| Sliced bread | Ankle spacing width (ukb-b-4080) | rs7633045 | -0.128032308922483 | 0.04385032889774 | 0.0035030431247743 |
| Sliced bread | Ankle spacing width (ukb-b-4080) | rs7965336 | -0.14942038839504 | 0.0421443452281268 | 0.0003919532325241 |
| Sliced bread | Ankle spacing width (ukb-b-4080) | All - Inverse variance weighted | -0.0380819000838746 | 0.0155983138027985 | 0.0146299804823622 |
| Sliced bread | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs12191202 | 0.132895472792949 | 0.0652750186670487 | 0.0417572247826105 |
| Sliced bread | Heel bone mineral density (BMD) (right) (ukb-b-4657) | rs7209025 | -0.160197458525373 | 0.0687597508545024 | 0.0198159621019069 |
| Sliced bread | Heel bone mineral density (BMD) (right) (ukb-b-4657) | All - MR Egger | 0.157163508636403 | 0.0489112991214563 | 0.0067923032950628 |
| Sliced bread | Fractured bone site(s): Spine (ukb-b-873) | rs2826965 | -0.0052050471401989 | 0.0019503467882263 | 0.007612722183875 |
| Sliced bread | Fractured bone site(s): Spine (ukb-b-873) | rs7209025 | -0.0044154251074827 | 0.0019749782652708 | 0.0253725508709926 |
| Sliced bread | Fractured bone site(s): Spine (ukb-b-873) | All - Inverse variance weighted | -0.0031103356211446 | 0.0010181495244528 | 0.0022514247639848 |
| Sliced bread | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | rs7633045 | 0.0066851860233547 | 0.0032505054162517 | 0.039718896347436 |
| Sliced bread | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | All - Inverse variance weighted | 0.0017962726203251 | 0.0008925689642128 | 0.044169901935721 |
| Sliced bread | Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) | rs7675682 | -1.75827490321328 | 0.820569605870419 | 0.0321332388217155 |
| Sliced bread | Heel bone mineral density (BMD) (left) (ukb-e-4105_AFR) | All - Inverse variance weighted | -0.527065617202741 | 0.245033554438033 | 0.0314767016766828 |