ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Milk chocolate | Osteoporosis (bbj-a-137) | All - Inverse variance weighted | 0.530121532916094 | 0.259878962165327 | 0.0413624189189552 |
| Milk chocolate | Heel bone mineral density T score (ebi-a-GCST90025982) | rs112748887 | -0.41542781417375 | 0.117812679656618 | 0.0004216124875991 |
| Milk chocolate | Heel bone mineral density T score (ebi-a-GCST90025982) | rs189232607 | -0.256380765964404 | 0.112172730286612 | 0.0222783103729759 |
| Milk chocolate | Heel bone mineral density T score (ebi-a-GCST90025982) | All - Inverse variance weighted | -0.163426906515115 | 0.0613078888009839 | 0.0076833930684414 |
| Milk chocolate | Malignant neoplasm of bone and articular cartilage (finn-b-C3_BONE_CARTILAGE) | All - Inverse variance weighted | 5.17563203942 | 2.26200022987676 | 0.0221330029169139 |
| Milk chocolate | Malignant neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-C3_BONE_CARTILAGE_EXALLC) | All - Inverse variance weighted | 5.20376658272706 | 2.26561213141008 | 0.0216274450254005 |
| Milk chocolate | Benign neoplasm of bone and articular cartilage (finn-b-CD2_BENIGN_BONE_CARTILAGE) | rs73185404 | 14.049634461739 | 6.36382766415281 | 0.027262867751048 |
| Milk chocolate | Benign neoplasm of bone and articular cartilage (finn-b-CD2_BENIGN_BONE_CARTILAGE) | All - Inverse variance weighted | 2.11263497201274 | 0.724243155151301 | 0.0035338810033401 |
| Milk chocolate | Benign neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_EXALLC) | rs73185404 | 14.2464888641501 | 6.38928297480942 | 0.0257641988388579 |
| Milk chocolate | Benign neoplasm of bone and articular cartilage (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_EXALLC) | All - Inverse variance weighted | 2.11476237636667 | 0.725895449765544 | 0.0035761323010138 |
| Milk chocolate | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | rs189232607 | 15.0913062631419 | 6.97796932690867 | 0.0305636875822526 |
| Milk chocolate | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | rs2129730 | 9.24017517151871 | 4.24052208622259 | 0.0293303097603551 |
| Milk chocolate | Benign neoplasm: Long bones of lower limb (finn-b-CD2_BENIGN_BONE_LONG_LOWER) | All - Inverse variance weighted | 3.68657139302728 | 1.27270442257272 | 0.0037717772091663 |
| Milk chocolate | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | rs189232607 | 15.3592530189425 | 7.05176822151476 | 0.0294007390295346 |
| Milk chocolate | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | rs2129730 | 9.31772081120902 | 4.24460343567997 | 0.0281498058375997 |
| Milk chocolate | Benign neoplasm: Long bones of lower limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_LONG_LOWER_EXALLC) | All - Inverse variance weighted | 3.69282660224933 | 1.2720436525169 | 0.0036952882250297 |
| Milk chocolate | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | rs114672176 | 7.09809105876161 | 2.23240242611192 | 0.0014749116992204 |
| Milk chocolate | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | rs2065134 | -7.36140711888489 | 3.22138115185811 | 0.0223027969196008 |
| Milk chocolate | Ankylosing spondylitis (finn-b-M13_ANKYLOSPON) | All - MR Egger | 4.77085691690249 | 1.82483255534935 | 0.0226170080249418 |
| Milk chocolate | Infective bursitis (finn-b-M13_INFBURSA) | rs112748887 | 12.7338987069596 | 4.6170735905989 | 0.0058155822447217 |
| Milk chocolate | Infective bursitis (finn-b-M13_INFBURSA) | rs13036311 | 10.6296894131005 | 3.88074750992429 | 0.0061610822955452 |
| Milk chocolate | Infective bursitis (finn-b-M13_INFBURSA) | All - Inverse variance weighted | 3.4360066619034 | 1.26787094598586 | 0.0067270985575825 |
| Milk chocolate | Other juvenile arthritis (finn-b-M13_JUVEARTH) | rs62108673 | -11.1543109336416 | 3.95628644985026 | 0.0048115152478148 |
| Milk chocolate | Other juvenile arthritis (finn-b-M13_JUVEARTH) | All - MR Egger | 6.12644846542888 | 2.64270257627166 | 0.0388903119380861 |
| Milk chocolate | Tibial collateral bursitis [Pellegrini-Stieda] (finn-b-M13_TIBIALCOLLATERAL) | All - Inverse variance weighted | -6.62208876012734 | 2.1187745598924 | 0.0017754327250673 |
| Milk chocolate | Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) | rs114672176 | 12.8344013366873 | 6.21981895966069 | 0.0390681248365727 |
| Milk chocolate | Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) | rs1899433 | -14.5754150955711 | 6.49692977391287 | 0.0248690204726577 |
| Milk chocolate | Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) | rs62108673 | 17.679819261283 | 7.48699626963695 | 0.0182059090586114 |
| Milk chocolate | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | rs2065134 | 16.6254297216302 | 7.30424699705217 | 0.0228381152784547 |
| Milk chocolate | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | rs4708314 | 11.4865662247748 | 5.51217497344715 | 0.0371734767686771 |
| Milk chocolate | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | rs62108673 | -13.6184521620344 | 5.82672200914202 | 0.0194266690208271 |
| Milk chocolate | Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_LUMBAR_SPINE_PELVIS) | rs73185404 | 45.6396749865935 | 14.9168120447742 | 0.0022162301861416 |
| Milk chocolate | Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) | rs78656169 | 4.32003423202159 | 1.40679540798532 | 0.0021346226836822 |
| Milk chocolate | Injury of muscle and tendon at lower leg level (finn-b-ST19_INJURY_MUSCLE_TENDON_LOWER_LEG_LEVEL) | All - Inverse variance weighted | 1.48365251491886 | 0.583109083078976 | 0.0109471152465991 |
| Milk chocolate | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | All - Inverse variance weighted | -1.26055145689667 | 0.497202147278999 | 0.0112354383635169 |
| Milk chocolate | Psoriatic arthritis (ieu-b-5116) | rs149550488 | -2.86599093452602 | 1.10859013828859 | 0.0097306304349094 |
| Milk chocolate | Psoriatic arthritis (ieu-b-5116) | All - Inverse variance weighted | -0.804624962669205 | 0.385288177325878 | 0.0367643096484029 |
| Milk chocolate | Psoriatic arthritis (ieu-b-5116) | All - MR Egger | -3.05679612350459 | 0.871867454546423 | 0.0038690299242927 |
| Milk chocolate | Non-cancer illness code self-reported: osteoarthritis (ukb-a-106) | All - Inverse variance weighted | -0.0274594507878014 | 0.010160766976727 | 0.0068820631996856 |
| Milk chocolate | Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) | All - MR Egger | 0.0185648377453002 | 0.0071059542721441 | 0.0204699597334997 |
| Milk chocolate | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs13036311 | 0.0158178590644687 | 0.0074945877129433 | 0.0348092073175693 |
| Milk chocolate | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | All - Inverse variance weighted | 0.0044737303224412 | 0.0018298499651713 | 0.014490764747372 |
| Milk chocolate | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs2129730 | 0.0074467894064493 | 0.0029889068921748 | 0.0127213607049293 |
| Milk chocolate | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | rs78656169 | 0.0067477234826392 | 0.0030119782767342 | 0.0250716999008988 |
| Milk chocolate | Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level (ukb-a-592) | All - Inverse variance weighted | 0.0017000153484878 | 0.0008213798387361 | 0.0384798197492801 |
| Milk chocolate | Heel bone mineral density (BMD) (left) (ukb-b-1096) | rs112748887 | -0.762401787715304 | 0.219129917922301 | 0.0005028704771824 |
| Milk chocolate | Heel bone mineral density (BMD) (left) (ukb-b-1096) | rs73185404 | 0.442528696620214 | 0.221505325250989 | 0.0457357240110442 |
| Milk chocolate | Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) | rs13036311 | 0.0339941619322394 | 0.0113607188703466 | 0.0027692531635187 |
| Milk chocolate | Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) | rs4708314 | 0.032418472916093 | 0.011259391841391 | 0.0039863691451781 |
| Milk chocolate | Operative procedures - secondary OPCS: Z81.4 Shoulder joint (ukb-b-11427) | All - Inverse variance weighted | 0.0185979845338805 | 0.0052582211334692 | 0.0004047998115837 |
| Milk chocolate | Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) | rs13036311 | 0.0214277846269864 | 0.0101524337286103 | 0.0348062162269554 |
| Milk chocolate | Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) | rs4708314 | 0.0252394673694977 | 0.0100620058219582 | 0.0121281611769057 |
| Milk chocolate | Diagnoses - main ICD10: M75.4 Impingement syndrome of shoulder (ukb-b-1418) | All - Inverse variance weighted | 0.0145221897105011 | 0.0044601347050833 | 0.001129945446754 |
| Milk chocolate | Diagnoses - main ICD10: M65 Synovitis and tenosynovitis (ukb-d-M65) | All - Inverse variance weighted | 0.0067770047661849 | 0.003169795169399 | 0.0325171863514227 |
| Milk chocolate | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | rs149550488 | -0.0206903899958884 | 0.0096030846679168 | 0.0311965438885974 |
| Milk chocolate | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | rs4708314 | -0.0202465973014437 | 0.0102617914322804 | 0.0484946429950981 |
| Milk chocolate | Diagnoses - main ICD10: S42 Fracture of shoulder and upper arm (ukb-d-S42) | All - Inverse variance weighted | -0.0058869884762624 | 0.0025306999108131 | 0.0200063172841746 |
| Milk chocolate | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | rs114672176 | -0.0191348560796626 | 0.0092490008507304 | 0.038559549040873 |
| Milk chocolate | Diagnoses - main ICD10: S72 Fracture of femur (ukb-d-S72) | All - Inverse variance weighted | -0.0060658903594281 | 0.0025455197478422 | 0.0171737190521077 |
| Milk chocolate | Ankle spacing width (ukb-e-3143_CSA) | rs112748887 | 3.95934766580377 | 1.70521536057997 | 0.0202380643554937 |
| Milk chocolate | Ankle spacing width (ukb-e-3143_CSA) | rs899452 | 1.43929483838692 | 0.690513305932564 | 0.037125258391952 |
| Milk chocolate | Ankle spacing width (ukb-e-3143_CSA) | All - Inverse variance weighted | 0.886115513715644 | 0.388810442074496 | 0.0226645402870448 |
| Milk chocolate | Ankle spacing width (ukb-e-3143_CSA) | All - MR Egger | 2.03699936544372 | 0.806141361617862 | 0.0300325660704081 |
| Milk chocolate | Heel bone mineral density (BMD) (ukb-e-3148_CSA) | rs13036311 | -4.53318759347052 | 2.02552989573669 | 0.0252193911179805 |
| Milk chocolate | Heel bone mineral density (BMD) (ukb-e-3148_CSA) | rs899452 | -1.92911937209602 | 0.766540573605422 | 0.0118474247088719 |
| Milk chocolate | Heel bone mineral density (BMD) (ukb-e-3148_CSA) | All - Inverse variance weighted | -0.982937982591035 | 0.479104024501753 | 0.040206894439329 |
| Milk chocolate | Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_AFR) | rs78656169 | -4.23210951902251 | 1.98504693714262 | 0.0330072835139061 |
| Milk chocolate | Osteoarthrosis (ukb-e-740_CSA) | rs4708314 | -8.403485307423 | 3.33041579796231 | 0.0116274349881218 |
| Milk chocolate | Osteoarthrosis (ukb-e-740_CSA) | rs62108673 | 7.7549519256029 | 3.57957232175695 | 0.0302770839502837 |
| Milk chocolate | Osteoarthrosis (ukb-e-740_CSA) | rs899452 | -4.41306368995732 | 1.73295741428361 | 0.0108793447308483 |
| Milk chocolate | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) | rs13036311 | -4.32559302143308 | 2.01832763507416 | 0.0321004928944976 |
| Milk chocolate | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) | rs899452 | -1.93376225867146 | 0.763986985988929 | 0.0113690660663056 |
| Milk chocolate | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) | All - Inverse variance weighted | -0.947856822214434 | 0.470162063694792 | 0.043797729115943 |