ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Beer/cider (ukb-b-4961)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Beer/cider (👉 📊) Osteoprotegerin levels (ebi-a-GCST90010243) MR Egger 13 2.198381508 0.958626208 0.042532991
Beer/cider (👉 📊) Osteoprotegerin levels (ebi-a-GCST90010243) Weighted mode 13 1.383641247 0.574819097 0.033087985
Beer/cider (👉 📊) Osteopontin levels (ebi-a-GCST90010244) MR Egger 13 1.944978092 0.776107495 0.029189815
Beer/cider (👉 📊) Compression fracture (ebi-a-GCST90018608) Weighted median 8 0.736482757 0.317981195 0.020551692
Beer/cider (👉 📊) Compression fracture (ebi-a-GCST90018608) Weighted mode 8 0.727115579 0.292849293 0.04203122
Beer/cider (👉 📊) Compression fracture (ebi-a-GCST90018828) Weighted median 14 0.623802171 0.254217742 0.014135144
Beer/cider (👉 📊) Compression fracture (ebi-a-GCST90018828) Inverse variance weighted 14 0.432326464 0.183058607 0.018192174
Beer/cider (👉 📊) Rheumatoid arthritis (ebi-a-GCST90018910) Inverse variance weighted 15 0.224153602 0.113036619 0.047365467
Beer/cider (👉 📊) Sciatica (ebi-a-GCST90038692) Inverse variance weighted 15 0.004122431 0.001720273 0.016557815
Beer/cider (👉 📊) Cervical spondylosis (ebi-a-GCST90038693) MR Egger 15 -0.009015922 0.003832745 0.035072708
Beer/cider (👉 📊) Neck injury (ebi-a-GCST90038700) MR Egger 15 -0.009698912 0.004374266 0.045044871
Beer/cider (👉 📊) Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) MR Egger 14 6.050071566 2.464460872 0.030318659
Beer/cider (👉 📊) Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) MR Egger 14 5.989125988 2.463019016 0.03163874
Beer/cider (👉 📊) Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) Weighted median 14 1.451854734 0.669005592 0.029994098
Beer/cider (👉 📊) Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) Inverse variance weighted 14 1.264524793 0.484312884 0.009028669
Beer/cider (👉 📊) Other bursitis, not elsewhere classified (finn-b-M13_BURSITISOTH) Weighted median 14 -3.417894208 1.573815112 0.029876384
Beer/cider (👉 📊) Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) Weighted median 14 -1.600522969 0.622142488 0.010093816
Beer/cider (👉 📊) Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) Inverse variance weighted 14 -1.029729699 0.471009314 0.028799558
Beer/cider (👉 📊) Other juvenile arthritis (finn-b-M13_JUVEARTH) Weighted median 14 1.534225073 0.726016997 0.034582951
Beer/cider (👉 📊) Other juvenile arthritis (finn-b-M13_JUVEARTH) Inverse variance weighted 14 1.318458459 0.530895782 0.013011293
Beer/cider (👉 📊) Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) Weighted median 14 2.36104521 1.094964073 0.031062088
Beer/cider (👉 📊) Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) Inverse variance weighted 14 2.028566304 0.883817432 0.021719816
Beer/cider (👉 📊) Transient synovitis (finn-b-M13_TRANSSYNOVITIS) MR Egger 14 -7.515732124 3.251825771 0.039388003
Beer/cider (👉 📊) Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) MR Egger 14 -6.4193526 2.705331797 0.035218141
Beer/cider (👉 📊) Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) Weighted median 14 -2.215455741 0.928115693 0.016984322
Beer/cider (👉 📊) Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) Simple mode 14 -2.675146266 1.213234403 0.046074868
Beer/cider (👉 📊) Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) Inverse variance weighted 14 1.926774402 0.735235037 0.008776907
Beer/cider (👉 📊) Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) MR Egger 14 1.134322624 0.462771383 0.03052884
Beer/cider (👉 📊) Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) Inverse variance weighted 14 0.511488512 0.181317401 0.004788069
Beer/cider (👉 📊) Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) MR Egger 14 9.189323264 3.155730906 0.013033832
Beer/cider (👉 📊) Hip osteoarthritis (ieu-a-1169) Inverse variance weighted 3 -1.142266942 0.544693834 0.03598643
Beer/cider (👉 📊) Fractured/broken bones in last 5 years (ukb-a-308) Inverse variance weighted 14 0.015835228 0.00758328 0.036781898
Beer/cider (👉 📊) Heel bone mineral density (BMD) (left) (ukb-b-1096) Weighted median 15 -0.102909918 0.042960184 0.016598981
Beer/cider (👉 📊) Fractured/broken bones in last 5 years (ukb-b-13346) Weighted median 15 0.022288946 0.007286393 0.002220905
Beer/cider (👉 📊) Fractured/broken bones in last 5 years (ukb-b-13346) Inverse variance weighted 15 0.022327284 0.005341134 2.91e-05
Beer/cider (👉 📊) Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis (ukb-b-14753) Wald ratio 1 -0.012119296 0.003779109 0.001341648
Beer/cider (👉 📊) Fractured bone site(s): Other bones (ukb-b-17738) Weighted median 15 0.018277181 0.005932977 0.002065777
Beer/cider (👉 📊) Fractured bone site(s): Other bones (ukb-b-17738) Inverse variance weighted 15 0.014731306 0.004565016 0.001250955
Beer/cider (👉 📊) Fractured bone site(s): Other bones (ukb-b-17738) Weighted mode 15 0.021388018 0.009182788 0.035339379
Beer/cider (👉 📊) Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) MR Egger 15 -0.045016218 0.019537092 0.03836287
Beer/cider (👉 📊) Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) Weighted median 15 -0.024427906 0.01113324 0.028225222
Beer/cider (👉 📊) Ankle spacing width (left) (ukb-b-2122) Inverse variance weighted 15 0.068656615 0.034092955 0.044029853
Beer/cider (👉 📊) Operative procedures - main OPCS: T72.3 Release of constriction of sheath of tendon (ukb-b-5534) Weighted median 4 0.008132128 0.003307684 0.013949674
Beer/cider (👉 📊) Non-cancer illness code, self-reported: sciatica (ukb-b-8194) Weighted median 5 0.010659307 0.004602983 0.020572517
Beer/cider (👉 📊) Fractured bone site(s): Spine (ukb-b-873) Wald ratio 1 0.009351781 0.00353609 0.008177127
Beer/cider (👉 📊) Knee pain for 3+ months (ukb-b-8906) Inverse variance weighted 15 0.036318155 0.016082562 0.023931204
Beer/cider (👉 📊) Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) Inverse variance weighted 14 0.003059829 0.001551586 0.048602151
Beer/cider (👉 📊) Ankle spacing width (ukb-e-3143_CSA) Weighted median 12 0.918014874 0.369516704 0.012978221
Beer/cider (👉 📊) Ankle spacing width (ukb-e-3143_CSA) Inverse variance weighted 12 0.541489287 0.266727979 0.04234454
Beer/cider (👉 📊) Ankle spacing width (left) (ukb-e-4100_EAS) Weighted median 8 -1.036336407 0.376142331 0.005866148
Beer/cider (👉 📊) Ankle spacing width (left) (ukb-e-4100_EAS) Weighted mode 8 -1.079225582 0.387111529 0.026989991
Beer/cider (👉 📊) Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) Weighted median 8 0.850962921 0.411467819 0.038629176
Beer/cider (👉 📊) Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) Weighted median 8 0.816734801 0.411339798 0.047083565
Beer/cider (👉 📊) Ankle spacing width (right) (ukb-e-4119_EAS) Weighted median 8 -0.814910814 0.37635184 0.030365496
Beer/cider (👉 📊) Ankle spacing width (right) (ukb-e-4119_EAS) Weighted mode 8 -0.925080006 0.381870916 0.04592372
Beer/cider (👉 📊) Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS) Weighted median 8 0.981499925 0.396769514 0.013371139
Beer/cider (👉 📊) Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS) Inverse variance weighted 8 0.793624069 0.350958077 0.023740233
Beer/cider (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_EAS) Weighted median 8 0.89197732 0.411588537 0.030222822
Beer/cider (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_EAS) Inverse variance weighted 8 0.762117616 0.359073225 0.033799348
Beer/cider (👉 📊) Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_EAS) Weighted mode 8 0.962386899 0.40336226 0.048459102
Beer/cider (👉 📊) Spondylosis and allied disorders (ukb-e-721_CSA) Weighted median 11 2.937949301 1.385517545 0.033966373

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Beer/cider Osteoprotegerin levels (ebi-a-GCST90010243) rs1229984 1.13202414975051 0.538408027862269 0.0355060426356564
Beer/cider Osteoprotegerin levels (ebi-a-GCST90010243) All - MR Egger 2.19838150821902 0.958626208063952 0.0425329911956049
Beer/cider Osteopontin levels (ebi-a-GCST90010244) rs62565255 4.36622945876677 2.14896728478818 0.0421758993801946
Beer/cider Osteopontin levels (ebi-a-GCST90010244) All - MR Egger 1.94497809245872 0.776107495495206 0.0291898154848773
Beer/cider Compression fracture (ebi-a-GCST90018608) rs1229984 0.759478409498167 0.30347359425111 0.0123278602978084
Beer/cider Compression fracture (ebi-a-GCST90018828) rs1229984 0.701151432168423 0.291304068148611 0.0160868097841989
Beer/cider Compression fracture (ebi-a-GCST90018828) All - Inverse variance weighted 0.432326464228992 0.183058607153214 0.0181921736046147
Beer/cider Rheumatoid arthritis (ebi-a-GCST90018910) rs3212737 1.04513364032673 0.487495221494681 0.0320421110184302
Beer/cider Rheumatoid arthritis (ebi-a-GCST90018910) All - Inverse variance weighted 0.224153601575954 0.11303661918309 0.0473654673127784
Beer/cider Sciatica (ebi-a-GCST90038692) rs12473044 0.0147899300504699 0.0070766978256194 0.0366224763846366
Beer/cider Sciatica (ebi-a-GCST90038692) rs1450627 0.0166428364925336 0.0063653589924078 0.0089333284742993
Beer/cider Sciatica (ebi-a-GCST90038692) All - Inverse variance weighted 0.004122431439963 0.0017202729315243 0.0165578146592821
Beer/cider Cervical spondylosis (ebi-a-GCST90038693) rs184257876 -0.0120370107844907 0.0051843600262039 0.0202440847132532
Beer/cider Cervical spondylosis (ebi-a-GCST90038693) All - MR Egger -0.0090159221581166 0.0038327450676199 0.0350727084726456
Beer/cider Neck injury (ebi-a-GCST90038700) rs184257876 -0.0132242896516939 0.0054941212811264 0.0160846530205994
Beer/cider Neck injury (ebi-a-GCST90038700) All - MR Egger -0.0096989121434016 0.0043742664924207 0.0450448713612982
Beer/cider Benign neoplasm: Short bones of upper limb (finn-b-CD2_BENIGN_BONE_SHORT_UPPER) All - MR Egger 6.05007156644562 2.4644608723325 0.0303186585049528
Beer/cider Benign neoplasm: Short bones of upper limb (all cancers excluded) (finn-b-CD2_BENIGN_BONE_SHORT_UPPER_EXALLC) All - MR Egger 5.98912598808065 2.46301901622308 0.0316387399062866
Beer/cider Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) rs281392 3.92139790635528 1.74805269608664 0.0248777963581781
Beer/cider Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) All - Inverse variance weighted 1.2645247932126 0.484312883705981 0.0090286694913504
Beer/cider Calcific tendinitis of shoulder (finn-b-M13_CALCIFICTEND) All - Inverse variance weighted -1.02972969900979 0.471009314073389 0.0287995577533071
Beer/cider Other juvenile arthritis (finn-b-M13_JUVEARTH) All - Inverse variance weighted 1.31845845880267 0.530895781746299 0.0130112932110145
Beer/cider Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) rs62565255 6.93803708729082 2.92929292929293 0.0178602685625675
Beer/cider Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) rs6839368 7.93363521529404 3.41525513457878 0.0201791911703165
Beer/cider Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) All - Inverse variance weighted 2.02856630398801 0.883817432014742 0.0217198159077561
Beer/cider Transient synovitis (finn-b-M13_TRANSSYNOVITIS) All - MR Egger -7.51573212433326 3.25182577124886 0.0393880026306636
Beer/cider Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) rs72992184 -9.78272120538427 4.59152216666742 0.0331216772044894
Beer/cider Drug-induced osteoporosis with pathological fracture (finn-b-OSTPOPATFRACTURE) All - MR Egger -6.41935259965934 2.70533179678162 0.035218141315087
Beer/cider Other congenital malformations of face and neck (finn-b-Q17_OTHER_CONGEN_MALFO_FACE_NECK) rs72863060 5.83716752707739 2.57199809408662 0.0232375156046566
Beer/cider Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) rs6839368 7.2466444564278 3.25274119162117 0.0258900068000359
Beer/cider Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) rs72863060 6.04770447015485 2.84286433664242 0.0333928525152507
Beer/cider Dislocation, sprain and strain of joints and ligaments of thorax (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_THORAX) All - Inverse variance weighted 1.92677440185031 0.735235037075928 0.008776906839352
Beer/cider Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) rs75510754 0.964199757466676 0.417819894902226 0.0210162562275187
Beer/cider Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) All - Inverse variance weighted 0.511488511572402 0.18131740132497 0.0047880687019545
Beer/cider Fracture of shoulder and upper arm (finn-b-ST19_FRACT_SHOUL_UPPER_ARM) All - MR Egger 1.13432262384858 0.462771382833356 0.0305288400620445
Beer/cider Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) rs75510754 6.53925220128041 2.79123468251251 0.0191406030803632
Beer/cider Open wound of neck (finn-b-ST19_OPEN_WOUND_NECK) All - MR Egger 9.18932326407487 3.1557309055329 0.0130338320435368
Beer/cider Hip osteoarthritis (ieu-a-1169) All - Inverse variance weighted -1.14226694192867 0.544693834264844 0.0359864297760018
Beer/cider Fractured/broken bones in last 5 years (ukb-a-308) rs6839368 0.0960738108780924 0.0247452101477646 0.0001033788647407
Beer/cider Fractured/broken bones in last 5 years (ukb-a-308) All - Inverse variance weighted 0.0158352280598914 0.0075832797237084 0.0367818979159554
Beer/cider Heel bone mineral density (BMD) (left) (ukb-b-1096) rs281392 -0.24807312352236 0.124399734778212 0.0461344415973264
Beer/cider Fractured/broken bones in last 5 years (ukb-b-13346) rs6839368 0.0675942273077595 0.0212343672667371 0.0014563352627287
Beer/cider Fractured/broken bones in last 5 years (ukb-b-13346) All - Inverse variance weighted 0.0223272839093262 0.005341133612315 2.91186358529673e-05
Beer/cider Diagnoses - main ICD10: T84.0 Mechanical complication of internal joint prosthesis (ukb-b-14753) rs281392 -0.012119296224608 0.0037791090959017 0.0013416483293674
Beer/cider Fractured bone site(s): Other bones (ukb-b-17738) rs3817588 0.0506538316023937 0.015722198835146 0.0012738656975469
Beer/cider Fractured bone site(s): Other bones (ukb-b-17738) All - Inverse variance weighted 0.0147313059702855 0.0045650158522249 0.0012509547786671
Beer/cider Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) All - MR Egger -0.0450162175290871 0.0195370918580636 0.038362870152317
Beer/cider Ankle spacing width (left) (ukb-b-2122) rs1229984 0.270541531505867 0.0838778360794332 0.001257865107291
Beer/cider Ankle spacing width (left) (ukb-b-2122) rs3817588 0.315182001779786 0.104488098346504 0.0025576245581185
Beer/cider Ankle spacing width (left) (ukb-b-2122) All - Inverse variance weighted 0.0686566146201402 0.0340929550922994 0.0440298528730399
Beer/cider Non-cancer illness code, self-reported: sciatica (ukb-b-8194) rs12473044 0.0147311433522648 0.0072698496021857 0.0427305703382859
Beer/cider Fractured bone site(s): Spine (ukb-b-873) rs281392 0.0093517805356676 0.0035360895860262 0.0081771270116273
Beer/cider Knee pain for 3+ months (ukb-b-8906) All - Inverse variance weighted 0.0363181547526352 0.0160825619120208 0.0239312038509795
Beer/cider Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) All - Inverse variance weighted 0.003059828796229 0.0015515859315458 0.0486021510472155
Beer/cider Ankle spacing width (ukb-e-3143_CSA) rs1229984 1.10824197535402 0.55255878920429 0.0448931318792507
Beer/cider Ankle spacing width (ukb-e-3143_CSA) rs281392 1.9955260567012 0.938322539163748 0.0334454151328138
Beer/cider Ankle spacing width (ukb-e-3143_CSA) All - Inverse variance weighted 0.541489287321134 0.266727978723912 0.0423445399526245
Beer/cider Ankle spacing width (left) (ukb-e-4100_EAS) rs1229984 -1.1505132281453 0.364176032199667 0.0015819050010933
Beer/cider Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) rs1229984 0.999807022541605 0.408560847630512 0.0143993496255473
Beer/cider Heel bone mineral density (BMD) (left) (ukb-e-4105_EAS) rs3212737 7.42991817796031 3.4703346882661 0.0322756273057071
Beer/cider Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) rs1229984 0.918940278071328 0.405712132768491 0.0235123320336516
Beer/cider Heel bone mineral density (BMD) T-score, automated (left) (ukb-e-4106_EAS) rs3212737 7.30366042275305 3.44753814913145 0.0341314970086013
Beer/cider Ankle spacing width (right) (ukb-e-4119_EAS) rs1229984 -0.950184247525753 0.370700508173974 0.0103708494992043
Beer/cider Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS) rs1229984 0.990617619760892 0.399187656794185 0.013079995305863
Beer/cider Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS) rs3212737 7.38607867962445 3.38791643139469 0.029248254622252
Beer/cider Heel bone mineral density (BMD) (right) (ukb-e-4124_EAS) All - Inverse variance weighted 0.793624068718747 0.350958077234995 0.0237402333338089
Beer/cider Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_EAS) rs1229984 0.939156964188897 0.400657961239099 0.0190762943515201
Beer/cider Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_EAS) rs3212737 7.44570039736121 3.4036986507956 0.0287036952301549
Beer/cider Heel bone mineral density (BMD) T-score, automated (right) (ukb-e-4125_EAS) All - Inverse variance weighted 0.762117616309182 0.359073224502387 0.0337993478503069