ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Dairy smoothie | Rheumatoid Arthritis (bbj-a-74) | rs16861156 | -3.26529535401149 | 1.46247944350151 | 0.0255679448284919 |
| Dairy smoothie | Rheumatoid Arthritis (bbj-a-74) | rs6909603 | -0.697726484329447 | 0.341482496561803 | 0.0410299062674187 |
| Dairy smoothie | Rheumatoid Arthritis (bbj-a-74) | All - Inverse variance weighted | -0.531076461865989 | 0.246359315613594 | 0.0311071980277021 |
| Dairy smoothie | Rheumatoid arthritis (ebi-a-GCST002318) | rs16861156 | -3.44915619421164 | 1.27597154189129 | 0.0068683520055221 |
| Dairy smoothie | Rheumatoid arthritis (ebi-a-GCST002318) | rs6909603 | -0.761144310798277 | 0.388339160021945 | 0.0499959235835062 |
| Dairy smoothie | Rheumatoid arthritis (ebi-a-GCST002318) | All - Inverse variance weighted | -0.596758494583622 | 0.276583686287982 | 0.0309585133915176 |
| Dairy smoothie | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs113792963 | 6.78485175192118 | 2.74825478224114 | 0.013557242993482 |
| Dairy smoothie | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | rs144950069 | 6.92347553606424 | 2.83298931784075 | 0.0145304064456668 |
| Dairy smoothie | Osteoarthritis of the hip (hospital diagnosed) (ebi-a-GCST005810) | All - MR Egger | 2.96999261788674 | 1.05548619644894 | 0.0110836526328141 |
| Dairy smoothie | Menstruation quality of life impact (stiff neck) (ebi-a-GCST006652) | All - Inverse variance weighted | 3.78146707654527 | 1.53874458500763 | 0.0139907238927759 |
| Dairy smoothie | Rheumatoid arthritis (ebi-a-GCST90013534) | rs6909603 | -0.48958945832708 | 0.221422368087624 | 0.0270281437114247 |
| Dairy smoothie | Rheumatoid arthritis (ebi-a-GCST90013534) | All - Inverse variance weighted | -0.36204433340121 | 0.183005410828796 | 0.0478919596854747 |
| Dairy smoothie | Shoulder impingement (ebi-a-GCST90014054) | rs192392536 | -4.60647688359566 | 1.97099226937225 | 0.0194321164257299 |
| Dairy smoothie | Shoulder impingement (ebi-a-GCST90014054) | All - Inverse variance weighted | -1.56372523117481 | 0.550696520180111 | 0.0045178518838565 |
| Dairy smoothie | Shoulder impingement (ebi-a-GCST90014054) | All - MR Egger | -2.33213167779411 | 0.872891935669742 | 0.0203455922165431 |
| Dairy smoothie | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | rs144388020 | 4.07574458667257 | 1.73055821835165 | 0.0185146426736029 |
| Dairy smoothie | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | rs9940345 | 4.92023808792545 | 2.18677248352242 | 0.0244489453100894 |
| Dairy smoothie | Neck circumference (BMI adjusted) (ebi-a-GCST90017136) | All - Inverse variance weighted | 1.28281401460683 | 0.585819837960087 | 0.0285405117480814 |
| Dairy smoothie | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | rs58791769 | 6.77129712080736 | 3.28361531611754 | 0.0391937530446384 |
| Dairy smoothie | Neck circumference (BMI adjusted) (ebi-a-GCST90017138) | rs73646137 | 3.5330720497165 | 1.72098632915002 | 0.0400789394569628 |
| Dairy smoothie | Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) | rs116941302 | -27.0721984349623 | 11.9060977410306 | 0.0229774413875435 |
| Dairy smoothie | Benign neoplasm: Bone and articular cartilage, unspecified (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS) | rs58791769 | -28.1426239240131 | 14.145517957851 | 0.046645137987135 |
| Dairy smoothie | Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) | rs116941302 | -27.1371622619223 | 11.9001919385797 | 0.0225841520671477 |
| Dairy smoothie | Benign neoplasm: Bone and articular cartilage, unspecified (all cancers excluded) (finn-b-CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC) | rs58791769 | -28.1611754229742 | 14.1547937073316 | 0.0466443798759675 |
| Dairy smoothie | Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) | rs141362991 | 19.9078111690412 | 8.01415711708692 | 0.0129886453798983 |
| Dairy smoothie | Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) | rs144950069 | 14.9077244375042 | 6.87567274301782 | 0.0301446807540215 |
| Dairy smoothie | Drug-induced osteoporosis (finn-b-DRUGADVERS_OSTEOPO) | All - Inverse variance weighted | 5.27970394466423 | 2.17776419722308 | 0.0153350161056033 |
| Dairy smoothie | Cervical root disorders (finn-b-G6_CERVROOT) | rs116941302 | 21.5030267237561 | 10.0989221910527 | 0.0332344284038844 |
| Dairy smoothie | Cervical root disorders (finn-b-G6_CERVROOT) | All - Inverse variance weighted | -4.34871902629077 | 2.11055361844869 | 0.0393542367973047 |
| Dairy smoothie | Pain in joint (finn-b-JOINTPAIN) | rs144388020 | -1.37858027563606 | 0.661291892374745 | 0.0370985916887771 |
| Dairy smoothie | Pain in joint (finn-b-JOINTPAIN) | rs144950069 | -1.54067932481381 | 0.739039179510008 | 0.0370960063826136 |
| Dairy smoothie | Pain in joint (finn-b-JOINTPAIN) | rs9940345 | 4.07255661959373 | 1.2899500605048 | 0.0015932327100873 |
| Dairy smoothie | Infection of intervertebral disc (pyogenic) (finn-b-M13_DISCINFECTION) | All - Inverse variance weighted | 4.19924802311993 | 2.09564277077405 | 0.0450915379891597 |
| Dairy smoothie | Gluteal tendinitis (finn-b-M13_GLUTEALTEND) | rs144950069 | -11.8333214507426 | 4.26903808399311 | 0.0055731165384626 |
| Dairy smoothie | Gluteal tendinitis (finn-b-M13_GLUTEALTEND) | All - MR Egger | -5.27168787820116 | 2.07654202871977 | 0.0218982247727657 |
| Dairy smoothie | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | rs116941302 | 2.12018307987598 | 1.01579802155618 | 0.0368692189748458 |
| Dairy smoothie | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | rs142796081 | -1.2313714297364 | 0.512391864250134 | 0.0162530505994853 |
| Dairy smoothie | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | rs144388020 | -1.51590500328646 | 0.60396215170516 | 0.0120753805437798 |
| Dairy smoothie | Other specific joint derangements/joint disorders (finn-b-M13_JOINTOTH) | rs9940345 | 3.49515040203444 | 1.17324029312579 | 0.0028913642801222 |
| Dairy smoothie | Osteonecrosis (finn-b-M13_OSTEONECROSIS) | rs6449463 | -11.7127393264792 | 5.81809273733608 | 0.0440980211996215 |
| Dairy smoothie | Spondylosis (finn-b-M13_SPONDYLOSIS) | All - MR Egger | -1.08229316242848 | 0.426041945516126 | 0.0218250026651562 |
| Dairy smoothie | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | rs9940345 | -14.8344256958052 | 6.21018814843025 | 0.0169069966186577 |
| Dairy smoothie | Contusion of ankle (finn-b-ST19_CONTU_ANKLE) | All - MR Egger | 4.06852542762253 | 1.83337093963585 | 0.0412822892881861 |
| Dairy smoothie | Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) | rs13107704 | -3.78892256820061 | 1.52418021493524 | 0.0129233093391284 |
| Dairy smoothie | Open wound of wrist and hand (finn-b-ST19_OPEN_WOUND_WRIST_HAND) | All - MR Egger | 1.31833305609861 | 0.472240560248325 | 0.0130642543914174 |
| Dairy smoothie | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs116941302 | -11.9356267532851 | 5.26206998375904 | 0.0233147084843925 |
| Dairy smoothie | Other and unspecified injuries of ankle and foot (finn-b-ST19_OTHER_UNSPE_INJURI_ANKLE_FOOT) | rs13107704 | 12.357054284927 | 5.58866078809589 | 0.0270293290039169 |
| Dairy smoothie | Knee and hip osteoarthritis (ieu-a-1170) | rs6449463 | -4.73680020210217 | 2.07952414125717 | 0.0227367733165293 |
| Dairy smoothie | Knee and hip osteoarthritis (ieu-a-1170) | All - Inverse variance weighted | -2.77716740800804 | 1.00466137813389 | 0.0057048205004805 |
| Dairy smoothie | Knee osteoarthritis (ieu-a-1171) | All - Inverse variance weighted | -3.14377393397493 | 1.27905298620036 | 0.0139755246598268 |
| Dairy smoothie | Rheumatoid arthritis (ieu-a-833) | rs16861156 | -3.44915619421164 | 1.51787426018591 | 0.0230647978464157 |
| Dairy smoothie | Rheumatoid arthritis (ieu-a-833) | rs6909603 | -0.761144310798277 | 0.365691342139383 | 0.0373987213909692 |
| Dairy smoothie | Rheumatoid arthritis (ieu-a-833) | All - Inverse variance weighted | -0.621648529401092 | 0.268810047329139 | 0.0207449662389827 |
| Dairy smoothie | Psoriatic arthritis (ieu-b-5116) | rs28766334 | 5.30146983173034 | 2.67088612085756 | 0.0471544330472686 |
| Dairy smoothie | Psoriatic arthritis (ieu-b-5116) | All - MR Egger | 3.83859091850743 | 1.5527046569391 | 0.0310003254735842 |
| Dairy smoothie | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs144950069 | 0.0239356531628269 | 0.0116479008678928 | 0.0398854990199857 |
| Dairy smoothie | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | rs73646137 | 0.0250305480024478 | 0.0098179398466757 | 0.0107886638397808 |
| Dairy smoothie | Diagnoses - main ICD10: M24 Other specific joint derangements (ukb-a-567) | All - MR Egger | 0.0102759347160789 | 0.0041118742784281 | 0.0223503583441678 |
| Dairy smoothie | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | All - MR Egger | 0.0219318595972447 | 0.0095969302693932 | 0.03464256935607 |
| Dairy smoothie | Fractured bone site(s): Arm (ukb-b-19255) | All - Inverse variance weighted | -0.020807519669676 | 0.0081117687278617 | 0.0103145277560895 |
| Dairy smoothie | Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) | rs58791769 | 0.03480678613832 | 0.0174407279608192 | 0.0459645554067307 |
| Dairy smoothie | Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) | All - Inverse variance weighted | 0.0157472331482721 | 0.0070017234476062 | 0.0245092512790579 |
| Dairy smoothie | Operative procedures - main OPCS: W20.1 Primary open reduction of fracture of long bone and extramedullary fixation using plate NEC (ukb-b-8379) | All - Inverse variance weighted | -0.0166531846976215 | 0.0074476601801851 | 0.0253498667350458 |
| Dairy smoothie | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | All - Inverse variance weighted | 0.0165541397769765 | 0.0069819061246231 | 0.0177397536642903 |
| Dairy smoothie | Other specific joint derangements/joint disorders (ukb-d-M13_JOINTOTH) | All - MR Egger | 0.0251369941652775 | 0.0111549987299453 | 0.0362397715262528 |
| Dairy smoothie | Other joint disorders (ukb-d-M13_OTHERJOINT) | rs116941302 | 0.118150302672376 | 0.0594483980510852 | 0.0468733263593823 |
| Dairy smoothie | Other joint disorders (ukb-d-M13_OTHERJOINT) | All - Inverse variance weighted | 0.0252039027677962 | 0.0125776822494267 | 0.0450851581094567 |
| Dairy smoothie | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | All - Inverse variance weighted | 0.01455719492712 | 0.0068351898374986 | 0.0331928704865985 |
| Dairy smoothie | Diagnoses - main ICD10: M25 Other joint disorders, not elsewhere classified (ukb-d-M25) | All - MR Egger | 0.023985695238742 | 0.0109205877702536 | 0.0406772988699172 |
| Dairy smoothie | Diagnoses - main ICD10: M47 Spondylosis (ukb-d-M47) | rs58791769 | -0.0433154311368359 | 0.017672714455328 | 0.0142468732130454 |
| Dairy smoothie | Other disorders of synovium, tendon, and bursa (ukb-e-727_CSA) | All - Inverse variance weighted | -3.04931265591674 | 1.34336942174844 | 0.0232137231575945 |
| Dairy smoothie | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | rs6449463 | -6.57980356281626 | 3.12952146187235 | 0.0355099277649055 |
| Dairy smoothie | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | All - Inverse variance weighted | -1.00236935750338 | 0.473692390050698 | 0.0343382977222367 |