ONMR: An Orthopedic and Nutritional Mendelian Randomization Database
| Intake (exposure) | Outcome | SNP | b | se | P-value |
|---|---|---|---|---|---|
| Olives | Heel bone mineral density (ebi-a-GCST006979) | rs2308655 | -0.982767287659428 | 0.208677069981916 | 2.48309880394362e-06 |
| Olives | Heel bone mineral density (ebi-a-GCST006979) | rs2458265 | -0.932603017848871 | 0.209471432936144 | 8.50057097613586e-06 |
| Olives | Heel bone mineral density (ebi-a-GCST006979) | All - MR Egger | 0.25356444026005 | 0.0932493184177202 | 0.0122332278550134 |
| Olives | Bone morphogenetic protein 6 levels (ebi-a-GCST90010107) | All - Inverse variance weighted | 1.83909998038152 | 0.750404680469482 | 0.0142534806582481 |
| Olives | Osteopontin levels (ebi-a-GCST90010244) | rs60260736 | 15.079081788019 | 6.27601966916194 | 0.0162767354204009 |
| Olives | Osteopontin levels (ebi-a-GCST90010244) | All - Inverse variance weighted | 1.66645080118341 | 0.739475463740647 | 0.024223991983813 |
| Olives | Bone mineral density (ebi-a-GCST90014022) | rs1254930 | -0.664035486346207 | 0.227773940565904 | 0.0035531620017575 |
| Olives | Bone mineral density (ebi-a-GCST90014022) | rs2458265 | -1.10110089392192 | 0.234822546149828 | 2.74440720461274e-06 |
| Olives | Bone mineral density (ebi-a-GCST90014022) | rs76338277 | 0.540393719208433 | 0.242023780034679 | 0.0255613122116457 |
| Olives | Bone mineral density (ebi-a-GCST90014022) | All - MR Egger | 0.251471363834322 | 0.113863269849654 | 0.0379278578965354 |
| Olives | Shoulder impingement (ebi-a-GCST90014054) | rs151249774 | -4.94770296953534 | 2.45398566519643 | 0.0437800430775598 |
| Olives | Shoulder impingement (ebi-a-GCST90014054) | All - Inverse variance weighted | -1.22949272434737 | 0.533569520167187 | 0.0212070202362932 |
| Olives | Shoulder impingement (ebi-a-GCST90014054) | All - MR Egger | -2.87353245395804 | 0.938232207283885 | 0.0057002882293172 |
| Olives | Heel bone mineral density (ebi-a-GCST90029004) | rs2458265 | -0.971434907306112 | 0.21214531405537 | 4.66977758342622e-06 |
| Olives | Heel bone mineral density (ebi-a-GCST90029004) | All - MR Egger | 0.18641460317282 | 0.0772287307514556 | 0.0234405815534838 |
| Olives | Cervical disc disorders (finn-b-M13_CERVICDISC) | rs62171682 | 4.3759472324802 | 1.88557075871098 | 0.0203000857435503 |
| Olives | Cervical disc disorders (finn-b-M13_CERVICDISC) | All - Inverse variance weighted | 0.974197523442522 | 0.405161224106438 | 0.0161959885422343 |
| Olives | Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) | rs10256030 | 30.8457789470795 | 8.18097340448473 | 0.0001629671967571 |
| Olives | Ankylosing hyperostosis [Forestier] (finn-b-M13_FORESTIER) | All - Inverse variance weighted | 6.15560351821524 | 2.45204960588675 | 0.0120597511199265 |
| Olives | Osteomalacia (finn-b-M13_OSTEOMALACIA) | All - Inverse variance weighted | -6.16623641793617 | 2.92950027096358 | 0.0353020556126417 |
| Olives | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | rs1254930 | 23.4560661707972 | 8.60978109445324 | 0.0064427984260899 |
| Olives | Short Achilles tendon (acquired) (finn-b-M13_SHORTACHILLES) | All - Inverse variance weighted | 3.48960239437151 | 1.77836532793913 | 0.0497330561845769 |
| Olives | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | rs143594827 | 13.7040605979288 | 6.7605479184709 | 0.0426559088881415 |
| Olives | Bursitis of shoulder (finn-b-M13_SHOULDERBURSITIS) | All - Inverse variance weighted | 4.10666697552829 | 1.79298310763078 | 0.0219975430693037 |
| Olives | Spinal osteochondrosis (finn-b-M13_SPINALOSTEOCHON) | All - MR Egger | -8.70574844474426 | 4.14561405633877 | 0.0479894391483991 |
| Olives | Dislocation, sprain and strain of joint and ligaments of hip (finn-b-ST19_DISLO_SPRAIN_STRAIN_JOINT_LIGAM_HIP) | All - MR Egger | 7.41857016037363 | 2.81694195069774 | 0.0155292602873523 |
| Olives | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | rs117784231 | 9.23530704483413 | 3.87363939409184 | 0.0171189872360085 |
| Olives | Fracture at wrist and hand level (finn-b-ST19_FRACT_WRIST_HAND_LEVEL) | All - MR Egger | 1.64590735964406 | 0.775688172292186 | 0.0459121153599755 |
| Olives | Injuries to the elbow and forearm (finn-b-ST19_INJURI_ELBOW_FOREA) | All - Inverse variance weighted | -0.79438605657164 | 0.300602626017096 | 0.0082261209884522 |
| Olives | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | rs147867359 | -11.0065867542608 | 5.28354381519635 | 0.0372345788615622 |
| Olives | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | All - Inverse variance weighted | -1.96931837786503 | 0.898845421449797 | 0.028455974390484 |
| Olives | Open wound of ankle and foot (finn-b-ST19_OPEN_WOUND_ANKLE_FOOT) | All - MR Egger | -3.44347760510555 | 1.56979767124178 | 0.0396601719747903 |
| Olives | Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) | rs10256030 | 13.3487294299393 | 5.05993107044694 | 0.0083365905835319 |
| Olives | Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) | rs2458265 | -18.07555463568 | 8.86037274671555 | 0.0413458943347944 |
| Olives | Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) | rs77746944 | 15.2392969174421 | 5.50269000928798 | 0.0056155029372328 |
| Olives | Sequelae of injuries of neck and trunk (finn-b-ST19_SEQUEL_INJURI_NECK_TRUNK) | All - MR Egger | 7.49532883308587 | 3.55648414735029 | 0.0472659492973303 |
| Olives | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | rs3770136 | 6.3011917659805 | 3.09425785482124 | 0.0417087440274466 |
| Olives | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | rs78581117 | -7.19593618199008 | 3.10076759918293 | 0.0203033052304446 |
| Olives | Superficial injury of wrist and hand (finn-b-ST19_SUPERF_INJURY_WRIST_HAND) | All - MR Egger | -3.51384008506813 | 1.28522875025017 | 0.012433777858411 |
| Olives | Bone morphogenetic protein 6 (prot-a-256) | rs1382646 | -6.17536563694749 | 2.86831908390755 | 0.0313221132748421 |
| Olives | Bone morphogenetic protein 6 (prot-a-256) | All - Inverse variance weighted | -1.24295494160108 | 0.584622426857762 | 0.0334964718518217 |
| Olives | Bone morphogenetic protein 7 (prot-a-257) | rs147710942 | -5.89853741225872 | 2.77502307141274 | 0.0335381300816564 |
| Olives | Bone morphogenetic protein 7 (prot-a-257) | All - Inverse variance weighted | -1.39151088831544 | 0.584639906618294 | 0.0173071814766605 |
| Olives | Bone morphogenetic protein 7 (prot-a-257) | All - MR Egger | -2.33047510971977 | 1.04344750052544 | 0.0365301279242365 |
| Olives | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | rs12235254 | 0.314570555066951 | 0.12441053405063 | 0.0114554969229491 |
| Olives | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | rs17523972 | 0.292719728404376 | 0.139166629175765 | 0.0354329268673003 |
| Olives | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | All - Inverse variance weighted | 0.0598362324592035 | 0.0232156768003987 | 0.009954485582763 |
| Olives | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-a-472) | All - MR Egger | 0.127180778143643 | 0.0406096326017786 | 0.0045280817138166 |
| Olives | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs10256030 | -1.06797677254424 | 0.371717710346883 | 0.0040648406068495 |
| Olives | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs1254930 | -1.03213608775378 | 0.345574689584932 | 0.0028198452398561 |
| Olives | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs2308655 | -1.30565160717511 | 0.35510072181976 | 0.0002361330511819 |
| Olives | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | rs78581117 | -0.903582292804554 | 0.35602886212116 | 0.0111504949829356 |
| Olives | Heel bone mineral density (BMD) T-score automated (ukb-a-500) | All - Inverse variance weighted | -0.223805248719195 | 0.092319770672199 | 0.0153404783591346 |
| Olives | Diagnoses - main ICD10: M25 Other joint disorders not elsewhere classified (ukb-a-568) | All - MR Egger | -0.0267061577829856 | 0.0116072666775823 | 0.0303963543993034 |
| Olives | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | rs2308655 | 0.0556889276722238 | 0.0279244363299262 | 0.0461223132637685 |
| Olives | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | rs62171682 | -0.071572708319992 | 0.0293499405867327 | 0.0147443575610133 |
| Olives | Operative procedures - secondary OPCS: Z84.6 Knee joint (ukb-b-10001) | All - MR Egger | -0.230010486156316 | 0.0792725657044875 | 0.0272805376494523 |
| Olives | Heel bone mineral density (BMD) (left) (ukb-b-1096) | rs2458265 | -0.832275804973241 | 0.392150833308694 | 0.0338095379824993 |
| Olives | Heel bone mineral density (BMD) (left) (ukb-b-1096) | All - MR Egger | 0.279754174376696 | 0.132492904136925 | 0.0445000522542701 |
| Olives | Operation code: knee replacement/revision (ukb-b-11120) | rs62171682 | -0.0650960218014672 | 0.0270829864594673 | 0.0162355827664673 |
| Olives | Operation code: knee replacement/revision (ukb-b-11120) | All - Inverse variance weighted | -0.0235465042185487 | 0.0094198981495932 | 0.0124313979554397 |
| Olives | Diagnoses - secondary ICD10: M06.99 Rheumatoid arthritis, unspecified (Site unspecified) (ukb-b-11874) | All - Inverse variance weighted | 0.0122318979680413 | 0.0061701117525179 | 0.0474296245228684 |
| Olives | Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) | rs2458265 | -0.84443294600002 | 0.39227403092753 | 0.0313453430391853 |
| Olives | Heel bone mineral density (BMD) T-score, automated (left) (ukb-b-15730) | All - MR Egger | 0.280159431930737 | 0.132540378712471 | 0.0442858017975764 |
| Olives | Operative procedures - secondary OPCS: Z84.1 Sacroiliac joint (ukb-b-16715) | All - Inverse variance weighted | -0.0129693691711382 | 0.0064341607530575 | 0.0438308459641622 |
| Olives | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | rs12235254 | 0.231879704400864 | 0.104779690313836 | 0.026896165402066 |
| Olives | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | All - Inverse variance weighted | 0.0454279108312045 | 0.0190897242625292 | 0.0173265061574753 |
| Olives | Pain type(s) experienced in last month: Neck or shoulder pain (ukb-b-18596) | All - MR Egger | 0.105340047385454 | 0.0336945084363155 | 0.004321762732454 |
| Olives | Ankle spacing width (left) (ukb-b-2122) | rs2308655 | -1.31097222615133 | 0.345914221611941 | 0.0001507221205529 |
| Olives | Ankle spacing width (left) (ukb-b-2122) | rs3770136 | -0.73910465872156 | 0.346388732394366 | 0.0328637943711266 |
| Olives | Ankle spacing width (left) (ukb-b-2122) | rs60260736 | -0.947352951301083 | 0.359798965700773 | 0.0084632772030205 |
| Olives | Ankle spacing width (left) (ukb-b-2122) | All - Inverse variance weighted | -0.151682809992179 | 0.0766520911247172 | 0.0478331623582311 |
| Olives | Ankle spacing width (right) (ukb-b-8607) | rs2308655 | -1.47764143162733 | 0.350138074958708 | 2.44120537252413e-05 |
| Olives | Ankle spacing width (right) (ukb-b-8607) | All - Inverse variance weighted | -0.152927040341162 | 0.077002814993994 | 0.0470341173536857 |
| Olives | Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) | rs1382646 | 0.0500178809094562 | 0.0176592230468332 | 0.0046200852822012 |
| Olives | Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) | rs60260736 | 0.0390189780403393 | 0.0180673750883762 | 0.0308007547212228 |
| Olives | Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) | rs73119845 | 0.0392386263158773 | 0.0173241187167381 | 0.0235144598110031 |
| Olives | Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) | All - Inverse variance weighted | 0.0095162592379867 | 0.0039451559308058 | 0.0158592918585588 |
| Olives | Diagnoses - main ICD10: M06 Other rheumatoid arthritis (ukb-d-M06) | All - MR Egger | 0.0168837781056011 | 0.0072143767020638 | 0.0292202446733707 |
| Olives | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | rs1254930 | -0.0515905745778387 | 0.0253330835893741 | 0.0417011636568391 |
| Olives | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | rs17523972 | 0.0615589062808219 | 0.0308429569592918 | 0.045946755502829 |
| Olives | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | rs78581117 | 0.0534595847028798 | 0.0260430188642275 | 0.0400976582328467 |
| Olives | Impingement syndrome of shoulder (ukb-d-M13_IMPINGEMENT) | All - MR Egger | 0.0193632559789286 | 0.0088996047296308 | 0.0392342674248042 |
| Olives | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | rs1382646 | 0.0554105419943297 | 0.0183858884599928 | 0.0025803707553712 |
| Olives | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | rs147867359 | 0.0368409185149516 | 0.0165218421510234 | 0.0257586536453966 |
| Olives | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | rs60260736 | 0.0441573744793418 | 0.0188108471667986 | 0.018902811084508 |
| Olives | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | rs73119845 | 0.0355984217814184 | 0.0180370697852889 | 0.0484243362726211 |
| Olives | Rheumatoid arthritis (ukb-d-M13_RHEUMA) | All - Inverse variance weighted | 0.0086466674388909 | 0.004342131416505 | 0.0464433318696512 |
| Olives | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | rs73119845 | 0.0414601024340602 | 0.0161223536477536 | 0.0101232354374236 |
| Olives | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | rs887263 | 0.0378280074386767 | 0.0165711047192657 | 0.0224439672147212 |
| Olives | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | All - Inverse variance weighted | 0.0091310640434042 | 0.0036980452552768 | 0.013543079023098 |
| Olives | Other/unspecified rheumatoid arthritis (ukb-d-RHEUMA_NOS) | All - MR Egger | 0.0173881468924303 | 0.0074696752844582 | 0.031782642863882 |
| Olives | Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) | rs3770136 | -0.03890383531961 | 0.0186892307692308 | 0.0373773947978266 |
| Olives | Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) | All - Inverse variance weighted | 0.0117318932306223 | 0.0038790659423265 | 0.0024911700788702 |
| Olives | Diagnoses - main ICD10: S62 Fracture at wrist and hand level (ukb-d-S62) | All - MR Egger | 0.0147917621609421 | 0.0070424416626335 | 0.0473816069790123 |
| Olives | Heel bone mineral density (BMD) (ukb-e-3148_CSA) | All - MR Egger | -1.93473158291264 | 0.893181095920701 | 0.0439721727835364 |
| Olives | Heel bone mineral density (BMD) (ukb-e-3148_EAS) | rs2458265 | -19.100558824399 | 8.03741265288824 | 0.0174798383216718 |
| Olives | Heel bone mineral density (BMD) (ukb-e-3148_EAS) | All - Inverse variance weighted | -1.82697821756513 | 0.780961214913812 | 0.0193149036546607 |
| Olives | Knee pain for 3+ months (ukb-e-3773_CSA) | rs76338277 | -17.9451187625575 | 8.20191010926706 | 0.0286754693002886 |
| Olives | Ankle spacing width (left) (ukb-e-4100_AFR) | rs1382646 | -5.45644247324315 | 2.75034194935094 | 0.0472654046246712 |
| Olives | Ankle spacing width (left) (ukb-e-4100_AFR) | All - Inverse variance weighted | -0.835746877479386 | 0.404415329047413 | 0.0387760214983639 |
| Olives | Ankle spacing width (right) (ukb-e-4119_AFR) | All - Inverse variance weighted | -0.820635578048098 | 0.417449692355436 | 0.0493181267839396 |
| Olives | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) | rs147710942 | -5.03806514205322 | 2.53624201643072 | 0.0469856895438626 |
| Olives | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_CSA) | All - MR Egger | -1.91173178619027 | 0.890203431466497 | 0.0456197073898289 |
| Olives | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | rs2458265 | -20.0072932990351 | 8.16455259552743 | 0.0142655188244506 |
| Olives | Heel bone mineral density (BMD) T-score, automated (ukb-e-78_p1_EAS) | All - Inverse variance weighted | -1.73528060623678 | 0.792888130545487 | 0.028629078119826 |