ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Other bread | Osteoarthritis (self-reported) (ebi-a-GCST005811) | rs4530746 | 2.50957707005775 | 0.862507548573174 | 0.0036185789338371 |
| Other bread | Osteoarthritis (self-reported) (ebi-a-GCST005811) | rs74006323 | 2.04078880384399 | 0.840877222753133 | 0.0152252647401531 |
| Other bread | Osteoarthritis (self-reported) (ebi-a-GCST005811) | All - Inverse variance weighted | 0.647747773966287 | 0.237436582638488 | 0.0063702707224324 |
| Other bread | Osteoarthritis (self-reported) (ebi-a-GCST005811) | All - MR Egger | 0.928181242835705 | 0.425527062728411 | 0.0481247866156315 |
| Other bread | Shoulder impingement (ebi-a-GCST90014054) | All - Inverse variance weighted | -0.99329508010933 | 0.403429584103036 | 0.0138115551835643 |
| Other bread | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | rs9992062 | -1.81129909318688 | 0.864924406382599 | 0.0362448032383334 |
| Other bread | Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) | All - Inverse variance weighted | -0.401613510609756 | 0.18701130953455 | 0.0317506381966445 |
| Other bread | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | rs4794417 | 0.027804668508557 | 0.010847253272935 | 0.010368505481952 |
| Other bread | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | rs73017061 | 0.0255264098069645 | 0.0104626321606806 | 0.0146966399168662 |
| Other bread | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | rs74006323 | 0.0192515651933159 | 0.0082579420722177 | 0.019738663933204 |
| Other bread | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | rs79862891 | 0.0199593338307988 | 0.0099220565090309 | 0.0442607907927856 |
| Other bread | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | All - Inverse variance weighted | 0.0098961391347732 | 0.0037475281483994 | 0.0082732236534607 |
| Other bread | Arthritis (not osteoarthritis) (ebi-a-GCST90038699) | All - MR Egger | 0.0186755505159038 | 0.0070849839519279 | 0.0249071843158637 |
| Other bread | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | rs149685100 | -0.0235583668675344 | 0.0107844833322244 | 0.028927820860855 |
| Other bread | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | rs74006323 | -0.0177142372306126 | 0.0088734716478962 | 0.0458997360963206 |
| Other bread | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | All - Inverse variance weighted | -0.0067227353302279 | 0.0031898957770611 | 0.0350734478862998 |
| Other bread | Fracture of upper limb or shoulder (ebi-a-GCST90038704) | All - MR Egger | -0.0141914820331909 | 0.006252191980006 | 0.0465831661508127 |
| Other bread | Cervical root disorders (finn-b-G6_CERVROOT) | rs7780072 | 15.3034084864356 | 7.17603011579852 | 0.0329597654298513 |
| Other bread | Juvenile arthritis (FINNGEN) (finn-b-JUVEN_ARTHR) | All - MR Egger | -2.878394644502 | 1.16607935607569 | 0.0260785961399397 |
| Other bread | Bicipital tendinitis (finn-b-M13_BICIPITALTEND) | rs10797418 | 8.47915289224915 | 2.93742082338631 | 0.0038943152413498 |
| Other bread | Bicipital tendinitis (finn-b-M13_BICIPITALTEND) | rs149423073 | 6.80213967729632 | 2.62705535832757 | 0.009618134530991 |
| Other bread | Bicipital tendinitis (finn-b-M13_BICIPITALTEND) | All - Inverse variance weighted | 2.0573136345958 | 0.814291707052841 | 0.0115203118088425 |
| Other bread | Other juvenile arthritis (finn-b-M13_JUVEARTH) | All - MR Egger | -3.37658772527849 | 1.27964475538367 | 0.0186069315170882 |
| Other bread | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | rs7844293 | -1.3723247835321 | 0.626259325818221 | 0.0284297756478189 |
| Other bread | Lower back pain or/and sciatica (finn-b-M13_LOWBACKPAINORANDSCIATICA) | All - MR Egger | -0.65926431031843 | 0.255778760698526 | 0.0210197301893412 |
| Other bread | Osteoporosis with pathological fracture (FG) (finn-b-OSTEOPOROSIS_FRACTURE_FG) | rs114013769 | -4.29960557660015 | 1.82762525871832 | 0.0186444758552572 |
| Other bread | Osteoporosis with pathological fracture (FG) (finn-b-OSTEOPOROSIS_FRACTURE_FG) | All - Inverse variance weighted | -2.15286244196304 | 0.708157019154805 | 0.0023650594354054 |
| Other bread | Postmenopausal osteoporosis with pathological fracture (finn-b-OSTPOPATFRCTURE_POSTEMENO) | rs149685100 | -8.02506458528005 | 3.9185111682631 | 0.0405611568538045 |
| Other bread | Postmenopausal osteoporosis with pathological fracture (finn-b-OSTPOPATFRCTURE_POSTEMENO) | All - Inverse variance weighted | -2.00112642584528 | 0.788261116426606 | 0.0111278125314505 |
| Other bread | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | rs74006323 | -5.11579304616539 | 2.18635848062376 | 0.0192904903545645 |
| Other bread | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | rs7780072 | 3.72867138589959 | 1.55489177134907 | 0.0164836809514035 |
| Other bread | Other (seronegative) rheumatoid arthritis, wide (finn-b-RHEUMA_OTHER_WIDE) | All - MR Egger | -1.57753308903032 | 0.624238920756276 | 0.0232265343315427 |
| Other bread | Burn and corrosion of ankle and foot (finn-b-ST19_BURN_CORROSION_ANKLE_FOOT) | All - MR Egger | 5.49443492867511 | 2.41646462652138 | 0.0381065631509654 |
| Other bread | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | rs7844293 | -3.68131568915754 | 1.74263464575505 | 0.0346435859635324 |
| Other bread | Dislocation, sprain and strain of joints and ligaments at neck level (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_NECK_LEVEL) | All - Inverse variance weighted | -0.82490550215319 | 0.41976515081856 | 0.0493957720253001 |
| Other bread | Fracture of femur (finn-b-ST19_FRACT_FEMUR) | rs114013769 | -1.74171125082985 | 0.812277892763697 | 0.0320144008257361 |
| Other bread | Fracture of femur (finn-b-ST19_FRACT_FEMUR) | rs73017061 | -2.12964306847235 | 0.886188301756188 | 0.0162545360028952 |
| Other bread | Fracture of femur (finn-b-ST19_FRACT_FEMUR) | rs74006323 | -5.21403627854636 | 1.97558209115186 | 0.0083092008930072 |
| Other bread | Fracture of femur (finn-b-ST19_FRACT_FEMUR) | All - Inverse variance weighted | -0.848280195766548 | 0.423781320854865 | 0.0453177362908196 |
| Other bread | Fracture of femur (finn-b-ST19_FRACT_FEMUR) | All - MR Egger | -1.69462887645793 | 0.687663090954047 | 0.0262902331382576 |
| Other bread | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | rs73017061 | -2.33200102714109 | 0.85548571492369 | 0.0064119039339608 |
| Other bread | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | All - Inverse variance weighted | -0.640496409627127 | 0.306674083290544 | 0.0367505262311995 |
| Other bread | Fracture of rib(s), sternum and thoracic spine (finn-b-ST19_FRACT_RIBS_STERNUM_THORACIC_SPINE) | All - MR Egger | -1.35054390821682 | 0.517419430994302 | 0.0196966986536059 |
| Other bread | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | rs114013769 | -1.78466825477409 | 0.682430585386808 | 0.0089184485459988 |
| Other bread | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | rs73017061 | -1.61328138083489 | 0.725697506949949 | 0.0262106134444644 |
| Other bread | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | All - Inverse variance weighted | -0.645932569841251 | 0.262691817657303 | 0.0139363933746429 |
| Other bread | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | All - MR Egger | -0.997752024785787 | 0.443374610451146 | 0.0398605116105675 |
| Other bread | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs12950671 | 4.38730994094196 | 1.97651527891816 | 0.026437799387881 |
| Other bread | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs7780072 | 1.759482793895 | 0.79790498792913 | 0.0274450993754595 |
| Other bread | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | rs9992062 | 2.76930953433711 | 0.992917704188096 | 0.0052860862733435 |
| Other bread | Injuries to the ankle and foot (finn-b-ST19_INJURI_ANKLE_FOOT) | All - Inverse variance weighted | 0.424956349566279 | 0.209471339931696 | 0.0424879595870112 |
| Other bread | Injuries to the neck (finn-b-ST19_INJURI_NECK) | rs114013769 | -2.10391689772328 | 0.876713398680048 | 0.0164050498074779 |
| Other bread | Injuries to the neck (finn-b-ST19_INJURI_NECK) | All - Inverse variance weighted | -0.853456303672626 | 0.33701130550156 | 0.0113276170146784 |
| Other bread | Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) | rs115490527 | 13.364846233927 | 6.00808455961659 | 0.0261163647411916 |
| Other bread | Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) | All - Inverse variance weighted | 6.04819019564277 | 1.99617323432073 | 0.0024464084437129 |
| Other bread | Injury of blood vessels at wrist and hand level (finn-b-ST19_INJURY_BLOOD_VESSE_WRIST_HAND_LEVEL) | All - MR Egger | 10.1167508445688 | 3.37057585872904 | 0.0089455491517201 |
| Other bread | Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) | All - Inverse variance weighted | -1.85771369829554 | 0.597906001616498 | 0.0018897528033586 |
| Other bread | Open wound of shoulder and upper arm (finn-b-ST19_OPEN_WOUND_SHOUL_UPPER_ARM) | All - Inverse variance weighted | -2.96285175996688 | 1.2601782464655 | 0.0187161390754503 |
| Other bread | Femoral neck bone mineral density (ieu-a-980) | All - Inverse variance weighted | 0.318721695099027 | 0.111328110010095 | 0.0041977768432341 |
| Other bread | Lumbar spine bone mineral density (ieu-a-982) | rs10797418 | 1.29079961440043 | 0.526010306208456 | 0.0141299148640843 |
| Other bread | Lumbar spine bone mineral density (ieu-a-982) | All - MR Egger | -0.53684588505425 | 0.232010777425426 | 0.0363791609196585 |
| Other bread | Bone sialoprotein 2 (prot-a-1396) | rs7780072 | 3.38598142313515 | 1.52931789353083 | 0.0268255581403497 |
| Other bread | Bone sialoprotein 2 (prot-a-1396) | rs9992062 | 3.26576838643116 | 1.53591957366596 | 0.0334813981144989 |
| Other bread | Bone sialoprotein 2 (prot-a-1396) | All - Inverse variance weighted | 0.899421036737281 | 0.365267486520217 | 0.0138025005557294 |
| Other bread | Bone morphogenetic protein 6 (prot-a-256) | rs115490527 | 3.32479858942254 | 1.2230006658976 | 0.0065567103391231 |
| Other bread | Bone morphogenetic protein 6 (prot-a-256) | rs4794417 | 3.3290703009831 | 1.51809510792631 | 0.0283127078687761 |
| Other bread | Bone morphogenetic protein 6 (prot-a-256) | All - Inverse variance weighted | 1.09310460272001 | 0.365070624910499 | 0.0027514046396065 |
| Other bread | Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) | rs4794417 | 0.0260352334742412 | 0.0130632816237272 | 0.0462604982188867 |
| Other bread | Non-cancer illness code self-reported: arthritis (nos) (ukb-a-113) | rs73017061 | 0.0268136855385234 | 0.012371411984057 | 0.0302050618870464 |
| Other bread | Operative procedures - main OPCS: W20.5 Primary open reduction of fracture of ankle and extramedullary fixation NEC (ukb-b-13151) | rs7844293 | -0.0143806567554321 | 0.006743832707074 | 0.0329726633430799 |
| Other bread | Operative procedures - main OPCS: W87.9 Unspecified diagnostic endoscopic examination of knee joint (ukb-b-15942) | rs10797418 | 0.0193409477472203 | 0.0097441112787874 | 0.0471571827502275 |
| Other bread | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | rs114013769 | 0.116679033076893 | 0.0485332135744132 | 0.0162120322354804 |
| Other bread | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | rs145365130 | 0.102822302592171 | 0.050705730029703 | 0.0425782012829382 |
| Other bread | Pain type(s) experienced in last month: Knee pain (ukb-b-16254) | All - Inverse variance weighted | 0.0275427946331633 | 0.0120962938022903 | 0.0227885279812829 |
| Other bread | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | All - Inverse variance weighted | -0.0064069709736349 | 0.0032649819113476 | 0.0497241115842776 |
| Other bread | Ankle spacing width (left) (ukb-e-4100_AFR) | rs74006323 | -0.743076084917878 | 0.265792599605241 | 0.0051787620097019 |
| Other bread | Ankle spacing width (left) (ukb-e-4100_AFR) | rs79862891 | -2.58399616799559 | 1.03701989970315 | 0.0127114841881073 |
| Other bread | Ankle spacing width (left) (ukb-e-4100_AFR) | All - Inverse variance weighted | -0.614592943009037 | 0.249688237467072 | 0.0138380035003998 |
| Other bread | Ankle spacing width (right) (ukb-e-4119_AFR) | rs79862891 | -2.25325769252075 | 1.06341380759819 | 0.0340996998938069 |
| Other bread | Ankle spacing width (right) (ukb-e-4119_AFR) | All - Inverse variance weighted | -0.507301697661494 | 0.247821745300433 | 0.0406538909959233 |
| Other bread | Internal derangement of knee (ukb-e-835_CSA) | rs74006323 | 3.43494065215644 | 1.32539051684871 | 0.0095518500521474 |