ONMR: An Orthopedic and Nutritional Mendelian Randomization Database

Chocolate-covered biscuits (ukb-b-5068)

Mendelian Randomization Results

Intake (exposure) Outcome Method Number of SNPs b se P-value
Chocolate-covered biscuits (👉 📊) Rheumatoid Arthritis (bbj-a-73) Weighted median 8 -0.860870679 0.402690313 0.032533114
Chocolate-covered biscuits (👉 📊) Frozen shoulder (ebi-a-GCST90000512) MR Egger 7 1.32791852 0.428751266 0.02693925
Chocolate-covered biscuits (👉 📊) Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) Weighted median 7 -0.505689383 0.242456243 0.037006405
Chocolate-covered biscuits (👉 📊) Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) Inverse variance weighted 7 -0.430916432 0.197820315 0.029382039
Chocolate-covered biscuits (👉 📊) Bone disorder (ebi-a-GCST90038652) Inverse variance weighted 7 -0.008940157 0.004380495 0.041260649
Chocolate-covered biscuits (👉 📊) Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) MR Egger 8 -6.437086687 2.437172816 0.038478091
Chocolate-covered biscuits (👉 📊) Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) Inverse variance weighted 8 -1.659789876 0.793329262 0.036422162
Chocolate-covered biscuits (👉 📊) Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) Weighted median 8 1.73409139 0.845950052 0.040376685
Chocolate-covered biscuits (👉 📊) Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) Inverse variance weighted 8 1.559528505 0.667052154 0.019390315
Chocolate-covered biscuits (👉 📊) Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) Inverse variance weighted 8 -5.236592978 2.321316066 0.02407862
Chocolate-covered biscuits (👉 📊) Other and unspecified injuries of shoulder and upper arm (finn-b-ST19_OTHER_UNSPE_INJURI_SHOUL_UPPER_ARM) Weighted median 8 -3.69731893 1.601890416 0.020993726
Chocolate-covered biscuits (👉 📊) Bone sialoprotein 2 (prot-a-1395) Inverse variance weighted 8 -0.708479195 0.348732488 0.042195831
Chocolate-covered biscuits (👉 📊) Fractured/broken bones in last 5 years (ukb-a-308) MR Egger 8 0.053685547 0.02074105 0.041302159
Chocolate-covered biscuits (👉 📊) Operative procedures - secondary OPCS: Z85.6 Ankle joint (ukb-b-15453) Inverse variance weighted 2 -0.009905772 0.004126134 0.01636199
Chocolate-covered biscuits (👉 📊) Operative procedures - secondary OPCS: Z86.4 Metatarsophalangeal joint of great toe (ukb-b-17501) Inverse variance weighted 2 0.007739937 0.003414541 0.023405014
Chocolate-covered biscuits (👉 📊) Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) Inverse variance weighted 2 -0.012731855 0.005245378 0.015213676
Chocolate-covered biscuits (👉 📊) Other disorders of synovium, tendon, and bursa (ukb-e-727_AFR) Inverse variance weighted 5 -2.593885723 1.218422174 0.033263434

Mendelian Randomization Results (Single SNP)

Intake (exposure) Outcome SNP b se P-value
Chocolate-covered biscuits Frozen shoulder (ebi-a-GCST90000512) rs145988084 1.24262619546477 0.566166704035008 0.0281775021539548
Chocolate-covered biscuits Frozen shoulder (ebi-a-GCST90000512) rs9502103 -1.71655305349195 0.580469564354142 0.0031046670282578
Chocolate-covered biscuits Frozen shoulder (ebi-a-GCST90000512) All - MR Egger 1.32791852000775 0.428751266139087 0.0269392497252355
Chocolate-covered biscuits Medication use (drugs affecting bone structure and mineralization) (ebi-a-GCST90018993) All - Inverse variance weighted -0.430916432330996 0.197820314677908 0.0293820389927696
Chocolate-covered biscuits Bone disorder (ebi-a-GCST90038652) rs139382 -0.021693392471284 0.0105816672353008 0.0403554435488657
Chocolate-covered biscuits Bone disorder (ebi-a-GCST90038652) All - Inverse variance weighted -0.0089401572971051 0.0043804949006504 0.0412606485753748
Chocolate-covered biscuits Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) rs28434249 6.59669285798053 2.99050076228451 0.0273922381359285
Chocolate-covered biscuits Polyarthritis, unspecified (finn-b-M13_POLYARTHRITIS) All - MR Egger -6.43708668673738 2.43717281635713 0.0384780906794849
Chocolate-covered biscuits Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) rs16864539 -3.2878580384951 1.382942045483 0.017433405313637
Chocolate-covered biscuits Dislocation, sprain and strain of joints and ligaments of elbow (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINTS_LIGAM_ELBOW) All - Inverse variance weighted -1.65978987648699 0.793329262073887 0.0364221620444915
Chocolate-covered biscuits Injury of muscle and tendon at hip and thigh level (finn-b-ST19_INJURY_MUSCLE_TENDON_HIP_THIGH_LEVEL) All - Inverse variance weighted 1.55952850468274 0.667052154354489 0.0193903149158994
Chocolate-covered biscuits Injury of nerves at ankle and foot level (finn-b-ST19_INJURY_NERVES_ANKLE_FOOT_LEVEL) All - Inverse variance weighted -5.23659297759369 2.32131606597609 0.024078619902208
Chocolate-covered biscuits Bone sialoprotein 2 (prot-a-1395) rs16864539 -2.11100902764536 0.97653428559872 0.0306385542034369
Chocolate-covered biscuits Bone sialoprotein 2 (prot-a-1395) All - Inverse variance weighted -0.708479194707427 0.348732487986499 0.0421958308694401
Chocolate-covered biscuits Fractured/broken bones in last 5 years (ukb-a-308) All - MR Egger 0.0536855467348296 0.0207410498841395 0.0413021585730282
Chocolate-covered biscuits Operative procedures - secondary OPCS: Z85.6 Ankle joint (ukb-b-15453) All - Inverse variance weighted -0.0099057721470532 0.0041261340922726 0.016361990016578
Chocolate-covered biscuits Operative procedures - secondary OPCS: Z86.4 Metatarsophalangeal joint of great toe (ukb-b-17501) rs9502103 0.0111156703453068 0.0049325766475289 0.0242262506708857
Chocolate-covered biscuits Operative procedures - secondary OPCS: Z86.4 Metatarsophalangeal joint of great toe (ukb-b-17501) All - Inverse variance weighted 0.0077399371507247 0.0034145405853029 0.0234050137970577
Chocolate-covered biscuits Non-cancer illness code, self-reported: arthritis (nos) (ukb-b-8229) All - Inverse variance weighted -0.0127318547601964 0.0052453777948117 0.0152136761629549
Chocolate-covered biscuits Other disorders of synovium, tendon, and bursa (ukb-e-727_AFR) All - Inverse variance weighted -2.59388572266656 1.21842217376159 0.0332634342395111