ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Feta | Rheumatoid Arthritis (bbj-a-72) | All - MR Egger | -3.15412797536891 | 1.30420236861597 | 0.0361582567880391 |
| Feta | Joint disorder (ebi-a-GCST90038654) | rs2605616 | -0.375444642702967 | 0.156455953031916 | 0.0164092891455135 |
| Feta | Joint disorder (ebi-a-GCST90038654) | All - MR Egger | -0.116291432695697 | 0.0550982681691138 | 0.0458862159332303 |
| Feta | Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) | rs11113827 | -36.4392818250356 | 12.2352726155814 | 0.0028993180148658 |
| Feta | Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck (finn-b-CD2_BENIGN_LIPO_SKIN_HEADFACENECK) | All - Inverse variance weighted | -3.70541757032168 | 1.68890980698936 | 0.0282375611879569 |
| Feta | Cervical root disorders (finn-b-G6_CERVROOT) | rs112543687 | 95.1110278087422 | 24.760533091318 | 0.0001224168172431 |
| Feta | Cervical root disorders (finn-b-G6_CERVROOT) | rs2710434 | 35.7226812857327 | 14.273105087843 | 0.0123216275572062 |
| Feta | Cervical root disorders (finn-b-G6_CERVROOT) | All - Inverse variance weighted | 10.3759236680039 | 4.46091926642316 | 0.0200206381414357 |
| Feta | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs112543687 | -20.5038916455397 | 8.38997346381115 | 0.0145312028647473 |
| Feta | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs146508185 | 45.929028749177 | 17.2323311355591 | 0.0076923697781615 |
| Feta | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs2710434 | -11.2259878736267 | 5.55311608762569 | 0.0432212597235939 |
| Feta | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs73105356 | 35.2497261938697 | 12.1899989497847 | 0.00383173009193 |
| Feta | Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) | rs75355354 | -15.1698444475372 | 6.93723302893725 | 0.0287623574425028 |
| Feta | Osteonecrosis (finn-b-M13_OSTEONECROSIS) | rs144136424 | 22.0617475868551 | 10.8004049022089 | 0.0410843414493125 |
| Feta | Osteonecrosis (finn-b-M13_OSTEONECROSIS) | rs75355354 | 21.007968539791 | 8.5395054723492 | 0.013890142948436 |
| Feta | Osteonecrosis (finn-b-M13_OSTEONECROSIS) | All - Inverse variance weighted | 5.37351305976454 | 2.21528958259251 | 0.0152810776556417 |
| Feta | Collapsed vertebra, not elsewhere classified (finn-b-M13_VERTEBCOLLAPSE) | All - MR Egger | -21.8972537182995 | 10.4535818891627 | 0.046087762430893 |
| Feta | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | rs112543687 | 10.6835288198795 | 5.25791399907271 | 0.042164293483282 |
| Feta | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | rs149156175 | 20.0262773182331 | 9.57086548603786 | 0.0364008962665812 |
| Feta | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | All - Inverse variance weighted | 2.97290852008135 | 1.10754709735194 | 0.0072697590989771 |
| Feta | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | rs146508185 | 15.4146350772402 | 5.10004484604448 | 0.0025073676496237 |
| Feta | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | rs2605616 | 5.95734883587072 | 2.22321351483581 | 0.0073707617744791 |
| Feta | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | All - Inverse variance weighted | 1.50665715851177 | 0.537908217933781 | 0.0050951492566416 |
| Feta | Fracture of forearm (finn-b-ST19_FRACT_FOREA) | All - MR Egger | 2.62501303949638 | 0.993138916422769 | 0.0137313313736036 |
| Feta | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | rs73105356 | 11.4098390169985 | 5.55113798328657 | 0.0398398638432306 |
| Feta | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | All - MR Egger | 3.11633983287133 | 1.49521580481475 | 0.04710900585696 |
| Feta | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | rs142010203 | 6.66700682007585 | 3.06138068268789 | 0.0294225851047886 |
| Feta | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | rs146508185 | 12.8431438031354 | 4.47029188095761 | 0.0040659548989634 |
| Feta | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | rs2605616 | 3.92839669611765 | 1.95700348231502 | 0.0447120957809458 |
| Feta | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | rs60039560 | 4.00185285027603 | 2.01991054681864 | 0.0475685120968687 |
| Feta | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | All - Inverse variance weighted | 1.34808284907032 | 0.474327672809116 | 0.0044818566590578 |
| Feta | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | All - MR Egger | 1.90423652165691 | 0.883139224829424 | 0.0404959438976894 |
| Feta | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs117582379 | -7.92050600790166 | 3.41065405415591 | 0.0202176695105015 |
| Feta | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs117998163 | 2.96064532895776 | 1.2790395483105 | 0.0206271085672928 |
| Feta | Injuries to the knee and lower leg (finn-b-ST19_INJURI_KNEE_LOWER_LEG) | rs2710434 | 2.19108574064464 | 1.05562430419722 | 0.0379281612629803 |
| Feta | Injuries to the neck (finn-b-ST19_INJURI_NECK) | rs112543687 | 12.829112862653 | 4.24184431444891 | 0.0024911149362744 |
| Feta | Injuries to the neck (finn-b-ST19_INJURI_NECK) | All - Inverse variance weighted | 2.16196404516152 | 0.914753036058617 | 0.0181061513635823 |
| Feta | Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) | rs4704539 | 39.4750394156189 | 15.6989042854087 | 0.0119198189117884 |
| Feta | Injury of muscle and tendon at ankle and foot level (finn-b-ST19_INJURY_MUSCLE_TENDON_ANKLE_FOOT_LEVEL) | rs75024835 | -21.6777261057907 | 9.05587314425062 | 0.0166759581484741 |
| Feta | Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) | rs11113827 | -47.4561040556629 | 22.6809462282615 | 0.0364086911978141 |
| Feta | Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) | rs145057861 | 75.4252995166546 | 34.8315559521742 | 0.0303547634134459 |
| Feta | Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) | rs75024835 | 20.4124772530927 | 9.68390223578357 | 0.0350416081997374 |
| Feta | Injury of muscle and tendon at forearm level (finn-b-ST19_INJURY_MUSCLE_TENDON_FOREA_LEVEL) | All - Inverse variance weighted | 8.57092522922754 | 3.35497504679276 | 0.010628204023072 |
| Feta | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | rs2710434 | 38.1843261967808 | 14.1755263706483 | 0.0070668060847073 |
| Feta | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | rs75355354 | 40.8490259682329 | 17.6249968775314 | 0.0204669557455433 |
| Feta | Injury of nerves at shoulder and upper arm level (finn-b-ST19_INJURY_NERVES_SHOUL_UPPER_ARM_LEVEL) | All - MR Egger | 19.7071915619714 | 8.18330007710394 | 0.0234180943945211 |
| Feta | Shoulder region (finn-b-Z21_SHOUL_REGION) | rs145057861 | 136.806528594906 | 56.4387500050475 | 0.0153513555164565 |
| Feta | Shoulder region (finn-b-Z21_SHOUL_REGION) | rs16926827 | 57.0282834735086 | 27.0147982540189 | 0.0347721707241603 |
| Feta | Shoulder region (finn-b-Z21_SHOUL_REGION) | All - Inverse variance weighted | 11.9992735042001 | 4.46796093944276 | 0.0072394003257113 |
| Feta | Rheumatoid arthritis (ieu-a-831) | rs268264 | 10.8830417965979 | 5.42338628728971 | 0.0447829414196219 |
| Feta | Rheumatoid arthritis (ieu-a-831) | All - MR Egger | -3.96897146939127 | 1.36894645406436 | 0.0230092503335284 |
| Feta | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs112543687 | 0.0635901786506989 | 0.0251765297767606 | 0.0115444315297188 |
| Feta | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs268264 | 0.0564831792002927 | 0.0279977872651757 | 0.0436521367871524 |
| Feta | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | All - Inverse variance weighted | 0.0100193369303956 | 0.0050651304518821 | 0.0479173735073338 |
| Feta | Operative procedures - secondary OPCS: Z48.2 Skin of neck (ukb-b-14873) | rs35061773 | -0.0827519361167521 | 0.0370551750249544 | 0.0255351904428742 |
| Feta | Operative procedures - secondary OPCS: Z48.2 Skin of neck (ukb-b-14873) | All - Inverse variance weighted | -0.0456952243385766 | 0.0196197541954293 | 0.0198568602812451 |
| Feta | Operative procedures - main OPCS: W26.2 Manipulation of fracture of bone NEC (ukb-b-1935) | rs268264 | 0.0452847780796495 | 0.0230140035778495 | 0.0491019493357955 |
| Feta | Operative procedures - secondary OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-19546) | rs10198693 | 0.0633245670599698 | 0.024238577397569 | 0.0089868768065459 |
| Feta | Operative procedures - secondary OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-19546) | rs268264 | 0.0578790758263182 | 0.025394924093381 | 0.02265760123729 |
| Feta | Operative procedures - secondary OPCS: W85.2 Endoscopic irrigation of knee joint (ukb-b-19546) | All - Inverse variance weighted | 0.0607286200695268 | 0.017533810049221 | 0.0005331661942219 |
| Feta | Diagnoses - main ICD10: M54.56 Low back pain (Lumbar region) (ukb-b-19813) | All - Inverse variance weighted | -0.037515774419403 | 0.0182961228665821 | 0.040317931062707 |
| Feta | Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) | rs6583325 | 0.0649679958503312 | 0.0324583192814088 | 0.045329679232551 |
| Feta | Diagnoses - main ICD10: M13 Other arthritis (ukb-d-M13) | All - Inverse variance weighted | 0.0138681505318189 | 0.0066977069605327 | 0.0383978888815499 |
| Feta | Ohter specific/unspecified arthritis (ukb-d-M13_ARTHRITISNAS) | rs6583325 | 0.0770968752514367 | 0.0306736535403146 | 0.0119554726654328 |
| Feta | Ohter specific/unspecified arthritis (ukb-d-M13_ARTHRITISNAS) | All - Inverse variance weighted | 0.0134570890005302 | 0.0063294802896763 | 0.0334951844036551 |
| Feta | Cervicalgia (ukb-d-M13_CERVICALGIA) | All - MR Egger | 0.0487228729523371 | 0.0135217227341544 | 0.0018941554182149 |
| Feta | Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) | rs6583325 | 0.0649679958503312 | 0.0324583192814088 | 0.045329679232551 |
| Feta | Other arthritis (FG) (ukb-d-RHEU_ARTHRITIS_OTH) | All - Inverse variance weighted | 0.0138681505318189 | 0.0066977069605327 | 0.0383978888815499 |
| Feta | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | rs60039560 | 0.118102119387344 | 0.0397743926979474 | 0.0029847866947948 |
| Feta | Diagnoses - main ICD10: S61 Open wound of wrist and hand (ukb-d-S61) | All - MR Egger | 0.0324996815636033 | 0.014137122145473 | 0.0301459410828484 |
| Feta | Ankle spacing width (left) (ukb-e-4100_CSA) | rs10198693 | -10.7317783136817 | 5.18901392563963 | 0.0386237615310159 |
| Feta | Ankle spacing width (left) (ukb-e-4100_CSA) | All - Inverse variance weighted | -1.25869411094793 | 0.596330843112524 | 0.0347954233893118 |
| Feta | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | rs10198693 | 68.6275897060637 | 28.5223944257013 | 0.0161240725481056 |
| Feta | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | All - MR Egger | -11.7243341763937 | 5.25011274167809 | 0.0392707023173848 |
| Feta | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | rs35061773 | -12.7091866588648 | 5.65862389426221 | 0.0247049429971552 |
| Feta | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | rs4704539 | 8.7783931103875 | 3.73398616690039 | 0.0187258419407041 |
| Feta | M17 Gonarthrosis [arthrosis of knee] (ukb-e-M17_AFR) | All - Inverse variance weighted | 4.04294859442969 | 1.65343975552946 | 0.014478210440632 |